Resorcinol-sn-Glycerol Derivatives: Novel 2-Arachidonoylglycerol Mimetics Endowed with High Affinity and Selectivity for Cannabinoid Type 1 Receptor (English)
- New search for: Brizzi, Antonella
- New search for: Brizzi, Antonella
- New search for: Cascio, Maria Grazia
- New search for: Frosini, Maria
- New search for: Ligresti, Alessia
- New search for: Aiello, Francesca
- New search for: Biotti, Irene
- New search for: Brizzi, Vittorio
- New search for: Pertwee, Roger Guy
- New search for: Corelli, Federico
- New search for: Di Marzo, Vincenzo
In:
Journal of medicinal chemistry
;
54
, 24
; 8278-8289
;
2011
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ISSN:
- Article (Journal) / Print
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Title:Resorcinol-sn-Glycerol Derivatives: Novel 2-Arachidonoylglycerol Mimetics Endowed with High Affinity and Selectivity for Cannabinoid Type 1 Receptor
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Contributors:
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Published in:Journal of medicinal chemistry ; 54, 24 ; 8278-8289
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Publisher:
- New search for: American Chemical Society
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Place of publication:Easton, Pa.
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Publication date:2011
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ISSN:
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ZDBID:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 770/4230
- New search for: 44.42 / 44.42
- Further information on Basic classification
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Keywords:
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Classification:
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Source:
Table of contents – Volume 54, Issue 24
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 8235
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My Farewell to the Journal of Medicinal ChemistryPortoghese, Philip S. et al. | 2011
- 8236
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Lysine Demethylases InhibitorsSuzuki, Takayoshi / Miyata, Naoki et al. | 2011
- 8251
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Synthesis, Biological Evaluation, and Molecular Modeling of Donepezil and N-[(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids as New Multipotent Cholinesterase/Monoamine Oxidase Inhibitors for the Treatment of Alzheimer’s DiseaseBolea, Irene / Juárez-Jiménez, Jordi / de los Rı́os, Cristóbal / Chioua, Mourad / Pouplana, Ramón / Luque, F. Javier / Unzeta, Mercedes / Marco-Contelles, José / Samadi, Abdelouahid et al. | 2011
- 8271
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Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast TumorsTouisni, Nadia / Maresca, Alfonso / McDonald, Paul C. / Lou, Yuanmei / Scozzafava, Andrea / Dedhar, Shoukat / Winum, Jean-Yves / Supuran, Claudiu T. et al. | 2011
- 8278
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Resorcinol-sn-Glycerol Derivatives: Novel 2-Arachidonoylglycerol Mimetics Endowed with High Affinity and Selectivity for Cannabinoid Type 1 ReceptorBrizzi, Antonella / Cascio, Maria Grazia / Frosini, Maria / Ligresti, Alessia / Aiello, Francesca / Biotti, Irene / Brizzi, Vittorio / Pertwee, Roger Guy / Corelli, Federico / Di Marzo, Vincenzo et al. | 2011
- 8289
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Novel 1-Hydroxypiperazine-2,6-diones as New Leads in the Inhibition of MetalloproteinasesMarques, Sérgio M. / Tuccinardi, Tiziano / Nuti, Elisa / Santamaria, Salvatore / André, Vânia / Rossello, Armando / Martinelli, Adriano / Santos, M. Amélia et al. | 2011
