1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel (Unknown)
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In:
Journal of Medicinal Chemistry
;
50
, 9
;
2011-2029
;
2007
- Article (Journal) / Electronic Resource
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Title:1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion Channel
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Additional title:J. Med. Chem.
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Contributors:Dinges, Jürgen ( author ) / Albert, Daniel H. ( author ) / Arnold, Lee D. ( author ) / Ashworth, Kimba L. ( author ) / Akritopoulou-Zanze, Irini ( author ) / Bousquet, Peter F. ( author ) / Bouska, Jennifer J. ( author ) / Cunha, George A. ( author ) / Davidsen, Steven K. ( author ) / Diaz, Gilbert J. ( author )
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Published in:Journal of Medicinal Chemistry ; 50, 9 ; 2011-2029
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Publisher:
- New search for: American Chemical Society
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Publication date:2007-05-03
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Source:
Table of contents – Volume 50, Issue 9
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1999
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Scaffold Targeting Drug-Resistant Colon CancersOtrubova, Katerina / McGuire, Kathleen L. / McAlpine, Shelli R. et al. | 2007
- 2003
-
Design and Synthesis of a Potent Histone Deacetylase InhibitorLiu, Tao / Kapustin, Galina / Etzkorn, Felicia A. et al. | 2007
- 2007
-
9-(2-C-Cyano-2-deoxy-β-d-arabino- pentofuranosyl)guanine, a Potential Antitumor Agent against B-Lymphoma Infected with Kaposi's Sarcoma-Associated HerpesvirusOhtawa, Masaki / Ichikawa, Satoshi / Teishikata, Yasuhiro / Fujimuro, Masahiro / Yokosawa, Hideyoshi / Matsuda, Akira et al. | 2007
- 2007
-
9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a Potential Antitumor Agent against B-Lymphoma Infected with Kaposi's Sarcoma-Associated HerpesvirusOhtawa, M. / Ichikawa, S. / Teishikata, Y. / Fujimuro, M. / Yokosawa, H. / Matsuda, A. et al. | 2007
- 2011
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1,4-Dihydroindeno[1,2-c]pyrazoles with Acetylenic Side Chains as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors with Low Affinity for the hERG Ion ChannelDinges, Jürgen / Albert, Daniel H. / Arnold, Lee D. / Ashworth, Kimba L. / Akritopoulou-Zanze, Irini / Bousquet, Peter F. / Bouska, Jennifer J. / Cunha, George A. / Davidsen, Steven K. / Diaz, Gilbert J. et al. | 2007
- 2030
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Structure−Activity Relationship of Uridine 5‘-Diphosphoglucose Analogues as Agonists of the Human P2Y14 ReceptorKo, Hyojin / Fricks, Ingrid / Ivanov, Andrei A. / Harden, T. Kendall / Jacobson, Kenneth A. et al. | 2007
- 2040
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Investigation of the Lactam Side Chain Length Necessary for Optimal Indenoisoquinoline Topoisomerase I Inhibition and Cytotoxicity in Human Cancer Cell CulturesMorrell, Andrew / Placzek, Michael S. / Steffen, Jamin D. / Antony, Smitha / Agama, Keli / Pommier, Yves / Cushman, Mark et al. | 2007
- 2049
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Quantitative Structure−Activity Relationship of Peptides Binding to the Class II Major Histocompatibility Complex Molecule Aq Associated with Autoimmune ArthritisHolm, Lotta / Frech, Kristina / Dzhambazov, Balik / Holmdahl, Rikard / Kihlberg, Jan / Linusson, Anna et al. | 2007
- 2060
-
