Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors (English)
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In:
Bioorganic Chemistry
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98
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2020
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors
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Contributors:Jin, Ru-Yi ( author ) / Tang, Tian ( author ) / Zhou, Sha ( author ) / Long, Xu ( author ) / Guo, Hui ( author ) / Zhou, Jing ( author ) / Yan, Hao ( author ) / Li, Zhi ( author ) / Zuo, Zheng-Yu ( author ) / Xie, Hong-Lei ( author )
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Published in:Bioorganic Chemistry ; 98
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Publisher:
- New search for: Elsevier Inc.
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Publication date:2020-03-07
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 98
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
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Anti-influenza virus activity of benzo[d]thiazoles that target heat shock protein 90Lamut, Andraž / Gjorgjieva, Marina / Naesens, Lieve / Liekens, Sandra / Lillsunde, Katja-Emilia / Tammela, Päivi / Kikelj, Danijel / Tomašič, Tihomir et al. | 2020
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Identification of natural products as selective PTP1B inhibitors via virtual screeningYang, Ying / Tian, Jin-Ying / Ye, Fei / Xiao, Zhiyan et al. | 2020
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Synthesis and evaluation of 18F-PTTCO-Cys40-Exendin-4 for PET imaging of ectopic insulinomas in rodentsLi, Junfeng / Peng, Jiangling / Tang, Wei / Rawson, Jeffrey / Karunananthan, Johann / Jung, Min / Ma, Yuelong / Shively, John E. / Kandeel, Fouad et al. | 2020
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Expeditious and eco-friendly synthesis of new multifunctionalized pyrrole derivatives and evaluation of their antioxidant propertyKundu, Tania / Pramanik, Animesh et al. | 2020
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Design, synthesis and biological evaluation of coumarin linked 1,2,4-oxadiazoles as selective carbonic anhydrase IX and XII inhibitorsThacker, Pavitra S. / Angeli, Andrea / Argulwar, Omkar S. / Tiwari, Prerna L. / Arifuddin, Mohammed / Supuran, Claudiu T. et al. | 2020
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Euphoresulanes A–M, structurally diverse jatrophane diterpenoids from Euphorbia esulaXie, Xing-Lin / Fan, Run-Zhu / Hu, Rong / Luo, Si-Yuan / Tang, Gui-Hua / Yin, Sheng et al. | 2020
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Synthesis and biological evaluation of 2-epi-jaspine B analogs as selective sphingosine kinase 1 inhibitorsYang, Haoran / Li, Ying / Chai, Huining / Yakura, Takayuki / Liu, Bo / Yao, Qingqiang et al. | 2019
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Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from DisopyramideDawidowski, Maciej / Król, Marek / Szulczyk, Bartłomiej / Chodkowski, Andrzej / Podsadni, Piotr / Konopelski, Piotr / Ufnal, Marcin / Szuberski, Piotr / Wróbel, Martyna Zofia / Zhang, Yihong et al. | 2020
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Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitorsLin, Shu-Yu / Chang, Chun-Feng / Coumar, Mohane Selvaraj / Chen, Pei-Yi / Kuo, Fu-Ming / Chen, Chun-Hwa / Li, Mu-Chun / Lin, Wen-Hsing / Kuo, Po-Chu / Wang, Sing-Yi et al. | 2020
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Aminobenzosuberone derivatives as PfA-M1 inhibitors: Molecular recognition and antiplasmodial evaluationSalomon, Emmanuel / Schmitt, Marjorie / Mouray, Elisabeth / McEwen, Alastair G. / Bounaadja, Lotfi / Torchy, Morgan / Poussin-Courmontagne, Pierre / Alavi, Sarah / Tarnus, Céline / Cavarelli, Jean et al. | 2020
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Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitorsTang, Yan-Ling / Zheng, Xi / Qi, Yan / Pu, Xiao-Jia / Liu, Bei / Zhang, Xia / Li, Xiao-Si / Xiao, Wei-Lie / Wan, Chun-Ping / Mao, Ze-Wei et al. | 2020
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The insertion of functional groups in organic selenium compounds promote changes in mitochondrial parameters and raise the antibacterial activityStefanello, Sílvio Terra / Mizdal, Caren Rigon / Gonçalves, Débora Farina / Hartmann, Diane Duarte / Dobrachinski, Fernando / de Carvalho, Nélson Rodrigues / Salman, Syed Muhammad / Sauer, André C. / Dornelles, Luciano / de Campos, Marli Matiko Anraku et al. | 2020
