1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells (English)
- New search for: Che, Haiyan
- New search for: Che, Haiyan
- New search for: Tuyen, Truong Ngoc
- New search for: Kim, Hyun Pyo
- New search for: Park, Haeil
In:
Bioorganic & medicinal chemistry letters
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20
, 14
; 4035-4038
;
2010
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ISSN:
- Article (Journal) / Print
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Title:1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cells
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Contributors:
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Published in:Bioorganic & medicinal chemistry letters ; 20, 14 ; 4035-4038
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Publisher:
- New search for: Elsevier
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Place of publication:Amsterdam [u.a.]
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Publication date:2010
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ISSN:
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ZDBID:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 35.70 / 44.33 / 44.42
- Further information on Basic classification
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Keywords:
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Source:
Table of contents – Volume 20, Issue 14
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 3987
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Graphical contents list| 2010
- 4004
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Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituentsNilsson, Magnus / Belfrage, Anna Karin / Lindström, Stefan / Wähling, Horst / Lindquist, Charlotta / Ayesa, Susana / Kahnberg, Pia / Pelcman, Mikael / Benkestock, Kurt / Agback, Tatiana et al. | 2010
- 4012
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Studies on the structure–activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituentsBen, Li / Jones, Eric Dale / Zhou, Enkun / Li, Chen / Baylis, Dean Cameron / Yu, Shanghai / Wang, Miao / He, Xing / Coates, Jonathan Alan Victor / Rhodes, David Ian et al. | 2010
- 4015
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One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activityChen, Nai-Dong / Yue, Lei / Zhang, Jian / Kou, Jun-Ping / Yu, Bo-Yang et al. | 2010
- 4018
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Synthesis and biological activity of 2-hydroxynicotinoyl-serine-butyl esters related to antibiotic UK-3AArsianti, Ade / Hanafi, Muhammad / Saepudin, Endang / Morimoto, Tsumoru / Kakiuchi, Kiyomi et al. | 2010
- 4021
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Exploring structural requirements of 1-N-substituted thiocarbamoyl-3-phenyl-2-pyrazolines as antiamoebic agents using comparative QSAR modellingAdhikari, Nilanjan / Maiti, Milan Kumar / Jha, Tarun et al. | 2010
- 4027
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Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarialsDeng, Xianming / Nagle, Advait / Wu, Tao / Sakata, Tomoyo / Henson, Kerstin / Chen, Zhong / Kuhen, Kelli / Plouffe, David / Winzeler, Elizabeth / Adrian, Francisco et al. | 2010
- 4032
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A novel organogermanium protected atopic dermatitis induced by oxazoloneLim, Doo Hyeon / Li, Minghua / Seo, Jung-A / Lim, Kyung-Min / Ham, Seung Wook et al. | 2010
- 4035
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1,5-Diarylimidazoles with strong inhibitory activity against COX-2 catalyzed PGE2 production from LPS-induced RAW 264.7 cellsChe, Haiyan / Tuyen, Truong Ngoc / Kim, Hyun Pyo / Park, Haeil et al. | 2010
- 4038
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Subtype-selectivity of metal-dependent methionine aminopeptidase inhibitorsAltmeyer, Markus A. / Marschner, Aline / Schiffmann, Rolf / Klein, Christian D. et al. | 2010
- 4045
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Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinasesMatthews, Thomas P. / McHardy, Tatiana / Klair, Suki / Boxall, Kathy / Fisher, Martin / Cherry, Michael / Allen, Charlotte E. / Addison, Glynn J. / Ellard, John / Aherne, G. Wynne et al. | 2010
- 4050
