Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom (English)
- New search for: Faist, Johanna
- New search for: Seebacher, Werner
- New search for: Kaiser, Marcel
- New search for: Brun, Reto
- New search for: Saf, Robert
- New search for: Weis, Robert
- New search for: Faist, Johanna
- New search for: Seebacher, Werner
- New search for: Kaiser, Marcel
- New search for: Brun, Reto
- New search for: Saf, Robert
- New search for: Weis, Robert
In:
Bioorganic and Medicinal Chemistry
;
21
, 17
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4988-4996
;
2013
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom
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Contributors:Faist, Johanna ( author ) / Seebacher, Werner ( author ) / Kaiser, Marcel ( author ) / Brun, Reto ( author ) / Saf, Robert ( author ) / Weis, Robert ( author )
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Published in:Bioorganic and Medicinal Chemistry ; 21, 17 ; 4988-4996
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Publisher:
- New search for: Elsevier Ltd
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Publication date:2013-06-24
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Size:9 pages
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ISSN:
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DOI:
-
Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 21, Issue 17
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 4853
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Graphical contents list| 2013
- 4874
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Inhibition of Mycobacterium tuberculosis strains H37Rv and MDR MS-115 by a new set of C5 modified pyrimidine nucleosidesShmalenyuk, Eduard R. / Chernousova, Larisa N. / Karpenko, Inna L. / Kochetkov, Sergey N. / Smirnova, Tatiana G. / Andreevskaya, Sofia N. / Chizhov, Alexander O. / Efremenkova, Olga V. / Alexandrova, Ludmila A. et al. | 2013
- 4885
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Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growthThévenin, Marion / Thoret, Sylviane / Grellier, Philippe / Dubois, Joëlle et al. | 2013
- 4893
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Analogs of iso-azepinomycin as potential transition-state analog inhibitors of guanase: Synthesis, biochemical screening, and structure–activity correlations of various selectively substituted imidazo[4,5-e][1,4]diazepinesTantravedi, Saritha / Chakraborty, Saibal / Shah, Niti H. / Fishbein, James C. / Hosmane, Ramachandra S. et al. | 2013
- 4904
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Tetrazole-based deoxyamodiaquines: Synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agentsTukulula, Matshawandile / Njoroge, Mathew / Mugumbate, Grace C. / Gut, Jiri / Rosenthal, Philip J. / Barteau, Samuel / Streckfuss, Judith / Heudi, Olivier / Kameni-Tcheudji, Jacques / Chibale, Kelly et al. | 2013
- 4914
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3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: Synthesis, molecular docking and antibacterial evaluationWang, Xu-Dong / Deng, Rui-Cheng / Dong, Jing-Jun / Peng, Zhi-Yun / Gao, Xiao-Ming / Li, Shu-Ting / Lin, Wan-Qiang / Lu, Chun-Lei / Xiao, Zhu-Ping / Zhu, Hai-Liang et al. | 2013
- 4923
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Effect of ring-constrained phenylpropyloxyethylamines on sigma receptorsStavitskaya, Lidiya / Seminerio, Michael J. / Healy, Jason R. / Noorbakhsh, Bahar / Matsumoto, Rae R. / Coop, Andrew et al. | 2013
- 4928
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Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitorsAlpan, Ayşe Selcen / Parlar, Sülünay / Carlino, Luca / Tarikogullari, Ayse Hande / Alptüzün, Vildan / Güneş, Hasan Semih et al. | 2013
- 4938
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Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: Identification of an efficient lead for potent inhibitors of GABA transportsNakada, Kazuaki / Yoshikawa, Mamie / Ide, Soichiro / Suemasa, Akihiro / Kawamura, Shuhei / Kobayashi, Takaaki / Masuda, Eiji / Ito, Yoshihiko / Hayakawa, Wataru / Katayama, Takahiro et al. | 2013
