Novel Multipotent Tacrine-Dihydropyridine Hybrids with Improved Acetylcholinesterase Inhibitory and Neuroprotective Activities as Potential Drugs for the Treatment of Alzheimer's Disease (English)
- New search for: Marco-Contelles, J.
- New search for: Marco-Contelles, J.
- New search for: Leon, R.
- New search for: de los Rios, C.
- New search for: Guglietta, A.
- New search for: Terencio, J.
- New search for: Lopez, M.G.
- New search for: Garcia, A.G.
- New search for: Villarroya, M.
In:
Journal of medicinal chemistry
;
49
, 26
; 7607-7610
;
2006
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ISSN:
- Article (Journal) / Print
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Title:Novel Multipotent Tacrine-Dihydropyridine Hybrids with Improved Acetylcholinesterase Inhibitory and Neuroprotective Activities as Potential Drugs for the Treatment of Alzheimer's Disease
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Contributors:Marco-Contelles, J. ( author ) / Leon, R. / de los Rios, C. / Guglietta, A. / Terencio, J. / Lopez, M.G. / Garcia, A.G. / Villarroya, M.
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Published in:Journal of medicinal chemistry ; 49, 26 ; 7607-7610
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Publisher:
- New search for: American Chemical Society
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Place of publication:Easton, Pa.
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Publication date:2006
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ISSN:
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ZDBID:
-
Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 770/4230
- New search for: 44.42 / 44.42
- Further information on Basic classification
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Keywords:
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Classification:
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Source:
Table of contents – Volume 49, Issue 26
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 7559
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Structure−Brain Exposure RelationshipsHitchcock, Stephen A. / Pennington, Lewis D. et al. | 2006
- 7584
-
Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of ObesityLin, Linus S. / Lanza,, Thomas J. / Jewell, James P. / Liu, Ping / Shah, Shrenik K. / Qi, Hongbo / Tong, Xinchun / Wang, Junying / Xu, Suoyu S. / Fong, Tung M. et al. | 2006
- 7588
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Scaffold of the Cyclooxygenase-2 (COX-2) Inhibitor Carprofen Provides Alzheimer γ-Secretase ModulatorsNarlawar, Rajeshwar / Pérez Revuelta, Blanca I. / Haass, Christian / Steiner, Harald / Schmidt, Boris / Baumann, Karlheinz et al. | 2006
- 7588
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Scaffold of the Cyclooxygenase-2 (COX-2) Inhibitor Carprofen Provides Alzheimer gamma-Secretase ModulatorsNarlawar, R. / Revuelta, B. I. P. / Haass, C. / Steiner, H. / Schmidt, B. / Baumann, K. et al. | 2006
- 7592
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Synthesis of Low-Hemolytic Antimicrobial Dehydropeptides Based on Gramicidin SYamada, Keiichi / Shinoda, Shun-suke / Oku, Hiroyuki / Komagoe, Keiko / Katsu, Takashi / Katakai, Ryoichi et al. | 2006
- 7596
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Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin Scaffold †Sun, Chongqing / Robl, Jeffrey A. / Wang, Tammy C. / Huang, Yanting / Kuhns, Joyce E. / Lupisella, John A. / Beehler, Blake C. / Golla, Rajasree / Sleph, Paul G. / Seethala, Ramakrishna et al. | 2006
- 7596
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Discovery of Potent, Orally-Active, and Muscle-Selective Androgen Receptor Modulators Based on an N-Aryl-hydroxybicyclohydantoin ScaffoldFNR RID="jm061101wAF2" SSYMBOL="dagger">Sun, C. et al. | 2006