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Synthesis of isosteric selenium analog of the PPARβ/δ agonist GW501516 and comparison of biological activitySharma, Arun K. / Sk, Ugir Hossain / He, Pengfei / Peters, Jeffrey M. / Amin, Shantu et al. | 2010
- 4050
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Synthesis of isosteric selenium analog of the PPARb/d agonist GW501516 and comparison of biological activitySharma, A. K. / Sk, U. H. / He, P. / Peters, J. M. / Amin, S. et al. | 2010
- 4053
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Synthesis and anti-HIV activity of 2prime-deoxy-2prime-fluoro-4prime-C-ethynyl nucleoside analogsWang, Q. / Li, Y. / Song, C. / Qian, K. / Chen, C. H. / Lee, K. H. / Chang, J. et al. | 2010
- 4053
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Synthesis and anti-HIV activity of 2′-deoxy-2′-fluoro-4′-C-ethynyl nucleoside analogsWang, Qiang / Li, Yanfeng / Song, Chuanjun / Qian, Keduo / Chen, Chin-Ho / Lee, Kuo-Hsiung / Chang, Junbiao et al. | 2010
- 4057
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7′,8′-Dihydroobolactone, a typanocidal α-pyrone from the rainforest tree Cryptocarya obovataDavis, Rohan A. / Demirkiran, Ozlem / Sykes, Melissa L. / Avery, Vicky M. / Suraweera, Lekha / Fechner, Gregory A. / Quinn, Ronald J. et al. | 2010
- 4057
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7prime,8prime-Dihydroobolactone, a typanocidal a-pyrone from the rainforest tree Cryptocarya obovataDavis, R. A. / Demirkiran, O. / Sykes, M. L. / Avery, V. M. / Suraweera, L. / Fechner, G. A. / Quinn, R. J. et al. | 2010
- 4060
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Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitorsAmeriks, Michael K. / Bembenek, Scott D. / Burdett, Matthew T. / Choong, Ingrid C. / Edwards, James P. / Gebauer, Damara / Gu, Yin / Karlsson, Lars / Purkey, Hans E. / Staker, Bart L. et al. | 2010
- 4065
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Epsilon substituted lysinol derivatives as HIV-1 protease inhibitorsJones, Kristen L.G. / Holloway, M. Katharine / Su, Hua-Poo / Carroll, Steven S. / Burlein, Christine / Touch, Sinoeun / DiStefano, Daniel J. / Sanchez, Rosa I. / Williams, Theresa M. / Vacca, Joseph P. et al. | 2010
- 4069
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Structure–activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptorAntipas, Amy S. / Blumberg, Laura C. / Brissette, William H. / Brown, Matthew F. / Casavant, Jeffrey M. / Doty, Jonathan L. / Driscoll, James / Harris, Thomas M. / Jones, Christopher S. / McCurdy, Sandra P. et al. | 2010
- 4073
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Monastrol analogs: A synthesis of pyrazolopyridine, benzopyranopyrazolopyridine, and oxygen-bridged azolopyrimidine derivatives and their biological screeningSvetlik, Jan / Veizerová, Lucia / Mayer, Thomas U. / Catarinella, Mario et al. | 2010
- 4077
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Synthesis and biological evaluation of novel biotin–iminoalditol conjugatesPototschnig, Gerit / De Csáky, Christian Morales / Montenegro Burke, Jose R. / Schitter, Georg / Stütz, Arnold E. / Tarling, Chris A. / Withers, Stephen G. / Wrodnigg, Tanja M. et al. | 2010
- 4080
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Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of painLee, Yeon Sun / Fernandes, Steve / Kulkarani, Vinod / Mayorov, Alexander / Davis, Peg / Ma, Shou-wu / Brown, Kathy / Gillies, Robert J. / Lai, Josephine / Porreca, Frank et al. | 2010
- 4085
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Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agentsDong, Yizhou / Nakagawa-Goto, Kyoko / Lai, Chin-Yu / Morris-Natschke, Susan L. / Bastow, Kenneth F. / Lee, Kuo-Hsiung et al. | 2010
- 4088
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Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virusKazakova, Oxana B. / Giniyatullina, Gul’nara V. / Yamansarov, Emil Yu. / Tolstikov, Genrikh A. et al. | 2010
- 4091
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Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agentsKozaka, Takashi / Nakagawa-Goto, Kyoko / Shi, Qian / Lai, Chin-Yu / Hamel, Ernest / Bastow, Kenneth F. / Brossi, Arnold / Lee, Kuo-Hsiung et al. | 2010
- 4095
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Structure-based optimization of potent PDK1 inhibitorsAngiolini, Mauro / Banfi, Patrizia / Casale, Elena / Casuscelli, Francesco / Fiorelli, Claudio / Saccardo, Maria B. / Silvagni, Marco / Zuccotto, Fabio et al. | 2010
