Synthesis of ‘clickable’ acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activation (English)
- New search for: Garner, Amanda L.
- New search for: Yu, Jing
- New search for: Struss, Anjali Kumari
- New search for: Lowery, Colin A.
- New search for: Zhu, Jie
- New search for: Kim, Sook Kyung
- New search for: Park, Junguk
- New search for: Mayorov, Alexander V.
- New search for: Kaufmann, Gunnar F.
- New search for: Kravchenko, Vladimir V.
- New search for: Janda, Kim D.
- New search for: Garner, Amanda L.
- New search for: Yu, Jing
- New search for: Struss, Anjali Kumari
- New search for: Lowery, Colin A.
- New search for: Zhu, Jie
- New search for: Kim, Sook Kyung
- New search for: Park, Junguk
- New search for: Mayorov, Alexander V.
- New search for: Kaufmann, Gunnar F.
- New search for: Kravchenko, Vladimir V.
- New search for: Janda, Kim D.
In:
Bioorganic and Medicinal Chemistry Letters
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21
, 9
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2702-2705
;
2010
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Synthesis of ‘clickable’ acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activation
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Contributors:Garner, Amanda L. ( author ) / Yu, Jing ( author ) / Struss, Anjali Kumari ( author ) / Lowery, Colin A. ( author ) / Zhu, Jie ( author ) / Kim, Sook Kyung ( author ) / Park, Junguk ( author ) / Mayorov, Alexander V. ( author ) / Kaufmann, Gunnar F. ( author ) / Kravchenko, Vladimir V. ( author )
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Published in:Bioorganic and Medicinal Chemistry Letters ; 21, 9 ; 2702-2705
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Publisher:
- New search for: Elsevier Ltd
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Publication date:2010-11-29
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Size:4 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 21, Issue 9
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 2573
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Graphical contents list| 2011
- 2585
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Recent advances in medicinal chemistryBlagg, Brian S.J. / Johnson, Douglas S. / Garbaccio, Robert M. et al. | 2011
- 2587
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Improved synthesis of 15-deoxyspergualin analogs using the Ugi multi-component reactionEvans, Christopher G. / Smith, Matthew C. / Carolan, James P. / Gestwicki, Jason E. et al. | 2011
- 2591
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Effect of carbohydrate amino group modifications on the cytotoxicity of glycosylated 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furansShi, Wei et al. | 2011
- 2591
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Reprint of “Effect of carbohydrate amino group modifications on the cytotoxicity of glycosylated 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans” [Bioorg. Med. Chem. Lett. 21 (2011) 2591–2596]Shi, Wei / Lowary, Todd L. et al. | 2011
- 2597
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2-(4-Carbonylphenyl)benzoxazole inhibitors of CETP: Attenuation of hERG binding and improved HDLc-raising efficacySweis, Ramzi F. / Hunt, Julianne A. / Sinclair, Peter J. / Chen, Ying / Eveland, Suzanne S. / Guo, Qiu / Hyland, Sheryl A. / Milot, Denise P. / Cumiskey, Anne-Marie / Latham, Melanie et al. | 2011
- 2601
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Discovery of histone deacetylase 8 selective inhibitorsTang, Weiping / Luo, Tuoping / Greenberg, Edward F. / Bradner, James E. / Schreiber, Stuart L. et al. | 2011
- 2606
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Potent antiprotozoal activity of a novel semi-synthetic berberine derivativeBahar, Mark / Deng, Ye / Zhu, Xiaohua / He, Shanshan / Pandharkar, Trupti / Drew, Mark E. / Navarro-Vázquez, Armando / Anklin, Clemens / Gil, Roberto R. / Doskotch, Raymond W. et al. | 2011
- 2611
