Rational Design, Synthesis, and Crystallographic Analysis of a Hydroxyethylene-Based HIV-1 Protease Inhibitor Containing a Heterocyclic P1'-P2' Amide Bond Isostere (English)
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- New search for: Thompson, Scott K.
- New search for: Murthy, Krishna H. M.
- New search for: Zhao, Baoguang
- New search for: Winborne, Evon
- New search for: Green, David W.
- New search for: Fisher, Seth M.
- New search for: DesJarlais, Renee L.
- New search for: Tomaszek, Thaddeus A. Jr.
- New search for: Meek, Thomas D.
- New search for: Thompson, Scott K.
- New search for: Murthy, Krishna H. M.
- New search for: Zhao, Baoguang
- New search for: Winborne, Evon
- New search for: Green, David W.
- New search for: Fisher, Seth M.
- New search for: DesJarlais, Renee L.
- New search for: Tomaszek, Thaddeus A. Jr.
- New search for: Meek, Thomas D.
In:
Journal of Medicinal Chemistry
;
37
, 19
;
3100-3107
;
1994
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Rational Design, Synthesis, and Crystallographic Analysis of a Hydroxyethylene-Based HIV-1 Protease Inhibitor Containing a Heterocyclic P1'-P2' Amide Bond Isostere
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Additional title:J. Med. Chem.
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Contributors:Thompson, Scott K. ( author ) / Murthy, Krishna H. M. ( author ) / Zhao, Baoguang ( author ) / Winborne, Evon ( author ) / Green, David W. ( author ) / Fisher, Seth M. ( author ) / DesJarlais, Renee L. ( author ) / Tomaszek, Thaddeus A. Jr. ( author ) / Meek, Thomas D. ( author )
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Published in:Journal of Medicinal Chemistry ; 37, 19 ; 3100-3107
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Publisher:
- New search for: American Chemical Society
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Publication date:1994-09-01
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Source:
Table of contents – Volume 37, Issue 19
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 2985
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Combinatorial Technologies Involving Reiterative Division/Coupling/Recombination: Statistical ConsiderationsBurgess, Kevin / Liaw, Andy I. / Wang, Naisyin et al. | 1994
- 2988
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Reductive Hydrolysis of the 59,60-Amide Bond of Teicoplanin Antibiotics: A Key Step from Natural to Synthetic GlycopeptidesMalabarba, Adriano / Ciabatti, Romeo et al. | 1994
- 2991
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Nonpeptide Renin Inhibitors with Good Intraduodenal Bioavailability and Efficacy in DogBoyd, Steven A. / Fung, Anthony K. L. / Baker, William R. / Mantei, Robert A. / Stein, Herman H. / Cohen, Jerome / Barlow, Jennifer L. / Klinghofer, Vered / Wessale, Jerry L. et al. | 1994
- 3008
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Synthesis, Resolution, and SAR of ((plus-minus))-2-Amino-N-methyl-a-(3-methyl-2-thienyl) benzeneethanamine and Related Analogs as Noncompetitive NMDA Antagonists vdth Neuroprotective PropertiesMartin, Lawrence L. et al. | 1994
- 3008
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Synthesis, Resolution, and SAR of (.+-.)-2-Amino-N-methyl-.alpha.-(3-methyl-2-thienyl)benzeneethanamine and Related Analogs as Noncompetitive NMDA Antagonists with Neuroprotective PropertiesMartin, Lawrence L. / Lee, George E. / Lee, Thomas B. K. / Rush, Douglas K. / Wilmot, Carole A. / Paulus, Erich / Elben, Ulrich / Grome, John J. / Porsche-Wiebking, Elena et al. | 1994
- 3008
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Synthesis, Resolution, and SAR of ()-2-Amino-N-methyl-(3-methyl-2-thienyl)benzeneethanamine and Related Analogs as Noncompetitive NMDA Antagonists with Neuroprotective PropertiesMartin, L. L. / Lee, G. E. / Lee, T. B. K. / Rush, D. K. et al. | 1994
- 3016
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Synthesis and Quantitative Structure-Activity Relationships of Anticonvulsant 2,3,6-TriaminopyridinesSeydel, Joachim K. / Schaper, Klaus-J. / Coats, Eugene A. / Cordes, Hans P. / Emig, Peter / Engel, Juergen / Kutscher, Bernhard / Polymeropoulos, Emmanuel E. et al. | 1994
- 3023
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Synthesis and Biological Activity of 3-(2-(Dimethylamino)ethyl)-5-((1,1-dioxo-5-methyl-1,2, 5-thiadiazolidin-2-yl)-methyl)-1H-indole and Analogues: Agonists for the 5-HT1D ReceptorCastro, José L. et al. | 1994
- 3023