- 4100
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Eudistomidin G, a new β-carboline alkaloid from the Okinawan marine tunicate Eudistoma glaucus and structure revision of eudistomidin BTakahashi, Yohei / Ishiyama, Haruaki / Kubota, Takaaki / Kobayashi, Jun’ichi et al. | 2010
- 4100
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Eudistomidin G, a new b-carboline alkaloid from the Okinawan marine tunicate Eudistoma glaucus and structure revision of eudistomidin BTakahashi, Y. / Ishiyama, H. / Kubota, T. / Kobayashi, J. i. et al. | 2010
- 4104
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Benzofuran-substituted urea derivatives as novel P2Y1 receptor antagonistsThalji, Reema K. / Aiyar, Nambi / Davenport, Elizabeth A. / Erhardt, Joseph A. / Kallal, Lorena A. / Morrow, Dwight M. / Senadhi, Shobha / Burns-Kurtis, Cynthia L. / Marino, Joseph P. Jr. et al. | 2010
- 4108
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Motualevic acids and analogs: Synthesis and antimicrobial structure–activity relationshipsCheruku, Pradeep / Keffer, Jessica L. / Dogo-Isonagie, Cajetan / Bewley, Carole A. et al. | 2010
- 4112
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Acid-catalyzed synthesis of 10-substituted triazolyl artemisinins and their growth inhibitory activity against various cancer cellsOh, Sangtae / Shin, Woon-Seob / Ham, Jungyeob / Lee, Seokjoon et al. | 2010
- 4116
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Recombination of diterpenoid structure units: Synthesis of antitumor amides bearing functionalized bicyclo[3.2.1]octane ringMao, Zewei / Li, Yan / Chen, Jingbo / Wang, Yuanyuan / Zhang, Hongbin et al. | 2010
- 4120
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Hydroxysafflor Yellow A suppresses thrombin generation and inflammatory responses following focal cerebral ischemia–reperfusion in ratsSun, Xia / Wei, Xinbing / Qu, Sifeng / Zhao, Yunxue / Zhang, Xiumei et al. | 2010
- 4125
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Efficient synthesis of 5′-O-laurate of 1-β-d-arabinofuranosylcytosine via highly regioselective enzymatic acylation in binary solvent mixturesLi, Xiao-feng / Zong, Min-hua / Zhao, Guang-lei et al. | 2010
- 4125
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Efficient synthesis of 5prime-O-laurate of 1-b-d-arabinofuranosylcytosine via highly regioselective enzymatic acylation in binary solvent mixturesLi, X. f. / Zong, M. h. / Zhao, G. l. et al. | 2010
- 4128
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AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effectNguyen, Phi Hung / Le, Thi Van Thu / Kang, Hu Won / Chae, Jooyoung / Kim, Sang Kyum / Kwon, Kwang-iI / Seo, Dae Bang / Lee, Sang Jun / Oh, Won Keun et al. | 2010
- 4132
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Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agentsZhao, Wanyi / Feng, Xiue / Ban, Shurong / Lin, Wenhan / Li, Qingshan et al. | 2010
- 4135
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An analysis of the ‘legal high’ mephedroneGibbons, Simon / Zloh, Mire et al. | 2010
- 4140
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4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: Drug-like and non-xanthine based A2B adenosine receptor antagonistsCheung, Adrian Wai-Hing / Brinkman, John / Firooznia, Fariborz / Flohr, Alexander / Grimsby, Joseph / Gubler, Mary Lou / Guertin, Kevin / Hamid, Rachid / Marcopulos, Nicholas / Norcross, Roger D. et al. | 2010
- 4147
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Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsulesCheng, Shuk-Yan / Yuen, Marcus Chun-Wah / Lam, Pik-Ling / Gambari, Roberto / Wong, Raymond Siu-Ming / Cheng, Gregory Yin-Ming / Lai, Paul Bo-San / Tong, See-Wai / Chan, Kit-Wah / Lau, Fung-Yi et al. | 2010
- 4152
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Probe molecule equipped with boronic acid moiety as a reversible cross-linking group improves its binding affinityKotoku, Naoyuki / Guo, Xiu-Han / Arai, Masayoshi / Kobayashi, Motomasa et al. | 2010
- 4156
