Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the -ligands (English)
- New search for: Ghosh, Arun K.
- New search for: Schiltz, Gary
- New search for: Perali, Ramu Sridhar
- New search for: Leshchenko, Sofiya
- New search for: Kay, Stephanie
- New search for: Walters, D. Eric
- New search for: Koh, Yasuhiro
- New search for: Maeda, Kenji
- New search for: Mitsuya, Hiroaki
- New search for: Ghosh, Arun K.
- New search for: Schiltz, Gary
- New search for: Perali, Ramu Sridhar
- New search for: Leshchenko, Sofiya
- New search for: Kay, Stephanie
- New search for: Walters, D. Eric
- New search for: Koh, Yasuhiro
- New search for: Maeda, Kenji
- New search for: Mitsuya, Hiroaki
In:
Bioorganic and Medicinal Chemistry Letters
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16
, 7
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1869-1873
;
2006
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the -ligands
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Contributors:Ghosh, Arun K. ( author ) / Schiltz, Gary ( author ) / Perali, Ramu Sridhar ( author ) / Leshchenko, Sofiya ( author ) / Kay, Stephanie ( author ) / Walters, D. Eric ( author ) / Koh, Yasuhiro ( author ) / Maeda, Kenji ( author ) / Mitsuya, Hiroaki ( author )
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Published in:Bioorganic and Medicinal Chemistry Letters ; 16, 7 ; 1869-1873
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Publisher:
- New search for: Elsevier Ltd
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Publication date:2006-01-04
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Size:5 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 16, Issue 7
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1759
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Graphical contents list| 2006
- 1775
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Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSPFraley, Mark E. / Garbaccio, Robert M. / Arrington, Kenneth L. / Hoffman, William F. / Tasber, Edward S. / Coleman, Paul J. / Buser, Carolyn A. / Walsh, Eileen S. / Hamilton, Kelly / Fernandes, Christine et al. | 2006
- 1780
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Kinesin spindle protein (KSP) inhibitors. Part 3: Synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubilityGarbaccio, Robert M. / Fraley, Mark E. / Tasber, Edward S. / Olson, Christy M. / Hoffman, William F. / Arrington, Kenneth L. / Torrent, Maricel / Buser, Carolyn A. / Walsh, Eileen S. / Hamilton, Kelly et al. | 2005
- 1784
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How cyclodextrins can mask their toxic effect on the blood–brain barrierBinkowski-Machut, Cécile / Hapiot, Frédéric / Martin, Patrick / Cecchelli, Roméo / Monflier, Eric et al. | 2006
- 1788
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Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385Miller, John F. / Andrews, C. Webster / Brieger, Michael / Furfine, Eric S. / Hale, Michael R. / Hanlon, Mary H. / Hazen, Richard J. / Kaldor, Istvan / McLean, Ed W. / Reynolds, David et al. | 2006
- 1795
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Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitorsQuan, Mimi L. / Han, Qi / Fevig, John M. / Lam, Patrick Y.S. / Bai, Steve / Knabb, Robert M. / Luettgen, Joseph M. / Wong, Pancras C. / Wexler, Ruth R. et al. | 2006
- 1799
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Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized ratsCameron, Kimberly O. / Lefker, Bruce A. / Chu-Moyer, Margaret Y. / Crawford, David T. / Jardine, Paul DaSilva / DeNinno, Shari L. / Gilbert, Sandra / Grasser, William A. / Ke, HuaZhu / Lu, Bihong et al. | 2006
- 1803
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Azolylchromans as a novel scaffold for anticonvulsant activityEmami, Saeed / Kebriaeezadeh, Abbas / Zamani, Mohammad Jafar / Shafiee, Abbas et al. | 2006
- 1807
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Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphataseLai, Chunqiu / Gum, Rebecca J. / Daly, Melissa / Fry, Elizabeth H. / Hutchins, Charles / Abad-Zapatero, Celerino / von Geldern, Thomas W. et al. | 2006
- 1811
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Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding modevon Geldern, Thomas W. / Lai, Chunqiu / Gum, Rebecca J. / Daly, Melissa / Sun, Chaohong / Fry, Elizabeth H. / Abad-Zapatero, Celerino et al. | 2006
- 1816
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Dda helicase unwinds a DNA–PNA chimeric substrate: Evidence for an inchworm mechanismSpurling, Travis L. / Eoff, Robert L. / Raney, Kevin D. et al. | 2006
- 1821
