Development and Characterization of Benzoselenazole Derivatives as Potent and Selective c‑MYC Transcription Inhibitors (English)
- New search for: Wu, Tian-Ying
- New search for: Chen, Xiu-Cai
- Further information on Chen, Xiu-Cai:
- https://orcid.org/0000-0001-6411-9711
- New search for: Tang, Gui-Xue
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- New search for: Chen, Shuo-Bin
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- New search for: Huang, Zhi-Shu
- Further information on Huang, Zhi-Shu:
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- New search for: Tan, Jia-Heng
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- New search for: Wu, Tian-Ying
- New search for: Chen, Xiu-Cai
- Further information on Chen, Xiu-Cai:
- https://orcid.org/0000-0001-6411-9711
- New search for: Tang, Gui-Xue
- New search for: Shao, Wen
- New search for: Li, Zhang-Chi
- New search for: Chen, Shuo-Bin
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In:
Journal of Medicinal Chemistry
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66
, 8
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5484-5499
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2023
- Article (Journal) / Electronic Resource
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Title:Development and Characterization of Benzoselenazole Derivatives as Potent and Selective c‑MYC Transcription Inhibitors
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Additional title:J. Med. Chem.
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Contributors:Wu, Tian-Ying ( author ) / Chen, Xiu-Cai ( author ) / Tang, Gui-Xue ( author ) / Shao, Wen ( author ) / Li, Zhang-Chi ( author ) / Chen, Shuo-Bin ( author ) / Huang, Zhi-Shu ( author ) / Tan, Jia-Heng ( author )
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Published in:Journal of Medicinal Chemistry ; 66, 8 ; 5484-5499
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Publisher:
- New search for: American Chemical Society
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Publication date:2023-04-27
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Source:
Table of contents – Volume 66, Issue 8
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 5305
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“Magic Chloro”: Profound Effects of the Chlorine Atom in Drug DiscoveryChiodi, Debora / Ishihara, Yoshihiro et al. | 2023
- 5332
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Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and PerspectivesXie, Zhouling / Meng, Zhiwei / Yang, Xiaoxiao / Duan, Yajun / Wang, Qin / Liao, Chenzhong et al. | 2023
- 5364
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Catalytically Active Snake Venom PLA2 Enzymes: An Overview of Its Elusive Mechanisms of ReactionCastro-Amorim, Juliana / Novo de Oliveira, Ana / Da Silva, Saulo Luís / Soares, Andreimar M. / Mukherjee, Ashis K. / Ramos, Maria João / Fernandes, Pedro A. et al. | 2023
- 5377
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Macrocycles in Drug DiscoveryLearning from the Past for the FutureGarcia Jimenez, Diego / Poongavanam, Vasanthanathan / Kihlberg, Jan et al. | 2023
- 5397
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Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain InjuryFritzemeier, Russell G. / van der Westhuyzen, Aletta E. / D’Erasmo, Michael / Sharma, Savita K. / Bartsch, Perry / Hodson, Luke E. / Liu, Ken / Wali, Bushra / Sayeed, Iqbal / Liotta, Dennis C. et al. | 2023
- 5415
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Structural Dynamics-Driven Discovery of Anticancer and Antimetastatic Effects of Diltiazem and Glibenclamide Targeting Urokinase ReceptorZhou, Yang / Song, Meiru / Xie, Daoqing / Yan, Shufeng / Yu, Shujuan / Xie, Song / Cai, Meiqin / Li, Hanlin / Shang, Le / Jiang, Longguang et al. | 2023