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Structure-based design and synthesis of pyrrole derivatives as MEK inhibitorsWallace, Michael B. / Adams, Mark E. / Kanouni, Toufike / Mol, Clifford D. / Dougan, Douglas R. / Feher, Victoria A. / O’Connell, Shawn M. / Shi, Lihong / Halkowycz, Petro / Dong, Qing et al. | 2010
- 4159
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Folacin C60 derivative exerts a protective activity against oxidative stress-induced apoptosis in rat pheochromocytoma cellsHu, Zhen / Guan, Wenchao / Wang, Wei / Zhu, Zhou / Wang, Yanhong et al. | 2010
- 4163
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Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agentsLiu, Xin-Hua / Liu, Hui-Feng / Shen, Xu / Song, Bao-An / Bhadury, Pinaki S. / Zhu, Hai-Liang / Liu, Jin-Xing / Qi, Xing-Bao et al. | 2010
- 4168
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Novel semicarbazones based 2,5-disubstituted-1,3,4-oxadiazoles: One more step towards establishing four binding site pharmacophoric model hypothesis for anticonvulsant activityRajak, Harish / Deshmukh, Ravitas / Veerasamy, Ravichandran / Sharma, Ajay Kumar / Mishra, Pradeep / Kharya, Murli Dhar et al. | 2010
- 4173
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In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicumBibi, Nazia / Tanoli, Sheraz Ahmad. K. / Farheen, Sadia / Afza, Nighat / Siddiqi, Salman / Zhang, Ying / Kazmi, Shahana U. / Malik, Abdul et al. | 2010
- 4177
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Synthesis and characterization of multifunctional hyperbranched polyesters as prospective contrast agents for targeted MRISideratou, Zili / Tsiourvas, Dimitris / Theodossiou, Theodossis / Fardis, Michael / Paleos, Constantinos M. et al. | 2010
- 4182
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Interaction of aminoadamantane derivatives with the influenza A virus M2 channel-Docking using a pore blocking modelEleftheratos, Stelios / Spearpoint, Philip / Ortore, Gabriella / Kolocouris, Antonios / Martinelli, Adriano / Martin, Stephen / Hay, Alan et al. | 2010
- 4188
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High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical librariesBuller, Fabian / Steiner, Martina / Scheuermann, Jörg / Mannocci, Luca / Nissen, Ina / Kohler, Manuel / Beisel, Christian / Neri, Dario et al. | 2010
- 4193
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Synthesis of diaryl-azo derivatives as potential antifungal agentsXu, Hui / Zeng, Xiwen et al. | 2010
- 4196
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Broad spectrum alkynyl inhibitors of T315I Bcr-AblDeng, Xianming / Lim, Sang Min / Zhang, Jianming / Gray, Nathanael S. et al. | 2010
- 4201
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Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the ratColeman, Paul J. / Schreier, John D. / Roecker, Anthony J. / Mercer, Swati P. / McGaughey, Georgia B. / Cox, Christopher D. / Hartman, George D. / Harrell, C. Meacham / Reiss, Duane R. / Doran, Scott M. et al. | 2010
- 4206
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Synthesis of two marine farnesylacetones that dilate the basilar arteries of rabbitsOh, Sangtae / Park, Byong-Gon / Ham, Jungyeob / Lee, Seokjoon et al. | 2010
- 4210
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Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: Identification of candidates for clinical developmentLetavic, Michael A. / Aluisio, Leah / Atack, John R. / Bonaventure, Pascal / Carruthers, Nicholas I. / Dugovic, Christine / Everson, Anita / Feinstein, Mark A. / Fraser, Ian C. / Hoey, Kenway et al. | 2010
- 4215
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Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Benzyl derivatives with broad potency against resistant mutant virusesKertesz, Denis J. / Brotherton-Pleiss, Christine / Yang, Minmin / Wang, Zhanguo / Lin, Xianfeng / Qiu, Zongxing / Hirschfeld, Donald R. / Gleason, Shelley / Mirzadegan, Taraneh / Dunten, Pete W. et al. | 2010
- 4219
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Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockersLee, Jie Eun / Koh, Hun Yeong / Seo, Seon Hee / Baek, Yi Yeon / Rhim, Hyewhon / Cho, Yong Seo / Choo, Hyunah / Pae, Ae Nim et al. | 2010
- 4223
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Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitorsCho, Sung Yun / Han, Sun-Young / Ha, Jae Du / Ryu, Jae Wook / Lee, Chong Ock / Jung, Heejung / Kang, Nam Sook / Kim, Hyoung Rae / Koh, Jong Sung / Lee, Jongkook et al. | 2010