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Isolation of benzolactones, Ganodumones A–F from Ganoderma lucidum and their antibacterial activitiesLu, Shuang-Yang / Shi, Qiang-Qiang / Peng, Xing-Rong / Zhou, Lin / Li, Xiao-Nian / Qiu, Ming-Hua et al. | 2020
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Synthesis of indole based acetohydrazide analogs: Their in vitro and in silico thymidine phosphorylase studiesTaha, Muhammad / Aldhamin, Ebaa Ahmed Jassim / Almandil, Noor Barak / Anouar, El Hassane / Uddin, Nizam / Alomari, Munther / Rahim, Fazal / Adalat, Bushra / Ibrahim, Mohamad / Nawaz, Fasial et al. | 2020
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Design and Synthesis of some new 2,4,6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agentsAllam, Heba Abdelrasheed / Aly, Enayat E. / Farouk, Ahmed K.B.A.W. / El Kerdawy, Ahmed M. / Rashwan, Essam / Abbass, Safinaz E.S. et al. | 2020
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Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitorsMoi, Davide / Nocentini, Alessio / Deplano, Alessandro / Osman, Sameh M. / AlOthman, Zeid A. / Piras, Valentina / Balboni, Gianfranco / Supuran, Claudiu T. / Onnis, Valentina et al. | 2020
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N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay studyMarques, Carolina S. / López, Óscar / Bagetta, Donatella / Carreiro, Elisabete P. / Petralla, Sabrina / Bartolini, Manuela / Hoffmann, Matthias / Alcaro, Stefano / Monti, Barbara / Bolognesi, Maria Laura et al. | 2020
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Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activityFarghaly, Thoraya A. / Masaret, Ghada S. / Muhammad, Zeinab A. / Harras, Marwa F. et al. | 2020
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Corrigendum to “Synthesis of novel 2-aminobenzothiazole derivatives as potential antimicrobial agents with dual DNA gyrase/topoisomerase IV inhibition” [Bioorg. Chem. 94 (2020) 103437]Ismail, Magda M.F. / Abdulwahab, Hanan Gaber / Nossier, Eman Samir / El Menofy, Nagwan Galal / Abdelkhalek, Basma Abdelhameed et al. | 2019
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Issue TOC| 2020
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Design, synthesis and evaluation of wound healing activity for β-sitosterols derivatives as potent Na+/K+-ATPase inhibitorsCui, Shaoyu / Jiang, Hongli / Chen, Lei / Xu, Jian / Sun, Wenzhuo / Sun, Haopeng / Xie, Zijian / Xu, Yunhui / Yang, Fubai / Liu, Wenyuan et al. | 2019
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Bioactive bisbenzylisoquinoline alkaloids from the roots of Stephania tetrandraWang, Renzhong / Liu, Yanfei / Shi, Guoru / Zhou, Jie / Li, Jiayuan / Li, Li / Yuan, Jiqiao / Li, Xuyu / Yu, Dequan et al. | 2020
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Technetium-99 m-PEGylated dendrimer-G2-(Dabcyle-Lys6,Phe7)-pHBSP: A novel Nano-Radiotracer for molecular and early detecting of cardiac ischemic regionMohtavinejad, Naser / Amanlou, Massoud / Bitarafan-Rajabi, Ahmad / khalaj, Ali / Pormohammad, Ali / Ardestani, Mehdi Shafiee et al. | 2020
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Benzo[a]phenoxazinium chlorides: Synthesis, antifungal activity, in silico studies and evaluation as fluorescent probesLeitão, Maria Inês P.S. / Rama Raju, B. / Cerqueira, Nuno M.F.S.A. / Sousa, Maria João / Gonçalves, M. Sameiro T. et al. | 2020
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Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ringÁlvarez, Raquel / Aramburu, Laura / Gajate, Consuelo / Vicente-Blázquez, Alba / Mollinedo, Faustino / Medarde, Manuel / Peláez, Rafael et al. | 2020
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Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitorsJin, Ru-Yi / Tang, Tian / Zhou, Sha / Long, Xu / Guo, Hui / Zhou, Jing / Yan, Hao / Li, Zhi / Zuo, Zheng-Yu / Xie, Hong-Lei et al. | 2020
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Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivoHu, Yang Sheng / Han, Xu / Yu, Pei Jing / Jiao, Ming Ming / Liu, Xin Hua / Shi, Jing Bo et al. | 2020