- 5427
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Bioactivity-Driven Synthesis of the Marine Natural Product Naamidine J and Its Derivatives as Potential Tumor Immunological Agents by Inhibiting Programmed Death-Ligand 1Fu, Pan-Pan / Wang, Qun / Zhang, Qing / Jin, Yang / Liu, Jin / Chen, Kai-Xian / Guo, Yue-Wei / Liu, San-Hong / Li, Xu-Wen et al. | 2023
- 5439
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Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Inhibitors of CDK8 for the Treatment of CancerLi, Yangguang / Liu, Yingtao / Wu, Jianping / Liu, Xiaosong / Wang, Lin / Wang, Ju / Yu, Jiaojiao / Qi, Hongyun / Qin, Luoheng / Ding, Xiao et al. | 2023
- 5453
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Design and Synthesis of Orexin 1 Receptor-Selective AgonistsIio, Keita / Hashimoto, Kao / Nagumo, Yasuyuki / Amezawa, Mao / Hasegawa, Taisei / Yamamoto, Naoshi / Kutsumura, Noriki / Takeuchi, Katsuhiko / Ishikawa, Yukiko / Yamamoto, Hikari et al. | 2023
- 5465
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N′‑Phenylacetohydrazide Derivatives as Potent Ebola Virus Entry Inhibitors with an Improved Pharmacokinetic ProfileGarcia-Rubia, Alfonso / Lasala, Fátima / Ginex, Tiziana / Morales-Tenorio, Marcos / Olal, Catherine / Heung, Michelle / Oquist, Paola / Galindo, Inmaculada / Cuesta-Geijo, Miguel Ángel / Casasnovas, José M. et al. | 2023
- 5484
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Development and Characterization of Benzoselenazole Derivatives as Potent and Selective c‑MYC Transcription InhibitorsWu, Tian-Ying / Chen, Xiu-Cai / Tang, Gui-Xue / Shao, Wen / Li, Zhang-Chi / Chen, Shuo-Bin / Huang, Zhi-Shu / Tan, Jia-Heng et al. | 2023
- 5500
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Discovery of Novel Sesquiterpene Lactone Derivatives as Potent PKM2 Activators for the Treatment of Ulcerative ColitisWang, Ping / Yang, Hongqiong / Lin, Weijiang / Zhou, Jingxian / Liu, Yi / Ma, Lingyu / Li, Mengting / Hu, Yang / Yu, Chengli / Zhang, Yinan et al. | 2023
- 5524
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Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic FusionsGao, Yang / Jiang, Baishan / Kim, Hellen / Berberich, Matthew J. / Che, Jianwei / Donovan, Katherine A. / Hatcher, John M. / Huerta, Fidel / Kwiatkowski, Nicholas P. / Liu, Yingpeng et al. | 2023
- 5536
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Novel Synthesis of C‑Methylated Phytocannabinoids Bearing Anti-inflammatory PropertiesLavi, Yarden / Kogan, Natalya M. / Topping, Louise M. / Liu, Caojie / McCann, Fiona E. / Williams, Richard O. / Breuer, Aviva / Yekhtin, Zhanna / Ezra, Aviva Friedman / Gallily, Ruth et al. | 2023
- 5550
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Novel Benzo Five-Membered Heterocycle Derivatives as P‑Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance ActivityYang, Zhikun / Cai, Yue / Yang, Xue / Li, Yasheng / Wu, Qihao / Yu, Yanlei / Chen, Zhen / Wei, Bin / Tian, Jin-Miao / Bao, Xiaoze et al. | 2023
- 5567
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Lead Optimization of Androgen Receptor-HSP27 Disrupting Agents in GlioblastomaLi, Yaxin / Orahoske, Cody / Salem, Fatma / Johnson, Aidyn / Tannous, Christia / Devole, Lucas / Zhang, Wenjing / Lathia, Justin D. / Wang, Bingcheng / Su, Bin et al. | 2023
- 5584
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Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) ReceptorChen, Nan-Nan / Zhang, Han / Zhu, Qiang-Sheng / Zeng, Ting / Dai, Wei / Zhou, Ye-Ling / Xin, Guo-Feng / Wu, Bei-Duo / Gong, Si-Jia / Jiang, Zheng-Yu et al. | 2023
- 5611
