Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists (English)
- New search for: Kim, Kyoung Soon
- New search for: Zhang, Liping
- New search for: Williams, David
- New search for: Perez, Heidi L.
- New search for: Stang, Erik
- New search for: Borzilleri, Robert M.
- New search for: Posy, Shana
- New search for: Lei, Ming
- New search for: Chaudhry, Charu
- New search for: Emanuel, Stuart
- New search for: Talbott, Randy
- New search for: Kim, Kyoung Soon
- New search for: Zhang, Liping
- New search for: Williams, David
- New search for: Perez, Heidi L.
- New search for: Stang, Erik
- New search for: Borzilleri, Robert M.
- New search for: Posy, Shana
- New search for: Lei, Ming
- New search for: Chaudhry, Charu
- New search for: Emanuel, Stuart
- New search for: Talbott, Randy
In:
Bioorganic and Medicinal Chemistry Letters
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24
, 21
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5022-5029
;
2014
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists
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Contributors:Kim, Kyoung Soon ( author ) / Zhang, Liping ( author ) / Williams, David ( author ) / Perez, Heidi L. ( author ) / Stang, Erik ( author ) / Borzilleri, Robert M. ( author ) / Posy, Shana ( author ) / Lei, Ming ( author ) / Chaudhry, Charu ( author ) / Emanuel, Stuart ( author )
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Published in:Bioorganic and Medicinal Chemistry Letters ; 24, 21 ; 5022-5029
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Publisher:
- New search for: Elsevier Ltd
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Publication date:2014-09-08
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Size:8 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 24, Issue 21
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 4903
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Graphical contents list| 2014
- 4915
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An update on therapeutic opportunities offered by cancer glycolytic metabolismGranchi, Carlotta / Fancelli, Daniele / Minutolo, Filippo et al. | 2014
- 4926
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Synthesis and cytotoxic activity of novel 1-((indol-3-yl)methyl)–1H-imidazolium saltsXu, Xiao-Liang / Wang, Jia / Yu, Chun-Lei / Chen, Wen / Li, Ying-Chao / Li, Yan / Zhang, Hong-Bin / Yang, Xiao-Dong et al. | 2014
- 4931
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Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligandsNour, Afshin / Hayashi, Tomoko / Chan, Michael / Yao, Shiyin / Tawatao, Rommel I. / Crain, Brian / Tsigelny, Igor F. / Kouznetsova, Valentina L. / Ahmadiiveli, Alast / Messer, Karen et al. | 2014
- 4939
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New antibacterial xanthone from the marine sponge-derived Micrococcus sp. EG45Eltamany, Enas E. / Abdelmohsen, Usama Ramadan / Ibrahim, Amany K. / Hassanean, Hashim A. / Hentschel, Ute / Ahmed, Safwat A. et al. | 2014
- 4943
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Inhibition of the ANT(2″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolonesHirsch, Danielle R. / Cox, Georgina / D’Erasmo, Michael P. / Shakya, Tushar / Meck, Christine / Mohd, Noushad / Wright, Gerard D. / Murelli, Ryan P. et al. | 2014
- 4948
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Synthesis and preliminary investigations into novel 1,2,3-triazole-derived androgen receptor antagonists inspired by bicalutamideAltimari, Jarrad M. / Niranjan, Birunthi / Risbridger, Gail P. / Schweiker, Stephanie S. / Lohning, Anna E. / Henderson, Luke C. et al. | 2014
- 4954
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Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylaseRydzik, Anna M. / Brem, Jürgen / Struwe, Weston B. / Kochan, Grazyna T. / Benesch, Justin L.P. / Schofield, Christopher J. et al. | 2014
- 4958
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Bioavailable pyrrolo-benzo-1,4-diazines as Nav1.7 sodium channel blockers for the treatment of painYang, Shu-Wei / Ho, Ginny D. / Tulshian, Deen / Bercovici, Ana / Tan, Zheng / Hanisak, Jennifer / Brumfield, Stephanie / Matasi, Julius / Sun, Xianfeng / Sakwa, Samuel A. et al. | 2014
- 4963
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Study the interactions between human serum albumin and two antifungal drugs: Fluconazole and its analogue DTPZhang, Shao-Lin / Yao, Huankai / Wang, Chenyin / Tam, Kin Y. et al. | 2014
- 4969
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Scaffold hopping towards potent and selective JAK3 inhibitors: Discovery of novel C-5 substituted pyrrolopyrazinesde Vicente, Javier / Lemoine, Remy / Bartlett, Mark / Hermann, Johannes C. / Hekmat-Nejad, Mohammad / Henningsen, Robert / Jin, Sue / Kuglstatter, Andreas / Li, Hongju / Lovey, Allen J. et al. | 2014
- 4976
