Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead (English)
- New search for: Faist, Johanna
- New search for: Seebacher, Werner
- New search for: Saf, Robert
- New search for: Brun, Reto
- New search for: Kaiser, Marcel
- New search for: Weis, Robert
- New search for: Faist, Johanna
- New search for: Seebacher, Werner
- New search for: Saf, Robert
- New search for: Brun, Reto
- New search for: Kaiser, Marcel
- New search for: Weis, Robert
In:
Bioorganic and Medicinal Chemistry
;
24
, 16
;
3781-3789
;
2016
-
ISSN:
- Article (Journal) / Electronic Resource
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Title:Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead
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Contributors:Faist, Johanna ( author ) / Seebacher, Werner ( author ) / Saf, Robert ( author ) / Brun, Reto ( author ) / Kaiser, Marcel ( author ) / Weis, Robert ( author )
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Published in:Bioorganic and Medicinal Chemistry ; 24, 16 ; 3781-3789
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Publisher:
- New search for: Elsevier Ltd
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Publication date:2016-06-11
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Size:9 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 24, Issue 16
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 3343
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The design strategy of selective PTP1B inhibitors over TCPTPLi, XiangQian / Wang, LiJun / Shi, DaYong et al. | 2016
- 3353
-
Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2Qiang, Hao / Gu, Weijie / Huang, DanDan / Shi, Wei / Qiu, Qianqian / Dai, Yuxuan / Huang, Wenlong / Qian, Hai et al. | 2016
- 3359
-
6-Oxooxazolidine–quinazolines as noncovalent inhibitors with the potential to target mutant forms of EGFRShao, Jiaan / Chen, En / Shu, Ke / Chen, Wenteng / Zhang, Guolin / Yu, Yongping et al. | 2016
- 3371
-
Arabinoamidine synthesis and its inhibition toward β-glucosidase (sweet almonds) in comparison to a library of galactonoamidinesPickens, Jessica B. / Striegler, Susanne / Fan, Qiu-Hua et al. | 2016
- 3378
-
Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interfaceBhakkiyalakshmi, Elango / Dineshkumar, Kesavan / Karthik, Suresh / Sireesh, Dornadula / Hopper, Waheeta / Paulmurugan, Ramasamy / Ramkumar, Kunka Mohanram et al. | 2016
- 3387
-
Synthesis and in vitro α-chymotrypsin inhibitory activity of 6-chlorobenzimidazole derivativesSiddiqui, Hina / Farooq, Rabia / Marasini, Bishnu P. / Malik, Rizwana / Syed, Naima / Moin, Syed Tarique / Atta-ur-Rahman / Choudhary, M. Iqbal et al. | 2016
- 3396
-
Synthetic sulfoglycolipids targeting the serine–threonine protein kinase AktCosta, Barbara / Dangate, Milind / Vetro, Maria / Donvito, Giulia / Gabrielli, Luca / Amigoni, Loredana / Cassinelli, Giuliana / Lanzi, Cinzia / Ceriani, Michela / De Gioia, Luca et al. | 2016
- 3406
-
Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerizationToyama, Kei / Mizuguchi, Takaaki / Nomura, Wataru / Tamamura, Hirokazu et al. | 2016
- 3413
-
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio choleraeDel Prete, Sonia / Vullo, Daniela / De Luca, Viviana / Carginale, Vincenzo / di Fonzo, Pietro / Osman, Sameh M. / AlOthman, Zeid / Supuran, Claudiu T. / Capasso, Clemente et al. | 2016