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3D-QSAR studies of farnesyltransferase inhibitors: A comparative molecular field analysis approachPuntambekar, Devendra / Giridhar, Rajani / Yadav, Mange Ram et al. | 2006
- 1828
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Solid-phase synthesis of 1,3,4-oxadiazoline-5-thione derivatives from resin-bound acylhydrazinesLiu, Zhanxiang / Zhao, Jinlong / Huang, Xian et al. | 2006
- 1831
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Synthesis and preliminary biological evaluation of the 99mTc labeled nitrobenzoimidazole and nitrotriazole as tumor hypoxia markersZhang, Yu / Chu, Taiwei / Gao, Xuguang / Liu, Xinqi / Yang, Zhi / Guo, Zhenquan / Wang, Xiangyun et al. | 2006
- 1834
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First dual M3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivativesProvins, Laurent / Christophe, Bernard / Danhaive, Pierre / Dulieu, Jacques / Durieu, Véronique / Gillard, Michel / Lebon, Florence / Lengelé, Sébastien / Quéré, Luc / van Keulen, BerendJan et al. | 2006
- 1840
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Synthesis and activity of small molecule GPR40 agonistsGarrido, Dulce M. / Corbett, David F. / Dwornik, Kate A. / Goetz, Aaron S. / Littleton, Thomas R. / McKeown, Steve C. / Mills, Wendy Y. / Smalley, Terrence L. Jr. / Briscoe, Celia P. / Peat, Andrew J. et al. | 2006
- 1846
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Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile intermediates for the design and synthesis of topoisomerase I inhibitorsMorrell, Andrew / Antony, Smitha / Kohlhagen, Glenda / Pommier, Yves / Cushman, Mark et al. | 2006
- 1850
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Synthesis and antifungal activity of 6-hydroxycinnolinesRyu, Chung-Kyu / Lee, Jung Yoon et al. | 2006
- 1854
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Synthesis and evaluation of febrifugine analogues as potential antimalarial agentsZhu, Shuren / Meng, Li / Zhang, Quan / Wei, Lai et al. | 2006
- 1859
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Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazoleIshida, Tomio / Suzuki, Takayoshi / Hirashima, Shintaro / Mizutani, Kenji / Yoshida, Atsuhito / Ando, Izuru / Ikeda, Satoru / Adachi, Tsuyoshi / Hashimoto, Hiromasa et al. | 2006
- 1864
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Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: Side chain explorationLiu, Bo / Liu, Mei / Xin, Zhili / Zhao, Hongyu / Serby, Michael D. / Kosogof, Christi / Nelson, Lissa T.J. / Szczepankiewicz, Bruce G. / Kaszubska, Wiweka / Schaefer, Verlyn G. et al. | 2006
- 1869
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Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the -ligandsGhosh, Arun K. et al. | 2006
- 1869
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Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the -ligandsGhosh, Arun K. / Schiltz, Gary / Perali, Ramu Sridhar / Leshchenko, Sofiya / Kay, Stephanie / Walters, D. Eric / Koh, Yasuhiro / Maeda, Kenji / Mitsuya, Hiroaki et al. | 2006
- 1869
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Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the Formula Not Shown -ligandsGhosh, A. K. / Schiltz, G. / Perali, R. S. / Leshchenko, S. / Kay, S. / Walters, D. E. / Koh, Y. / Maeda, K. / Mitsuya, H. et al. | 2006
- 1874
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Synthesis and stability of two indomethacin prodrugsChandrasekaran, Shyamala / Al-Ghananeem, Abeer M. / Riggs, Robert M. / Crooks, Peter A. et al. | 2006
- 1880
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Synthesis of constrained ceramide analogs and their potent antileukemic activitiesHa, Hyun-Joon / Hong, Myeng Chan / Ko, Seung Whan / Kim, Yong Woo / Lee, Won Koo / Park, Jungchan et al. | 2005
- 1884
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Antioxidant activity of novel chitin derivativeJe, Jae-Young / Kim, Se-Kwon et al. | 2005
- 1888
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Synthesis of α-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitorsHaemers, Timothy / Wiesner, Jochen / Poecke, Sara Van / Goeman, Jan / Henschker, Dajana / Beck, Edwald / Jomaa, Hassan / Calenbergh, Serge Van et al. | 2005
- 1888
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Synthesis of a-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitorsHaemers, Timothy et al. | 2006
- 1892
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Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonistsBüttelmann, Bernd / Peters, Jens-Uwe / Ceccarelli, Simona / Kolczewski, Sabine / Vieira, Eric / Prinssen, Eric P. / Spooren, Will / Schuler, Franz / Huwyler, Jörg / Porter, Richard H.P. et al. | 2005
