Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs (English)
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In:
Bioorganic and Medicinal Chemistry Letters
;
20
, 2
;
618-622
;
2009
-
ISSN:
- Article (Journal) / Electronic Resource
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Title:Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs
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Contributors:Kleanthous, Savvas ( author ) / Borthwick, Alan D. ( author ) / Brown, David ( author ) / Burns-Kurtis, Cynthia L. ( author ) / Campbell, Matthew ( author ) / Chaudry, Laiq ( author ) / Chan, Chuen ( author ) / Clarte, Marie-Olive ( author ) / Convery, Máire A. ( author ) / Harling, John D. ( author )
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Published in:Bioorganic and Medicinal Chemistry Letters ; 20, 2 ; 618-622
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Publisher:
- New search for: Elsevier Ltd
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Publication date:2009-11-17
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Size:5 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 20, Issue 2
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 425
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Graphical contents list| 2009
- 444
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Protection of a single-cysteine redox switch from oxidative destruction: On the functional role of sulfenyl amide formation in the redox-regulated enzyme PTP1BSivaramakrishnan, Santhosh / Cummings, Andrea H. / Gates, Kent S. et al. | 2009
- 448
-
Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)Torrisi, Caterina / Bisbocci, Monica / Ingenito, Raffaele / Ontoria, Jesus M. / Rowley, Michael / Schultz-Fademrecht, Carsten / Toniatti, Carlo / Jones, Philip et al. | 2009
- 453
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Conversion of 4-cyanomethyl-pyrazole-3-carboxamides into CB1 antagonists with lowered propensity to pass the blood–brain-barrierReceveur, Jean-Marie / Murray, Anthony / Linget, Jean-Michel / Nørregaard, Pia K. / Cooper, Martin / Bjurling, Emelie / Nielsen, Peter Aadal / Högberg, Thomas et al. | 2009
- 458
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Synthesis and antiproliferating activity of iron chelators of hydroxyamino-1,3,5-triazine familySun, Daekyu / Melman, Galina / LeTourneau, Nickolas J. / Hays, Allison M. / Melman, Artem et al. | 2009
- 461
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Synthesis and in vivo evaluation of bicyclic gababutinsBlakemore, David C. / Bryans, Justin S. / Carnell, Pauline / Carr, Christopher L. / Chessum, Nicola E.A. / Field, Mark J. / Kinsella, Natasha / Osborne, Simon A. / Warren, Andrew N. / Williams, Sophie C. et al. | 2009
- 465
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Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB2 agonists for the treatment of inflammatory painGleave, Robert J. / Beswick, Paul J. / Brown, Andrew J. / Giblin, Gerard M.P. / Goldsmith, Paul / Haslam, Carl P. / Mitchell, William L. / Nicholson, Neville H. / Page, Lee W. / Patel, Sadhana et al. | 2009
- 469
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Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibitionJerome, Kevin D. / Rucker, Paul V. / Xing, Li / Shieh, Huey S. / Baldus, John E. / Selness, Shaun R. / Letavic, Michael A. / Braganza, John F. / McClure, Kim F. et al. | 2009
- 474
-
Carbonic anhydrase inhibitors. X-ray crystal studies of the carbonic anhydrase II–trithiocarbonate adduct—An inhibitor mimicking the sulfonamide and urea binding to the enzymeTemperini, Claudia / Scozzafava, Andrea / Supuran, Claudiu T. et al. | 2009
- 479
-