- 7600
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New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic PropertiesBreschi, Maria C. / Calderone, Vincenzo / Martelli, Alma / Minutolo, Filippo / Rapposelli, Simona / Testai, Lara / Tonelli, Federica / Balsamo, Aldo et al. | 2006
- 7603
-
Discovery of 2-Hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): A Potent, Orally Bioavailable CXCR2/CXCR1 Receptor AntagonistDwyer, Michael P. / Yu, Younong / Chao, Jianping / Aki, Cynthia / Chao, Jianhua / Biju, Purakkattle / Girijavallabhan, Viyyoor / Rindgen, Diane / Bond, Richard / Mayer-Ezel, Rosemary et al. | 2006
- 7607
-
Novel Multipotent Tacrine−Dihydropyridine Hybrids with Improved Acetylcholinesterase Inhibitory and Neuroprotective Activities as Potential Drugs for the Treatment of Alzheimer's DiseaseMarco-Contelles, José / León, Rafael / de los Ríos, Cristóbal / Guglietta, Antonio / Terencio, José / López, Manuela G. / García, Antonio G. / Villarroya, Mercedes et al. | 2006
- 7611
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Design, Synthesis, Potency, and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from α-Aminosuberic AcidKahnberg, Pia / Lucke, Andrew J. / Glenn, Matthew P. / Boyle, Glen M. / Tyndall, Joel D. A. / Parsons, Peter G. / Fairlie, David P. et al. | 2006
- 7611
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Design, Synthesis, Potency, and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from alpha-Aminosuberic AcidKahnberg, P. / Lucke, A. J. / Glenn, M. P. / Boyle, G. M. / Tyndall, J. D. A. / Parsons, P. G. / Fairlie, D. P. et al. | 2006
- 7623
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Antitubercular Nucleosides That Inhibit Siderophore Biosynthesis: SAR of the Glycosyl DomainSomu, Ravindranadh V. / Wilson, Daniel J. / Bennett, Eric M. / Boshoff, Helena I. / Celia, Laura / Beck, Brian J. / Barry, Clifton E. / Aldrich, Courtney C. et al. | 2006
- 7636
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Synthesis of Novel Caspase Inhibitors for Characterization of the Active Caspase Proteome in Vitro and in VivoHenzing, Alexander J. / Dodson, Helen / Reid, Joel M. / Kaufmann, Scott H. / Baxter, Robert L. / Earnshaw, William C. et al. | 2006
- 7646
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A Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) of Anthranilamide Derivatives That Are Multidrug Resistance ModulatorsLabrie, Philippe / Maddaford, Shawn P. / Fortin, Sebastien / Rakhit, Suman / Kotra, Lakshmi P. / Gaudreault, René C. et al. | 2006
- 7661
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Modeling Subtype-Selective Agonists Binding with alpha4beta2 and alpha7 Nicotinic Acetylcholine Receptors: Effects of Local Binding and Long-Range Electrostatic InteractionsHuang, X. / Zheng, F. / Chen, X. / Crooks, P. A. / Dwoskin, L. P. / Zhan, C.-G. et al. | 2006
- 7661
-
Modeling Subtype-Selective Agonists Binding with α4β2 and α7 Nicotinic Acetylcholine Receptors: Effects of Local Binding and Long-Range Electrostatic InteractionsHuang, Xiaoqin / Zheng, Fang / Chen, Xi / Crooks, Peter A. / Dwoskin, Linda P. / Zhan, Chang-Guo et al. | 2006
- 7675
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Insights on Resistance to Reverse Transcriptase: The Different Patterns of Interaction of the Nucleoside Reverse Transcriptase Inhibitors in the Deoxyribonucleotide Triphosphate Binding Site Relative to the Normal SubstrateCarvalho, Alexandra T. P. / Fernandes, Pedro A. / Ramos, Maria J. et al. | 2006
- 7683
-
2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents: Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo Activity †Leese, Mathew P. / Leblond, Bertrand / Smith, Andrew / Newman, Simon P. / Di Fiore, Anna / De Simone, Giuseppina / Supuran, Claudiu T. / Purohit, Atul / Reed, Michael J. / Potter, Barry V. L. et al. | 2006