Synthesis, Biological Testing, and Binding Mode Prediction of 6,9-Diarylpurin-8-ones as p38 MAP Kinase InhibitorsHauser, Dominik R. J. / Scior, Thomas / Domeyer, David M. / Kammerer, Bernd / Laufer, Stefan A. et al. | 2007
- 2067
-
Structure−Activity Relationship Studies of Gonadotropin-Releasing Hormone Antagonists Containing S-Aryl/Alkyl Norcysteines and Their Oxidized DerivativesSamant, Manoj P. / White, Richard / Hong, Doley J. / Croston, Glenn / Conn, P. Michael / Janovick, Jo Ann / Rivier, Jean et al. | 2007
- 2078
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Radiolabeled Phenethylguanidines: Novel Imaging Agents for Cardiac Sympathetic Neurons and Adrenergic TumorsRaffel, David M. / Jung, Yong-Woon / Gildersleeve, David L. / Sherman, Phillip S. / Moskwa, James J. / Tluczek, Louis J. / Chen, Wei et al. | 2007
- 2089
-
Structure-Based Design and Synthesis of N^o^m^e^g^a-Nitro-L-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural WaterSeo, J. / Igarashi, J. / Li, H. / Martasek, P. / Roman, L. J. / Poulos, T. L. / Silverman, R. B. et al. | 2007
- 2089
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Structure-Based Design and Synthesis of N ω-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural WaterSeo, Jiwon / Igarashi, Jotato / Li, Huiying / Martásek, Pavel / Roman, Linda J. / Poulos, Thomas L. / Silverman, Richard B. et al. | 2007
- 2100
-
Highly Photocytotoxic Glucosylated Silicon(IV) Phthalocyanines. Effects of Peripheral Chloro Substitution on the Photophysical and Photodynamic PropertiesLo, Pui-Chi / Chan, Crystal M. H. / Liu, Jian-Yong / Fong, Wing-Ping / Ng, Dennis K. P. et al. | 2007
- 2108
-
Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B PolymeraseNittoli, Thomas / Curran, Kevin / Insaf, Shabana / DiGrandi, Martin / Orlowski, Mark / Chopra, Rajiv / Agarwal, Atul / Howe, Anita Y. M. / Prashad, Amar / Floyd, M. Brawner et al. | 2007
- 2117
-
Virtual Screening for Novel Openers of Pancreatic KATP ChannelsCarosati, Emanuele / Mannhold, Raimund / Wahl, Philip / Hansen, John Bondo / Fremming, Tinna / Zamora, Ismael / Cianchetta, Giovanni / Baroni, Massimo et al. | 2007
- 2127
-
A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A MetalloproteaseBurnett, James C. / Opsenica, Dejan / Sriraghavan, Kamaraj / Panchal, Rekha G. / Ruthel, Gordon / Hermone, Ann R. / Nguyen, Tam L. / Kenny, Tara A. / Lane, Douglas J. / McGrath, Connor F. et al. | 2007
- 2137
-
Development of Molecular Probes for Second-Site Screening and Design of Protein Tyrosine Phosphatase InhibitorsVazquez, Jesus / Tautz, Lutz / Ryan, Jennifer J. / Vuori, Kristiina / Mustelin, Tomas / Pellecchia, Maurizio et al. | 2007
- 2144
-
Indium-Labeled Macrocyclic Conjugates of Naltrindole: High-Affinity Radioligands for In Vivo Studies of Peripheral δ Opioid ReceptorsDuval, Romain A. / Allmon, Rachel L. / Lever, John R. et al. | 2007
- 2144
-
Indium-Labeled Macrocyclic Conjugates of Naltrindole: High-Affinity Radioligands for In Vivo Studies of Peripheral delta Opioid ReceptorsDuval, R. A. / Allmon, R. L. / Lever, J. R. et al. | 2007
- 2157
-
Novel Styrylpyridines as Probes for SPECT Imaging of Amyloid PlaquesQu, Wenchao / Kung, Mei-Ping / Hou, Catherine / Benedum, Tyler E. / Kung, Hank F. et al. | 2007
- 2166
-
Development of Ruthenium Antitumor Drugs that Overcome Multidrug Resistance MechanismsVock, Carsten A. / Ang, Wee Han / Scolaro, Claudine / Phillips, Andrew D. / Lagopoulos, Lucienne / Juillerat-Jeanneret, Lucienne / Sava, Gianni / Scopelliti, Rosario / Dyson, Paul J. et al. | 2007
- 2176
-
