Further Studies on 2,4-Diamino-5-(2',5'-disubstituted benzyl)pyrimidines as Potent and Selective Inhibitors of Dihydrofolate Reductases from Three Major Opportunistic Pathogens of AIDS (English)
- New search for: Rosowsky, A.
- New search for: Rosowsky, A.
- New search for: Forsch, R.A.
- New search for: Queener, S.F.
In:
Journal of medicinal chemistry
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46
, 9
; 1726-1736
;
2003
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ISSN:
- Article (Journal) / Print
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Title:Further Studies on 2,4-Diamino-5-(2',5'-disubstituted benzyl)pyrimidines as Potent and Selective Inhibitors of Dihydrofolate Reductases from Three Major Opportunistic Pathogens of AIDS
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Contributors:
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Published in:Journal of medicinal chemistry ; 46, 9 ; 1726-1736
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Publisher:
- New search for: American Chemical Society
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Place of publication:Easton, Pa.
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Publication date:2003
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ISSN:
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ZDBID:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 770/4230
- New search for: 44.42 / 44.42
- Further information on Basic classification
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Source:
Table of contents – Volume 46, Issue 9
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1567
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The Pharmacophore of Short Cationic Antibacterial PeptidesStrøm, Morten B. / Haug, Bengt Erik / Skar, Merete L. / Stensen, Wenche / Stiberg, Trine / Svendsen, John S. et al. | 2003
- 1571
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Differential Binding Modes of Diacylglycerol (DAG) and DAG Lactones to Protein Kinase C (PK-C)Sigano, Dina M. / Peach, Megan L. / Nacro, Kassoum / Choi, Yongseok / Lewin, Nancy E. / Nicklaus, Marc C. / Blumberg, Peter M. / Marquez, Victor E. et al. | 2003
- 1580
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Thyroid Receptor Ligands. 1. Agonist Ligands Selective for the Thyroid Receptor β1Ye, Liu / Li, Yi-Lin / Mellström, Karin / Mellin, Charlotta / Bladh, Lars-Göran / Koehler, Konrad / Garg, Neeraj / Garcia Collazo, Ana Maria / Litten, Chris / Husman, Bolette et al. | 2003
- 1580
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Thyroid Receptor Ligands. 1. Agonist Ligands Selective for the Thyroid Receptor b1Ye, L. et al. | 2003
- 1589
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Bridged Bicyclic Cores Containing a 1,1-Diarylethylene Motif Are High-Affinity Subtype-Selective Ligands for the Estrogen ReceptorMuthyala, Rajeev S. / Sheng, Shubin / Carlson, Kathryn E. / Katzenellenbogen, Benita S. / Katzenellenbogen, John. A. et al. | 2003
- 1603
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Tripeptide Probes for Tripeptidyl Protease I Production via Gene TransferKim, MeeKyoung / Mao, Qinwen / Davidson, Beverly L. / Wiemer, David F. et al. | 2003
- 1609
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CoMFA and Homology-Based Models of the Glycine Binding Site of N-Methyl-d-aspartate ReceptorTikhonova, Irina G. / Baskin, Igor I. / Palyulin, Vladimir A. / Zefirov, Nikolai S. et al. | 2003
- 1617
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Pharmacophore and Quantitative Structure−Activity Relationship Modeling: Complementary Approaches for the Rationalization and Prediction of UDP-Glucuronosyltransferase 1A4 Substrate SelectivitySmith, Paul A. / Sorich, Michael J. / McKinnon, Ross A. / Miners, John O. et al. | 2003
- 1627
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Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabKSeefeld, Mark A. / Miller, William H. / Newlander, Kenneth A. / Burgess, Walter J. / DeWolf, Walter E. / Elkins, Patricia A. / Head, Martha S. / Jakas, Dalia R. / Janson, Cheryl A. / Keller, Paul M. et al. | 2003
- 1636
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An Ethylenamine Inhibitor Binds Tightly to Both Wild Type and Mutant HIV-1 Proteases. Structure and Energy StudySkálová, Tereza / Hašek, Jindřich / Dohnálek, Jan / Petroková, Hana / Buchtelová, Eva / Dušková, Jarmila / Souček, Milan / Majer, Pavel / Uhlíková, Táňa / Konvalinka, Jan et al. | 2003
- 1645
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Construction and Assessment of Models of CYP2E1: Predictions of Metabolism from Docking, Molecular Dynamics, and Density Functional Theoretical CalculationsPark, Jin-Young / Harris, Dan et al. | 2003
- 1661
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Aromatic Reduced Amide Bond Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide SynthaseHah, Jung-Mi / Martásek, Pavel / Roman, Linda J. / Silverman, Richard B. et al. | 2003
- 1670
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Synthesis, Anticancer Activity, and Inhibition of Tubulin Polymerization by Conformationally Restricted Analogues of Lavendustin AMu, Fanrong / Hamel, Ernest / Lee, Debbie J. / Pryor, Donald E. / Cushman, Mark et al. | 2003
- 1683