- 4951
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1-Hydroxypyrazole as a bioisostere of the acetic acid moiety in a series of aldose reductase inhibitorsPapastavrou, Nikolaos / Chatzopoulou, Maria / Pegklidou, Kyriaki / Nicolaou, Ioannis et al. | 2013
- 4958
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Synthesis and biological evaluation of potential threonine synthase inhibitors: Rhizocticin A and Plumbemycin AGahungu, Mathias / Arguelles-Arias, Anthony / Fickers, Patrick / Zervosen, Astrid / Joris, Bernard / Damblon, Christian / Luxen, André et al. | 2013
- 4968
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Synthesis and insecticidal activities of 2,3-dihydroquinazolin-4(1H)-one derivatives targeting calcium channelZhou, Yunyun / Feng, Qi / Di, Fengjuan / Liu, Qiaoxiao / Wang, Duoyi / Chen, Youwei / Xiong, Lixia / Song, Haibin / Li, Yuxin / Li, Zhengming et al. | 2013
- 4976
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Quantification of free ligand conformational preferences by NMR and their relationship to the bioactive conformationBlundell, Charles D. / Packer, Martin J. / Almond, Andrew et al. | 2013
- 4988
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Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atomFaist, Johanna / Seebacher, Werner / Kaiser, Marcel / Brun, Reto / Saf, Robert / Weis, Robert et al. | 2013
- 4997
-
Discovery of two new inhibitors of Botrytis cinerea chitin synthase by a chemical library screeningMagellan, Hervé / Boccara, Martine / Drujon, Thierry / Soulié, Marie-Christine / Guillou, Catherine / Dubois, Joëlle / Becker, Hubert F. et al. | 2013
- 5004
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Solid phase synthesis of Smac/DIABLO-derived peptides using a ‘Safety-Catch’ resin: Identification of potent XIAP BIR3 antagonistsElsawy, Mohamed A. / Martin, Lorraine / Tikhonova, Irina G. / Walker, Brian et al. | 2013
- 5012
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Exploring pyrimidine-substituted curcumin analogues: Design, synthesis and effects on EGFR signalingQiu, Peiju / Xu, Lingling / Gao, Lei / Zhang, Meng / Wang, Shixi / Tong, Sheng / Sun, Yue / Zhang, Lijuan / Jiang, Tao et al. | 2013
- 5021
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Rapid modifications of N-substitution in iminosugars: Development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher diseaseCheng, Wei-Chieh / Weng, Chen-Yi / Yun, Wen-Yi / Chang, Shang-Yu / Lin, Yu-Chun / Tsai, Fuu-Jen / Huang, Fu-Yung / Chen, Yun-Ru et al. | 2013
- 5021
-
Rapid modifications of N-substitution in iminosugars: Development of new @b-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher diseaseCheng, W. C. / Weng, C. Y. / Yun, W. Y. / Chang, S. Y. / Lin, Y. C. / Tsai, F. J. / Huang, F. Y. / Chen, Y. R. et al. | 2013
- 5029
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Synthesis and Characterization of Time-resolved Fluorescence Probes for Evaluation of Competitive Binding to Melanocortin ReceptorsAlleti, Ramesh / Vagner, Josef / Dehigaspitiya, Dilani Chathurika / Moberg, Valerie E. / Elshan, N.G.R.D. / Tafreshi, Narges K. / Brabez, Nabila / Weber, Craig S. / Lynch, Ronald M. / Hruby, Victor J. et al. | 2013
- 5039
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Tocopheramines and tocotrienamines as antioxidants: ESR spectroscopy, rapid kinetics and DFT calculationsBamonti, Luca / Hosoya, Takashi / Pirker, Katharina F. / Böhmdorfer, Stefan / Mazzini, Francesco / Galli, Francesco / Netscher, Thomas / Rosenau, Thomas / Gille, Lars et al. | 2013
- 5047
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Synthesis of novel psoralen analogues and their in vitro antitumor activityFrancisco, Carla S. / Rodrigues, Lígia R. / Cerqueira, Nuno M.F.S.A. / Oliveira-Campos, Ana M.F. / Rodrigues, Lígia M. / Esteves, Ana P. et al. | 2013
- 5054