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Synthesis and Biological Activity of 3-[2-(Dimethylamino)ethyl]-5-[(1,1-dioxo-5-methyl-1,2,5-thiadiazolidin-2-yl)methyl]-1H-indole and Analogs: Agonists for the 5-HT1D ReceptorCastro, Jose L. / Baker, Raymond / Guiblin, Alexander R. / Hobbs, Sarah C. / Jenkins, Matthew R. / Russell, Michael G. N. / Beer, Margaret S. / Stanton, Josephine A. / Scholey, Kate et al. | 1994
- 3033
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Antitumor Agents. 7. Synthesis and Antitumor Activity of Novel Hexacyclic Camptothecin AnaloguesSugimori, Masamichi et al. | 1994
- 3033
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Antitumor Agents. VII. Synthesis and Antitumor Activity of Novel Hexacyclic Camptothecin AnalogsSugimori, Masamichi / Ejima, Akio / Ohsuki, Satoru / Uoto, Kouichi / Mitsui, Ikuo / Matsumoto, Kensuke / Kawato, Yasuyoshi / Yasuoka, Megumi / Sato, Keiki et al. | 1994
- 3040
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Design, Synthesis, and Biological Evaluation of Cosalane, a Novel Anti-HIV Agent Which Inhibits Multiple Features of Virus ReproductionCushman, Mark / Golebiewski, W. Marek / McMahon, James B. / Buckheit, Robert W. / Clanton, David J. / Weislow, Owen / Haugwitz, Rudiger D. / Bader, John P. / Graham, Lisa / Rice, William G. et al. | 1994
- 3051
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Cancer Chemopreventive 3-Substituted-4-oxoretinoic AcidsShealy, Y. Fulmer / Hosmer, Carla A. / Riordan, James M. / Wille, John W. / Rogers, Tina S. / Hill, Donald L. et al. | 1994
- 3057
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Synthesis of New Acyclic Pyrimidine Nucleoside Analogs as Potential Antiviral DrugsEger, Kurt / Kluender, Eberhard M. / Schmidt, Mathias et al. | 1994
- 3062
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Novel Dual Inhibitors of 5-Lipoxygenase and Thromboxane A2 Synthetase: Synthesis and Structure-Activity Relationships of 3-Pyridylmethyl-Substituted 2-Amino-6-hydroxybenzothiazole DerivativesHibi, Shigeki / Okamoto, Yasushi / Tagami, Katsuya / Numata, Hirotoshi / Kobayashi, Naoki / Shinoda, Masanobu / Kawahara, Tetsuya / Murakami, Manabu / Oketani, Kiyoshi et al. | 1994
- 3071
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Heteroaryl-Fused 2-Phenylisothiazolone Inhibitors of Cartilage BreakdownWright, Stephen W. / Petraitis, Joseph J. / Abelman, Matthew M. / Batt, Douglas G. / Bostrom, Lori L. / Corbett, Ronald L. / Decicco, Carl P. / Di Meo, Susan V. / Freimark, Bruce et al. | 1994
- 3079
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Inhibitors of HIV-1 Proteinase Containing 2-Heterosubstituted 4-Amino-3-hydroxy-5-phenylpentanoic Acid: Synthesis, Enzyme Inhibition, and Antiviral ActivityScholz, Dieter / Billich, Andreas / Charpiot, Brigitte / Ettmayer, Peter / Lehr, Philipp / Rosenwirth, Brigitte / Schreiner, Erwin / Gstach, Hubert et al. | 1994
- 3090
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Non-peptidic Inhibitors of Human Leukocyte Elastase. 1. The Design and Synthesis of Pyridone-Containing InhibitorsWarner, Peter / Green, Rosalyn C. / Gomes, Bruce / Strimpler, Anne M. et al. | 1994
- 3100
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Rational Design, Synthesis, and Crystallographic Analysis of a Hydroxyethylene-Based HIV-1 Protease Inhibitor Containing a Heterocyclic P~1'-P~2'2 Amide Bond IsostereThompson, S. K. / Murthy, K. H. M. / Zhao, B. / Winborne, E. et al. | 1994
- 3100
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Rational Design, Synthesis, and Crystallographic Analysis of a Hydroxyethylene-Based HIV-1 Protease Inhibitor Containing a Heterocyclic P1'-P2' Amide Bond IsostereThompson, Scott K. / Murthy, Krishna H. M. / Zhao, Baoguang / Winborne, Evon / Green, David W. / Fisher, Seth M. / DesJarlais, Renee L. / Tomaszek, Thaddeus A. Jr. / Meek, Thomas D. et al. | 1994
- 3108
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Bromobenzofuran-Based Non-peptide Antagonists of Angiotensin II: GR138950, a Potent Antihypertensive Agent with High Oral BioavailabilityJudd, Duncan B. / Dowle, Michael D. / Middlemiss, David / Scopes, David I. C. / Ross, Barry C. / Jack, Torquil I. / Pass, Martin / Tranquillini, Elvira / Hobson, Julie E. et al. | 1994
- 3121
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Synthesis and Opioid Activity of 7-Oxygenated 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolinolsCheng, Chen-Yu / Hsin, Ling-Wei / Tsai, Ming-Cheng / Schmidt, William K. / Smith, Christine / Tam, S. William et al. | 1994
- 3121
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Synthesis and Opioid Activity of 7-Oxygenated 2,3,4,4a,5,6,7,7a-Octahydro-1H-benzofuro(3,2-e)isoquinolin-9-olsCheng, Chen-Yu et al. | 1994