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Mitomycin Antitumor Compounds. 2. † Interaction of Transition Metal Ions with Mitomycin C. Solution Structure and Biological Activity of a Pd2+−MMC Complex ‡Fiallo, Marina M. L. / Deydier, Eric / Bracci, Michela / Garnier-Suillerot, Arlette / Halvorsen, Karin et al. | 2003
- 1690
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Self-Immolative Nitrogen Mustards Prodrugs Cleavable by Carboxypeptidase G2 (CPG2) Showing Large Cytotoxicity Differentials in GDEPTNiculescu-Duvaz, Dan / Niculescu-Duvaz, Ion / Friedlos, Frank / Martin, Jan / Lehouritis, Panos / Marais, Richard / Springer, Caroline J. et al. | 2003
- 1706
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Synthesis and Biological Evaluation of N-Heterocyclic Indolyl Glyoxylamides as Orally Active Anticancer AgentsLi, Wen-Tai / Hwang, Der-Ren / Chen, Ching-Ping / Shen, Chien-Wei / Huang, Chen-Long / Chen, Tung-Wei / Lin, Chi-Hung / Chang, Yee-Ling / Chang, Ying-Ying / Lo, Yue-Kan et al. | 2003
- 1716
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Comparison of in Vitro P-Glycoprotein Screening Assays: Recommendations for Their Use in Drug DiscoverySchwab, Dietmar / Fischer, Holger / Tabatabaei, Ali / Poli, Sonia / Huwyler, Jörg et al. | 2003
- 1726
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Further Studies on 2,4-Diamino-5-(2‘,5‘-disubstituted benzyl)pyrimidines as Potent and Selective Inhibitors of Dihydrofolate Reductases from Three Major Opportunistic Pathogens of AIDSRosowsky, Andre / Forsch, Ronald A. / Queener, Sherry F. et al. | 2003
- 1737
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Antitumor Activity of the Mixed Phosphine Gold Species Chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I)Caruso, Francesco / Rossi, Miriam / Tanski, Joseph / Pettinari, Claudio / Marchetti, Fabio et al. | 2003
- 1743
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New Cytotoxic and Water-Soluble Bis(2-phenylazopyridine)ruthenium(II) ComplexesHotze, Anna C. G. / Bacac, Marina / Velders, Aldrik H. / Jansen, Bart A. J. / Kooijman, Huub / Spek, Anthony L. / Haasnoot, Jaap G. / Reedijk, Jan et al. | 2003
- 1751
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Solid-Phase Synthesis of Peptide Radiopharmaceuticals Using Fmoc-N-e-(Hynic-Boc)-Lysine, a Technetium-Binding Amino Acid: Application to Tc-99m-Labeled Salmon CalcitoninGreenland, W.E.P. et al. | 2003
- 1751
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Solid-Phase Synthesis of Peptide Radiopharmaceuticals Using Fmoc-N-ε-(Hynic-Boc)−Lysine, a Technetium-Binding Amino Acid: Application to Tc-99m-Labeled Salmon CalcitoninGreenland, William E. P. / Howland, Kevin / Hardy, Judith / Fogelman, Ignac / Blower, Philip J. et al. | 2003
- 1758
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Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 18. N-Substituted 14-Phenylpropyloxymorphinan-6-ones with Unanticipated Agonist Properties: Extending the Scope of Common Structure−Activity RelationshipsGreiner, Elisabeth / Spetea, Mariana / Krassnig, Roland / Schüllner, Falko / Aceto, Mario / Harris, Louis S. / Traynor, John R. / Woods, James H. / Coop, Andrew / Schmidhammer, Helmut et al. | 2003
- 1758
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Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 18.1 N-Substituted 14-Phenylpropyloxymorphinan-6-ones with Unanticipated Agonist Properties: Extending the Scope of Common Structure-Activity RelationshipsGreiner, E. et al. | 2003
- 1764
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Reduction of Peptide Character of HIV Protease Inhibitors That Exhibit Nanomolar Potency against Multidrug Resistant HIV-1 StrainsTamamura, Hirokazu / Koh, Yasuhiro / Ueda, Satoshi / Sasaki, Yoshikazu / Yamasaki, Tomonori / Aoki, Manabu / Maeda, Kenji / Watai, Yoriko / Arikuni, Hisashi / Otaka, Akira et al. | 2003
- 1769
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Design and Structure−Activity Relationships of 2-Alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as Potent GnRH Receptor AntagonistsZhu, Yun-Fei / Guo, Zhiqiang / Gross, Timothy D. / Gao, Yinghong / Connors,, Patrick J. / Struthers, R. Scott / Xie, Qiu / Tucci, Fabio C. / Reinhart, Greg J. / Wu, Dongpei et al. | 2003
- 1773
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Combinatorial Library Methods and Protocols Edited by Lisa Bellavance English. Humana Press, Totowa, NJ. 2002. xi + 383 pp. 16 × 23.5 cm. ISBN 0-86093-980-3. $99.50.Wasley, Jan W. F. et al. | 2003
- 1773
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Medicinal Chemistry: Principles and Practice. Second Edition Edited by F. D. King. The Royal Society of Chemistry, Cambridge, U.K. 2002. xxii + 450 pp. 15.5 × 23.5 cm. ISBN 0-85404-631-3(PB). £39.50.Vennerstrom, Jonathan L. et al. | 2003
- 1773
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Combinatorial Library Methods and Protocols Edited by Lisa Bellavance English. Humana Press, Totowa, NJ. 2002. xi + 383 pp. 16 x 23.5 cm. ISBN 0-86093-980-3. 99.50.Wasley, J.W.F. et al. | 2003
- 1773
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Medicinal Chemistry: Principles and Practice. Second Edition Edited by F. D. King. The Royal Society of Chemistry, Cambridge, U.K. 2002. xxii + 450 pp. 15.5 x 23.5 cm. ISBN 0-85404-631-3(PB). (GBP)39.50.Vennerstrom, J.L. et al. | 2003