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Design, synthesis and structure–activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenesRoman, Bart I. / De Coen, Laurens M. / Thérèse F.C. Mortier, Séverine / De Ryck, Tine / Vanhoecke, Barbara W.A. / Katritzky, Alan R. / Bracke, Marc E. / Stevens, Christian V. et al. | 2013
- 5064
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Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phaseChen, Yi-Fong / Lin, Yi-Chien / Huang, Po-Kai / Chan, Hsu-Chin / Kuo, Sheng-Chu / Lee, Kuo-Hsiung / Huang, Li-Jiau et al. | 2013
- 5076
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Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitorsLiang, Lin-Fu / Gao, Li-Xin / Li, Jia / Taglialatela-Scafati, Orazio / Guo, Yue-Wei et al. | 2013
- 5081
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Defining the key pharmacophore elements of PF-04620110: Discovery of a potent, orally-active, neutral DGAT-1 inhibitorDow, Robert L. / Andrews, Melissa P. / Li, Jian-Cheng / Michael Gibbs, E. / Guzman-Perez, Angel / LaPerle, Jennifer L. / Li, Qifang / Mather, Dawn / Munchhof, Michael J. / Niosi, Mark et al. | 2013
- 5098
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Structure–activity relationships for ketamine esters as short-acting anaestheticsJose, Jiney / Gamage, Swarna A. / Harvey, Martyn G. / Voss, Logan J. / Sleigh, James W. / Denny, William A. et al. | 2013
- 5107
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Design, synthesis and in vitro evaluation against human cancer cells of 5-methyl-5-styryl-2,5-dihydrofuran-2-ones, a new series of goniothalamin analoguesBruder, Marjorie / Vendramini-Costa, Débora Barbosa / de Carvalho, João Ernesto / Pilli, Ronaldo Aloise et al. | 2013
- 5118
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Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitorsGunaherath, G.M. Kamal B. / Marron, Marilyn T. / Wijeratne, E.M. Kithsiri / Whitesell, Luke / Gunatilaka, A.A. Leslie et al. | 2013
- 5130
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5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: Solution and X-ray crystallographic studiesLeitans, Janis / Sprudza, Agnese / Tanc, Muhammet / Vozny, Igor / Zalubovskis, Raivis / Tars, Kaspars / Supuran, Claudiu T. et al. | 2013
- 5139
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Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer’s disease brainsAnumala, Upendra Rao / Gu, Jiamin / Lo Monte, Fabio / Kramer, Thomas / Heyny-von Haußen, Roland / Hölzer, Jana / Goetschy-Meyer, Valerie / Schön, Christian / Mall, Gerhard / Hilger, Ingrid et al. | 2013
- 5145
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Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor propertiesSalerno, Loredana / Pittalà, Valeria / Romeo, Giuseppe / Modica, Maria N. / Siracusa, Maria A. / Di Giacomo, Claudia / Acquaviva, Rosaria / Barbagallo, Ignazio / Tibullo, Daniele / Sorrenti, Valeria et al. | 2013
- 5154
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2-Substituted 4-hydroxybutanamides as potential inhibitors of γ-aminobutyric acid transporters mGAT1–mGAT4: Synthesis and biological evaluationKowalczyk, Paula / Sałat, Kinga / Höfner, Georg C. / Guzior, Natalia / Filipek, Barbara / Wanner, Klaus T. / Kulig, Katarzyna et al. | 2013
- 5154
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2-Substituted 4-hydroxybutanamides as potential inhibitors of @c-aminobutyric acid transporters mGAT1-mGAT4: Synthesis and biological evaluationKowalczyk, P. / Salat, K. / Hofner, G. C. / Guzior, N. / Filipek, B. / Wanner, K. T. / Kulig, K. et al. | 2013
- 5168
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Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moietySethi, Kalyan K. / Verma, Saurabh M. / Tanç, Muhammet / Carta, Fabrizio / Supuran, Claudiu T. et al. | 2013
- 5175
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Synthesis and initial in vitro biological evaluation of two new zinc-chelating compounds: Comparison with TPEN and PAC-1Åstrand, O. Alexander H. / Aziz, Gulzeb / Ali, Sidra Farzand / Paulsen, Ragnhild E. / Hansen, Trond Vidar / Rongved, Pål et al. | 2013