- 7683
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2-Substituted Estradiol Bis-sulfamates, Multitargeted Antitumor Agents: Synthesis, In Vitro SAR, Protein Crystallography, and In Vivo ActivityFNR RID="jm060705xAF2" SSYMBOL="dagger">Leese, M.P. et al. | 2006
- 7697
-
Rapid Discovery and Structure−Activity Profiling of Novel Inhibitors of Human Immunodeficiency Virus Type 1 Protease Enabled by the Copper(I)-Catalyzed Synthesis of 1,2,3-Triazoles and Their Further FunctionalizationWhiting, Matthew / Tripp, Jonathan C. / Lin, Ying-Chuan / Lindstrom, William / Olson, Arthur J. / Elder, John H. / Sharpless, K. Barry / Fokin, Valery V. et al. | 2006
- 7711
-
Synthesis and Characterization of a Novel Liver-Targeted Prodrug of Cytosine-1-β-d-arabinofuranoside Monophosphate for the Treatment of Hepatocellular CarcinomaBoyer, Serge H. / Sun, Zhili / Jiang, Hongjian / Esterbrook, Julie / Gómez-Galeno, Jorge E. / Craigo, William / Reddy, K. Raja / Ugarkar, Bheemarao G. / MacKenna, Deidre A. / Erion, Mark D. et al. | 2006
- 7711
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Synthesis and Characterization of a Novel Liver-Targeted Prodrug of Cytosine-1-beta-D-arabinofuranoside Monophosphate for the Treatment of Hepatocellular CarcinomaBoyer, S. H. / Sun, Z. / Jiang, H. / Esterbrook, J. / Gomez-Galeno, J. E. / Craigo, W. / Reddy, K. R. / Ugarkar, B. G. / MacKenna, D. A. / Erion, M. D. et al. | 2006
- 7721
-
Small-Molecule Targeting of Heat Shock Protein 90 Chaperone Function: Rational Identification of a New Anticancer LeadMeli, Massimiliano / Pennati, Marzia / Curto, Maria / Daidone, Maria Grazia / Plescia, Janet / Toba, Sam / Altieri, Dario C. / Zaffaroni, Nadia / Colombo, Giorgio et al. | 2006
- 7731
-
Structure−Activity Relationship Studies of Ethyl 2-Amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an Antagonist for Antiapoptotic Bcl-2 Proteins To Overcome Drug Resistance in CancerDoshi, Jignesh M. / Tian, Defeng / Xing, Chengguo et al. | 2006
- 7740
-
A Systematic Study of Nitrated Indenoisoquinolines Reveals a Potent Topoisomerase I InhibitorMorrell, Andrew / Antony, Smitha / Kohlhagen, Glenda / Pommier, Yves / Cushman, Mark et al. | 2006
- 7754
-
Topomimetics of Amphipathic β-Sheet and Helix-Forming Bactericidal Peptides Neutralize Lipopolysaccharide EndotoxinsChen, Xuemei / Dings, Ruud P. M. / Nesmelova, Irina / Debbert, Stefan / Haseman, Judith R. / Maxwell, Jacques / Hoye, Thomas R. / Mayo, Kevin H. et al. | 2006
- 7754
-
Topomimetics of Amphipathic beta-Sheet and Helix-Forming Bactericidal Peptides Neutralize Lipopolysaccharide EndotoxinsChen, X. / Dings, R. P. M. / Nesmelova, I. / Debbert, S. / Haseman, J. R. / Maxwell, J. / Hoye, T. R. / Mayo, K. H. et al. | 2006
- 7766
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N -Substituted Thymine Derivatives as Mitochondrial Thymidine Kinase (TK-2) InhibitorsHernández, Ana-Isabel / Familiar, Olga / Negri, Ana / Rodríguez-Barrios, Fátima / Gago, Federico / Karlsson, Anna / Camarasa, María-José / Balzarini, Jan / Pérez-Pérez, María-Jesús et al. | 2006
- 7766
-
N1BBR RID="jm0610550b00001">-Substituted Thymine Derivatives as Mitochondrial Thymidine Kinase (TK-2) InhibitorsHernandez, A.-I. et al. | 2006
- 7766
-
N^1-Substituted Thymine Derivatives as Mitochondrial Thymidine Kinase (TK-2) InhibitorsHernandez, A.-I. / Familiar, O. / Negri, A. / Rodriguez-Barrios, F. / Gago, F. / Karlsson, A. / Camarasa, M.-J. / Balzarini, J. / Perez-Perez, M.-J. et al. | 2006
- 7774
-
Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric DamagePerissutti, Elisa / Fiorino, Ferdinando / Renner, Christian / Severino, Beatrice / Roviezzo, Fiorentina / Sautebin, Lidia / Rossi, Antonietta / Cirino, Giuseppe / Santagada, Vincenzo / Caliendo, Giuseppe et al. | 2006
- 7781
-
