(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent (Unknown)
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In:
Journal of Medicinal Chemistry
;
41
, 24
;
4890-4902
;
1998
- Article (Journal) / Electronic Resource
-
Title:(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent
-
Additional title:J. Med. Chem.
-
Contributors:Njoroge, F. George ( author ) / Taveras, Arthur G. ( author ) / Kelly, Joseph ( author ) / Remiszewski, Stacy ( author ) / Mallams, Alan K. ( author ) / Wolin, Ronald ( author ) / Afonso, Adriano ( author ) / Cooper, Alan B. ( author ) / Rane, Dinananth F. ( author ) / Liu, Yi-Tsung ( author )
-
Published in:Journal of Medicinal Chemistry ; 41, 24 ; 4890-4902
-
Publisher:
- New search for: American Chemical Society
-
Publication date:1998-11-19
-
ISSN:
-
Coden:
-
DOI:
-
Type of media:Article (Journal)
-
Type of material:Electronic Resource
-
Language:Unknown
-
Source:
Table of contents – Volume 41, Issue 24
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 4677
-
COMMUNICATIONS TO THE EDITOR - Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-a-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica GelPeng, Hairuo et al. | 1998
- 4677
-
Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-α-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica GelPeng, Hairuo / Zalkow, Leon H. / Abraham, Robert T. / Powis, Garth et al. | 1998
- 4681
-
Syntheses of New Isodethiaazacephems as Potent Antibacterial AgentsHwu, Jih Ru / Tsay, Shwu-Chen / Hakimelahi, Shahram et al. | 1998
- 4681
-
EXPEDITED ARTICLES - Syntheses of New Isodethiaazacephems as Potent Antibacterial AgentsHwu, Jih Ru et al. | 1998
- 4686
-
Synthesis and Evaluation of 11β-Substituted 21-Chloro/Iodo-(17α,20E/Z)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols: High-Affinity Ligands for the Estrogen ReceptorHanson, Robert N. / Napolitano, Elio / Fiaschi, Rita et al. | 1998
- 4686
-
ARTICLES - Synthesis and Evaluation of 11b-Substituted 21-Chloro-Iodo-(17a,20E-Z)-19-norpregna-1, 3,5(10),20-tetraene-3,17b-diols: High-Affinity Ligands for the Estrogen ReceptorHanson, Robert N. et al. | 1998
- 4693
-
Nonpeptide Somatostatin Agonists with sst4 Selectivity: Synthesis and Structure−Activity Relationships of ThioureasLiu, Shenquan / Tang, Cheng / Ho, Bin / Ankersen, Michael / Stidsen, Carsten E. / Crider, A. Michael et al. | 1998
- 4693
-
ARTICLES - Nonpeptide Somatostatin Agonists with sst4 Selectivity: Synthesis and Structure-Activity Relationships of ThioureasLiu, Shenquan et al. | 1998
- 4706
-
ARTICLES - Synthesis, Activity, and Molecular Modeling of New 2,4-Dioxo-5-(naphthylmethylene)-3-thiazolidineacetic Acids and 2-Thioxo Analogues as Potent Aldose Reductase InhibitorsFresneau, Patrick et al. | 1998
- 4706
-
Synthesis, Activity, and Molecular Modeling of New 2,4-Dioxo-5-(naphthylmethylene)-3-thiazolidineacetic Acids and 2-Thioxo Analogues as Potent Aldose Reductase InhibitorsFresneau, Patrick / Cussac, Max / Morand, Jean-Marc / Szymonski, Barbara / Tranqui, Duc / Leclerc, Gérard et al. | 1998
- 4716
-
ARTICLES - Synthesis and Cytotoxicity of 2-Methyl-4,9-dihydro-1-substituted-1H-imidazo(4,5-g)quinoxaline-4, 9-diones and 2,3-Disubstituted-5,10-pyrazino(2,3-g)quinoxalinedionesYoo, Hee-Won et al. | 1998
- 4716
-
Synthesis and Cytotoxicity of 2-Methyl-4,9-dihydro-1-substituted-1H-imidazo[4,5-g]quinoxaline-4,9-diones and 2,3-Disubstituted-5,10-pyrazino[2,3-g]quinoxalinedionesYoo, Hee-Won / Suh, Myung-Eun / Park, Sang Woo et al. | 1998
- 4723
-
Conformationally Restricted Analogues of ^1N,^1^2N-Bisethylspermine: Synthesis and Growth Inhibitory Effects on Human Tumor Cell LinesReddy, V. K. / Valasinas, A. / Sarkar, A. / Basu, H. S. / Marton, L. J. / Frydman, B. et al. | 1998
- 4723
-
Conformationally Restricted Analogues of 1 N, N-Bisethylspermine: Synthesis and Growth Inhibitory Effects on Human Tumor Cell LinesReddy, Venodhar K. / Valasinas, Aldonia / Sarkar, Aparajita / Basu, Hirak S. / Marton, Laurence J. / Frydman, Benjamin et al. | 1998