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New thymol and isothymol derivatives from Eupatorium fortunei and their cytotoxic effectsYu, Yue / Liu, Yuguo / Shi, Ranran / Zhang, Dongming / Li, Chuangjun / Shi, Jing et al. | 2020
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New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studiesFadaly, Wael A.A. / Elshaier, Yaseen A.M.M. / Hassanein, Emad H.M. / Abdellatif, Khaled R.A. et al. | 2020
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Synthesis of neocryptolepines and carbocycle-fused quinolines and evaluation of their anticancer and antiplasmodial activitiesAkkachairin, Bhornrawin / Rodphon, Warabhorn / Reamtong, Onrapak / Mungthin, Mathirut / Tummatorn, Jumreang / Thongsornkleeb, Charnsak / Ruchirawat, Somsak et al. | 2020
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NMR for screening and a biochemical assay: Identification of new FPPS inhibitors exerting anticancer activityGrimaldi, Manuela / Randino, Rosario / Ciaglia, Elena / Scrima, Mario / Buonocore, Michela / Stillitano, Ilaria / Abate, Mario / Covelli, Verdiana / Tosco, Alessandra / Gazzerro, Patrizia et al. | 2019
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Development of a classification model for the antigenotoxic activity of flavonoidsTuenter, Emmy / Creylman, Jan / Verheyen, Geert / Pieters, Luc / Van Miert, Sabine et al. | 2020
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S-benzyldithiocarbazate imine coordinated metal complexes kill Candida albicans by causing cellular apoptosis and necrosisMalik, Manzoor Ahmad / Lone, Shabir Ahmad / Wani, Mohmmad Younus / Talukdar, Md. Ikbal Ahmed / Dar, Ovas Ahmad / Ahmad, Aijaz / Hashmi, Athar Adil et al. | 2020
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Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluationHsu, Ming-Hua / Hsieh, Cheng-Ying / Kapoor, Mohit / Chang, Jui-Hsun / Chu, Hsueh-Liang / Cheng, Tsai-Mu / Hsu, Kai-Cheng / Lin, Tony Eight / Tsai, Fu-Yuan / Horng, Jia-Cherng et al. | 2020
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Extending the use of tadalafil scaffold: Development of novel selective phosphodiesterase 5 inhibitors and histone deacetylase inhibitorsElHady, Ahmed K. / Shih, Shou-Ping / Chen, Yu-Cheng / Liu, Yi-Chang / Ahmed, Nermin S. / Keeton, Adam B. / Piazza, Gary A. / Engel, Matthias / Abadi, Ashraf H. / Abdel-Halim, Mohammad et al. | 2020
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Synthetic homoserine lactone analogues as antagonists of bacterial quorum sensingQin, Xiaofei / Thota, Ganesh Kumar / Singh, Ratna / Balamurugan, Rengarajan / Goycoolea, Francisco M. et al. | 2020
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Design and characterization of a novel structural class of Kv1.3 inhibitorsHendrickx, Louise Antonia / Dobričić, Vladimir / Toplak, Žan / Peigneur, Steve / Mašič, Lucija Peterlin / Tomašič, Tihomir / Tytgat, Jan et al. | 2020
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Synthesis, anticancer evaluation and molecular docking studies of new heterocycles linked to sulfonamide moiety as novel human topoisomerase types I and II poisonsHalawa, Ahmed H. / Elgammal, Walid E. / Hassan, Saber M. / Hassan, Ahmed H. / Nassar, Hesham S. / Ebrahim, Hassan Y. / Mehany, Ahmed B.M. / El-Agrody, Ahmed M. et al. | 2020
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Diterpenoids from the leaves of Casearia kurzii showing cytotoxic activitiesLiang, Yue / Zhang, Qi / Yang, Xueyuan / Li, Ying / Zhang, Xuke / Li, Yuhao / Du, Qing / Jin, Da-Qing / Cui, Jianlin / Lall, Namrita et al. | 2020
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Design, synthesis and docking studies of novel benzopyrone derivatives as anticonvulsantsAbd-Allah, Walaa Hamada / Osman, Essam Eldin A. / Anwar, Mostafa Abd-El-Mohsen / Attia, Hanan Naeim / El Moghazy, Samir M. et al. | 2020
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Design, synthesis and biological evaluation of novel 5,6,7-trimethoxy-N-aryl-2-styrylquinolin-4-amines as potential anticancer agents and tubulin polymerization inhibitorsMirzaei, Salimeh / Eisvand, Farhad / Hadizadeh, Farzin / Mosaffa, Fatemeh / Ghasemi, Ali / Ghodsi, Razieh et al. | 2020
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Design, synthesis and anti-HBV activity evaluation of new substituted imidazo[4,5-b]pyridinesGerasi, Maria / Frakolaki, Efseveia / Papadakis, Georgios / Chalari, Anna / Lougiakis, Nikolaos / Marakos, Panagiotis / Pouli, Nicole / Vassilaki, Niki et al. | 2020