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High-Contrast PET Imaging with [18F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous SystemTurkman, Nashaat / Xu, Sulan / Huang, Chun-Han / Eyermann, Christopher / Salino, Julia / Khan, Palwasha et al. | 2023
- 5622
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Discovery of a Potent, Selective, and Orally Bioavailable Tool Compound for Probing the Role of Lysophosphatidic Acid Type 2 Receptor Antagonists in Fibrotic DisordersArmani, Elisabetta / Rizzi, Andrea / Iotti, Nicolò / Saccani, Francesca / Di Lascia, Maria Rosaria / Tigli, Laura / Pappani, Alice / Marchini, Gessica / Murgo, Annalisa / Capelli, Anna Maria et al. | 2023
- 5657
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Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney InjuryZhou, Hua-Lin / Hausladen, Alfred / Anand, Puneet / Rajavel, Malligarjunan / Stomberski, Colin T. / Zhang, Rongli / Premont, Richard T. / Greenlee, William J. / van den Akker, Focco / Stamler, Jonathan S. et al. | 2023
- 5669
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Developing an Anticancer Platinum(II) Compound Based on the Uniqueness of Human Serum AlbuminZhang, Zhenlei / Zhang, Juzheng / Yang, Tongfu / Li, Shanhe / Xu, Gang / Liang, Hong / Yang, Feng et al. | 2023
- 5685
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Discovery of Dual Lysine Methyltransferase G9a and EZH2 Inhibitors with In Vivo Efficacy against Malignant Rhabdoid TumorShi, Yajie / Zhang, Qiuyue / Zhang, Maoying / Chen, Yongsong / Sun, Jianwen / Chen, Lu / Liu, Sen / Liu, Zhongbo / Yang, Jingyu / Wu, Chunfu et al. | 2023
- 5703
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Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative EffectIvanova, Jekateri̅na / Nocentini, Alessio / Ta̅rs, Kaspars / Leita̅ns, Ja̅nis / Dvinskis, Elviss / Kazaks, Andris / Domračeva, Ilona / Supuran, Claudiu T. / Žalubovskis, Raivis et al. | 2023
- 5719
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Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small-cell Lung CancerPei, Junping / Wang, Guan / Wang, Aoxue / Wu, Chengyong / Pan, Xiaoli / Shuai, Wen / Bu, Faqian / Zhu, Yumeng / Wang, Yuxi / Ouyang, Liang et al. | 2023
- 5753
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Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid CancersQiu, Qianqian / Chi, Fanglian / Zhou, Daoguang / Xie, Zhancheng / Liu, Yunxiao / Wu, Hanyu / Yin, Ziyu / Shi, Wei / Qian, Hai et al. | 2023
- 5774
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Acetyl-Click Screening Platform Identifies Small-Molecule Inhibitors of Histone Acetyltransferase 1 (HAT1)Gaddameedi, Jitender D. / Chou, Tristan / Geller, Benjamin S. / Rangarajan, Amithvikram / Swaminathan, Tarun A. / Dixon, Danielle / Long, Katherine / Golder, Caiden J. / Vuong, Van A. / Banuelos, Selene et al. | 2023
- 5802
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1‑O‑Octadecyl-2‑O‑benzyl-sn-glyceryl-3-phospho-GS-441524 (V2043). Evaluation of Oral V2043 in a Mouse Model of SARS-CoV‑2 Infection and Synthesis and Antiviral Evaluation of Additional Phospholipid Esters with Enhanced Anti-SARS-CoV‑2 ActivityCarlin, Aaron F. / Beadle, James R. / Clark, Alex E. / Gully, Kendra L. / Moreira, Fernando R. / Baric, Ralph S. / Graham, Rachel L. / Valiaeva, Nadejda / Leibel, Sandra L. / Bray, William et al. | 2023
- 5820
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Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung InflammationLi, Shao-Xian / Wang, Si-Wei / Chen, Lin-Hai / Zhang, Qing / Lu, Dan / Chen, Jing / Fang, You-Chen / Gu, Min / Xie, Xin / Nan, Fa-Jun et al. | 2023
- 5839
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Discovery of the First Raptor (Regulatory-Associated Protein of mTOR) Inhibitor as a New Type of Antiadipogenic AgentYan, Xue-Long / Pan, Yue-Hua / Fan, Run-Zhu / Song, Qin-Qin / Li, Shen / Huang, Jia-Luo / Li, Wei / Huang, Dong / Yuan, Fang-Yu / Tang, Gui-Hua et al. | 2023