Synthesis and Pharmacological Evaluation of a Selected Library of New Potential Anti-inflammatory Agents Bearing the gamma-Hydroxybutenolide Scaffold: a New Class of Inhibitors of Prostanoid Production through the Selective Modulation of Microsomal Prostaglandin E Synthase-1 ExpressionGuerrero, M. D. / Aquino, M. / Bruno, I. / Terencio, M. C. / Paya, M. / Riccio, R. / Gomez-Paloma, L. et al. | 2007
- 2176
-
Synthesis and Pharmacological Evaluation of a Selected Library of New Potential Anti-inflammatory Agents Bearing the γ-Hydroxybutenolide Scaffold: a New Class of Inhibitors of Prostanoid Production through the Selective Modulation of Microsomal Prostaglandin E Synthase-1 ExpressionGuerrero, Maria D. / Aquino, Maurizio / Bruno, Ines / Terencio, María C. / Paya, Miguel / Riccio, Raffaele / Gomez-Paloma, Luigi et al. | 2007
- 2185
-
Structure−Activity Relationships for NAMI-A-type Complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = Imidazole, Indazole, 1,2,4-Triazole, 4-Amino-1,2,4-triazole, and 1-Methyl-1,2,4-triazole): Aquation, Redox Properties, Protein Binding, and Antiproliferative ActivityGroessl, Michael / Reisner, Erwin / Hartinger, Christian G. / Eichinger, Rene / Semenova, Olga / Timerbaev, Andrei R. / Jakupec, Michael A. / Arion, Vladimir B. / Keppler, Bernhard K. et al. | 2007
- 2194
-
New trans-Platinum Drugs with Phosphines and Amines as Carrier Ligands Induce Apoptosis in Tumor Cells Resistant to CisplatinRamos-Lima, Francisco J. / Quiroga, Adoración G. / García-Serrelde, Beatriz / Blanco, Fernando / Carnero, Amancio / Navarro-Ranninger, Carmen et al. | 2007
- 2200
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Potent Nonpeptide Antagonists of the Bradykinin B1 Receptor: Structure−Activity Relationship Studies with Novel Diaminochroman CarboxamidesBiswas, Kaustav / Li, Aiwen / Chen, Jian Jeffrey / D'Amico, Derin C. / Fotsch, Christopher / Han, Nianhe / Human, Jason / Liu, Qingyian / Norman, Mark H. / Riahi, Bobby et al. | 2007
- 2213
-
Discovery, Synthesis, and in Vivo Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B KinaseMortlock, Andrew A. / Foote, Kevin M. / Heron, Nicola M. / Jung, Frédéric H. / Pasquet, Georges / Lohmann, Jean-Jacques M. / Warin, Nicolas / Renaud, Fabrice / De Savi, Chris / Roberts, Nicola J. et al. | 2007
- 2225
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Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase InhibitorsPace, Paola / Di Francesco, M. Emilia / Gardelli, Cristina / Harper, Steven / Muraglia, Ester / Nizi, Emanuela / Orvieto, Federica / Petrocchi, Alessia / Poma, Marco / Rowley, Michael et al. | 2007
- 2240
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A Swift All-Atom Energy-Based Computational Protocol to Predict DNA−Ligand Binding Affinity and ΔT mShaikh, Saher Afshan / Jayaram, B. et al. | 2007
- 2240
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A Swift All-Atom Energy-Based Computational Protocol to Predict DNA-Ligand Binding Affinity and DeltaT~mShaikh, S. A. / Jayaram, B. et al. | 2007
- 2245
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Novel 3-O-Glycosyl-3-demethylthiocolchicines as Ligands for Glycine and γ-Aminobutyric Acid ReceptorsGelmi, Maria Luisa / Fontana, Gabriele / Pocar, Donato / Pontremoli, Guido / Pellegrino, Sara / Bombardelli, Ezio / Riva, Antonella / Balduini, Walter / Carloni, Silvia / Cimino, Mauro et al. | 2007
- 2245
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Novel 3-O-Glycosyl-3-demethylthiocolchicines as Ligands for Glycine and gamma-Aminobutyric Acid ReceptorsGelmi, M. L. / Fontana, G. / Pocar, D. / Pontremoli, G. / Pellegrino, S. / Bombardelli, E. / Riva, A. / Balduini, W. / Carloni, S. / Cimino, M. et al. | 2007