- 5182
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Improved synthesis of 17β-hydroxy-16α-iodo-wortmannin, 17β-hydroxy-16α-iodoPX866, and the [131I] analogue as useful PET tracers for PI3-kinaseSun, Duoli / Bhanu Prasad, Basvoju A. / Schuber, Paul T. Jr. / Peng, Zhenghong / Maxwell, David S. / Martin, Diana V. / Guo, Liwei / Han, Dongmei / Kurihara, Hiroaki / Yang, David J. et al. | 2013
- 5182
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Improved synthesis of 17@b-hydroxy-16@a-iodo-wortmannin, 17@b-hydroxy-16@a-iodoPX866, and the [^1^3^1I] analogue as useful PET tracers for PI3-kinaseSun, D. / Bhanu Prasad, B. A. / Schuber, P. T. / Peng, Z. / Maxwell, D. S. / Martin, D. V. / Guo, L. / Han, D. / Kurihara, H. / Yang, D. J. et al. | 2013
- 5188
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Macamides and their synthetic analogs: Evaluation of in vitro FAAH inhibitionWu, Hui / Kelley, Charles J. / Pino-Figueroa, Alejandro / Vu, Huyen D. / Maher, Timothy J. et al. | 2013
- 5198
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4β-[4′-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agentsKamal, Ahmed / Suresh, Paidakula / Ramaiah, M. Janaki / Srinivasa Reddy, T. / Kapavarapu, Ravi Kumar / Rao, Bolla Narasimha / Imthiajali, Syed / Lakshminarayan Reddy, T. / Pushpavalli, S.N.C.V.L. / Shankaraiah, Nagula et al. | 2013
- 5198
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4@b-[4'-(1-(Aryl)ureido)benzamide]podophyllotoxins as DNA topoisomerase I and II@a inhibitors and apoptosis inducing agentsKamal, A. / Suresh, P. / Ramaiah, M. J. / Srinivasa Reddy, T. / Kapavarapu, R. K. / Rao, B. N. / Imthiajali, S. / Lakshminarayan Reddy, T. / Pushpavalli, S. N. C. V. L. / Shankaraiah, N. et al. | 2013
- 5209
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Design and synthesis of novel 1,25-dihydroxyvitamin D3 analogues having a spiro-oxetane fused at the C2 position in the A-ringFujishima, Toshie / Nozaki, Takato / Suenaga, Tsutomu et al. | 2013
- 5218
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One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPsWoon, Esther C.Y. / Sunderland, Peter T. / Paine, Helen A. / Lloyd, Matthew D. / Thompson, Andrew S. / Threadgill, Michael D. et al. | 2013
- 5228
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Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamidesAkdemir, Atilla / Güzel-Akdemir, Özlen / Scozzafava, Andrea / Capasso, Clemente / Supuran, Claudiu T. et al. | 2013
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Antitumor properties of substituted (αE)-α-(1H-indol-3-ylmethylene)benzeneacetic acids or amidesForte, Giuseppe / Fortuna, Cosimo Gianluca / Salerno, Loredana / Modica, Maria N. / Siracusa, Maria A. / Cardile, Venera / Romeo, Giuseppe / Bulbarelli, Alessandra / Lonati, Elena / Pittalà, Valeria et al. | 2013
- 5233
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Antitumor properties of substituted (@aE)-@a-(1H-indol-3-ylmethylene)benzeneacetic acids or amidesForte, G. / Fortuna, C. G. / Salerno, L. / Modica, M. N. / Siracusa, M. A. / Cardile, V. / Romeo, G. / Bulbarelli, A. / Lonati, E. / Pittala, V. et al. | 2013
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Discovery and optimization of novel 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazones as c-Met kinase inhibitorsQi, Baohui / Mi, Bin / Zhai, Xin / Xu, Ziyi / Zhang, Xiaolong / Tian, Zeru / Gong, Ping et al. | 2013
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Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: A novel, potent and selective type 5 17@b-hydroxysteroid dehydrogenase inhibitorWatanabe, K. / Kakefuda, A. / Yasuda, M. / Enjo, K. / Kikuchi, A. / Furutani, T. / Naritomi, Y. / Otsuka, Y. / Okada, M. / Ohta, M. et al. | 2013
- 5261
