α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors (English)
- New search for: Bhattarai, Sanjay
- New search for: Bhattarai, Sanjay
- New search for: Freundlieb, Marianne
- New search for: Pippel, Jan
- New search for: Meyer, Anne
- New search for: Abdelrahman, Aliaa
- New search for: Fiene, Amelie
- New search for: Lee, Sang-Yong
- New search for: Zimmermann, Herbert
- New search for: Yegutkin, Gennady G
- New search for: Sträter, Norbert
- New search for: El-Tayeb, Ali
- New search for: Müller, Christa E
In:
Journal of medicinal chemistry
;
58
, 15
; 6248
;
2015
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ISSN:
- Article (Journal) / Print
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Title:α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors
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Contributors:
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Published in:Journal of medicinal chemistry ; 58, 15 ; 6248
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Publisher:
- New search for: American Chemical Society
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Place of publication:Easton, Pa.
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Publication date:2015
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ISSN:
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ZDBID:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 770/4230
- New search for: 44.42 / 44.42
- Further information on Basic classification
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Keywords:
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Classification:
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Source:
Table of contents – Volume 58, Issue 15
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 5691
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Volume of Distribution in Drug DesignSmith, Dennis A. / Beaumont, Kevin / Maurer, Tristan S. / Di, Li et al. | 2015
- 5699
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Progress Toward the Development of Noscapine and Derivatives as Anticancer AgentsDeBono, Aaron / Capuano, Ben / Scammells, Peter J. et al. | 2015
- 5728
-
Structural Requirements for CNS Active Opioid GlycopeptidesLefever, Mark / Li, Yingxue / Anglin, Bobbi / Muthu, Dhanasekaran / Giuvelis, Denise / Lowery, John J. / Knapp, Brian I. / Bidlack, Jean M. / Bilsky, Edward J. / Polt, Robin et al. | 2015
- 5742
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Ethyl 2‑((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4Cheng, Xinlai / Yoshida, Hiroki / Raoofi, Dena / Saleh, Sawsan / Alborzinia, Hamed / Wenke, Frank / Göhring, Axel / Reuter, Stefanie / Mah, Nancy / Fuchs, Heiko et al. | 2015
- 5751
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Development of Quinoline-2,4(1H,3H)‑diones as Potent and Selective Ligands of the Cannabinoid Type 2 ReceptorHan, Shuang / Zhang, Fei-Fei / Qian, Hai-Yan / Chen, Li-Li / Pu, Jian-Bin / Xie, Xin / Chen, Jian-Zhong et al. | 2015
- 5770
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Biological Efficacy and Toxicity of Diamidines in Myotonic Dystrophy Type 1 ModelsSiboni, Ruth B. / Bodner, Micah J. / Khalifa, Muhammad M. / Docter, Aaron G. / Choi, Jessica Y. / Nakamori, Masayuki / Haley, Michael M. / Berglund, J. Andrew et al. | 2015
- 5781
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Effect of Chirality on Common in Vitro Experiments: An Enantiomeric Pair AnalysisBagdanoff, Jeffrey T. / Xu, Yongjin / Dollinger, Gavin / Martin, Eric et al. | 2015
- 5789
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New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent CancerLa Regina, Giuseppe / Bai, Ruoli / Coluccia, Antonio / Famiglini, Valeria / Pelliccia, Sveva / Passacantilli, Sara / Mazzoccoli, Carmela / Ruggieri, Vitalba / Verrico, Annalisa / Miele, Andrea et al. | 2015
- 5808
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SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro ProbesKnapinska, Anna M. / Dreymuller, Daniela / Ludwig, Andreas / Smith, Lyndsay / Golubkov, Vladislav / Sohail, Anjum / Fridman, Rafael / Giulianotti, Marc / LaVoi, Travis M. / Houghten, Richard A. et al. | 2015
- 5825
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Cyclometalated Iminophosphorane Gold(III) and Platinum(II) Complexes. A Highly Permeable Cationic Platinum(II) Compound with Promising Anticancer PropertiesFrik, Malgorzata / Fernández-Gallardo, Jacob / Gonzalo, Oscar / Mangas-Sanjuan, Víctor / González-Alvarez, Marta / Serrano del Valle, Alfonso / Hu, Chunhua / González-Alvarez, Isabel / Bermejo, Marival / Marzo, Isabel et al. | 2015