Design, Synthesis, and Biological Evaluation of Peptidomimetic Inhibitors of Factor XIa as Novel AnticoagulantsLin, Jian / Deng, Hongfeng / Jin, Lei / Pandey, Pramod / Quinn, Jesse / Cantin, Susan / Rynkiewicz, Michael J. / Gorga, Joan C. / Bibbins, Frank / Celatka, Cassandra A. et al. | 2006
- 7792
-
Transplatin Is Cytotoxic When Photoactivated: Enhanced Formation of DNA Cross-LinksHeringova, Pavla / Woods, Julie / Mackay, Fiona S. / Kasparkova, Jana / Sadler, Peter J. / Brabec, Viktor et al. | 2006
- 7799
-
Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel α-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and (R)-9-[2-(Phosphonomethoxy)propyl]adenineBarral, Karine / Priet, Stéphane / Sire, Joséphine / Neyts, Johan / Balzarini, Jan / Canard, Bruno / Alvarez, Karine et al. | 2006
- 7799
-
Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel alpha-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and (R)-9-[2-(Phosphonomethoxy)propyl]adenineBarral, K. / Priet, S. / Sire, J. / Neyts, J. / Balzarini, J. / Canard, B. / Alvarez, K. et al. | 2006
- 7807
-
Synthesis and Evaluation of Multisubstrate Bicyclic Pyrimidine Nucleoside Inhibitors of Human Thymidine PhosphorylaseAllan, Amy L. / Gladstone, Patricia L. / Price, Melissa L. P. / Hopkins, Stephanie A. / Juarez, Jose C. / Doñate, Fernando / Ternansky, Robert J. / Shaw, David E. / Ganem, Bruce / Li, Yingbo et al. | 2006
- 7816
-
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as Novel Antimicrotubule AgentsSynthesis, Antiproliferative Activity, and Inhibition of Tubulin PolymerizationZuse, Anne / Schmidt, Peter / Baasner, Silke / Böhm, Konrad J. / Müller, Klaus / Gerlach, Matthias / Günther, Eckhard G. / Unger, Eberhard / Prinz, Helge et al. | 2006
- 7826
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Arylpiperazinylalkylpyridazinones and Analogues as Potent and Orally Active Antinociceptive Agents: Synthesis and Studies on Mechanism of ActionCesari, Nicoletta / Biancalani, Claudio / Vergelli, Claudia / Dal Piaz, Vittorio / Graziano, Alessia / Biagini, Pierfrancesco / Ghelardini, Carla / Galeotti, Nicoletta / Giovannoni, Maria Paola et al. | 2006
- 7836
-
Biological Mechanisms of Action of Novel C-10 Non-Acetal Trioxane Dimers in Prostate Cancer Cell LinesAlagbala, Adebusola A. / McRiner, Andrew J. / Borstnik, Kristina / Labonte, Tanzina / Chang, Wonsuk / D'Angelo, John G. / Posner, Gary H. / Foster, Barbara A. et al. | 2006
- 7843
-
Synthesis and Structure−Activity Relationships of 3,8-Diazabicyclo[4.2.0]octane Ligands, Potent Nicotinic Acetylcholine Receptor AgonistsFrost (née Pac, Jennifer M. / Bunnelle, William H. / Tietje, Karin R. / Anderson, David J. / Rueter, Lynne E. / Curzon, Peter / Surowy, Carol S. / Ji, Jianquo / Daanen, Jerome F. / Kohlhaas, Kathy L. et al. | 2006
- 7854
-
Synthesis and Antituberculosis Activity of a Novel Series of Optically Active 6-Nitro-2,3-dihydroimidazo[2,1-b]oxazolesSasaki, Hirofumi / Haraguchi, Yoshikazu / Itotani, Motohiro / Kuroda, Hideaki / Hashizume, Hiroyuki / Tomishige, Tatsuo / Kawasaki, Masanori / Matsumoto, Makoto / Komatsu, Makoto / Tsubouchi, Hidetsugu et al. | 2006
- 7861
-
Synthesis and Anti-Human Immunodeficiency Virus Activity of 4‘-Branched (±)-4‘-ThiostavudinesKumamoto, Hiroki / Nakai, Takahito / Haraguchi, Kazuhiro / Nakamura, Kazuo T. / Tanaka, Hiromichi / Baba, Masanori / Cheng, Yung-Chi et al. | 2006
- 7868
-
Synthesis and Src Kinase Inhibitory Activity of a Series of 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitrilesBoschelli, Diane H. / Wu, Biqi / Ye, Fei / Wang, Yan / Golas, Jennifer M. / Lucas, Judy / Boschelli, Frank et al. | 2006
- 7877
-
Synthesis, Antifungal Activity, and Structure−Activity Relationships of Coruscanone A AnaloguesBabu, K. Suresh / Li, Xing-Cong / Jacob, Melissa R. / Zhang, Qifeng / Khan, Shabana I. / Ferreira, Daneel / Clark, Alice M. et al. | 2006