- 4723
-
ARTICLES - Conformationally Restricted Analogues of 1N,12N-Bisethylspermine: Synthesis and Growth Inhibitory Effects on Human Tumor Cell LinesReddy, Venodhar K. et al. | 1998
- 4733
-
Synthesis of 7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and Novel Derivatives Free of Positional Isomers. Potent Inhibitors of cAMP-Specific Phosphodiesterase and of Malignant Tumor Cell GrowthMerz, Karl-Heinz / Marko, Doris / Regiert, Thomas / Reiss, Guido / Frank, Walter / Eisenbrand, Gerhard et al. | 1998
- 4733
-
ARTICLES - Synthesis of 7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine and Novel Derivatives Free of Positional Isomers. Potent Inhibitors of cAMP-Specific Phosphodiesterase and of Malignant Tumor Cell GrowthMerz, Karl-Heinz et al. | 1998
- 4744
-
DNA-Directed Alkylating Agents. 7. Synthesis, DNA Interaction, and Antitumor Activity of Bis(hydroxymethyl)- and Bis(carbamate)-Substituted Pyrrolizines and ImidazolesAtwell, Graham J. / Fan, Jun-Yao / Tan, Karin / Denny, William A. et al. | 1998
- 4744
-
ARTICLES - DNA-Directed Alkylating Agents. 7. Synthesis, DNA Interaction, and Antitumor Activity of Bis(hydroxymethyl)- and Bis(carbamate)-Substituted Pyrrolizines and ImidazolesAtwell, Graham J. et al. | 1998
- 4755
-
ARTICLES - Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro CytotoxicityBeall, Howard D. et al. | 1998
- 4755
-
Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro CytotoxicityBeall, Howard D. / Winski, Shannon / Swann, Elizabeth / Hudnott, Anna R. / Cotterill, Ann S. / O'Sullivan, Noeleen / Green, Stephen J. / Bien, Richard / Siegel, David / Ross, David et al. | 1998
- 4767
-
De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor ‖Liao, Subo / Alfaro-Lopez, Josue / Shenderovich, Mark D. / Hosohata, Keiko / Lin, Jun / Li, Xiaoping / Stropova, Dagmar / Davis, Peg / Jernigan, Kevin A. / Porreca, Frank et al. | 1998
- 4767
-
ARTICLES - De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the d-Opioid ReceptorLiao, Subo et al. | 1998
- 4777
-
Conformational Analysis and Automated Receptor Docking of Selective Arylacetamide-Based kappa-Opioid AgonistsSubramanian, G. / Paterlini, M. G. / Larson, D. L. / Portoghese, P. S. / Ferguson, D. M. et al. | 1998
- 4777
-
Conformational Analysis and Automated Receptor Docking of Selective Arylacetamide-Based κ-Opioid AgonistsSubramanian, Govindan / Paterlini, M. Germana / Larson, Dennis L. / Portoghese, Philip S. / Ferguson, David M. et al. | 1998
- 4777
-
ARTICLES - Conformational Analysis and Automated Receptor Docking of Selective Arylacetamide-Based k-Opioid AgonistsSubramanian, Govindan et al. | 1998
- 4790
-
Selective Tight Binding Inhibitors of Trypanosomal Glyceraldehyde-3-phosphate Dehydrogenase via Structure-Based Drug DesignAronov, Alex M. / Verlinde, Christophe L. M. J. / Hol, Wim G. J. / Gelb, Michael H. et al. | 1998
- 4790
-
ARTICLES - Selective Tight Binding Inhibitors of Trypanosomal Glyceraldehyde-3-phosphate Dehydrogenase via Structure-Based Drug DesignAronov, Alex M. et al. | 1998
- 4800
-
ARTICLES - Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 InactivatorsKalgutkar, Amit S. et al. | 1998
- 4800
-
Covalent Modification of Cyclooxygenase-2 (COX-2) by 2-Acetoxyphenyl Alkyl Sulfides, a New Class of Selective COX-2 Inactivators †Kalgutkar, Amit S. / Kozak, Kevin R. / Crews, Brenda C. / Hochgesang, G. Phillip / Marnett, Lawrence J. et al. | 1998
- 4819
-
Antileishmanial Chalcones: Statistical Design, Synthesis, and Three-Dimensional Quantitative Structure−Activity Relationship AnalysisNielsen, Simon Feldbæk / Christensen, Søren Brøgger / Cruciani, Gabriele / Kharazmi, Arsalan / Liljefors, Tommy et al. | 1998
- 4819
-
ARTICLES - Antileishmanial Chalcones: Statistical Design, Synthesis, and Three-Dimensional Quantitative Structure-Activity Relationship AnalysisNielsen, Simon Feldbaek et al. | 1998
- 4833
-
Design and Synthesis of Hydrazinopeptides and Their Evaluation as Human Leukocyte Elastase InhibitorsGuy, Laure / Vidal, Joëlle / Collet, André / Amour, Augustin / Reboud-Ravaux, Michèle et al. | 1998