- 3128
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Molecular Modeling Studies of Some Choline Acetyltransferase InhibitorsKontoyianni, M. / McGaughey, G. B. / Stewart, E. L. / Cavallito, C. J. / Bowen, J. P. et al. | 1994
- 3132
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Comparison of a DSB-120 DNA Interstrand Cross-Linked Adduct with the Corresponding Bis-tomaymycin Adduct: An Example of a Successful Template-Directed Approach to Drug Design Based upon the Monoalkylating Compound TomaymycinMountzouris, John A. / Wang, Jeh-Jeng / Thurston, David / Hurley, Laurence H. et al. | 1994
- 3141
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Docking Analysis of a Series of Benzylamino Acetylcholinesterase Inhibitors with a Phthalimide, Benzoyl, or Indanone MoietyYamamoto, Yoshio / Ishihara, Yuji / Kuntz, Irwin D. et al. | 1994
- 3154
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Sugar-Linked Dithiocarbamates as Modulators of Metabolic and Genotoxic Properties of N-Nitroso CompoundsLee, Byung-Hoon / Bertram, Barbara / Schmezer, Peter / Frank, Norbert / Wiessler, Manfred et al. | 1994
- 3163
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A Marked Change of Receptor Affinity of the 2-Methyl-5-(3-hydroxyphenyl)morphans upon Attachment of an (E)-8-Benzylidene Moiety: Synthesis and Evaluation of a New Class of .sigma. Receptor LigandsBertha, Craig M. / Mattson, Mariena V. / Flippen-Anderson, Judith L. / Rothman, Richard B. / Xu, Heng / Cha, Xian-Yuan / Becketts, Karen / Rice, Kenner C. et al. | 1994
- 3163
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A Marked Change of Receptor Affinity of the 2-Methyl-5-(3-hydroxyphenyl)morphans upon Attachment of an (E)-8-Benzylidene Moiety: Synthesis and Evaluation of a New Class of Receptor LigandsBertha, C. M. / Mattson, M. V. / Flippen-Anderson, J. L. / Rothman, R. B. et al. | 1994
- 3163
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A Marked Change of Receptor Affinity of the 2-Methyl-5-(3-hydroxyphenyl)morphans upon Attachment of an (E)-8-Benzylidene Moiety: Synthesis and Evaluation of a New Class of s Receptor LigandsBertha, Craig M. et al. | 1994
- 3171
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Decapeptide Agonists of Human C5a: The Relationship between Conformation and Spasmogenic and Platelet Aggregatory ActivitiesSanderson, Sam D. / Kirnarsky, Leonid / Sherman, Simon A. / Ember, Julia A. / Finch, Angela M. / Taylor, Stephen M. et al. | 1994
- 3181
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Analogues of the Marine Immunosuppresant Microcolin A: Preparation and Biological ActivityKoehn, Frank E. et al. | 1994
- 3181
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Analogs of the Marine Immunosuppressant Microcolin A: Preparation and Biological ActivityKoehn, Frank E. / McConnell, Oliver J. / Longley, Ross E. / Sennett, Susan H. / Reed, John K. et al. | 1994
- 3187
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Tricyclic Analogues of Acyclovir and Ganciclovir. Influence of Substituents in the Heterocyclic Moiety on the Antiviral ActivityGolankiewicz, Bozenna et al. | 1994
- 3187
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Tricyclic Analogs of Acyclovir and Ganciclovir. Influence of Substituents in the Heterocyclic Moiety on the Antiviral ActivityGolankiewicz, Bozenna / Ostrowski, Tomasz / Andrei, Graciela / Snoeck, Robert / De Clercq, Erik et al. | 1994
- 3191
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Inhibition of Topoisomerase I by Anthracycline Antibiotics: Evidence for General Inhibition of Topoisomerase I by DNA-Binding AgentsCrow, Robert T. / Crothers, Donald M. et al. | 1994
- 3195
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Book Reviews| 1994
- 3195
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Drug Design For NeuroscienceHamilton, Gregory S. et al. | 1994
- 3196
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Comparative molecular field analysis of the antitumor activity of 9H-thioxanthen-9-one derivatives against pancreatic ductal carcinoma 03. [Erratum to document cited in CA120:315145]Horowitz, Jerome P. / Massova, Irina / Wiese, Thomas E. / Besler, Brent H. / Corbett, Thomas H. et al. | 1994
- 3196
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Comparative Molecular Field Analysis of the Antitumor Activity of 9H-Thioxanthen-9-one Derivatives against Pancreatic Ductal Carcinoma 03Horwitz, Jerome P. et al. | 1994
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Masthead| 1994