Asymmetric Hydrogenation of Indazole-Containing Enamides Relevant to the Synthesis of Zavegepant Using Neutral and Cationic Cobalt Precatalysts (English)
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In:
Organic Letters
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26
, 14
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2718-2723
;
2024
- Article (Journal) / Electronic Resource
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Title:Asymmetric Hydrogenation of Indazole-Containing Enamides Relevant to the Synthesis of Zavegepant Using Neutral and Cationic Cobalt Precatalysts
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Additional title:Org. Lett.
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Contributors:Mendelsohn, Lauren N. ( author ) / MacNeil, Connor S. ( author ) / Esposito, Madison R. ( author ) / Pabst, Tyler P. ( author ) / Leahy, David K. ( author ) / Davies, Ian W. ( author ) / Chirik, Paul J. ( author )
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Published in:Organic Letters ; 26, 14 ; 2718-2723
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Publisher:
- New search for: American Chemical Society
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Publication date:2024-04-12
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Source:
Table of contents – Volume 26, Issue 14
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 2669
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Academic-Industrial Collaborations: Merging Paths to ThriveBao, Hongli / Bravo-Altamirano, Karla / Buchan, Zachary / Cabrera, Pablo J. / Ryan, Sarah J. / Roth, Joshua J. / Sartillo-Piscil, Fernando / Sawai, Yasuhiro / Tambar, Uttam K. / Zarate, Cayetana et al. | 2024
- 2672
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Should You Start a Chemistry Podcast?Campeau, Louis-Charles / Horwitz, Matthew A. / Schultz, Danielle M. et al. | 2024
- 2677
-
Better Together: Catalyzing Innovation in Organic Synthesis via Academic-Industrial ConsortiaAlcázar, Jesús / Anderson, Edward A. / Davies, Huw M. L. / Febrian, Rio / Kelly, Christopher B. / Noël, Timothy / Voight, Eric A. / Zarate, Cayetana / Zysman-Colman, Eli et al. | 2024
- 2682
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Academia or Industry: Lessons on Choosing Career PathsThere May Be More Than One Fork in the Road AheadBlackmond, Donna G. / Emmert, Marion / Huryn, Donna M. / Neidig, Michael L. / Schaub, Thomas / Topczewski, Joseph J. / Bravo-Altamirano, Karla / Buchan, Zachary / Cabrera, Pablo J. et al. | 2024
- 2686
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Carbohydrate–DNA Conjugation Enabled by Glycosyl Radicals Generated from Glycosyl SulfinatesZeng, Hongxin / Li, Yanjing / Wu, Rongfeng / Liu, Daqi / Zhang, Yang / Xu, Shiyang / Niu, Dawen et al. | 2024
- 2691
-
Mild Approach to Nucleoside Analogues via Photoredox/Cu-Catalyzed Decarboxylative C–N Bond Formation. Total Synthesis of Oxetanocin AWang, Ruonan / Xu, Hao / Banerjee, Arpan / Cui, Zhongwen / Ma, Yuyong / Whittingham, William G. / Yang, Peng / Li, Ang et al. | 2024
- 2697
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eFluorination of Activated Alcohols Using Collidinium TetrafluoroborateKiaku, Cyrille / Martinage, Dorian / Sicim, Yasemin / Leech, Matthew C. / Walsh, Jamie M. / Poole, Darren L. / Mason, Joseph / Goodall, Iain C. A. / Devo, Perry / Lam, Kevin et al. | 2024
- 2702
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Redefining the Synthetic Logic of Medicinal Chemistry. Photoredox-Catalyzed Reactions as a General Tool for Aliphatic Core FunctionalizationFernández, David F. / González-Esguevillas, María / Keess, Sebastian / Schäfer, Felix / Mohr, Jens / Shavnya, Andre / Knauber, Thomas / Blakemore, David C. / MacMillan, David W. C. et al. | 2024
- 2708
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Automated, Capsule-Based Suzuki–Miyaura Cross CouplingsCoin, Guillaume / Jiang, Tuo / Bordi, Samuele / Nichols, Paula L. / Bode, Jeffrey W. / Wanner, Benedikt M. et al. | 2024
- 2713
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Mechanistic Insights of Copper Catalyzed Trifluoromethyl Aziridine Opening: Regioselective and Stereospecific Aryl Grignard AdditionLee, Miseon / Sulwey, Dennis / Rotella, Madeline E. / Kim, Wan Shin / Ju, Xuan / Jiang, Qi / Kozlowski, Marisa C. / Lee, Jaehee et al. | 2024
- 2718