- 8299
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Synthesis of Monomeric Derivatives To Probe Memoquin’s Bivalent InteractionsBolognesi, Maria Laura / Chiriano, GianPaolo / Bartolini, Manuela / Mancini, Francesca / Bottegoni, Giovanni / Maestri, Valentina / Czvitkovich, Stefan / Windisch, Manfred / Cavalli, Andrea / Minarini, Anna et al. | 2011
- 8305
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Optimization of the Potency and Pharmacokinetic Properties of a Macrocyclic Ghrelin Receptor Agonist (Part I): Development of Ulimorelin (TZP-101) from Hit to ClinicHoveyda, Hamid R. / Marsault, Eric / Gagnon, René / Mathieu, Axel P. / Vézina, Martin / Landry, Annick / Wang, Zhigang / Benakli, Kamel / Beaubien, Sylvie / Saint-Louis, Carl et al. | 2011
- 8321
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Synthesis, Antimalarial Activity, and Structure–Activity Relationship of 7-(2-Phenoxyethoxy)-4(1H)-quinolonesCross, R. Matthew / Namelikonda, Niranjan K. / Mutka, Tina S. / Luong, Lisa / Kyle, Dennis E. / Manetsch, Roman et al. | 2011
- 8328
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Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold MorphingReader, John C. / Matthews, Thomas P. / Klair, Suki / Cheung, Kwai-Ming J. / Scanlon, Jane / Proisy, Nicolas / Addison, Glynn / Ellard, John / Piton, Nelly / Taylor, Suzanne et al. | 2011
- 8343
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Evaluation of 18F-Labeled Benzodioxine Piperazine-Based Dopamine D4 Receptor Ligands: Lipophilicity as a Determinate of Nonspecific BindingKügler, Fabian / Sihver, Wiebke / Ermert, Johannes / Hübner, Harald / Gmeiner, Peter / Prante, Olaf / Coenen, Heinz H. et al. | 2011
- 8353
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Hydroxylated Analogues of ATP-Sensitive Potassium Channel Openers Belonging to the Group of 6- and/or 7-Substituted 3-Isopropylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides: Toward an Improvement in Sulfonylurea Receptor 1 Selectivity and Metabolism Stabilityde Tullio, Pascal / Servais, Anne-Catherine / Fillet, Marianne / Gillotin, Florian / Somers, Fabian / Chiap, Patrice / Lebrun, Philippe / Pirotte, Bernard et al. | 2011
- 8362
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Toward the Definition of Stereochemical Requirements for MT2-Selective Antagonists and Partial Agonists by Studying 4-Phenyl-2-propionamidotetralin DerivativesBedini, Annalida / Lucarini, Simone / Spadoni, Gilberto / Tarzia, Giorgio / Scaglione, Francesco / Dugnani, Silvana / Pannacci, Marilou / Lucini, Valeria / Carmi, Caterina / Pala, Daniele et al. | 2011
- 8373
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Design, Synthesis, and Qualitative Structure-Activity Evaluations of Novel beta -Secretase Inhibitors as Potential Alzheimer's Drug LeadsAl-Tel, T.H. / Semreen, M.H. / Al-Qawasmeh, R.A. / Schmidt, M.F. / El-Awadi, R. / Ardah, M. / Zaarour, R. / Rao, S.N. / El-Agnaf, O. et al. | 2011
- 8373
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Design, Synthesis, and Qualitative Structure–Activity Evaluations of Novel β-Secretase Inhibitors as Potential Alzheimer’s Drug LeadsAl-Tel, Taleb H. / Semreen, Mohammad H. / Al-Qawasmeh, Raed A. / Schmidt, Marco F. / El-Awadi, Raafat / Ardah, Mustafa / Zaarour, Rania / Rao, Shashidhar N. / El-Agnaf, Omar et al. | 2011
- 8386
