2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: An Appealing Scaffold for the Design of Rac1–Tiam1 Protein–Protein Interaction Inhibitors (English)
- New search for: Ruffoni, Alessandro
- New search for: Ruffoni, Alessandro
- New search for: Ferri, Nicola
- New search for: Bernini, Sergio K.
- New search for: Ricci, Chiara
- New search for: Corsini, Alberto
- New search for: Maffucci, Irene
- New search for: Clerici, Francesca
- New search for: Contini, Alessandro
In:
Journal of medicinal chemistry
;
57
, 7
; 2953-2962
;
2014
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ISSN:
- Article (Journal) / Print
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Title:2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: An Appealing Scaffold for the Design of Rac1–Tiam1 Protein–Protein Interaction Inhibitors
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Contributors:
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Published in:Journal of medicinal chemistry ; 57, 7 ; 2953-2962
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Publisher:
- New search for: American Chemical Society
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Place of publication:Easton, Pa.
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Publication date:2014
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ISSN:
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ZDBID:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 770/4230
- New search for: 44.42 / 44.42
- Further information on Basic classification
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Keywords:
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Classification:
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Source:
Table of contents – Volume 57, Issue 7
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 2821
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Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?Rosini, Michela / Simoni, Elena / Milelli, Andrea / Minarini, Anna / Melchiorre, Carlo et al. | 2014
- 2832
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Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and DiscoveryIlardi, Elizabeth A. / Vitaku, Edon / Njardarson, Jon T. et al. | 2014
- 2843
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Efficient Hit and Lead Compound Evaluation Strategy Based on Off-Rate Screening by Surface Plasmon ResonanceLiu, Liu et al. | 2014
- 2845
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Off-Rate Screening (ORS) By Surface Plasmon Resonance. An Efficient Method to Kinetically Sample Hit to Lead Chemical Space from Unpurified Reaction ProductsMurray, James B. / Roughley, Stephen D. / Matassova, Natalia / Brough, Paul A. et al. | 2014
- 2851
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Structure–Activity Relationships for Withanolides as Inducers of the Cellular Heat-Shock ResponseWijeratne, E. M. Kithsiri / Xu, Ya-Ming / Scherz-Shouval, Ruth / Marron, Marilyn T. / Rocha, Danilo D. / Liu, Manping X. / Costa-Lotufo, Leticia V. / Santagata, Sandro / Lindquist, Susan / Whitesell, Luke et al. | 2014
- 2864
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Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coliJahnsen, Rasmus D. / Sandberg-Schaal, Anne / Vissing, Karina Juul / Nielsen, Hanne Mørck / Frimodt-Møller, Niels / Franzyk, Henrik et al. | 2014
- 2874
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Chromodomain Antagonists That Target the Polycomb-Group Methyllysine Reader Protein Chromobox Homolog 7 (CBX7)Simhadri, Chakravarthi / Daze, Kevin D. / Douglas, Sarah F. / Quon, Taylor T. H. / Dev, Amarjot / Gignac, Michael C. / Peng, Fangni / Heller, Markus / Boulanger, Martin J. / Wulff, Jeremy E. et al. | 2014
- 2884