- 4833
-
ARTICLES - Design and Synthesis of Hydrazinopeptides and Their Evaluation as Human Leukocyte Elastase InhibitorsGuy, Laure et al. | 1998
- 4844
-
ARTICLES - Design, Synthesis, and Biological Activity of Prazosin-Related Antagonists. Role of the Piperazine and Furan Units of Prazosin on the Selectivity for a1-Adrenoreceptor SubtypesBolognesi, Maria L. et al. | 1998
- 4844
-
Design, Synthesis, and Biological Activity of Prazosin-Related Antagonists. Role of the Piperazine and Furan Units of Prazosin on the Selectivity for α1-Adrenoreceptor SubtypesBolognesi, Maria L. / Budriesi, Roberta / Chiarini, Alberto / Poggesi, Elena / Leonardi, Amedeo / Melchiorre, Carlo et al. | 1998
- 4844
-
Design, Synthesis, and Biological Activity of Prazosin-Related Antagonists. Role of the Piperazine and Furan Units of Frazosin on the Selectivity for ~1-Adrenoreceptor SubtypesBolognesi, M. L. / Budriesi, R. / Chiarini, A. / Poggesi, E. / Leonardi, A. / Melchiorre, C. et al. | 1998
- 4854
-
1,2-Benzisothiazol-3-one 1,1-Dioxide Inhibitors of Human Mast Cell TryptaseCombrink, Keith D. / Gülgeze, H. Belgin / Meanwell, Nicholas A. / Pearce, Bradley C. / Zulan, Pi / Bisacchi, Gregory S. / Roberts, Daniel G. M. / Stanley, Paul / Seiler, Steven M. et al. | 1998
- 4854
-
ARTICLES - 1,2-Benzisothiazol-3-one 1,1-Dioxide Inhibitors of Human Mast Cell TryptaseCombrink, Keith D. et al. | 1998
- 4861
-
Exploration of Biologically Relevant Conformations of Anandamide, 2-Arachidonylglycerol, and Their Analogues Using Conformational MemoriesBarnett-Norris, Judy / Guarnieri, Frank / Hurst, Dow P. / Reggio, Patricia H. et al. | 1998
- 4861
-
ARTICLES - Exploration of Biologically Relevant Conformations of Anandamide, 2-Arachidonylglycerol, and Their Analogues Using Conformational MemoriesBarnett-Norris, Judy et al. | 1998
- 4873
-
ARTICLES - Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-dionesPerry, Philip J. et al. | 1998
- 4873
-
Human Telomerase Inhibition by Regioisomeric Disubstituted Amidoanthracene-9,10-dionesPerry, Philip J. / Reszka, Anthony P. / Wood, Alexis A. / Read, Martin A. / Gowan, Sharon M. / Dosanjh, Harvinder S. / Trent, John O. / Jenkins, Terence C. / Kelland, Lloyd R. / Neidle, Stephen et al. | 1998
- 4885
-
Synthesis and Biological Evaluation of 4-Chloro-3,5-dinitrobenzotrifluoride Analogues as Antileishmanial AgentsPitzer, Kevin K. / Werbovetz, Karl A. / Brendle, James J. / Scovill, John P. et al. | 1998
- 4885
-
ARTICLES - Synthesis and Biological Evaluation of 4-Chloro-3,5-dinitrobenzotrifluoride Analogues as Antileishmanial AgentsPitzer, Kevin K. et al. | 1998
- 4890
-
(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor AgentNjoroge, F. George / Taveras, Arthur G. / Kelly, Joseph / Remiszewski, Stacy / Mallams, Alan K. / Wolin, Ronald / Afonso, Adriano / Cooper, Alan B. / Rane, Dinananth F. / Liu, Yi-Tsung et al. | 1998
- 4890
-
ARTICLES - (+)-4-(2-(4-(8-Chloro-3,10-dibromo-6, 11-dihydro-5H-benzo(5,6)cyclohepta(1, 2-b)-pyridin-11 (R)-yl)-1-piperidinyl)-2-oxo-ethyl)-1-piperidinecarboxamide (SCH-66336): A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor AgentNjoroge, F.George et al. | 1998
- 4903
-
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: A Potent and Selective Dopamine D4 LigandPerrone, Roberto / Berardi, Francesco / Colabufo, Nicola A. / Leopoldo, Marcello / Tortorella, Vincenzo et al. | 1998
- 4903
-
NOTES - N-(2-(4-(4-Chlorophenyl)piperazin-1-yl)ethyl)-3-methoxybenzamide: A Potent and Selective Dopamine D4 LigandPerrone, Roberto et al. | 1998
- 4910
-
Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial DrugsChan, Cecil / Yin, Hong / Garforth, Jacqui / McKie, James H. / Jaouhari, Rabih / Speers, Peter / Douglas, Kenneth T. / Rock, Peter J. / Yardley, Vanessa / Croft, Simon L. et al. | 1998
- 4910
-
ADDITIONS AND CORRECTIONS - Phenothiazine Inhibitors of Trypanothione Reductase as Potential Antitrypanosomal and Antileishmanial DrugsChan, Cecil et al. | 1998