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Genistein Binding Mode to Doubly Nicked Dumbbell DNA. Dynamic and Diffusion Ordered NMR StudyHyz, Karolina / Kawęcki, Robert / Misior, Aleksandra / Bocian, Wojciech / Bednarek, Elżbieta / Sitkowski, Jerzy / Kozerski, Lech et al. | 2011
- 8394
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Design and Synthesis of 2-Heterocyclyl-3-arylthio-1H-indoles as Potent Tubulin Polymerization and Cell Growth Inhibitors with Improved Metabolic StabilityLa Regina, Giuseppe / Bai, Ruoli / Rensen, Willeke / Coluccia, Antonio / Piscitelli, Francesco / Gatti, Valerio / Bolognesi, Alessio / Lavecchia, Antonio / Granata, Ilaria / Porta, Amalia et al. | 2011
- 8407
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Investigating the Role of Metal Chelation in HIV-1 Integrase Strand Transfer InhibitorsBacchi, Alessia / Carcelli, Mauro / Compari, Carlotta / Fisicaro, Emilia / Pala, Nicolino / Rispoli, Gabriele / Rogolino, Dominga / Sanchez, Tino W. / Sechi, Mario / Sinisi, Valentina et al. | 2011
- 8421
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Mechanistic Analysis of Muraymycin Analogues: A Guide to the Design of MraY InhibitorsTanino, Tetsuya / Al-Dabbagh, Bayan / Mengin-Lecreulx, Dominique / Bouhss, Ahmed / Oyama, Hiroshi / Ichikawa, Satoshi / Matsuda, Akira et al. | 2011
- 8440
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Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 InhibitorsSchenkel, Laurie B. / Huang, Xin / Cheng, Alan / Deak, Holly L. / Doherty, Elizabeth / Emkey, Renee / Gu, Yan / Gunaydin, Hakan / Kim, Joseph L. / Lee, Josie et al. | 2011
- 8451
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C-Terminal Tetrapeptides Inhibit Aβ42-Induced Neurotoxicity Primarily through Specific Interaction at the N-Terminus of Aβ42Li, Huiyuan / Du, Zhenming / Lopes, Dahabada H. J. / Fradinger, Erica A. / Wang, Chunyu / Bitan, Gal et al. | 2011
- 8451
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C-Terminal Tetrapeptides Inhibit A beta 42-Induced Neurotoxicity Primarily through Specific Interaction at the N-Terminus of A beta 42Li, H. / Du, Z. / Lopes, D.H.J. / Fradinger, E.A. / Wang, C. / Bitan, G. et al. | 2011
- 8461
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Exploring the Binding Sites of Glycogen Synthase Kinase 3. Identification and Characterization of Allosteric Modulation CavitiesPalomo, Valle / Soteras, Ignacio / Perez, Daniel I. / Perez, Concepción / Gil, Carmen / Campillo, Nuria Eugenia / Martinez, Ana et al. | 2011
- 8471
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Design and Synthesis of Novel Small-Molecule Inhibitors of the Hypoxia Inducible Factor PathwayMooring, Suazette Reid / Jin, Hui / Devi, Narra S. / Jabbar, Adnan A. / Kaluz, Stefan / Liu, Yuan / Van Meir, Erwin G. / Wang, Binghe et al. | 2011
- 8490
-
Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1)Murphy, Sean T. / Alton, Gordon / Bailey, Simon / Baxi, Sangita M. / Burke, Benjamin J. / Chappie, Thomas A. / Ermolieff, Jacques / Ferre, RoseAnn / Greasley, Samantha / Hickey, Michael et al. | 2011
- 8501
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Engineering pH-Gated Transitions for Selective and Efficient Double-Strand DNA Photocleavage in Hypoxic TumorsYang, Wang-Yong / Roy, Saumya / Phrathep, Boondaniwon / Rengert, Zach / Kenworthy, Rachael / Zorio, Diego A. R. / Alabugin, Igor V. et al. | 2011
- 8517
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5-Amino-2-aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors. Part 2. The Impact of Bridging Groups at Position C-2Lee, Hsueh-Yun / Chang, Jang-Yang / Nien, Chih-Ying / Kuo, Ching-Chuan / Shih, Kuang-Hsing / Wu, Chun-Hsein / Chang, Chi-Yen / Lai, Wen-Yang / Liou, Jing-Ping et al. | 2011