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Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: A novel, potent and selective type 5 17β-hydroxysteroid dehydrogenase inhibitorWatanabe, Kazushi / Kakefuda, Akio / Yasuda, Minoru / Enjo, Kentaro / Kikuchi, Aya / Furutani, Takashi / Naritomi, Yoichi / Otsuka, Yukio / Okada, Minoru / Ohta, Mitsuaki et al. | 2013
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Catalytic asymmetric total synthesis of (S)-(−)-zearalenone, a novel lipoxygenase inhibitorBaggelaar, Marc P. / Huang, Yange / Feringa, Ben L. / Dekker, Frank J. / Minnaard, Adriaan J. et al. | 2013
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Liver-targeting of primaquine-(poly-γ-glutamic acid) and its degradation in rat hepatocytesTomiya, Noboru / Jardim, Juliette G. / Hou, Jennifer / Pastrana-Mena, Rebecca / Dinglasan, Rhoel R. / Lee, Yuan C. et al. | 2013
- 5275
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Liver-targeting of primaquine-(poly-@c-glutamic acid) and its degradation in rat hepatocytesTomiya, N. / Jardim, J. G. / Hou, J. / Pastrana-Mena, R. / Dinglasan, R. R. / Lee, Y. C. et al. | 2013
- 5282
-
Synthesis of novel isothiazolopyridines and their in vitro evaluation against Mycobacterium and Propionibacterium acnesMalinka, Wiesław / Świątek, Piotr / Śliwińska, Małgorzata / Szponar, Bogumiła / Gamian, Andrzej / Karczmarzyk, Zbigniew / Fruziński, Andrzej et al. | 2013
- 5292
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Gene suppression via U1 small nuclear RNA interference (U1i) machinery using oligonucleotides containing 2′-modified-4′-thionucleosidesKikuchi, Yusaku / Yamazaki, Naoshi / Tarashima, Noriko / Furukawa, Kazuhiro / Takiguchi, Yoshiharu / Itoh, Kohji / Minakawa, Noriaki et al. | 2013
- 5297
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Structure–activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effectKaraki, Fumika / Ohgane, Kenji / Dodo, Kosuke / Hashimoto, Yuichi et al. | 2013
- 5310
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Biodistribution of 125I-labeled polymeric vaccine carriers after subcutaneous injectionToita, Riki / Kanai, Yasukazu / Watabe, Hiroshi / Nakao, Kenshi / Yamamoto, Seiichi / Hatazawa, Jun / Akashi, Mitsuru et al. | 2013
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Synthesis and evaluation of 1-[2-(4-[11C]methoxyphenyl)phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brainShimoda, Yoko / Yui, Joji / Xie, Lin / Fujinaga, Masayuki / Yamasaki, Tomoteru / Ogawa, Masanao / Nengaki, Nobuki / Kumata, Katsushi / Hatori, Akiko / Kawamura, Kazunori et al. | 2013
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In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structuresJing, Qing / Li, Huiying / Fang, Jianguo / Roman, Linda J. / Martásek, Pavel / Poulos, Thomas L. / Silverman, Richard B. et al. | 2013
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Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoeiSinisi, Annamaria / Calcinai, Barbara / Cerrano, Carlo / Dien, Henny A. / Zampella, Angela / D’Amore, Claudio / Renga, Barbara / Fiorucci, Stefano / Taglialatela-Scafati, Orazio et al. | 2013
- 5339
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Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2)Feng, Taotao / Wang, Hai / Su, Hong / Lu, Hui / Yu, Liqin / Zhang, Xiaojin / Sun, Haopeng / You, Qidong et al. | 2013
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Synthesis and bioevaluation of some new isoniazid derivativesMatei, Lilia / Bleotu, Coralia / Baciu, Ion / Draghici, Constantin / Ionita, Petre / Paun, Anca / Chifiriuc, Mariana Carmen / Sbarcea, Adriana / Zarafu, Irina et al. | 2013
- 5362
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- 5373
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A sphingosine 1-phosphate receptor 2 selective allosteric agonistSatsu, Hideo / Schaeffer, Marie-Therese / Guerrero, Miguel / Saldana, Adrian / Eberhart, Christina / Hodder, Peter / Cayanan, Charmagne / Schürer, Stephan / Bhhatarai, Barun / Roberts, Ed et al. | 2013
- 5383