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Structure–activity relationships of non-opioid [des-Arg7]-dynorphin A analogues for bradykinin receptorsLee, Yeon Sun / Rankin, David / Hall, Sara M. / Ramos-Colon, Cyf / Ortiz, Jose Juan / Kupp, Robert / Porreca, Frank / Lai, Josephine / Hruby, Victor J. et al. | 2014
- 4980
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Design, synthesis, and structure–activity relationship of novel opioid κ receptor selective agonists: α-Iminoamide derivatives with an azabicyclo[2.2.2]octene skeletonWatanabe, Yoshikazu / Kitazawa, Shota / Fujii, Hideaki / Nemoto, Toru / Hirayama, Shigeto / Iwai, Takashi / Gouda, Hiroaki / Hirono, Shuichi / Nagasea, Hiroshi et al. | 2014
- 4984
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Derivatives of imidazotriazine and pyrrolotriazine C-nucleosides as potential new anti-HCV agentsDraffan, Alistair G. / Frey, Barbara / Fraser, Benjamin H. / Pool, Brett / Gannon, Carlie / Tyndall, Edward M. / Cianci, Julia / Harding, Michael / Lilly, Michael / Hufton, Richard et al. | 2014
- 4989
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In vitro apoptotic effect of cassaine-type diterpene amides from Erythrophleum fordii on PC-3 prostate cancer cellsHung, Tran Manh / Cuong, To Dao / Kim, Jeong Ah / Lee, Jeong Hyung / Woo, Mi Hee / Min, Byung Sun et al. | 2014
- 4995
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Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9Guo, Kai / Fang, Tingting / Wang, Jingyi / Wu, An-an / Wang, Yuezhou / Jiang, Jie / Wu, Xinrui / Song, Siyang / Su, Wenjing / Xu, Qingyan et al. | 2014
- 4999
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An eco-friendly and water mediated product selective synthesis of 2-aminopyrimidines and their in vitro anti-bacterial evaluationNagarajan, Sangaraiah / Shanmugavelan, Poovan / Sathishkumar, Murugan / Selvi, Ramasamy / Ponnuswamy, Alagusundaram / Harikrishnan, Hariharan / Shanmugaiah, Vellasamy / Murugavel, Saminathan et al. | 2014
- 5008
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Oxo- and thiooxo-imidazo[1,5-c]pyrimidine molecule library: Beyond their interest in inhibition of Brucella suis histidinol dehydrogenase, a powerful protection tool in the synthesis of histidine analoguesTurtaut, François / Lopez, Marie / Ouahrani-Bettache, Safia / Köhler, Stephan / Winum, Jean-Yves et al. | 2014
- 5011
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The discovery of isoxazoline oxime ethers as a new class of ectoparasiticides for the control of Haematobia irritans (horn fly) in cattleCurtis, Michael P. / Chubb, Nathan / Ellsworth, Edmund / Goodwin, Richard / Holzmer, Sue / Koch, Jason / McTier, Tom / Menon, Sanjay / Mills, Kent / Pullins, Aleah et al. | 2014
- 5015
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Synthesis of new 1-(4-methane(amino)sulfonylphenyl)-5-(4-substituted-aminomethylphenyl)-3-trifluoromethyl-1H-pyrazoles: A search for novel nitric oxide donor anti-inflammatory agentsAbdellatif, Khaled R.A. / Moawad, Abeer / Knaus, Edward E. et al. | 2014
- 5022
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Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonistsKim, Kyoung Soon / Zhang, Liping / Williams, David / Perez, Heidi L. / Stang, Erik / Borzilleri, Robert M. / Posy, Shana / Lei, Ming / Chaudhry, Charu / Emanuel, Stuart et al. | 2014
- 5030
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Antimycobacterial activity generated by the amide coupling of (−)-fenchone derived aminoalcohol with cinnamic acids and analoguesSlavchev, Ivaylo / Dobrikov, Georgi M. / Valcheva, Violeta / Ugrinova, Iva / Pasheva, Evdokia / Dimitrov, Vladimir et al. | 2014
- 5034
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Glutathione-S-transferase selective release of metformin from its sulfonamide prodrugRautio, Jarkko / Vernerová, Monika / Aufderhaar, Imke / Huttunen, Kristiina M. et al. | 2014
- 5037
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Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitorsBruel, Amélie / Bénéteau, Romain / Chabanne, Mylène / Lozach, Olivier / Le Guevel, Rémy / Ravache, Myriam / Bénédetti, Hélène / Meijer, Laurent / Logé, Cédric / Robert, Jean-Michel et al. | 2014
- 5041
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Rational design, synthesis and anti-proliferative evaluation of novel benzosuberone tethered with hydrazide–hydrazonesYadagiri, Bandi / Holagunda, Uma Devi / Bantu, Rajashaker / Nagarapu, Lingaiah / Guguloth, Vijayacharan / Polepally, Sowjanya / Jain, Nishanth et al. | 2014
- 5045
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Discovery of pyridyl sulfonamide 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors for the treatment of metabolic disordersYoon, David S. / Wu, Shung C. / Seethala, Ramakrishna / Golla, Rajasree / Nayeem, Akbar / Everlof, John G. / Gordon, David A. / Hamann, Lawrence G. / Robl, Jeffrey A. et al. | 2014
- 5050