- 4228
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Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-β type 1 receptor kinase inhibitorsDewang, Purushottam M. / Kim, Dae-Kee et al. | 2010
- 4228
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Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-b type 1 receptor kinase inhibitorsDewang, P. M. / Kim, D. K. et al. | 2010
- 4233
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In vitro and in vivo antimalarial evaluation of semi-synthetic derivatives of gomphosteninSathe, Manisha / Kaushik, M.P. et al. | 2010
- 4237
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Chemoselective regulation of TREK2 channel: Activation by sulfonate chalcones and inhibition by sulfonamide chalconesKim, Eun-Jin / Ryu, Hyung Won / Curtis-Long, Marcus J. / Han, Jaehee / Kim, Jun Young / Cho, Jung Keun / Kang, Dawon / Park, Ki Hun et al. | 2010
- 4240
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Synthesis of Tc-99m labeled 1,2,3-triazole-4-yl c-met binding peptide as a potential c-met receptor kinase positive tumor imaging agentKim, Eun-Mi / Joung, Min-Hee / Lee, Chang-Moon / Jeong, Hwan-Jeong / Lim, Seok Tae / Sohn, Myung-Hee / Kim, Dong Wook et al. | 2010
- 4244
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Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-N′-arylguanidines: Access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivativesDebray, Julien / Zeghida, Walid / Baldeyrou, Brigitte / Mahieu, Christine / Lansiaux, Amélie / Demeunynck, Martine et al. | 2010
- 4244
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Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-Nprime-arylguanidines: Access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivativesDebray, J. / Zeghida, W. / Baldeyrou, B. / Mahieu, C. / Lansiaux, A. / Demeunynck, M. et al. | 2010
- 4248
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Novel coumarin derivatives as potential antidyslipidemic agentsSashidhara, Koneni V. / Kumar, Abdhesh / Kumar, Manoj / Sonkar, Ravi / Bhatia, Gitika / Khanna, A.K. et al. | 2010
- 4252
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One-pot multicomponent synthesis and anti-microbial evaluation of 2′-(indol-3-yl)-2-oxospiro(indoline-3,4′-pyran) derivativesNandakumar, A. / Thirumurugan, Prakasam / Perumal, Paramasivan T. / Vembu, P. / Ponnuswamy, M.N. / Ramesh, P. et al. | 2010
- 4252
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One-pot multicomponent synthesis and anti-microbial evaluation of 2prime-(indol-3-yl)-2-oxospiro(indoline-3,4prime-pyran) derivativesNandakumar, A. / Thirumurugan, P. / Perumal, P. T. / Vembu, P. / Ponnuswamy, M. N. / Ramesh, P. et al. | 2010
- 4259
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Screening and characterization of an inhibitory chemical specific to Arabidopsis gibberellin 2-oxidasesOtani, Masato / Yoon, Jung-Min / Park, Seung-Hyun / Asami, Tadao / Nakajima, Masatoshi et al. | 2010
- 4263
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Synthesis and biological activity of glycosyl-1H-1,2,3-triazolesSlámová, Kristýna / Marhol, Petr / Bezouška, Karel / Lindkvist, Lise / Hansen, Signe G. / Křen, Vladimír / Jensen, Henrik H. et al. | 2010
- 4266
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Antioxidative activities of histidine containing caffeic acid-dipeptidesSeo, Hyo-Suk / Kwak, Seon-Yeong / Lee, Yoon-Sik et al. | 2010
- 4273
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Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitorsShi, Jianyou / Xu, Guobin / Zhu, Wei / Ye, Haoyu / Yang, Shengyong / Luo, Youfu / Han, Jing / Yang, Jincheng / Li, Rui / Wei, Yuquan et al. | 2010
- 4279
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A new approach for PEGylation of dendrimersKhambete, Hemant / Gautam, Surya P. / Karthikeyan, C. / Ramteke, Suman / Hari Narayana Moorthy, N.S. / Trivedi, Piyush et al. | 2010
- 4282
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Corrigendum to “Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives of naproxen” [Bioorg. Med. Chem. Lett. 17 (2007) 4504]Amir, Mohammad / Kumar, Harish / Javed, Sadique A. et al. | 2010
- IFC
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Editorial board| 2010