Novel thioamide derivatives as neutral CB1 receptor antagonistsBoström, Jonas / Olsson, Roine I. / Tholander, Joakim / Greasley, Peter J. / Ryberg, Erik / Nordberg, Henrik / Hjorth, Stephan / Cheng, Leifeng et al. | 2009
- 483
-
Inhibition of Yersinia protein tyrosine phosphatase by phosphonate derivatives of calixarenesVovk, Andriy I. / Kononets, Lyudmyla A. / Tanchuk, Vsevolod Yu. / Cherenok, Sergiy O. / Drapailo, Andriy B. / Kalchenko, Vitaly I. / Kukhar, Valery P. et al. | 2009
- 488
-
Synthesis and biological evaluation of substituted 2-phenyl-2H-indazole-7-carboxamides as potent poly(ADP-ribose) polymerase (PARP) inhibitorsScarpelli, Rita / Boueres, Julia K. / Cerretani, Mauro / Ferrigno, Federica / Ontoria, Jesus M. / Rowley, Michael / Schultz-Fademrecht, Carsten / Toniatti, Carlo / Jones, Philip et al. | 2009
- 493
-
The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulatorsWang, Yingcai / Jiao, Xianyun / Kayser, Frank / Liu, Jiwen / Wang, Zhongyu / Wanska, Malgorzata / Greenberg, Joanne / Weiszmann, Jennifer / Ge, Hongfei / Tian, Hui et al. | 2009
- 499
-
Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438)Léger, Serge / Black, W. Cameron / Deschenes, Denis / Dolman, Sarah / Falgueyret, Jean-Pierre / Gagnon, Marc / Guiral, Sébastien / Huang, Zheng / Guay, Jocelyne / Leblanc, Yves et al. | 2009
- 503
-
Biaryl piperidines as potent and selective delta opioid receptor ligandsLiras, Spiros / McHardy, Stanton F. / Allen, Martin P. / Segelstein, Barb E. / Heck, Steven D. / Bryce, Dianne K. / Schmidt, Anne W. / Vanase-Frawley, Michelle / Callegari, Ernesto / McLean, Stafford et al. | 2009
- 508
-
Antitubercular potential of some semisynthetic analogues of phytolSaikia, Dharmendra / Parihar, Swati / Chanda, D. / Ojha, S. / Kumar, J.K. / Chanotiya, C.S. / Shanker, K. / Negi, Arvind S. et al. | 2009
- 513
-
Evaluation of human neutrophil elastase inhibitory effect of iridoid glycosides from Hedyotis diffusaXu, Guang-Hua / Kim, Young-Hee / Chi, Seung-Wook / Choo, Soo-Jin / Ryoo, In-Ja / Ahn, Jong-Seog / Yoo, Ick-Dong et al. | 2009
- 516
-
Triazole oxytocin antagonists: Identification of an aryloxyazetidine replacement for a biaryl substituentBrown, Alan / Brown, T. Bruce / Calabrese, Andrew / Ellis, Dave / Puhalo, Nicholas / Ralph, Michael / Watson, Lesa et al. | 2009
- 521
-
3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonistsSinghaus, Robert R. / Bernotas, Ronald C. / Steffan, Robert / Matelan, Edward / Quinet, Elaine / Nambi, Ponnal / Feingold, Irene / Huselton, Christine / Wilhelmsson, Anna / Goos-Nilsson, Annika et al. | 2009
- 526
-
1-(3-Aryloxyaryl)benzimidazole sulfones are liver X receptor agonistsTravins, Jeremy M. / Bernotas, Ronald C. / Kaufman, David H. / Quinet, Elaine / Nambi, Ponnal / Feingold, Irene / Huselton, Christine / Wilhelmsson, Anna / Goos-Nilsson, Annika / Wrobel, Jay et al. | 2009
- 531
-
Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulatorsYang, Feng V. / Shipe, William D. / Bunda, Jaime L. / Nolt, M. Brad / Wisnoski, David D. / Zhao, Zhijian / Barrow, James C. / Ray, William J. / Ma, Lei / Wittmann, Marion et al. | 2009
- 537
-
Proposed structural basis of interaction of piperine and related compounds with monoamine oxidasesRahman, Taufiq / Rahmatullah, Mohammed et al. | 2009
- 541
-
Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agentsLee, Myung Yun / Kim, Myung Hee / Kim, Jinho / Kim, Seok Hwan / Kim, Bum Tae / Jeong, In Howa / Chang, Sukbok / Kim, Seong Hwan / Chang, Sung-Youn et al. | 2009
- 546
-
Evaluation of pyrrolin-2-one derivatives synthesized by a new practical method as inhibitors of plasminogen activator inhibitor-1 (PAI-1)Miyazaki, Hiroshi / Miyake, Tsutomu / Terakawa, Yoshihiro / Ohmizu, Hiroshi / Ogiku, Tsuyoshi / Ohtani, Akio et al. | 2009