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Syntheses and studies of amamistatin B analogs reveals that anticancer activity is relatively independent of stereochemistry, ester or amide linkage and select replacement of one of the metal chelating groupsWu, Chunrui / Miller, Patricia A. / Miller, Marvin J. et al. | 2011
- 2616
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Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: Sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitorsMajmudar, Jaimeen D. / Hahne, Kalub / Hrycyna, Christine A. / Gibbs, Richard A. et al. | 2011
- 2621
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Discovery of PF-00217830: Aryl piperazine napthyridinones as D2 partial agonists for schizophrenia and bipolar disorderJohnson, Douglas S. / Choi, Chung / Fay, Lorraine K. / Favor, David A. / Repine, Joseph T. / White, Andrew D. / Akunne, Hyacinth C. / Fitzgerald, Lawrence / Nicholls, Kim / Snyder, Bradley J. et al. | 2011
- 2626
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Discovery of ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxy-tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone, PF-4254196, a CCR2 antagonist with an improved cardiovascular profileHughes, Robert O. / Rogier, D.J. / Devraj, Rajesh / Zheng, Changsheng / Cao, Ganfeng / Feng, Hao / Xia, Michael / Anand, Rajan / Xing, Li / Glenn, Joseph et al. | 2011
- 2631
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Diamide amino-imidazoles: A novel series of g-secretase inhibitors for the treatment of Alzheimer's diseaseBrodney, M. A. / Auperin, D. D. / Becker, S. L. / Bronk, B. S. / Brown, T. M. / Coffman, K. J. / Finley, J. E. / Hicks, C. D. / Karmilowicz, M. J. / Lanz, T. A. et al. | 2011
- 2631
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Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s diseaseBrodney, Michael A. / Auperin, David D. / Becker, Stacey L. / Bronk, Brian S. / Brown, Tracy M. / Coffman, Karen J. / Finley, James E. / Hicks, Carol D. / Karmilowicz, Michael J. / Lanz, Thomas A. et al. | 2010
- 2637
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Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014Brodney, Michael A. / Auperin, David D. / Becker, Stacey L. / Bronk, Brian S. / Brown, Tracy M. / Coffman, Karen J. / Finley, James E. / Hicks, Carol D. / Karmilowicz, Michael J. / Lanz, Thomas A. et al. | 2010
- 2637
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Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as g-secretase inhibitors: Discovery of PF-3084014Brodney, M. A. / Auperin, D. D. / Becker, S. L. / Bronk, B. S. / Brown, T. M. / Coffman, K. J. / Finley, J. E. / Hicks, C. D. / Karmilowicz, M. J. / Lanz, T. A. et al. | 2011
- 2641
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Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonistsGriffith, David A. / Hargrove, Diane M. / Maurer, Tristan S. / Blum, Charles A. / De Lombaert, Stéphane / Inthavongsay, John K. / Klade, Lee E. / Mack, Christine M. / Rose, Colin R. / Sanders, Martin J. et al. | 2010
- 2646
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High concentration electrophysiology-based fragment screen: Discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitorsWolkenberg, Scott E. / Zhao, Zhijian / Mulhearn, James J. / Harrison, Scott T. / Sanders, John M. / Cato, Matthew J. / Jovanovska, Aneta / Panigel, Jacqueline / Cook, Sean P. / Henze, Darrell A. et al. | 2010
- 2650
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Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5Zou, Mu-Fa / Cao, Jianjing / Rodriguez, Alice L. / Jeffrey Conn, P. / Newman, Amy Hauck et al. | 2010
- 2655
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Multitargeted drugs discovery: Balancing anti-amyloid and anticholinesterase capacity in a single chemical entityBolognesi, Maria Laura / Bartolini, Manuela / Tarozzi, Andrea / Morroni, Fabiana / Lizzi, Federica / Milelli, Andrea / Minarini, Anna / Rosini, Michela / Hrelia, Patrizia / Andrisano, Vincenza et al. | 2010
- 2659
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Identification and initial SAR of silybin: An Hsp90 inhibitorZhao, Huiping / Brandt, Gary E. / Galam, Lakshmi / Matts, Robert L. / Blagg, Brian S.J. et al. | 2010
- 2665