- 8526
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A New Class of Antimalarial Dioxanes Obtained through a Simple Two-Step Synthetic Approach: Rational Design and Structure–Activity Relationship StudiesPersico, Marco / Quintavalla, Arianna / Rondinelli, Francesca / Trombini, Claudio / Lombardo, Marco / Fattorusso, Caterina / Azzarito, Valeria / Taramelli, Donatella / Parapini, Silvia / Corbett, Yolanda et al. | 2011
- 8541
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Benzimidazolones: A New Class of Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) ModulatorsLiu, Weiguo / Lau, Fiona / Liu, Kun / Wood, Harold B. / Zhou, Gaochao / Chen, Yuli / Li, Ying / Akiyama, Taro E. / Castriota, Gino / Einstein, Monica et al. | 2011
- 8541
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Benzimidazolones: A New Class of Selective Peroxisome Proliferator-Activated Receptor gamma (PPAR gamma ) ModulatorsLiu, W. / Lau, F. / Liu, K. / Wood, H.B. / Zhou, G. / Chen, Y. / Li, Y. / Akiyama, T.E. / Castriota, G. / Einstein, M. et al. | 2011
- 8555
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Binding of Ibuprofen, Ketorolac, and Diclofenac to COX-1 and COX-2 Studied by Saturation Transfer Difference NMRViegas, Aldino / Manso, João / Corvo, Marta C. / Marques, M. Manuel B. / Cabrita, Eurico J. et al. | 2011
- 8563
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Targeting the Binding Function 3 (BF3) Site of the Human Androgen Receptor through Virtual Screening.Lack, Nathan A. / Axerio-Cilies, Peter / Tavassoli, Peyman / Han, Frank Q. / Chan, Ka Hong / Feau, Clementine / LeBlanc, Eric / Guns, Emma Tomlinson / Guy, R. Kiplin / Rennie, Paul S. et al. | 2011
- 8574
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Inhibition of Glutathione S-Transferase M1 by New Gabosine Analogues Is Essential for Overcoming Cisplatin Resistance in Lung Cancer CellsWang, Chie-Hong / Wu, Ho T. / Cheng, Hau M. / Yen, Tien-Jui / Lu, I-Hsuan / Chang, Hui Chuan / Jao, Shu-Chuan / Shing, Tony K. M. / Li, Wen-Shan et al. | 2011
- 8582
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Computationally-Guided Optimization of a Docking Hit to Yield Catechol Diethers as Potent Anti-HIV AgentsBollini, Mariela / Domaoal, Robert A. / Thakur, Vinay V. / Gallardo-Macias, Ricardo / Spasov, Krasimir A. / Anderson, Karen S. / Jorgensen, William L. et al. | 2011
- 8592
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Novel 3,4-Isoxazolediamides as Potent Inhibitors of Chaperone Heat Shock Protein 90Baruchello, Riccardo / Simoni, Daniele / Grisolia, Giuseppina / Barbato, Giuseppina / Marchetti, Paolo / Rondanin, Riccardo / Mangiola, Stefania / Giannini, Giuseppe / Brunetti, Tiziana / Alloatti, Domenico et al. | 2011
- 8605
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NHC Gold Halide Complexes Derived from 4,5-Diarylimidazoles: Synthesis, Structural Analysis, and Pharmacological Investigations as Potential Antitumor AgentsLiu, Wukun / Bensdorf, Kerstin / Proetto, Maria / Abram, Ulrich / Hagenbach, Adelheid / Gust, Ronald et al. | 2011
- 8616
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Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor AntagonistsHasui, Tomoaki / Matsunaga, Nobuyuki / Ora, Taiichi / Ohyabu, Norio / Nishigaki, Nobuhiro / Imura, Yoshimi / Igata, Yumiko / Matsui, Hideki / Motoyaji, Takashi / Tanaka, Toshimasa et al. | 2011
- 8632