- 3418
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Design, synthesis, and anticancer activity of C8-substituted-4′-thionucleosides as potential HSP90 inhibitorsQu, Shuhao / Mulamoottil, Varughese A. / Nayak, Akshata / Ryu, Seungyeon / Hou, Xiyan / Song, Jayoung / Yu, Jinha / Sahu, Pramod K. / Zhao, Long Xuan / Choi, Sun et al. | 2016
- 3429
-
Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluoridesBrouwer, Arwin J. / Herrero Álvarez, Natalia / Ciaffoni, Adriano / van de Langemheen, Helmus / Liskamp, Rob M.J. et al. | 2016
- 3436
-
Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonistKoura, Minoru / Yamaguchi, Yuki / Kurobuchi, Sayaka / Sumida, Hisashi / Watanabe, Yuichiro / Enomoto, Takashi / Matsuda, Takayuki / Okuda, Ayumu / Koshizawa, Tomoaki / Matsumoto, Yuki et al. | 2016
- 3447
-
Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocketYoshikawa, Masato / Hitaka, Takenori / Hasui, Tomoaki / Fushimi, Makoto / Kunitomo, Jun / Kokubo, Hironori / Oki, Hideyuki / Nakashima, Kosuke / Taniguchi, Takahiko et al. | 2016
- 3456
-
Bacterial Peptide deformylase inhibition of cyano substituted biaryl analogs: Synthesis, in vitro biological evaluation, molecular docking study and in silico ADME predictionKhan, Firoz A. Kalam / Patil, Rajendra H. / Shinde, Devanand B. / Sangshetti, Jaiprakash N. et al. | 2016
- 3464
-
Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligandsOfori, Edward / Zhu, Xue Y. / Etukala, Jagan R. / Peprah, Kwakye / Jordan, Kamanski R. / Adkins, Adia A. / Bricker, Barbara A. / Kang, Hye J. / Huang, Xi-Ping / Roth, Bryan L. et al. | 2016
- 3472
-
Discovery of 3-benzyl-1,3-benzoxazine-2,4-dione analogues as allosteric mitogen-activated kinase kinase (MEK) inhibitors and anti-enterovirus 71 (EV71) agentsSun, Jing / Niu, Yan / Wang, Chao / Zhang, Hao / Xie, Bingyu / Xu, Fengrong / Jin, Hongwei / Peng, Yihong / Liang, Lei / Xu, Ping et al. | 2016
- 3483
-
Synthesis and biological evaluation of new [1,2,4]triazolo[4,3-a]pyridine derivatives as potential c-Met inhibitorsZhao, Junjun / Fang, Lei / Zhang, Xiaobing / Liang, Yan / Gou, Shaohua et al. | 2016
- 3494
-
Development of novel NK3 receptor antagonists with reduced environmental impactYamamoto, Koki / Okazaki, Shiho / Ohno, Hiroaki / Matsuda, Fuko / Ohkura, Satoshi / Maeda, Kei-ichiro / Fujii, Nobutaka / Oishi, Shinya et al. | 2016
- 3501
-
Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivativesMowafy, Samar / Galanis, A. / Doctor, Zainab M. / Paranal, Raymond M. / Lasheen, Deena S. / Farag, Nahla A. / Jänne, Pasi A. / Abouzid, Khaled A.M. et al. | 2016
- 3513
-
Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding networkSciabola, Simone / Goetz, Gilles H. / Bai, Guoyun / Rogers, Bruce N. / Gray, David L. / Duplantier, Allen / Fonseca, Kari R. / Vanase-Frawley, Michelle A. / Kablaoui, Natasha M. et al. | 2016
- 3521
-
Identification of anticancer agents based on the thieno[2,3-b]pyridine and 1H-pyrazole molecular scaffoldsEurtivong, Chatchakorn / Reynisdóttir, Inga / Kuczma, Stephanie / Furkert, Daniel P. / Brimble, Margaret A. / Reynisson, Jóhannes et al. | 2016
- 3527
-