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Asymmetric Hydrogenation of Indazole-Containing Enamides Relevant to the Synthesis of Zavegepant Using Neutral and Cationic Cobalt PrecatalystsMendelsohn, Lauren N. / MacNeil, Connor S. / Esposito, Madison R. / Pabst, Tyler P. / Leahy, David K. / Davies, Ian W. / Chirik, Paul J. et al. | 2024
- 2724
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Fully Automated Flow Protocol for C(sp3)–C(sp3) Bond Formation from Tertiary Amides and Alkyl HalidesPijper, Brenda / Martín, Raúl / Huertas-Alonso, Alberto J. / Linares, Maria Lourdes / López, Enol / Llaveria, Josep / Díaz-Ortiz, Ángel / Dixon, Darren J. / de la Hoz, Antonio / Alcázar, Jesús et al. | 2024
- 2729
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Synthesis of Highly Substituted Aminotetrahydropyrans Enabled by Stereospecific Multivector C–H FunctionalizationKang, Guowei / Xiao, Li-Jun / Hesp, Kevin D. / Huh, Chan Woo / Lian, Yajing / Richardson, Paul / Schmitt, Daniel C. / Hong, Kai / Yu, Jin-Quan et al. | 2024
- 2733
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Electroreductive Access to 1,2-Aminoalcohols via Cross Aza-Pinacol Coupling of N‑Acyl Diarylketimines and AldehydesKwak, Dongmin / Jung, Sehwa / Ha, Hyeonbin / Han, Taedong / Ryu, Do Hyun / Kim, Hyunwoo / Kwak, Jaesung et al. | 2024
- 2739
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One-Flow Syntheses of Unsymmetrical Sulfamides and N‑Substituted Sulfamate EstersSugisawa, Naoto / Nakabayashi, Kohei / Sugisawa, Hiroki / Fuse, Shinichiro et al. | 2024
- 2745
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Beyond Amide Bond Formation: TCFH as a Reagent for EsterificationLuis, Nathaniel R. / Chung, Kasey K. / Hickey, Matthew R. / Lin, Ziqing / Beutner, Gregory L. / Vosburg, David A. et al. | 2024
- 2751
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Design and Discovery of Water-Soluble Benzooxaphosphole-Based Ligands for Hindered Suzuki–Miyaura Coupling Reactions with Low Catalyst LoadShada, Arun D. R. / Mangunuru, Hari P. R. / Terrab, Leila / Tenneti, Srinivasarao / Kalikinidi, Nageswara Rao / Naini, Santhosh Reddy / Gajula, Praveen / Crull, Emily B. / Janganati, Venumadhav / Kovvuri, Raghavendra et al. | 2024
- 2758
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Molybdenum-Catalyzed Regio- and Enantioselective Amination of Allylic Carbonates: Total Synthesis of (S)‑ClopidogrelKhan, Shahid / Zhang, Junjie / Khan, Ajmal et al. | 2024
- 2763
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Macrocyclizing DNA-Linked Peptides via Three-Component Cyclization and Photoinduced ChemistryBao, Yandan / Xing, Minyan / Matthew, Naylor / Chen, Xiaohua / Wang, Xuan / Lu, Xiaojie et al. | 2024
- 2768
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Decarboxylative Nickel- and Photoredox-Catalyzed Aminocarbonylation of (Hetero)Aryl BromidesHutskalova, Valeriia / Bou Hamdan, Farhan / Sparr, Christof et al. | 2024
- 2773
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nBu4N+[AgI(CF3)2]−: Trifluoromethylated Argentate Derived from Fluoroform and Its Reaction with (Hetero)Aryl Diazonium SaltsLu, Zehai / Wang, Linhua / Hughes, Matthew / Smith, Stephen / Shen, Qilong et al. | 2024
- 2778
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Impact of Nonionic Surfactants on Reactions of IREDs. Applications to Tandem Chemoenzymatic Sequences in WaterLi, Xiaohan / Hu, Yuting / Bailey, J. Daniel / Lipshutz, Bruce H. et al. | 2024
- 2784
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Reactivity and Selectivity of Azaspirocycles in Radical C–H FunctionalizationUngarean, Chad N. / Larin, Egor M. / Egger, Dominic T. / Ziegler, Philipp / Lefebvre, Quentin / Fessard, Thomas C. / Morandi, Bill et al. | 2024
- 2790
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Electrochemical Synthesis of S-Aryl Dibenzothiophenium Triflates as Precursors for Selective Nucleophilic Aromatic (Radio)fluorinationSchüll, Aaron / Grothe, Lisa / Rodrigo, Eduardo / Erhard, Thomas / Waldvogel, Siegfried R. et al. | 2024
- 2795
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On-Resin Photochemical Decarboxylative Arylation of PeptidesPal, Sunit / Openy, Joseph / Krzyzanowski, Adrian / Noisier, Anaïs et al. | 2024
- 2800
-
Selective C–H Iodination of Weinreb Amides and Benzamides through Iridium Catalysis in Solution and under Mechanochemical ConditionsSanz-Marco, Amparo / Saavedra, Beatriz / Erbing, Elis / Malmberg, Jesper / Johansson, Magnus J. / Martín-Matute, Belén et al. | 2024