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Design, synthesis and exploring the quantitative structure–activity relationship of some antioxidant flavonoid analoguesDas, Sreeparna / Mitra, Indrani / Batuta, Shaikh / Niharul Alam, Md. / Roy, Kunal / Begum, Naznin Ara et al. | 2014
- 5055
-
Synthesis and structure–activity relationship of 4-azaheterocycle benzenesulfonamide derivatives as new microtubule-targeting agentsYang, Jun / Zhou, Shanshan / Ji, Liyan / Zhang, Chao / Yu, Siwang / Li, Zhongjun / Meng, Xiangbao et al. | 2014
- 5059
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Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoformsZoraghi, Roya / Campbell, Sara / Kim, Catrina / Dullaghan, Edie M. / Blair, Lachlan M. / Gillard, Rachel M. / Reiner, Neil E. / Sperry, Jonathan et al. | 2014
- 5063
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Vanillin-derived antiproliferative compounds influence Plk1 activityCarrasco-Gomez, Roberto / Keppner-Witter, Sarah / Hieke, Martina / Lange, Lisa / Schneider, Gisbert / Schubert-Zsilavecz, Manfred / Proschak, Ewgenij / Spänkuch, Birgit et al. | 2014
- 5070
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Synthesis, characterization, molecular docking and anti-tubercular activity of Plumbagin–Isoniazid Analog and its β-cyclodextrin conjugateDandawate, Prasad / Vemuri, Kiranmayi / Venkateswara Swamy, K. / Khan, Ejazuddin M. / Sritharan, Manjula / Padhye, Subhash et al. | 2014
- 5076
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Discovery of quinoline small molecules with potent dispersal activity against methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a scaffold hopping strategyAbouelhassan, Yasmeen / Garrison, Aaron T. / Burch, Gena M. / Wong, Wilson / Norwood, Verrill M. IV / Huigens, Robert W. III et al. | 2014
- 5081
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2-Guanidinoquinazolines as new inhibitors of the STAT3 pathwayLaPorte, Matthew G. / da Paz Lima, Dimas José / Zhang, Feng / Sen, Malabika / Grandis, Jennifer R. / Camarco, Daniel / Hua, Yun / Johnston, Paul A. / Lazo, John S. / Resnick, Lynn O. et al. | 2014
- 5086
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Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1Desrat, Sandy / Pujals, Anaïs / Colas, Claire / Dardenne, Jérémy / Gény, Charlotte / Favre, Loëtitia / Dumontet, Vincent / Iorga, Bogdan I. / Litaudon, Marc / Raphaël, Martine et al. | 2014
- 5089
-
Two new antioxidant actinosporin analogues from the calcium alginate beads culture of sponge-associated Actinokineospora sp. strain EG49Grkovic, Tanja / Abdelmohsen, Usama Ramadan / Othman, Eman Maher / Stopper, Helga / Edrada-Ebel, RuAngelie / Hentschel, Ute / Quinn, Ronald J. et al. | 2014
- 5093
-
Discovery of substituted 6-pheny-3H-pyridazin-3-one derivatives as novel c-Met kinase inhibitorsKang, Seung-Tae / Kim, Eun-Young / Archary, Raghavendra / Jung, Heejung / Park, Chi Hoon / Yun, Chang-Soo / Hwang, Jong Yeon / Choi, Sang Un / Chae, Chonghak / Lee, Chong Ock et al. | 2014
- 5098
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Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic propertiesXia, Guoyao / Benmohamed, Radhia / Morimoto, Richard I. / Kirsch, Donald R. / Silverman, Richard B. et al. | 2014
- 5102
-
Discovery of potent and selective GIRK1/2 modulators via ‘molecular switches’ within a series of 1-(3-cyclopropyl-1-phenyl-1H-pyrazol-5-yl)ureasWen, Wandong / Wu, Wenjun / Weaver, C. David / Lindsley, Craig W. et al. | 2014
- 5107
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Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitroShelton, Jadd R. / Balzarini, Jan / Peterson, Matt A. et al. | 2014
- 5111
-
Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonistsAndrés, Miriam / Buil, Maria Antonia / Calbet, Marta / Casado, Oscar / Castro, Jordi / Eastwood, Paul R. / Eichhorn, Peter / Ferrer, Manel / Forns, Pilar / Moreno, Imma et al. | 2014
- 5118
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Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists IAlonso, Juan Antonio / Andrés, Miriam / Bravo, Mónica / Buil, Maria Antonia / Calbet, Marta / Castro, Jordi / Eastwood, Paul R. / Eichhorn, Peter / Esteve, Cristina / Gómez, Elena et al. | 2014
- 5123
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Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: Lead optimizationAlonso, Juan Antonio / Andrés, Miriam / Bravo, Mónica / Calbet, Marta / Eastwood, Paul R. / Eichhorn, Peter / Esteve, Cristina / Ferrer, Manel / Gómez, Elena / González, Jacob et al. | 2014
- 5127
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Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: The role of a hydrogen-bond acceptor in long receptor residence timesAlonso, Juan Antonio / Andrés, Miriam / Bravo, Mónica / Buil, Maria Antonia / Calbet, Marta / Castro, Jordi / Eastwood, Paul R. / Esteve, Cristina / Ferrer, Manel / Forns, Pilar et al. | 2014
- IFC
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Editorial board| 2014