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Design of potent and selective GPR119 agonists for type II diabetesSzewczyk, Jason W. / Acton, John / Adams, Alan D. / Chicchi, Gary / Freeman, Stanley / Howard, Andrew D. / Huang, Yong / Li, Cai / Meinke, Peter T. / Mosely, Ralph et al. | 2010
- 2670
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Aromatic ring functionalization of benzolactam derivatives: New potent dopamine D3 receptor ligandsOrtega, Raquel / Hübner, Harald / Gmeiner, Peter / Masaguer, Christian F. et al. | 2010
- 2675
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Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinasesTestero, Sebastian A. / Bouley, Renee / Fisher, Jed F. / Chang, Mayland / Mobashery, Shahriar et al. | 2010
- 2679
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Enediol mimics as inhibitors of the d-arabinose 5-phosphate isomerase (KdsD) from Francisella tularensisYep, Alejandra / Sorenson, Roderick J. / Wilson, Michael R. / Hollis Showalter, H.D. / Larsen, Scott D. / Keller, Paul R. / Woodard, Ronald W. et al. | 2010
- 2683
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Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: Discovery of MK-2918Paone, Daniel V. / Nguyen, Diem N. / Shaw, Anthony W. / Burgey, Christopher S. / Potteiger, Craig M. / Deng, James Z. / Mosser, Scott D. / Salvatore, Christopher A. / Yu, Sean / Roller, Shane et al. | 2010
- 2687
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(+)-Arisugacin A—Computational evidence of a dual binding site covalent inhibitor of acetylcholinesteraseAl-Rashid, Ziyad F. / Hsung, Richard P. et al. | 2010
- 2692
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Acylideneoxoindoles: A new class of reversible inhibitors of human transglutaminase 2Klöck, Cornelius / Jin, Xi / Choi, Kihang / Khosla, Chaitan / Madrid, Peter B. / Spencer, Andrew / Raimundo, Brian C. / Boardman, Paul / Lanza, Guido / Griffin, John H. et al. | 2010
- 2697
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Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probeReid, Paul R. / Bridges, Thomas M. / Sheffler, Douglas J. / Cho, Hyekyung P. / Lewis, L. Michelle / Days, Emily / Daniels, J. Scott / Jones, Carrie K. / Niswender, Colleen M. / Weaver, C. David et al. | 2010
- 2702
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Synthesis of ‘clickable’ acylhomoserine lactone quorum sensing probes: Unanticipated effects on mammalian cell activationGarner, Amanda L. / Yu, Jing / Struss, Anjali Kumari / Lowery, Colin A. / Zhu, Jie / Kim, Sook Kyung / Park, Junguk / Mayorov, Alexander V. / Kaufmann, Gunnar F. / Kravchenko, Vladimir V. et al. | 2010
- 2706
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Experimental and theoretical investigation of the scope of enantioselective ketone allylations employing Nakamura’s allylzinc–bisoxazoline reagentJohnson, A. George / Loertscher, Brad M. / Moeck, Adam R. / Matthews, Sam S. / Ess, Daniel H. / Castle, Steven L. et al. | 2010
- 2711
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Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonistsLamb, Jeffrey P. / Engers, Darren W. / Niswender, Colleen M. / Rodriguez, Alice L. / Venable, Daryl F. / Conn, P. Jeffrey / Lindsley, Craig W. et al. | 2010
- 2715
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Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinenceAndrews, Mark D. / Fish, Paul V. / Blagg, Julian / Brabham, Tiffini K. / Brennan, Paul E. / Bridgeland, Alison / Brown, Alan D. / Bungay, Peter J. / Conlon, Kelly M. / Edmunds, Nicholas J. et al. | 2010
- 2721
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The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME propertiesImbriglio, Jason E. / DiRocco, Daniel / Bodner, Rena / Raghavan, Subharekha / Chen, Weichun / Marley, Daria / Esser, Craig / Holt, Tom G. / Wolff, Michael S. / Taggart, Andrew K.P. et al. | 2010
- 2725
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Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: A bench-to-bedside case study on tissue selective drug distributionPfefferkorn, Jeffrey A. / Litchfield, John / Hutchings, Richard / Cheng, Xue-Min / Larsen, Scott D. / Auerbach, Bruce / Bush, Mark R. / Lee, Chitase / Erasga, Noe / Bowles, Daniel M. et al. | 2010