- 549
-
A new benzil derivative from Derris scandens: Structure-insecticidal activity studySreelatha, T. / Hymavathi, A. / Rama Subba Rao, V. / Devanand, P. / Usha Rani, P. / Madhusudana Rao, J. / Suresh Babu, K. et al. | 2009
- 554
-
Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeabilityXue, Fengtian / Fang, Jianguo / Lewis, William W. / Martásek, Pavel / Roman, Linda J. / Silverman, Richard B. et al. | 2009
- 558
-
Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M5 PAMBridges, Thomas M. / Kennedy, J. Phillip / Cho, Hyekyung P. / Breininger, Micah L. / Gentry, Patrick R. / Hopkins, Corey R. / Conn, P. Jeffrey / Lindsley, Craig W. et al. | 2009
- 563
-
The comparative antimalarial properties of weak base and neutral synthetic ozonidesTang, Yuanqing / Wittlin, Sergio / Charman, Susan A. / Chollet, Jacques / Chiu, Francis C.K. / Morizzi, Julia / Johnson, Lisa M. / Tomas, Josefina Santo / Scheurer, Christian / Snyder, Chistopher et al. | 2009
- 567
-
P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profileNair, Latha G. / Sannigrahi, Mousumi / Bogen, Stephane / Pinto, Patrick / Chen, Kevin X. / Prongay, Andrew / Tong, Xiao / Cheng, K.-C. / Girijavallabhan, Viyyoor / George Njoroge, F. et al. | 2009
- 571
-
Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolaseEldrup, Anne B. / Soleymanzadeh, Fariba / Farrow, Neil A. / Kukulka, Alison / De Lombaert, Stéphane et al. | 2009
- 576
-
Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritisSchnute, Mark E. / O’Brien, Patrick M. / Nahra, Joe / Morris, Mark / Howard Roark, W. / Hanau, Cathleen E. / Ruminski, Peter G. / Scholten, Jeffrey A. / Fletcher, Theresa R. / Hamper, Bruce C. et al. | 2009
- 581
-
A profile of the in vitro anti-tumor activity of imidazolium-based ionic liquidsMalhotra, Sanjay V. / Kumar, Vineet et al. | 2009
- 586
-
Structure-guided design of α-amino acid-derived Pin1 inhibitorsPotter, Andrew J. / Ray, Stuart / Gueritz, Louisa / Nunns, Claire L. / Bryant, Christopher J. / Scrace, Simon F. / Matassova, Natalia / Baker, Lisa / Dokurno, Pawel / Robinson, David A. et al. | 2009
- 586
-
Structure-guided design of a-amino acid-derived Pin1 inhibitorsPotter, A. J. / Ray, S. / Gueritz, L. / Nunns, C. L. / Bryant, C. J. / Scrace, S. F. / Matassova, N. / Baker, L. / Dokurno, P. / Robinson, D. A. et al. | 2010
- 591
-
Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell linesPenthala, Narsimha Reddy / Yerramreddy, Thirupathi Reddy / Crooks, Peter A. et al. | 2009
- 594
-
Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of Type-2 diabetesKitas, Eric / Mohr, Peter / Kuhn, Bernd / Hebeisen, Paul / Wessel, Hans Peter / Haap, Wolfgang / Ruf, Armin / Benz, Jörg / Joseph, Catherine / Huber, Walter et al. | 2009
- 600
-
Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agentsReddy, Y. Thirupathi / Sekhar, Konjeti R. / Sasi, Nidhish / Reddy, P. Narsimha / Freeman, Michael L. / Crooks, Peter A. et al. | 2009
- 603
-
Macrocyclic BACE-1 inhibitors acutely reduce Ab in brain after po applicationLerchner, A. / Machauer, R. / Betschart, C. / Veenstra, S. / Rueeger, H. / McCarthy, C. / Tintelnot-Blomley, M. / Jaton, A. L. / Rabe, S. / Desrayaud, S. et al. | 2010
- 603
-
Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po applicationLerchner, Andreas / Machauer, Rainer / Betschart, Claudia / Veenstra, Siem / Rueeger, Heinrich / McCarthy, Clive / Tintelnot-Blomley, Marina / Jaton, Anne-Lise / Rabe, Sabine / Desrayaud, Sandrine et al. | 2009
- 608
-
Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitorsGilbert, Eric J. / Zhou, Guowei / Wong, Michael K.C. / Tong, Ling / Shankar, Bandarpalle B. / Huang, Chunli / Kelly, Joseph / Lavey, Brian J. / McCombie, Stuart W. / Chen, Lei et al. | 2009