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3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitisTourteau, Aurélien / Andrzejak, Virginie / Body-Malapel, Mathilde / Lemaire, Lucas / Lemoine, Amélie / Mansouri, Roxane / Djouina, Madjid / Renault, Nicolas / El Bakali, Jamal / Desreumaux, Pierre et al. | 2013
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-
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Fluorescent probes for investigation of isoprenoid configuration and size discrimination by bactoprenol-utilizing enzymesMostafavi, Anahita Z. / Lujan, Donovan K. / Erickson, Katelyn M. / Martinez, Christina D. / Troutman, Jerry M. et al. | 2013
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Effect of single pyrrole replacement with @b-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5'-GCGC-3'Han, Y. W. / Kashiwazaki, G. / Morinaga, H. / Matsumoto, T. / Hashiya, K. / Bando, T. / Harada, Y. / Sugiyama, H. et al. | 2013
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-
Effect of single pyrrole replacement with β-alanine on DNA binding affinity and sequence specificity of hairpin pyrrole/imidazole polyamides targeting 5′-GCGC-3′Han, Yong-Woon / Kashiwazaki, Gengo / Morinaga, Hironobu / Matsumoto, Tomoko / Hashiya, Kaori / Bando, Toshikazu / Harada, Yoshie / Sugiyama, Hiroshi et al. | 2013
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Synthesis and α-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-β-d-glucopyranosidesBian, Xiaoli / Fan, Xiangni / Ke, Changhu / Luan, Yajun / Zhao, Guilan / Zeng, Aiguo et al. | 2013
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-
Synthesis and @a-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-@b-d-glucopyranosidesBian, X. / Fan, X. / Ke, C. / Luan, Y. / Zhao, G. / Zeng, A. et al. | 2013
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Solid-phase synthesis of 5′-triphosphate 2′-5′-oligoadenylates analogs with 3′-O-biolabile groups and their evaluation as RNase L activators and antiviral drugsThillier, Yann / Stevens, Sarah K. / Moy, Christabel / Taylor, Joshua / Vasseur, Jean-Jacques / Beigelman, Leonid / Debart, Françoise et al. | 2013
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Antiproliferative activity on human prostate carcinoma cell lines of new peptidomimetics containing the spiroazepinoindolinone scaffoldPellegrino, Sara / Ruscica, Massimiliano / Magni, Paolo / Vistoli, Giulio / Gelmi, Maria Luisa et al. | 2013
- 5480
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Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson’s diseasePark, Hye Ri / Kim, Jiyoon / Kim, Taekeun / Jo, Seonmi / Yeom, Miyoung / Moon, Bongjin / Choo, Il Han / Lee, Jaeick / Lim, Eun Jeong / Park, Ki Duk et al. | 2013
- 5488
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Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential mapHirayama, Takaharu / Okaniwa, Masanori / Imada, Takashi / Ohashi, Akihiro / Ohori, Momoko / Iwai, Kenichi / Mori, Kouji / Kawamoto, Tomohiro / Yokota, Akihiro / Tanaka, Toshimasa et al. | 2013
- 5503
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Functionalized hydroxyethylamine based peptide nanostructures as potential inhibitors of falcipain-3, an essential proteases of Plasmodium falciparumRathi, Brijesh / Singh, Anil K. / Kishan, Ram / Singh, Neelu / Latha, N. / Srinivasan, S. / Pandey, Kailash C. / Tiwari, Hemandra K. / Singh, Brajendra K. et al. | 2013
- 5510
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Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoidsCaldarelli, Antonio / Penucchini, Eleonora / Caprioglio, Diego / Genazzani, Armando A. / Minassi, Alberto et al. | 2013
- 5518
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Investigations on synthesis and structure elucidation of novel [1,2,4]triazolo[1,2-a]pyridazine-1-thiones and their inhibitory activity against inducible nitric oxide synthaseSchulz, Ulrike / Grossmann, Antje / Witetschek, Manja / Lemmerhirt, Christian / Polzin, Marcus / Haertel, Beate / Wanka, Heike / Morgenstern, Olaf et al. | 2013
- 5532