- 7887
-
Quinol-4-ones as Steroid A-Ring Mimetics in Nonsteroidal Dissociated Glucocorticoid AgonistsRegan, John / Lee, Thomas W. / Zindell, Renée M. / Bekkali, Younes / Bentzien, Jörg / Gilmore, Thomas / Hammach, Abdelhakim / Kirrane, Thomas M. / Kukulka, Alison J. / Kuzmich, Daniel et al. | 2006
- 7897
-
Synthesis and Antitumor Activity of Guanylhydrazones from 6-(2,4-Dichloro-5-nitrophenyl)imidazo[2,1-b]thiazoles and 6-Pyridylimidazo[2,1-b]thiazolesAndreani, Aldo / Burnelli, Silvia / Granaiola, Massimiliano / Leoni, Alberto / Locatelli, Alessandra / Morigi, Rita / Rambaldi, Mirella / Varoli, Lucilla / Farruggia, Giovanna / Stefanelli, Claudio et al. | 2006
- 7897
-
Synthesis and Antitumor Activity of Guanylhydrazones from 6-(2,4-Dichloro-5-nitrophenyl)imidazo[2,1-b]thiazoles and 6-Pyridylimidazo[2,1-b]thiazoles1BBR RID="jm061077mb00001">Andreani, A. et al. | 2006
- 7902
-
Binding Properties of Aromatic Carbon-Bound FluorineRazgulin, Andrew V. / Mecozzi, Sandro et al. | 2006
- 7907
-
N,N‘-Bisbenzylidenebenzene-1,4-diamines and N,N‘-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) InhibitorsKiviranta, Päivi H. / Leppänen, Jukka / Kyrylenko, Sergiy / Salo, Heikki S. / Lahtela-Kakkonen, Maija / Tervo, Anu J. / Wittekindt, Carsten / Suuronen, Tiina / Kuusisto, Erkki / Järvinen, Tomi et al. | 2006
- 7912
-
Design, Synthesis, and Biological Evaluation of Phenylamino-Substituted 6,11-Dihydro-dibenzo[b,e]oxepin-11-ones and Dibenzo[a,d]cycloheptan-5-ones: Novel p38 MAP Kinase InhibitorsLaufer, Stefan A. / Ahrens, Gabriele M. / Karcher, Solveigh C. / Hering, Jörg S. / Niess, Raimund et al. | 2006
- 7916
-
Design, Synthesis, and Evaluation of a Potent, Cell-Permeable, Conformationally Constrained Second Mitochondria Derived Activator of Caspase (Smac) MimeticSun, Haiying / Nikolovska-Coleska, Zaneta / Lu, Jianfeng / Qiu, Su / Yang, Chao-Yie / Gao, Wei / Meagher, Jennifer / Stuckey, Jeanne / Wang, Shaomeng et al. | 2006
- 7921
-
Fundamentals of Early Clinical Drug Development. From Synthesis Design to FormulationPinder, R. M. et al. | 2006
- 7921
-
Fundamentals of Early Clinical Drug Development. From Synthesis Design to Formulation Edited by A. F. Abdel-Magid and Stéphane Caron. John Wiley & Sons, New York. 2006. xv + 323 pp. 16 × 24 cm. ISBN 0-471-69278-6. $99.95.Pinder, Roger M. et al. | 2006
- 7921
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Combinatorial Chemistry: From Theory to Application. Second Revised Edition Edited by Willi Bannwarth and Berthold Hinzen. Wiley/VCH, Weinheim, Germany. 2006. xxii+ 629 pp. 15.5 × 24.5 cm. ISBN 3527306935. $205.00Wasley, Jan W. F. et al. | 2006
- 7921
-
Combinatorial Chemistry: From Theory to Application. Second Revised EditionWasley, J. W. F. et al. | 2006
- 7922
-
Microwave Assisted Organic SynthesisBuolamwini, J. K. et al. | 2006
- 7922
-
Microwave Assisted Organic Synthesis Edited by Jason P. Tierney and Pelle Lidstrom. Blackwell Publishing, Oxford, U.K. 2005. xi + 280 pp. 18 × 21 cm. ISBN 0-8493-2371-1. £89.50.Buolamwini, John K. et al. | 2006
- 7923
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Organic Synthesis. State of the Art 2003 − 2005 By Douglas F. Taber. John Wiley and Sons, Inc., Hoboken, New Jersey. 2006. ix + 216 pp. 16 × 24.5 cm. ISBN 0-470-05331-3. $99.95.Kerns, Robert J. et al. | 2006
- 7923
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Computer Applications in Pharmaceutical Research and Development Edited by Sean Ekins. John Wiley & Sons, Inc., Hoboken, NJ. 2006. xix + 805 pp. 16 × 24 cm. ISBN 0-471-73779-8. $125.00.Kellogg, Glen E. et al. | 2006
- 7923
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Organic Synthesis. State of the Art 2003-2005Kerns, R. J. et al. | 2006
- 7923
-
Computer Applications in Pharmaceutical Research and DevelopmentKellogg, G. E. et al. | 2006