- 612
-
Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocketStewart, Kent D. / Huth, Jeffrey R. / Ng, Teresa I. / McDaniel, Keith / Hutchinson, Rebecca Newlin / Stoll, Vincent S. / Mendoza, Renaldo R. / Matayoshi, Edmund D. / Carrick, Robert / Mo, HongMei et al. | 2009
- 618
-
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifsKleanthous, Savvas / Borthwick, Alan D. / Brown, David / Burns-Kurtis, Cynthia L. / Campbell, Matthew / Chaudry, Laiq / Chan, Chuen / Clarte, Marie-Olive / Convery, Máire A. / Harling, John D. et al. | 2009
- 623
-
Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK1 receptor antagonistsSabbatini, Fabio M. / Fabio, Romano Di / Griffante, Cristiana / Pentassuglia, Giorgio / Zonzini, Laura / Melotto, Sergio / Alvaro, Giuseppe / Capelli, Anna M. / Pippo, Lara / Perdona’, Elisabetta et al. | 2009
- 628
-
Synthetic studies and pharmacological evaluations on the MDMA (‘Ecstasy’) antagonist nantenineLeGendre, Onica / Pecic, Stevan / Chaudhary, Sandeep / Zimmerman, Sarah M. / Fantegrossi, William E. / Harding, Wayne W. et al. | 2009
- 632
-
Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitorsNowak, Pawel / Cole, Derek C. / Aulabaugh, Ann / Bard, Jonathan / Chopra, Rajiv / Cowling, Rebecca / Fan, Kristi Y. / Hu, Baihua / Jacobsen, Steve / Jani, Minakshi et al. | 2009
- 632
-
Discovery and initial optimization of 5,5prime-disubstituted aminohydantoins as potent b-secretase (BACE1) inhibitorsNowak, P. / Cole, D. C. / Aulabaugh, A. / Bard, J. / Chopra, R. / Cowling, R. / Fan, K. Y. / Hu, B. / Jacobsen, S. / Jani, M. et al. | 2010
- 636
-
Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-a: Hit to lead studiesGilbert, A. M. / Nowak, P. / Brooijmans, N. / Bursavich, M. G. / Dehnhardt, C. / Santos, E. D. / Feldberg, L. R. / Hollander, I. / Kim, S. / Lombardi, S. et al. | 2010
- 636
-
Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studiesGilbert, Adam M. / Nowak, Pawel / Brooijmans, Natasja / Bursavich, Matthew G. / Dehnhardt, Christoph / Santos, Efren Delos / Feldberg, Larry R. / Hollander, Irwin / Kim, Stephen / Lombardi, Sabrina et al. | 2009
- 640
-
Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)Kaplan, Joshua / Verheijen, Jeroen C. / Brooijmans, Natasja / Toral-Barza, Lourdes / Hollander, Irwin / Yu, Ker / Zask, Arie et al. | 2009
- 644
-
Solid phase synthesis of 2-aminobenzothiazolesPiscitelli, Francesco / Ballatore, Carlo / Smith, Amos B. III et al. | 2009
- 649
-
Discovery of ectoparasiticidal hydrazonotrifluoromethanesulfonanilidesAli, Abdelselam / Fisara, Petr / Freemont, Jamie A. / Kyi, Stella / Meyer, Adam G. / Riches, Andrew G. / Sargent, Roger M. / Sawutz, David G. / Turner, Kathleen A. / Winzenberg, Kevin N. et al. | 2009
- 653
-
Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitorsVenkatesan, Aranapakam M. / Dehnhardt, Christoph M. / Chen, Zecheng / Santos, Efren Delos / Dos Santos, Osvaldo / Bursavich, Matthew / Gilbert, Adam M. / Ellingboe, John W. / Ayral-Kaloustian, Semiramis / Khafizova, Gulnaz et al. | 2009
- 657
-
Pyridine containing M1 positive allosteric modulators with reduced plasma protein bindingKuduk, Scott D. / Di Marco, Christina N. / Cofre, Victoria / Pitts, Daniel R. / Ray, William J. / Ma, Lei / Wittmann, Marion / Seager, Matthew / Koeplinger, Kenneth / Thompson, Chuck D. et al. | 2009
- 662
-
Identification of a new class of small molecule C5a receptor antagonistsChen, Jack J. / Cole, Derek C. / Ciszewski, Greg / Crouse, Kimberly / Ellingboe, John W. / Nowak, Pawel / Tawa, Gregory J. / Berstein, Gabriel / Li, Wei et al. | 2009
- 665
-
Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423Evelyn, Chris R. / Bell, Jessica L. / Ryu, Jenny G. / Wade, Susan M. / Kocab, Andrew / Harzdorf, Nicole L. / Hollis Showalter, H.D. / Neubig, Richard R. / Larsen, Scott D. et al. | 2009
- 673
-
2,3,5-Trisubstituted pyridines as selective AKT inhibitors—Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivityLin, Hong / Yamashita, Dennis S. / Zeng, Jin / Xie, Ren / Wang, Wenyong / Nidarmarthy, Sirishkumar / Luengo, Juan I. / Rhodes, Nelson / Knick, Victoria B. / Choudhry, Anthony E. et al. | 2009
- 679
-
2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazolesLin, Hong / Yamashita, Dennis S. / Zeng, Jin / Xie, Ren / Verma, Sharad / Luengo, Juan I. / Rhodes, Nelson / Zhang, Shuyun / Robell, Kimberly A. / Choudhry, Anthony E. et al. | 2009
- 684
-
Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridinesLin, Hong / Yamashita, Dennis S. / Xie, Ren / Zeng, Jin / Wang, Wenyong / Leber, Jack / Safonov, Igor G. / Verma, Sharad / Li, Mei / LaFrance, Louis et al. | 2009
- 689
-
Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRb and low blood-brain penetrationHu, B. / Bernotas, R. / Unwalla, R. / Collini, M. / Quinet, E. / Feingold, I. / Goos-Nilsson, A. / Wilhelmsson, A. / Nambi, P. / Evans, M. et al. | 2010
- 689
-
Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRβ and low blood–brain penetrationHu, Baihua / Bernotas, Ron / Unwalla, Rayomand / Collini, Michael / Quinet, Elaine / Feingold, Irene / Goos-Nilsson, Annika / Wilhelmsson, Anna / Nambi, Ponnal / Evans, Mark et al. | 2009
- 694
-
Optimization of orally bioavailable alkyl amine renin inhibitorsXu, Zhenrong / Cacatian, Salvacion / Yuan, Jing / Simpson, Robert D. / Jia, Lanqi / Zhao, Wei / Tice, Colin M. / Flaherty, Patrick T. / Guo, Joan / Ishchenko, Alexey et al. | 2009
- 700
-
Dendrimer-based tumor cell targeting of fibroblast growth factor-1Thomas, Thommey P. / Shukla, Rameshwer / Kotlyar, Alina / Kukowska-Latallo, Jola / Baker, James R. Jr. et al. | 2009
- 704
-
Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacyclesLemoine, Rémy C. / Petersen, Ann C. / Setti, Lina / Wanner, Jutta / Jekle, Andreas / Heilek, Gabrielle / deRosier, André / Ji, Changhua / Berry, Pamela / Rotstein, David et al. | 2009
- 709
-
Novel neofusapyrones isolated from Verticillium dahliae as potent antifungal substancesHonma, Miho / Kudo, Shinji / Takada, Noboru / Tanaka, Kazuaki / Miura, Tomisato / Hashimoto, Masaru et al. | 2009
- 713
-
Synthesis, spectral analysis and in vitro microbiological evaluation of 3-(3-alkyl-2,6-diarylpiperin-4-ylidene)-2-thioxoimidazolidin-4-ones as a new class of antibacterial and antifungal agentsThanusu, J. / Kanagarajan, V. / Gopalakrishnan, M. et al. | 2009
- 718
-
Discovery of novel taspine derivatives as antiangiogenic agentsZhang, Jie / Zhang, Yanmin / Zhang, Sanqi / Wang, Sicen / He, Langchong et al. | 2009
- 722
-
Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agentsBorate, Hanumant B. / Maujan, Suleman R. / Sawargave, Sangmeshwer P. / Chandavarkar, Mohan A. / Vaiude, Sharangi R. / Joshi, Vinay A. / Wakharkar, Radhika D. / Iyer, Ramki / Kelkar, Ramesh G. / Chavan, Subhash P. et al. | 2009
- 726
-
Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonistsNakamura, Masayuki / Kurihara, Hideki / Suzuki, Gentaroh / Mitsuya, Morihiro / Ohkubo, Mitsuru / Ohta, Hisashi et al. | 2009
- 730
-
Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agentsBandgar, Babasaheb P. / Patil, Sachin A. / Gacche, Rajesh N. / Korbad, Balaji L. / Hote, Balwant S. / Kinkar, Santosh N. / Jalde, Shivkumar S. et al. | 2009
- 734
-
Synthesis and PGE2 production inhibition of 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivativesMoon, Jong Taik / Jeon, Ji Young / Park, Hang Ah / Noh, Young-Soo / Lee, Kyung-Tae / Kim, Jungahn / Choo, Dong Joon / Lee, Jae Yeol et al. | 2009