- 2249
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In Vitro Optimization of Non-Small Cell Lung Cancer Activity with Troxacitabine, l-1,3-Dioxolane-cytidine, ProdrugsRadi, Marco / Adema, Auke D. / Daft, Jonathan R. / Cho, Jong H. / Hoebe, Eveline K. / Alexander, Lou-Ella M. M. / Peters, Godefridus J. / Chu, Chung K. et al. | 2007
- 2254
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Pharmacological Properties of Bivalent Ligands Containing Butorphan Linked to Nalbuphine, Naltrexone, and Naloxone at μ, δ, and κ Opioid ReceptorsPeng, Xuemei / Knapp, Brian I. / Bidlack, Jean M. / Neumeyer, John L. et al. | 2007
- 2254
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Pharmacological Properties of Bivalent Ligands Containing Butorphan Linked to Nalbuphine Naltrexone, and Naloxone at mu, delta, and kappa Opioid ReceptorsPeng, X. / Knapp, B. I. / Bidlack, J. M. / Neumeyer, J. L. et al. | 2007
- 2259
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Effect of the Diamine Nonleaving Group in Platinum−Acridinylthiourea Conjugates on DNA Damage and CytotoxicityGuddneppanavar, Rajsekhar / Choudhury, Jayati Roy / Kheradi, Alexander R. / Steen, Bartlett D. / Saluta, Gilda / Kucera, Gregory L. / Day, Cynthia S. / Bierbach, Ulrich et al. | 2007
- 2264
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Novel Selective Neuropeptide Y2 Receptor PEGylated Peptide Agonists Reduce Food Intake and Body Weight in MiceLumb, Kevin J. / DeCarr, Lynn B. / Milardo, Lucinda F. / Mays, Michelle R. / Buckholz, Thomas M. / Fisk, Stephen E. / Pellegrino, Carla M. / Ortiz, Astrid A. / Mahle, Cathy D. et al. | 2007
- 2269
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Dihydropyridopyrazinones and Dihydropteridinones as Corticotropin-Releasing Factor-1 Receptor Antagonists: Structure−Activity Relationships and Computational ModelingDzierba, Carolyn D. / Tebben, Andrew J. / Wilde, Richard G. / Takvorian, Amy G. / Rafalski, Maria / Kasireddy-Polam, Padmaja / Klaczkiewicz, John D. / Pechulis, Anthony D. / Davis, Amy L. / Sweet, Mark P. et al. | 2007
- 2273
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Synthesis and Biological Evaluation of 2- and 3-Aminobenzo[b]thiophene Derivatives as Antimitotic Agents and Inhibitors of Tubulin PolymerizationRomagnoli, Romeo / Baraldi, Pier Giovanni / Carrion, Maria Dora / Cara, Carlota Lopez / Preti, Delia / Fruttarolo, Francesca / Pavani, Maria Giovanna / Tabrizi, Mojgan Aghazadeh / Tolomeo, Manlio / Grimaudo, Stefania et al. | 2007
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In Silico Technologies in Drug Target Identification and Validation. Drug Discovery Series. Volume 6 Edited by Darryl León and Scott Markel. CRC Press, Boca Raton, FL. 2006. xi + 490 pp. 16 × 24.5 cm. ISBN-13 978-1-57444-478-0. $169.95.Gund, Peter et al. | 2007
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In Silico Technologies in Drug Target Identification and Validation. Drug Discovery Series. Volume 6Gund, P. et al. | 2007
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March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Sixth Edition By Michael B. Smith and Jerry March. John Wiley & Sons, Inc., Hoboken, NJ. 2007. xx + 2354 pp. 16 × 24 cm. ISBN 978-0-471-72091-1. $99.95.| 2007
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March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Sixth EditionUllrich, J. W. / Mewshaw, R. E. et al. | 2007