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Synthesis, Pharmacological Evaluation, and σ1 Receptor Interaction Analysis of Hydroxyethyl Substituted PiperazinesWeber, Frauke / Brune, Stefanie / Korpis, Katharina / Bednarski, Patrick J. / Laurini, Erik / Dal Col, Valentina / Pricl, Sabrina / Schepmann, Dirk / Wünsch, Bernhard et al. | 2014
- 2895
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1,2,3,4,8,9,10,11-Octahydrobenzo[j]phenanthridine-7,12-diones as New Leads against Mycobacterium tuberculosisCappoen, Davie / Claes, Pieter / Jacobs, Jan / Anthonissen, Roel / Mathys, Vanessa / Verschaeve, Luc / Huygen, Kris / Kimpe, Norbert De et al. | 2014
- 2908
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Structure–Activity Relationship Studies toward the Discovery of Selective Apelin Receptor AgonistsMargathe, Jean-François / Iturrioz, Xavier / Alvear-Perez, Rodrigo / Marsol, Claire / Riché, Stéphanie / Chabane, Hadjila / Tounsi, Nassera / Kuhry, Maxime / Heissler, Denis / Hibert, Marcel et al. | 2014
- 2920
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High Throughput Method for the Indirect Detection of Intramolecular Hydrogen BondingGoetz, Gilles H. / Farrell, William / Shalaeva, Marina / Sciabola, Simone / Anderson, Dennis / Yan, Jiangli / Philippe, Laurence / Shapiro, Michael J. et al. | 2014
- 2930
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Symmetric Bis-chalcones as a New Type of Breast Cancer Resistance Protein Inhibitors with a Mechanism Different from That of ChromonesWinter, Evelyn / Devantier Neuenfeldt, Patrícia / Chiaradia-Delatorre, Louise Domeneghini / Gauthier, Charlotte / Yunes, Rosendo Augusto / Nunes, Ricardo José / Creczynski-Pasa, Tânia Beatriz / Di Pietro, Attilio et al. | 2014
- 2942
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Imidazol-1-ylethylindazole Voltage-Gated Sodium Channel Ligands Are Neuroprotective during Optic Neuritis in a Mouse Model of Multiple SclerosisBrowne, Lorcan / Lidster, Katie / Al-Izki, Sarah / Clutterbuck, Lisa / Posada, Cristina / Chan, A. W. Edith / Riddall, Dieter / Garthwaite, John / Baker, David / Selwood, David L. et al. | 2014
- 2953
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2‑Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: An Appealing Scaffold for the Design of Rac1–Tiam1 Protein–Protein Interaction InhibitorsRuffoni, Alessandro / Ferri, Nicola / Bernini, Sergio K. / Ricci, Chiara / Corsini, Alberto / Maffucci, Irene / Clerici, Francesca / Contini, Alessandro et al. | 2014
- 2963
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Novel Inhibitors of the MDM2-p53 Interaction Featuring Hydrogen Bond Acceptors as Carboxylic Acid IsosteresGonzalez, Ana Z. / Li, Zhihong / Beck, Hilary P. / Canon, Jude / Chen, Ada / Chow, David / Duquette, Jason / Eksterowicz, John / Fox, Brian M. / Fu, Jiasheng et al. | 2014
- 2989
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Optimization of Potency and Pharmacokinetic Properties of Tetrahydroisoquinoline Transient Receptor Potential Melastatin 8 (TRPM8) AntagonistsHorne, Daniel B. / Tamayo, Nuria A. / Bartberger, Michael D. / Bo, Yunxin / Clarine, Jeffrey / Davis, Carl D. / Gore, Vijay K. / Kaller, Matthew R. / Lehto, Sonya G. / Ma, Vu V. et al. | 2014
- 3005
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A High-Throughput Cell-Based Method to Predict the Unbound Drug Fraction in the BrainMateus, André / Matsson, Pär / Artursson, Per et al. | 2014
- 3011
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Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced ActivityChen, Qi-Yin / Liu, Yanxia / Cai, Weijing / Luesch, Hendrik et al. | 2014
- 3030
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Targeting the GPIbα Binding Site of Thrombin To Simultaneously Induce Dual Anticoagulant and Antiplatelet EffectsMehta, Akul Y. / Thakkar, Jay N. / Mohammed, Bassem M. / Martin, Erika J. / Brophy, Donald F. / Kishimoto, Takao / Desai, Umesh R. et al. | 2014