- 1898
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New ligand-based approach for the discovery of antitrypanosomal compoundsVega, María Celeste / Montero-Torres, Alina / Marrero-Ponce, Yovani / Rolón, Miriam / Gómez-Barrio, Alicia / Escario, José Antonio / Arán, Vicente J. / Nogal, Juan José / Meneses-Marcel, Alfredo / Torrens, Francisco et al. | 2005
- 1905
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Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatasesHuang, Weigang / Li, Jingya / Zhang, Wei / Zhou, Yueyang / Xie, Chuanming / Luo, Yu / Li, Yunfei / Wang, Jingli / Li, Jia / Lu, Wei et al. | 2005
- 1909
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A novel ketone derivative of artemisinin biotransformed by Streptomyces griseus ATCC 13273Liu, Ji-Hua / Chen, You-Gen / Yu, Bo-Yang / Chen, Yi-Jun et al. | 2005
- 1913
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Inhibitors of VEGF receptors-1 and -2 based on the 2-((pyridin-4-yl)ethyl)pyridine templateKiselyov, Alexander S. / Semenova, Marina / Semenov, Victor V. / Milligan, Daniel et al. | 2005
- 1920
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b-Diketo acids with purine nucleobase scaffolds: Novel, selective inhibitors of the strand transfer step of HIV integraseNair, Vasu et al. | 2006
- 1920
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β-Diketo acids with purine nucleobase scaffolds: Novel, selective inhibitors of the strand transfer step of HIV integraseNair, Vasu / Uchil, Vinod / Neamati, Nouri et al. | 2005
- 1924
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Novel non-benzimidazole chk2 kinase inhibitorsMcClure, Kelly J. / Huang, Liming / Arienti, Kristen L. / Axe, Frank U. / Brunmark, Anders / Blevitt, Jon / Guy Breitenbucher, J. et al. | 2005
- 1929
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Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolidesGrant, Eugene B. / Guiadeen, Deodialsingh / Abbanat, Darren / Foleno, Barbara D. / Bush, Karen / Macielag, Mark J. et al. | 2005
- 1934
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Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: Variations on the 1H-pyrimidin-2-one themeGeneste, Hervé / Amberg, Wilhelm / Backfisch, Gisela / Beyerbach, Armin / Braje, Wilfried M. / Delzer, Jürgen / Haupt, Andreas / Hutchins, Charles W. / King, Linda L. / Sauer, Daryl R. et al. | 2005
- 1938
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Fluorescent non-imidazole histamine H3 receptor ligands with nanomolar affinitiesAmon, Michael / Ligneau, Xavier / Schwartz, Jean-Charles / Stark, Holger et al. | 2005
- 1941
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QSAR models of quail dietary toxicity based on the graph of atomic orbitalsToropov, Andrey A. / Benfenati, Emilio et al. | 2005
- 1944
-
Semi-synthetic preparation of the rare, cytotoxic, deep-sea sourced sponge metabolites discorhabdins P and UGrkovic, Tanja / Kaur, Balwinder / Webb, Victoria L. / Copp, Brent R. et al. | 2005
- 1947
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Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activitiesAoyagi, Yutaka / Hitotsuyanagi, Yukio / Hasuda, Tomoyo / Fukaya, Haruhiko / Takeya, Koichi / Aiyama, Ritsuo / Matsuzaki, Takeshi / Hashimoto, Shusuke et al. | 2005
- 1950
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Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesisMcDermott, Lee A. / Higgins, Brian / Simcox, Mary / Luk, Kin-Chun / Nevins, Tom / Kolinsky, Kenneth / Smith, Melissa / Yang, Hong / Li, Jia K. / Chen, Yingsi et al. | 2005
- 1954
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Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferaseLee, Jinho / Kim, Jonghyun / Koh, Jong Sung / Chung, Hyun-Ho / Kim, Kyoung-Hee et al. | 2005
- 1957
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Polyhydroxylated 4-thiaflavans as multipotent antioxidants: Protective effect on oxidative DNA damage in vitroLodovici, Maura / Menichetti, Stefano / Viglianisi, Caterina / Caldini, Silvia / Giuliani, Elisa et al. | 2005
- 1961
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A series of 23,24-dihydrodiscodermolide analogues with simplified lactone regionsShaw, Simon J. / Sundermann, Kurt F. / Burlingame, Mark A. / Zhang, Dan / Petryka, Joseph / Myles, David C. et al. | 2005
- 1965
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A novel series of urea-based peptidomimetic calpain inhibitorsSanders, M. Lee / Donkor, Isaac O. et al. | 2005
- 1969
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In silico identification of novel EGFR inhibitors with antiproliferative activity against cancer cellsCavasotto, Claudio N. / Ortiz, María A. / Abagyan, Ruben A. / Piedrafita, F. Javier et al. | 2005