- 2806
-
Electrochemical Ring-Opening of Cyclopropylamides with Alcohols toward the Synthesis of 1,3-OxazinesXu, Peng-Cheng / Qian, Shencheng / Meng, Xiangtai / Zheng, Yu / Huang, Shenlin et al. | 2024
- 2811
-
Development of a One-Step Synthesis of oxa-Spirocyclic Diphosphine Ligands Driven by Their Application in the Industrial Synthesis of SacubitrilChen, Gen-Qiang / Xiao, Renwei / Ding, Xiaobing / Wang, Jiang / Ma, Baode / Lang, Qiwei / Zhang, Xumu et al. | 2024
- 2817
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Copper-Catalyzed Synthesis of Masked (Hetero)Aryl SulfinatesMerino, May R. / Cook, Xinlan A. F. / Blakemore, David C. / Moses, Ian B. / Sach, Neal W. / Shavnya, Andre / Willis, Michael C. et al. | 2024
- 2821
-
Stereoselective Control of the Cu Activation of β,β-Diboryl Acrylates for Allylic Coupling Protocols with Concomitant LactonizationPujol, Mireia / Méndez, María / Fernández, Elena et al. | 2024
- 2827
-
The (±)-5-Aza[1.0]triblattane Skeleton via Azetine CycloadditionSu, Chuyi / Dallaston, Madeleine A. / Watson, Renée D. / Fahrenhorst-Jones, Tyler / Cameron, Jacob P. / Pierens, Gregory K. / Bernhardt, Paul V. / Savage, G. Paul / Williams, Craig M. et al. | 2024
- 2832
-
Stereoselective Synthesis of Either Exo- or Endo-3‑Azabicyclo[3.1.0]hexane-6-carboxylates by Dirhodium(II)-Catalyzed Cyclopropanation with Ethyl Diazoacetate under Low Catalyst LoadingsNguyen, Terrence-Thang H. / Navarro, Antonio / Ruble, J. Craig / Davies, Huw M. L. et al. | 2024
- 2837
-
Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical TrialsKaburagi, Yosuke / Kira, Kazunobu / Yahata, Kenzo / Iso, Kentaro / Sato, Yuki / Matsuura, Fumiyoshi / Ohashi, Isao / Matsumoto, Yasunobu / Isomura, Minetaka / Sasaki, Takeo et al. | 2024
- 2843
-
Synthesis of Heterocycle-Substituted Bicyclo[3.1.1]heptanes and Aza-bicyclo[3.1.1]heptanes via Photocatalytic Minisci ReactionRevie, Rebecca I. / Whitaker, Benjamin J. / Paul, Bhaskar / Smith, Russell C. / Anderson, Edward A. et al. | 2024
- 2847
-
Modular Synthesis of Benzoylpyridines Exploiting a Reductive Arylation StrategyAlfano, Antonella Ilenia / Smyth, Megan / Wharry, Scott / Moody, Thomas S. / Baumann, Marcus et al. | 2024
- 2852
-
A Platform for the Liebeskind–Srogl Coupling of Heteroaromatic Thioethers for Medicinal-Chemistry-Relevant TransformationsKoolma, Victor / Staiger, Roman / Schühle, Martin / Bixenmann, Achim / Bauschatz, Elmar / Schmid, Matthias / Miloserdov, Fedor M. / Herlé, Bart et al. | 2024
- 2857
-
Synthesis of 2,6-trans-Tetrahydropyrans Using a Palladium-Catalyzed Oxidative Heck Redox-Relay StrategyBonfield, Holly E. / Edge, Colin M. / Reid, Marc / Kennedy, Alan R. / Pascoe, David D. / Lindsay, David M. / Valette, Damien et al. | 2024
- 2862
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Application of sSPhos as a Chiral Ligand for Palladium-Catalyzed Asymmetric Allylic AlkylationDocherty, Philip J. / Kadarauch, Max / Mistry, Nisha / Phipps, Robert J. et al. | 2024
- 2867
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Conformational Sampling over Transition-Metal-Catalyzed Reaction Pathways: Toward Revealing AtroposelectivityKammeraad, Joshua A. / Das, Soumik / Argüelles, Alonso J. / Sayyed, Fareed Bhasha / Zimmerman, Paul M. et al. | 2024
- 2872
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Asymmetric Hydrogenation of α‑Alkyl-Substituted β‑Keto Esters and Amides through Dynamic Kinetic ResolutionYurino, Taiga / Nishihara, Ryo / Yasuda, Toshihisa / Yang, Shuangli / Utsumi, Noriyuki / Katayama, Takeaki / Arai, Noriyoshi / Ohkuma, Takeshi et al. | 2024
- 2877
-
Synthesis of CHF2‑Containing Heterocycles through Oxy-difluoromethylation Using Low-Cost 3D Printed PhotoFlow ReactorsZhang, Jinlei / Selmi-Higashi, Elias / Zhang, Shen / Jean, Alexandre / Hilton, Stephen T. / Cambeiro, Xacobe C. / Arseniyadis, Stellios et al. | 2024
- 2883
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Ruthenium-Catalyzed C–H Arylation of Aromatic Acids with ortho-Haloaniline To Access PhenanthridinonesLuo, Xianglin / Shen, Jiayi / Jiang, Huanfeng / Huang, Liangbin et al. | 2024
- 2888
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Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated DerivativesChalyk, Bohdan A. / Zginnyk, Oleksandr / Khutorianskyi, Andrii V. / Mykhailiuk, Pavel K. et al. | 2024