- 5859
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Rapid Elaboration of Fragments into Leads Applied to Bromodomain‑3 Extra-Terminal DomainAdams, Luke A. / Wilkinson-White, Lorna E. / Gunzburg, Menachem J. / Headey, Stephen J. / Mohanty, Biswaranjan / Scanlon, Martin J. / Capuano, Ben / Mackay, Joel P. / Doak, Bradley C. et al. | 2023
- 5873
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2‑Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2)Burgio, Ariel L. / Shrader, Christopher W. / Kharel, Yugesh / Huang, Tao / Salamoun, Joseph M. / Lynch, Kevin R. / Santos, Webster L. et al. | 2023
- 5892
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Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic QuinolinonesHarnden, Alice C. / Davis, Owen A. / Box, Gary M. / Hayes, Angela / Johnson, Louise D. / Henley, Alan T. / de Haven Brandon, Alexis K. / Valenti, Melanie / Cheung, Kwai-Ming J. / Brennan, Alfie et al. | 2023
- 5907
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HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other MalignanciesPasqua, A. Elisa / Sharp, Swee Y. / Chessum, Nicola E. A. / Hayes, Angela / Pellegrino, Loredana / Tucker, Michael J. / Miah, Asadh / Wilding, Birgit / Evans, Lindsay E. / Rye, Carl S. et al. | 2023
- 5937
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Phototunable Cell Killing by Photochromic Diarylethene of Thiazoyl and Thienyl DerivativesNakagawa, Yuma / Hishida, Tatsuya / Sumaru, Kimio / Morishita, Kana / Kirito, Keita / Yokojima, Satoshi / Sakamoto, Yuki / Nakamura, Shinichiro / Uchida, Kingo et al. | 2023
- 5950
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Discovery of BRD4–HDAC Dual Inhibitors with Improved Fungal Selectivity and Potent Synergistic Antifungal Activity against Fluconazole-Resistant Candida albicansLi, Zhuang / Huang, Yahui / Tu, Jie / Yang, Wanzhen / Liu, Na / Wang, Wei / Sheng, Chunquan et al. | 2023
- 5965
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Structure-Based Discovery of a New Selectivity-Enabling Motif for the FK506-Binding Protein 51Knaup, Fabian H. / Meyners, Christian / Sugiarto, Wisely Oki / Wedel, Saskia / Springer, Margherita / Walz, Carlo / Geiger, Thomas M. / Schmidt, Mathias / Sisignano, Marco / Hausch, Felix et al. | 2023
- 5981
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Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of CancerBrindani, Nicoletta / Vuong, Linh M. / Acquistapace, Isabella Maria / La Serra, Maria Antonietta / Ortega, José Antonio / Veronesi, Marina / Bertozzi, Sine Mandrup / Summa, Maria / Girotto, Stefania / Bertorelli, Rosalia et al. | 2023
- 6002
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Linearization of the Brevicidine and Laterocidine Lipopeptides Yields Analogues That Retain Full Antibacterial ActivityBallantine, Ross D. / Al Ayed, Karol / Bann, Samantha J. / Hoekstra, Michael / Martin, Nathaniel I. / Cochrane, Stephen A. et al. | 2023
- 6010
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Correction to “Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate”Hobson, Adrian D. / McPherson, Michael J. / Hayes, Martin E. / Goess, Christian / Li, Xiang / Zhou, Jian / Wang, Zhongyuan / Yu, Yajie / Yang, Jindong / Sun, Liang et al. | 2023
- 6011
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Correction to “Design and Development of Glucocorticoid Receptor Modulators as Immunology Antibody–Drug Conjugate Payloads”Hobson, Adrian D. / McPherson, Michael J. / Waegell, Wendy / Goess, Christian A. / Stoffel, Robert H. / Li, Xiang / Zhou, Jian / Wang, Zhongyuan / Yu, Yajie / Hernandez, Axel et al. | 2023