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Design, synthesis and evaluation of targeted hypoxia-activated prodrugs applied to chondrosarcoma chemotherapyGerard, Yvain / Voissière, Aurélien / Peyrode, Caroline / Galmier, Marie-Josephe / Maubert, Elise / Ghedira, Donia / Tarrit, Sebastien / Gaumet, Vincent / Canitrot, Damien / Miot-Noirault, Elisabeth et al. | 2020
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Application of carbamyl in structural optimizationWang, Kuanglei / Zhu, Hongxi / Zhao, Hongqian / Zhang, Kun / Tian, Yongshou et al. | 2020
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Synthesis of novel 2-oxospiro[indoline-3,4′-[1,3]dithiine]-5′-carbonitrile derivatives by new spiro[indoline-3,4′-[1,3]dithiine]@Cu(NO3)2 supported on Fe3O4@gly@CE MNPs as efficient catalyst and evaluation of biological activityMoghaddam-Manesh, Mohammadreza / Sheikhhosseini, Enayatollah / Ghazanfari, Dadkhoda / Akhgar, Mohammadreza et al. | 2020
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Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ1-42 aggregationPlazas, Erika / Hagenow, Stefanie / Avila Murillo, Monica / Stark, Holger / Cuca, Luis Enrique et al. | 2020
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Novel 1H-pyrazolo[3,4-d]pyrimidin-6-amino derivatives as potent selective Janus kinase 3 (JAK3) inhibitors. Evaluation of their improved effect for the treatment of rheumatoid arthritisYin, Yuan / Chen, Cheng-Juan / Yu, Ru-Nan / Shu, Lei / Wang, Zhi-Jian / Zhang, Tian-Tai / Zhang, Da-Yong et al. | 2020
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Synthesis and SAR studies of novel 1,2,4-oxadiazole-sulfonamide based compounds as potential anticancer agents for colorectal cancer therapyShamsi, Farheen / Hasan, Phool / Queen, Aarfa / Hussain, Afzal / Khan, Parvez / Zeya, Bushra / King, Hannah M. / Rana, Sandeep / Garrison, Jered / Alajmi, Mohamed F. et al. | 2020
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Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitorsChen, Dizhong / Soh, Chang Kai / Goh, Wei Huang / Wang, Zilong / Wang, Haishan et al. | 2020
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Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluationXu, Ana / He, Feng / Zhang, Xiangna / Li, Xiaoyang / Ran, Yingying / Wei, Chao / James Chou, C. / Zhang, Rui / Wu, Jingde et al. | 2020
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Multifunctional isoxazolidine derivatives as α-amylase and α-glucosidase inhibitorsGhabi, Ameni / Brahmi, Jihed / Alminderej, Fahad / Messaoudi, Sabri / Vidal, Sébastien / Kadri, Adel / Aouadi, Kaïss et al. | 2020
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Editorial Board| 2020
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Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoningClemente, F. / Matassini, C. / Faggi, C. / Giachetti, S. / Cresti, C. / Morrone, A. / Paoli, P. / Goti, A. / Martínez-Bailén, M. / Cardona, F. et al. | 2020
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Synthesis, antimicrobial and chitinase inhibitory activities of 3-amidocoumarinsSharma, Rajesh Kumar / Singh, Vineeta / Tiwari, Neha / Butcher, R.J. / Katiyar, Diksha et al. | 2020
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Incorporation of amino moiety to alepterolic acid improve activity against cancer cell lines: Synthesis and biological evaluationZhang, Sheng / Feng, Niping / Huang, Jinwen / Wang, Minglong / Zhang, Lei / Yu, Junjie / Dai, Xiling / Cao, Jianguo / Huang, Guozheng et al. | 2020
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Structural elucidation and in vivo anti-arthritic activity of β-amyrin and polpunonic acid isolated from the root bark of Ziziphus abyssinica HochstEx. A Rich (Rhamnaceae)Henneh, Isaac T. / Huang, Boshi / Musayev, Faik N. / Hashimi, Rana Al / Safo, Martin K. / Armah, Francis A. / Ameyaw, Elvis O. / Adokoh, Christian K. / Ekor, Martins / Zhang, Yan et al. | 2020
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Caseahomopene A, a ring-expanded homotriterpenoid from Casearia kurzii showing anti-inflammatory activities in vitro and in vivoAn, Lijun / Ma, Jun / Yang, Xueyuan / Liang, Yue / Wang, Huimei / Tuerhong, Muhetaer / Lall, Namrita / Abudukeremu, Munira / Zhang, Yi / Lee, Dongho et al. | 2020