- 3030
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Targeting the GPlb alpha Binding Site of Thrombin To Simultaneously Induce Dual Anticoagulant and Antiplatelet EffectsMehta, A.Y. / Thakkar, J.N. / Mohammed, B.M. / Martin, E.J. / Brophy, D.F. / Kishimoto, T. / Desai, U.R. et al. | 2014
- 3040
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Optimization of Chemical Functionalities of Indole-2-carboxamides To Improve Allosteric Parameters for the Cannabinoid Receptor 1 (CB1)Khurana, Leepakshi / Ali, Hamed I. / Olszewska, Teresa / Ahn, Kwang H. / Damaraju, Aparna / Kendall, Debra A. / Lu, Dai et al. | 2014
- 3053
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Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)Jansen, Koen / Heirbaut, Leen / Verkerk, Robert / Cheng, Jonathan D. / Joossens, Jurgen / Cos, Paul / Maes, Louis / Lambeir, Anne-Marie / De Meester, Ingrid / Augustyns, Koen et al. | 2014
- 3075
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Antibacterial Activity of a Series of N 2,N 4‑Disubstituted Quinazoline-2,4-diaminesVan Horn, Kurt S. / Burda, Whittney N. / Fleeman, Renee / Shaw, Lindsey N. / Manetsch, Roman et al. | 2014
- 3094
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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N‑Arylsulfonamido‑N′‑arylpiperazine SeriesNishimura, Nobuko / Norman, Mark H. / Liu, Longbin / Yang, Kevin C. / Ashton, Kate S. / Bartberger, Michael D. / Chmait, Samer / Chen, Jie / Cupples, Rod / Fotsch, Christopher et al. | 2014
- 3117
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NRLiSt BDB, the Manually Curated Nuclear Receptors Ligands and Structures Benchmarking DatabaseLagarde, Nathalie / Ben Nasr, Nesrine / Jérémie, Aurore / Guillemain, Hélène / Laville, Vincent / Labib, Taoufik / Zagury, Jean-François / Montes, Matthieu et al. | 2014
- 3126
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Multitarget Drug Discovery for Tuberculosis and Other Infectious DiseasesLi, Kai / Schurig-Briccio, Lici A. / Feng, Xinxin / Upadhyay, Ashutosh / Pujari, Venugopal / Lechartier, Benoit / Fontes, Fabio L. / Yang, Hongliang / Rao, Guodong / Zhu, Wei et al. | 2014
- 3140
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Effect of the 3- and 4‑Methyl Groups on the Opioid Receptor Properties of N‑Substituted trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidinesKormos, Chad M. / Cueva, Juan Pablo / Gichinga, Moses G. / Runyon, Scott P. / Thomas, James B. / Brieaddy, Lawrence E. / Mascarella, S. Wayne / Gilmour, Brian P. / Navarro, Hernán A. / Carroll, F. Ivy et al. | 2014
- 3148
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Development of a Bioavailable μ Opioid Receptor (MOPr) Agonist, δ Opioid Receptor (DOPr) Antagonist Peptide That Evokes Antinociception without Development of Acute ToleranceMosberg, Henry I. / Yeomans, Larisa / Anand, Jessica P. / Porter, Vanessa / Sobczyk-Kojiro, Katarzyna / Traynor, John R. / Jutkiewicz, Emily M. et al. | 2014
- 3148
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Development of a Bioavailable μ Opioid Receptor (MOPr) Agonist, delta Opioid Receptor (DOPr) Antagonist Peptide That Evokes Antinociception without Development of Acute ToleranceMosberg, H.I. / Yeomans, L. / Anand, J.P. / Porter, V. / Sobczyk-Kojiro, K. / Traynor, J.R. / Jutkiewicz, E.M. et al. | 2014
- 3154
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Oseltamivir Analogues Bearing N‑Substituted Guanidines as Potent Neuraminidase InhibitorsMooney, Caitlin A. / Johnson, Stuart A. / Quarles van Ufford, Linda / de Haan, Cornelis A. M. / Moret, Ed E. / Martin, Nathaniel I. et al. | 2014