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Anti-inflammatory and anti-apoptotic effects of (RS)-glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson’s diseaseGaluppo, Maria / Iori, Renato / De Nicola, Gina Rosalinda / Bramanti, Placido / Mazzon, Emanuela et al. | 2013
- 5548
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Autotaxin inhibition: Development and application of computational tools to identify site-selective lead compoundsNorman, Derek D. / Ibezim, Ayolah / Scott, Whitney E. / White, Stanley / Parrill, Abby L. / Baker, Daniel L. et al. | 2013
- 5561
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C-Glucosides with heteroaryl thiophene as novel sodium-dependent glucose cotransporter 2 inhibitorsKoga, Yuichi / Sakamaki, Shigeki / Hongu, Mitsuya / Kawanishi, Eiji / Sakamoto, Toshiaki / Yamamoto, Yasuo / Kimata, Hirotaka / Nakayama, Keiko / Kuriyama, Chiaki / Matsushita, Yasuaki et al. | 2013
- 5573
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Design and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable groupHayat, Faisal / Cho, Sungjin / Rhim, Hyewhon / Indu Viswanath, Ambily Nath / Pae, Ae Nim / Lee, Jae Yeol / Choo, Dong Joon / Choo, Hea-Young Park et al. | 2013
- 5583
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Triplex-forming ability of oligonucleotides containing 1-aryl-1,2,3-triazole nucleobases linked via a two atom-length spacerHari, Yoshiyuki / Nakahara, Motoi / Obika, Satoshi et al. | 2013
- 5589
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Design, synthesis and pharmacological evaluation of (E)-3,4-dihydroxy styryl sulfonamides derivatives as multifunctional neuroprotective agents against oxidative and inflammatory injuryNing, Xianling / Guo, Ying / Ma, Xiaoyan / Zhu, Renzong / Tian, Chao / Zhang, Zhili / Wang, Xiaowei / Ma, Zhizhong / Liu, Junyi et al. | 2013
- 5598
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Synthesis and in vivo evaluation of [18F]2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione ([18F]FECUMI-101) as an imaging probe for 5-HT1A receptor agonist in nonhuman primatesMajo, Vattoly J. / Milak, Matthew S. / Prabhakaran, Jaya / Mali, Pratap / Savenkova, Lyudmila / Simpson, Norman R. / Mann, J. John / Parsey, Ramin V. / Kumar, J. S. Dileep et al. | 2013
- 5605
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Synthesis, pH-dependent, and plasma stability of meropenem prodrugs for potential use against drug-resistant tuberculosisTeitelbaum, Aaron M. / Meissner, Anja / Harding, Ryan A. / Wong, Christopher A. / Aldrich, Courtney C. / Remmel, Rory P. et al. | 2013
- 5618
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A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cellsShahani, Vijay M. / Ball, Daniel P. / Ramos, Allan V. / Li, Zhihua / Spagnuolo, Paul A. / Haftchenary, Sina / Schimmer, Aaron D. / Trudel, Suzanne / Gunning, Patrick T. et al. | 2013
- 5629
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Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferaseClinch, Keith / Crump, Douglas R. / Evans, Gary B. / Hazleton, Keith Z. / Mason, Jennifer M. / Schramm, Vern L. / Tyler, Peter C. et al. | 2013
- 5647
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Corrigendum to “Integrated structure-based activity prediction model of benzothiadiazines on various genotypes of HCV NS5b polymerase (1a, 1b and 4) and its application in the discovery of new derivatives” [Bioorg. Med. Chem. 20(7) (2012) 2455–2478]Ismail, Mohamed A.H. / Abou El Ella, Dalal A. / Abouzid, Khaled A.M. / Mahmoud, Amr H. et al. | 2013
- 5648
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Corrigendum to “Nucleic acid changes during photodynamic inactivation of bacteria by cationic porphyrins” [Bioorg. Med. Chem. 21 (2013) 4311–4318]Alves, Eliana / Faustino, Maria A.F. / Tomé, João P.C. / Neves, Maria G.P.M.S. / Tomé, Augusto C. / Cavaleiro, José A.S. / Cunha, Ângela / Gomes, Newton C.M. / Almeida, Adelaide et al. | 2013
- IFC
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Editorial board| 2013