- 738
-
Enhanced cell permeability of kojic acid–phenylalanine amide with metal complexKwak, Seon-Yeong / Noh, Jin-Mi / Park, So-Hee / Byun, Jang-Woong / Choi, Hye-Ryung / Park, Kyoung-Chan / Lee, Yoon-Sik et al. | 2009
- 742
-
One pot synthesis and SAR of some novel 3-substituted 5,6-diphenyl-1,2,4-triazines as antifungal agentsSangshetti, Jaiprakash N. / Shinde, Devanand B. et al. | 2009
- 746
-
Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine]Uto, Yoshikazu / Kiyotsuka, Yohei / Ueno, Yuko / Miyazawa, Yuriko / Kurata, Hitoshi / Ogata, Tsuneaki / Deguchi, Tsuneo / Yamada, Makiko / Watanabe, Nobuaki / Konishi, Masahiro et al. | 2009
- 746
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Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1prime-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4prime-piperidine]Uto, Y. / Kiyotsuka, Y. / Ueno, Y. / Miyazawa, Y. / Kurata, H. / Ogata, T. / Deguchi, T. / Yamada, M. / Watanabe, N. / Konishi, M. et al. | 2010
- 755
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Fluorinated piperidine acetic acids as g-secretase modulatorsStanton, M. G. / Hubbs, J. / Sloman, D. / Hamblett, C. / Andrade, P. / Angagaw, M. / Bi, G. / Black, R. M. / Crispino, J. / Cruz, J. C. et al. | 2010
- 755
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Fluorinated piperidine acetic acids as γ-secretase modulatorsStanton, Matthew G. / Hubbs, Jed / Sloman, David / Hamblett, Christopher / Andrade, Paula / Angagaw, Minilik / Bi, Grace / Black, Regina M. / Crispino, Jamie / Cruz, Jonathan C. et al. | 2009
- 759
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The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2D’Alessandro, Pier L. / Corti, Corrado / Roth, Adelheid / Ugolini, Annarosa / Sava, Anna / Montanari, Dino / Bianchi, Federica / Garland, Stephen L. / Powney, Ben / Koppe, Emma L. et al. | 2009
- 763
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Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profilesNishizawa, Rena / Nishiyama, Toshihiko / Hisaichi, Katsuya / Hirai, Keisuke / Habashita, Hiromu / Takaoka, Yoshikazu / Tada, Hideaki / Sagawa, Kenji / Shibayama, Shiro / Maeda, Kenji et al. | 2009
- 767
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Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substratesKrzysiak, Amanda J. / Aditya, Animesh V. / Hougland, James L. / Fierke, Carol A. / Gibbs, Richard A. et al. | 2009
- 771
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Corrigendum to “GDC-0449—A potent inhibitor of the hedgehog pathway” [Bioorg. Med. Chem. Lett. 19 (2009) 5576]Robarge, Kirk D. / Brunton, Shirley A. / Castanedo, Georgette M. / Cui, Yong / Dina, Michael S. / Goldsmith, Richard / Gould, Stephen E. / Guichert, Oivin / Gunzner, Janet L. / Halladay, Jason et al. | 2009
- 772
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Corrigendum to “N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: Impact of small structural modifications on P-gp recognition and CNS penetration” [Bioorg. Med. Chem. Lett. 19 (2009) 5078]Wakenhut, Florian / Allan, Gill A. / Fish, Paul V. / Fray, M. Jonathan / Harrison, Anthony C. / McCoy, Rachel / Phillips, Stephen C. / Ryckmans, Thomas / Stobie, Alan / Westbrook, Dominique et al. | 2009
- 773
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Corrigendum to “Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 6307]Boezio, Alessandro A. / Berry, Loren / Albrecht, Brian K. / Bauer, David / Bellon, Steven F. / Bode, Christiane / Chen, April / Choquette, Deborah / Dussault, Isabelle / Fang, Mei et al. | 2009
- IFC
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Editorial board| 2009