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Phosphorodiamidates as a Promising New Phosphate Prodrug Motif for Antiviral Drug Discovery: Application to Anti-HCV AgentsMcGuigan, Christopher / Madela, Karolina / Aljarah, Mohamed / Bourdin, Claire / Arrica, Maria / Barrett, Emma / Jones, Sarah / Kolykhalov, Alexander / Bleiman, Blair / Bryant, K. Dawn et al. | 2011
- 8646
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Comparative in Vitro Evaluation of N-Heterocyclic Carbene Gold(I) Complexes of the Benzimidazolylidene TypeRubbiani, Riccardo / Can, Suzan / Kitanovic, Igor / Alborzinia, Hamed / Stefanopoulou, Maria / Kokoschka, Malte / Mönchgesang, Susann / Sheldrick, William S. / Wölfl, Stefan / Ott, Ingo et al. | 2011
- 8646
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Comparative in Vitro Evaluation of N-Heterocyclic Carbene Gold(I) Complexes of the Benzimidazolylldene TypeRubbiani, R. / Can, S. / Kitanovic, I. / Alborzinia, H. / Stefanopoulou, M. / Kokoschka, M. / Monchgesang, S. / Sheldrick, W.S. / Wolfl, S. / Ott, I. et al. | 2011
- 8658
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Retooling Manganese(III) Porphyrin-Based Peroxynitrite Decomposition Catalysts for Selectivity and Oral Activity: A Potential New Strategy for Treating Chronic PainRausaria, Smita / Ghaffari, Mahsa M. E. / Kamadulski, Andrew / Rodgers, Kenny / Bryant, Leesa / Chen, Zhoumou / Doyle, Tim / Shaw, Michael J. / Salvemini, Daniela / Neumann, William L. et al. | 2011
- 8670
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Thiazolides as Novel Antiviral Agents. 2. Inhibition of Hepatitis C Virus ReplicationStachulski, Andrew V. / Pidathala, Chandrakala / Row, Eleanor C. / Sharma, Raman / Berry, Neil G. / Lawrenson, Alexandre S. / Moores, Shelley L. / Iqbal, Mazhar / Bentley, Joanne / Allman, Sarah A. et al. | 2011
- 8681
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Structure–Activity Relationship Studies of Sulfonylpiperazine Analogues as Novel Negative Allosteric Modulators of Human Neuronal Nicotinic ReceptorsHenderson, Brandon J. / Carper, Daniel J. / González-Cestari, Tatiana F. / Yi, Bitna / Mahasenan, Kiran / Pavlovicz, Ryan E. / Dalefield, Martin L. / Coleman, Robert S. / Li, Chenglong / McKay, Dennis B. et al. | 2011
- 8693
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Synthesis and Properties of Molecular Probes for the Rescue Site on Mutant Cystic Fibrosis Transmembrane Conductance RegulatorAlkhouri, Bashar / Denning, Robert A. / Kim Chiaw, Patrick / Eckford, Paul D. W. / Yu, Wilson / Li, Canhui / Bogojeski, Jovanka J. / Bear, Christine E. / Viirre, Russell D. et al. | 2011
- 8702
-
Synthesis and Biological Characterization of 3-Substituted-1H-indoles as Ligands of GluN2B-Containing N-Methyl-d-aspartate ReceptorsGitto, Rosaria / De Luca, Laura / Ferro, Stefania / Buemi, Maria Rosa / Russo, Emilio / De Sarro, Giovambattista / Costa, Lara / Ciranna, Lucia / Prezzavento, Orazio / Arena, Emanuela et al. | 2011
- 8707
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Oral Delivery of the Appetite Suppressing Peptide hPYY(3–36) through the Vitamin B12 Uptake PathwayFazen, Christopher H. / Valentin, Debbie / Fairchild, Timothy J. / Doyle, Robert P. et al. | 2011
- 8712
-
Correction to Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic ReceptorsLouie, Anika S. / Vasdev, Neil / Valliant, John F. et al. | 2011
- 8713
-
Correction to Development of Indole Compounds as Small Molecule Fusion Inhibitors Targeting HIV-1 Glycoprotein-41Zhou, Guangyan / Wu, Dong / Snyder, Beth / Ptak, Roger G. / Kaur, Harmeet / Gochin, Miriam et al. | 2011