Synthesis, antimalarial properties and 2D-QSAR studies of novel triazole-quinine conjugatesFaidallah, Hassan M. / Panda, Siva S. / Serrano, Juan C. / Girgis, Adel S. / Khan, Khalid A. / Alamry, Khalid A. / Therathanakorn, Tanya / Meyers, Marvin J. / Sverdrup, Francis M. / Eickhoff, Christopher S. et al. | 2016
- 3540
-
Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole coreXu, Li-Li / Zhang, Xian / Jiang, Zheng-Yu / You, Qi-Dong et al. | 2016
- 3548
-
Microwave assisted synthesis of novel acridine–acetazolamide conjugates and investigation of their inhibition effects on human carbonic anhydrase isoforms hCA I, II, IV and VIIUlus, Ramazan / Aday, Burak / Tanç, Muhammet / Supuran, Claudiu T. / Kaya, Muharrem et al. | 2016
- 3556
-
Combined dual effect of modulation of human neutrophils’ oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivativesTavares-da-Silva, Elisiário J. / Varela, Carla L. / Pires, Ana S. / Encarnação, João C. / Abrantes, Ana M. / Botelho, Maria F. / Carvalho, Rui A. / Proença, Carina / Freitas, Marisa / Fernandes, Eduarda et al. | 2016
- 3565
-
Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibitionSweeney, Martin / Coyle, Robert / Kavanagh, Paul / Berezin, Andrey A. / Lo Re, Daniele / Zissimou, Georgia A. / Koutentis, Panayiotis A. / Carty, Michael P. / Aldabbagh, Fawaz et al. | 2016
- 3571
-
Synthesis and evaluation of antioxidant phenolic diaryl hydrazones as potent antiangiogenic agents in atherosclerosisVanucci-Bacqué, Corinne / Camare, Caroline / Carayon, Chantal / Bernis, Corinne / Baltas, Michel / Nègre-Salvayre, Anne / Bedos-Belval, Florence et al. | 2016
- 3579
-
Synthesis, photophysical properties of triazolyl-donor/acceptor chromophores decorated unnatural amino acids: Incorporation of a pair into Leu-enkephalin peptide and application of triazolylperylene amino acid in sensing BSABag, Subhendu Sekhar / Jana, Subhashis / Pradhan, Manoj Kumar et al. | 2016
- 3596
-
A sulfanyl-PEG derivative of relaxin-like peptide utilizable for the conjugation with KLH and the antibody productionKatayama, Hidekazu / Mita, Masatoshi et al. | 2016
- 3603
-
Sequence-specific DNA binding by long hairpin pyrrole–imidazole polyamides containing an 8-amino-3,6-dioxaoctanoic acid unitSawatani, Yoshito / Kashiwazaki, Gengo / Chandran, Anandhakumar / Asamitsu, Sefan / Guo, Chuanxin / Sato, Shinsuke / Hashiya, Kaori / Bando, Toshikazu / Sugiyama, Hiroshi et al. | 2016
- 3612
-
N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibitionNocentini, Alessio / Vullo, Daniela / Bartolucci, Gianluca / Supuran, Claudiu T. et al. | 2016
- 3618
-
Synthesis and evaluation of copper-64 labeled benzofuran derivatives targeting β-amyloid aggregatesWatanabe, Hiroyuki / Kawasaki, Azusa / Sano, Kohei / Ono, Masahiro / Saji, Hideo et al. | 2016
- 3624
-
Dihydropyrimidones: As novel class of β-glucuronidase inhibitorsAli, Farman / Khan, Khalid Mohammed / Salar, Uzma / Iqbal, Sarosh / Taha, Muhammad / Ismail, Nor Hadiani / Perveen, Shahnaz / Wadood, Abdul / Ghufran, Mehreen / Ali, Basharat et al. | 2016
- 3636
-
Bistacrine derivatives as new potent antimalarialsSchmidt, Ines / Pradel, Gabriele / Sologub, Ludmilla / Golzmann, Alexandra / Ngwa, Che J. / Kucharski, Anna / Schirmeister, Tanja / Holzgrabe, Ulrike et al. | 2016
- 3643
-
Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine–benzenesulfonamides acting as carbonic anhydrase inhibitorsVullo, Daniela / Supuran, Claudiu T. / Scozzafava, Andrea / De Simone, Giuseppina / Monti, Simona Maria / Alterio, Vincenzo / Carta, Fabrizio et al. | 2016
- 3649
-
Novel benzimidazol-2-ylidene carbene precursors and their silver(I) complexes: Potential antimicrobial agentsKaloğlu, Murat / Kaloğlu, Nazan / Özdemir, İlknur / Günal, Selami / Özdemir, İsmail et al. | 2016
- 3657
-
Ionophoric polyphenols selectively bind Cu2+, display potent antioxidant and anti-amyloidogenic properties, and are non-toxic toward Tetrahymena thermophilaMartínez, Alberto / Alcendor, Ralph / Rahman, Tanzeen / Podgorny, Magdalena / Sanogo, Ismaila / McCurdy, Rebecca et al. | 2016
- 3671
-
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophoresEtukala, Jagan R. / Zhu, Xue Y. / Eyunni, Suresh V.K. / Onyameh, Edem K. / Ofori, Edward / Bricker, Barbara A. / Kang, Hye J. / Huang, Xi-Ping / Roth, Bryan L. / Ablordeppey, Seth Y. et al. | 2016
- 3680
-
Synthesis and investigation of novel benzimidazole derivatives as antifungal agentsChandrika, Nishad Thamban / Shrestha, Sanjib K. / Ngo, Huy X. / Garneau-Tsodikova, Sylvie et al. | 2016
- 3687
-
Synthesis and Th1-immunostimulatory activity of α-galactosylceramide analogues bearing a halogen-containing or selenium-containing acyl chainHossain, Md. Imran / Hanashima, Shinya / Nomura, Takuto / Lethu, Sébastien / Tsuchikawa, Hiroshi / Murata, Michio / Kusaka, Hiroki / Kita, Shunsuke / Maenaka, Katsumi et al. | 2016
- 3696
-
Synthesis and biological evaluation of novel N-arylidenequinoline-3-carbohydrazides as potent β-glucuronidase inhibitorsTaha, Muhammad / Sultan, Sadia / Nuzar, Herizal Ali / Rahim, Fazal / Imran, Syahrul / Ismail, Nor Hadiani / Naz, Humera / Ullah, Hayat et al. | 2016
- 3705
-
Hydrophobic substituents increase the potency of salacinol, a potent α-glucosidase inhibitor from Ayurvedic traditional medicine ‘Salacia’Tanabe, Genzoh / Xie, Weijia / Balakishan, Gorre / Amer, Mumen F.A. / Tsutsui, Nozomi / Takemura, Haruka / Nakamura, Shinya / Akaki, Junji / Ninomiya, Kiyofumi / Morikawa, Toshio et al. | 2016
- 3716
-
Design, synthesis, and biological evaluation of a novel series of peripheral-selective noradrenaline reuptake inhibitors – Part 3Yukawa, Tomoya / Nakada, Yoshihisa / Sakauchi, Nobuki / Kamei, Taku / Yamada, Masami / Ohba, Yusuke / Fujimori, Ikuo / Ueno, Hiroyuki / Takiguchi, Maiko / Kuno, Masako et al. | 2016
- 3727
-
Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cellsYamamoto, Yumi / Arai, Jun / Hisa, Takuya / Saito, Yohei / Mukai, Takahiro / Ohshima, Takashi / Maeda, Minoru / Yamamoto, Fumihiko et al. | 2016
- 3734
-
A new motif for inhibitors of geranylgeranyl diphosphate synthaseFoust, Benjamin J. / Allen, Cheryl / Holstein, Sarah A. / Wiemer, David F. et al. | 2016
- 3742
-
2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesteraseLeong, Sze Wei / Abas, Faridah / Lam, Kok Wai / Shaari, Khozirah / Lajis, Nordin H. et al. | 2016
- 3752
-
Cyclopamine bioactivity by extraction method from Veratrum californicumTurner, Matthew W. / Cruz, Roberto / Mattos, Jared / Baughman, Nic / Elwell, Jordan / Fothergill, Jenny / Nielsen, Anna / Brookhouse, Jessica / Bartlett, Ashton / Malek, Petr et al. | 2016
- 3758
-