- 2732
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Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitorsNoël, Romain / Shin, Youseung / Song, Xinyi / He, Yuanjun / Koenig, Marcel / Chen, Weimin / Ling, Yuan Yuan / Lin, Li / Ruiz, Claudia H. / LoGrasso, Phil et al. | 2010
- 2736
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Structure–activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A)van Veldhoven, J.P.D. / Blad, C.C. / Artsen, C.M. / Klopman, C. / Wolfram, D.R. / Abdelkadir, M.J. / Lane, J.R. / Brussee, J. / IJzerman, A.P. et al. | 2010
- 2740
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Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffoldKumar, T. Santhosh / Mishra, Shilpi / Deflorian, Francesca / Yoo, Lena S. / Phan, Khai / Kecskés, Miklos / Szabo, Angela / Shinkre, Bidhan / Gao, Zhan-Guo / Trenkle, William et al. | 2010
- 2746
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Synthesis of novel antimitotic agents based on 2-amino-3-aroyl-5-(hetero)arylethynyl thiophene derivativesRomagnoli, Romeo / Baraldi, Pier Giovanni / Cruz-Lopez, Olga / Tolomeo, Manlio / Cristina, Antonietta Di / Pipitone, Rosaria Maria / Grimaudo, Stefania / Balzarini, Jan / Brancale, Andrea / Hamel, Ernest et al. | 2010
- 2752
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Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitorsBeck, Hilary P. / DeGraffenreid, Michael / Fox, Brian / Allen, John G. / Rew, Yosup / Schneider, Stephen / Saiki, Anne Y. / Yu, Dongyin / Oliner, Jonathan D. / Salyers, Kevin et al. | 2010
- 2756
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Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimerEllis, Gregory A. / Hornung, Megan L. / Raines, Ronald T. et al. | 2010
- 2759
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Inhalation by design: Dual pharmacology b-2 agonists/M3 antagonists for the treatment of COPDJones, L. H. / Baldock, H. / Bunnage, M. E. / Burrows, J. / Clarke, N. / Coghlan, M. / Entwistle, D. / Fairman, D. / Feeder, N. / Fulton, C. et al. | 2011
- 2759
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Inhalation by design: Dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPDJones, Lyn H. / Baldock, Helen / Bunnage, Mark E. / Burrows, Jane / Clarke, Nick / Coghlan, Michele / Entwistle, David / Fairman, David / Feeder, Neil / Fulton, Craig et al. | 2010
- 2764
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An inhibitor-like binding mode of a carbonic anhydrase activator within the active site of isoform IIDave, Khyati / Ilies, Marc A. / Scozzafava, Andrea / Temperini, Claudia / Vullo, Daniela / Supuran, Claudiu T. et al. | 2010
- 2769
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Fused heterocyclic M1 positive allosteric modulatorsKuduk, Scott D. / Di Marco, Christina N. / Cofre, Victoria / Ray, William J. / Ma, Lei / Wittmann, Marion / Seager, Matthew A. / Koeplinger, Kenneth A. / Thompson, Charles D. / Hartman, George D. et al. | 2010
- 2773
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A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected miceMoon, Deuk Kyu / Tripathi, Abhai / Sullivan, David / Siegler, Maxime A. / Parkin, Sean / Posner, Gary H. et al. | 2010
- 2776
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Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicaseGemma, Sandra / Butini, Stefania / Campiani, Giuseppe / Brindisi, Margherita / Zanoli, Samantha / Romano, Maria Pia / Tripaldi, Pierangela / Savini, Luisa / Fiorini, Isabella / Borrelli, Giuseppe et al. | 2010
- 2780
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Reprint of “MDCK cell permeability characteristics of a sulfenamide produg: Strategic implications in considering sulfenamide prodrugs for oral delivery of NH acids” [Bioorg. Med. Chem. Lett. 21 (2011) 172-175]Guarino, Victor R. / Nti-Addae, Kwame / Stella, Valentino J. et al. | 2010
- IFC
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Editorial board| 2011