- 1975
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Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: Heterocyclic P3Tully, David C. / Liu, Hong / Alper, Phil B. / Chatterjee, Arnab K. / Epple, Robert / Roberts, Michael J. / Williams, Jennifer A. / Nguyen, KhanhLinh T. / Woodmansee, David H. / Tumanut, Christine et al. | 2005
- 1981
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Synthesis and transdermal penetration-enhancing activity of carbonic and carbamic acid esters—Comparison with transkarbam 12Klimentová, Jana / Hrabálek, Alexandr / Vávrová, Kateřina / Holas, Tomáš / Kroutil, Aleš et al. | 2005
- 1985
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Identification of a potent and selective non-basic cathepsin K inhibitorLi, Chun Sing / Deschenes, Denis / Desmarais, Sylvie / Falgueyret, Jean-Pierre / Gauthier, Jacques Yves / Kimmel, Donald. B. / Léger, Serge / Massé, Frédéric / McGrath, Mary E. / McKay, Daniel J. et al. | 2005
- 1990
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Nitrobenzylcarbamate prodrugs of cytotoxic acridines for potential use with nitroreductase gene-directed enzyme prodrug therapyAsche, Christian / Dumy, Pascal / Carrez, Danièle / Croisy, Alain / Demeunynck, Martine et al. | 2005
- 1995
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BACE-1 inhibitory activities of new substituted phenyl-piperazine coupled to various heterocycles: Chromene, coumarin and quinolineGarino, Cédrik / Pietrancosta, Nicolas / Laras, Younes / Moret, Vincent / Rolland, Amandine / Quéléver, Gilles / Kraus, Jean-Louis et al. | 2005
- 2000
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Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancerLi, Qun / Woods, Keith W. / Thomas, Sheela / Zhu, Gui-Dong / Packard, Garrick / Fisher, John / Li, Tongmei / Gong, Jianchun / Dinges, Jurgen / Song, Xiaohong et al. | 2005
- 2008
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1-Phenyl-8-azabicyclo[3.2.1]octane ethers: A novel series of neurokinin (NK1) antagonistsHuscroft, Ian T. / Carlson, Emma J. / Chicchi, Gary G. / Kurtz, Marc M. / London, Clare / Raubo, Piotr / Wheeldon, Alan / Kulagowski, Janusz J. et al. | 2005
- 2013
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Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594Zhang, Chuan-Xin / Ge, Ze-Mei / Cheng, Tie-Ming / Li, Run-Tao et al. | 2005
- 2017
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Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocketFrédérick, Raphaël / Charlier, Caroline / Robert, Séverine / Wouters, Johan / Masereel, Bernard / Pochet, Lionel et al. | 2005
- 2022
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Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporterCases-Thomas, Manuel J. / Masters, John J. / Walter, Magnus W. / Campbell, Gordon / Haughton, Louise / Gallagher, Peter T. / Dobson, David R. / Mancuso, Vincent / Bonnier, Benjamin / Giard, Thierry et al. | 2005
- 2026
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Mild and efficient oxidation of Hantzsch 1,4-dihydropyridines with sodium periodate catalyzed by a new polystyrene-bound Mn(TPP)ClMoghadam, Majid / Nasr-Esfahani, Masoud / Tangestaninejad, Shahram / Mirkhani, Valiollah et al. | 2005
- 2031
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Fabrication and application of neoglycolipid arrays in a microtiter plateHuang, Gang-Liang / Zhang, Hou-Cheng / Wang, Peng-George et al. | 2005
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Small molecule inhibitors of plasma kallikreinYoung, Wendy B. / Rai, Roopa / Shrader, William D. / Burgess-Henry, Jana / Hu, Huiyong / Elrod, Kyle C. / Sprengeler, Paul A. / Katz, Bradley A. / Sukbuntherng, Juthamas / Mordenti, Joyce et al. | 2005
- 2037
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Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis modelYoung, Wendy B. / Mordenti, Joyce / Torkelson, Steven / Shrader, William D. / Kolesnikov, Aleksandr / Rai, Roopa / Liu, Liang / Hu, Huiyong / Leahy, Ellen M. / Green, Michael J. et al. | 2005
- 2042
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Chemo-enzymatic synthesis of allyl penta-N-acetyl-chitopentaoseHuang, Gang-Liang / Zhang, Da-Wei / Zhao, Hong-Juan / Zhang, Hou-Cheng / Wang, Peng-George et al. | 2005
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QSAR study on topically acting sulfonamides incorporating GABA moieties: A molecular connectivity approachAgrawal, Vijay K. / Singh, Jyoti / Khadikar, Padmakar V. / Supuran, Claudiu T. et al. | 2005
- CO2
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Editorial Board| 2006
- I
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Instructions to contributors| 2006