Discovery of a novel small molecule agonist scaffold for the APJ receptorNarayanan, Sanju / Maitra, Rangan / Deschamps, Jeffery R. / Bortoff, Katherine / Thomas, James B. / Zhang, Yanyan / Warner, Keith / Vasukuttan, Vineetha / Decker, Ann / Runyon, Scott P. et al. | 2016
- 3771
-
Synthesis and evaluation of antitubercular activity of fluorinated 5-aryl-4-(hetero)aryl substituted pyrimidinesVerbitskiy, Egor V. / Baskakova, Svetlana A. / Kravchenko, Marionella A. / Skornyakov, Sergey N. / Rusinov, Gennady L. / Chupakhin, Oleg N. / Charushin, Valery N. et al. | 2016
- 3781
-
Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgeheadFaist, Johanna / Seebacher, Werner / Saf, Robert / Brun, Reto / Kaiser, Marcel / Weis, Robert et al. | 2016
- 3790
-
5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream formsOrban, Oliver C.F. / Korn, Ricarda S. / Benítez, Diego / Medeiros, Andrea / Preu, Lutz / Loaëc, Nadège / Meijer, Laurent / Koch, Oliver / Comini, Marcelo A. / Kunick, Conrad et al. | 2016
- 3801
-
Identification of a novel boronic acid as a potent, selective, and orally active hormone sensitive lipase inhibitorOgiyama, Tomoko / Yamaguchi, Mitsuhiro / Kurikawa, Nobuya / Honzumi, Shoko / Yamamoto, Yuka / Sugiyama, Daisuke / Inoue, Shinichi et al. | 2016
- 3808
-
An expeditious four-component domino protocol for the synthesis of novel thiazolo[3,2-a]thiochromeno[4,3-d]pyrimidine derivatives as antibacterial and antibiofilm agentsSuresh, Lingala / Sagar Vijay Kumar, P. / Poornachandra, Y. / Ganesh Kumar, C. / Babu, Nanubolu Jagadeesh / Chandramouli, G.V.P. et al. | 2016
- 3818
-
Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studiesAbdel-Aziz, Alaa A.-M. / Abou-Zeid, Laila A. / ElTahir, Kamal Eldin H. / Mohamed, Menshawy A. / Abu El-Enin, Mohamed A. / El-Azab, Adel S. et al. | 2016
- 3829
-
Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer’s diseaseMishra, Chandra Bhushan / Manral, Apra / Kumari, Shikha / Saini, Vikas / Tiwari, Manisha et al. | 2016
- 3842
-
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteresKormos, Chad M. / Gichinga, Moses G. / Runyon, Scott P. / Thomas, James B. / Mascarella, S. Wayne / Decker, Ann M. / Navarro, Hernán A. / Carroll, F. Ivy et al. | 2016
- 3849
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Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivativesOgindo, Charles O. / Khraiwesh, Mozna H. / George, Matthew Jr. / Brandy, Yakini / Brandy, Nailah / Gugssa, Ayele / Ashraf, Mohammad / Abbas, Muneer / Southerland, William M. / Lee, Clarence M. et al. | 2016
- 3856
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Effects of 8-halo-7-deaza-2′-deoxyguanosine triphosphate on DNA synthesis by DNA polymerases and cell proliferationYin, Yizhen / Sasaki, Shigeki / Taniguchi, Yosuke et al. | 2016
- 3862
-
Synthesis and anticancer activity of novel 4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine derivatives bearing chromone moietySun, Chengyu / Chen, Chen / Xu, Shan / Wang, Jianqiang / Zhu, Yan / Kong, Dejia / Tao, Hong / Jin, Mengjia / Zheng, Pengwu / Zhu, Wufu et al. | 2016
- 3870
-
Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effectKitamura, Yoshiaki / Kito, Seiya / Nakashima, Remi / Tanaka, Katsuki / Nagaoka, Kumi / Kitade, Yukio et al. | 2016
- IFC
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Editorial board| 2016