- 5842
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Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis TherapyPieroni, Marco / Machado, Diana / Azzali, Elisa / Santos Costa, Sofia / Couto, Isabel / Costantino, Gabriele / Viveiros, Miguel et al. | 2015
- 5854
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Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β‑Catenin Pathway InhibitorsSoldi, Raffaella / Horrigan, Stephen K. / Cholody, Marek W. / Padia, Janak / Sorna, Venkataswamy / Bearss, Jared / Gilcrease, Glynn / Bhalla, Kapil / Verma, Anupam / Vankayalapati, Hariprasad et al. | 2015
- 5863
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Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt DiseaseCioffi, Christopher L. / Racz, Boglarka / Freeman, Emily E. / Conlon, Michael P. / Chen, Ping / Stafford, Douglas G. / Schwarz, Daniel M. C. / Zhu, Lei / Kitchen, Douglas B. / Barnes, Keith D. et al. | 2015
- 5889
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Discovery and Optimization of a Porcupine InhibitorDuraiswamy, Athisayamani Jeyaraj / Lee, May Ann / Madan, Babita / Ang, Shi Hua / Tan, Eldwin Sum Wai / Cheong, Wei Wen Vivien / Ke, Zhiyuan / Pendharkar, Vishal / Ding, Li Jun / Chew, Yun Shan et al. | 2015
- 5900
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Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and AutophagyTorrente, Esther / Parodi, Chiara / Ercolani, Luisa / De Mei, Claudia / Ferrari, Alessio / Scarpelli, Rita / Grimaldi, Benedetto et al. | 2015
- 5916
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Structure–Affinity Relationships (SARs) and Structure–Kinetics Relationships (SKRs) of Kv11.1 BlockersYu, Zhiyi / van Veldhoven, Jacobus P. D. / Louvel, Julien / Rook, Martin B. / van der Heyden, Marcel A. G. / Heitman, Laura H. / IJzerman, Adriaan P. et al. | 2015
- 5930
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Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor‑2Scheuermann, Thomas H. / Stroud, Daniel / Sleet, Christopher E. / Bayeh, Liela / Shokri, Cameron / Wang, Hanzhi / Caldwell, Charles G. / Longgood, Jamie / MacMillan, John B. / Bruick, Richard K. et al. | 2015
- 5942
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Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1‑Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral SclerosisZhang, Yinan / Zhao, Kevin Tianmeng / Fox, Susan G. / Kim, Jinho / Kirsch, Donald R. / Ferrante, Robert J. / Morimoto, Richard I. / Silverman, Richard B. et al. | 2015
- 5950
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A New Class of Potent N‑Methyl‑d‑Aspartate Receptor Inhibitors: Sulfated Neuroactive Steroids with Lipophilic D‑Ring ModificationsKudova, Eva / Chodounska, Hana / Slavikova, Barbora / Budesinsky, Milos / Nekardova, Michaela / Vyklicky, Vojtech / Krausova, Barbora / Svehla, Pavel / Vyklicky, Ladislav et al. | 2015
- 5967
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Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)Yang, Shyh-Ming / Yasgar, Adam / Miller, Bettina / Lal-Nag, Madhu / Brimacombe, Kyle / Hu, Xin / Sun, Hongmao / Wang, Amy / Xu, Xin / Nguyen, Kimloan et al. | 2015
- 5979
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Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid ReceptorsCawston, Erin E. / Connor, Mark / Di Marzo, Vincenzo / Silvestri, Romano / Glass, Michelle et al. | 2015
- 5989
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Triblock Conjugates: Identification of a Highly Potent Antiinflammatory AgentSingh, Palwinder / Kaur, Jagroop / Singh, Gurjit / Bhatti, Rajbir et al. | 2015
- 6002
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Design, Synthesis, and Characterization of 3‑(Benzylidene)indolin-2-one Derivatives as Ligands for α‑Synuclein FibrilsChu, Wenhua / Zhou, Dong / Gaba, Vrinda / Liu, Jialu / Li, Shihong / Peng, Xin / Xu, Jinbin / Dhavale, Dhruva / Bagchi, Devika P. / d’Avignon, André et al. | 2015
- 6018
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Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy StudiesSola, Irene / Aso, Ester / Frattini, Daniela / López-González, Irene / Espargaró, Alba / Sabaté, Raimon / Di Pietro, Ornella / Luque, F. Javier / Clos, M. Victòria / Ferrer, Isidro et al. | 2015
- 6033
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Structure–Activity Relationship Studies of Substituted 2‑(Isoxazol-3-yl)-2-oxo‑N′‑phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) AntagonistsYe, Na / Zhu, Yingmin / Chen, Haijun / Liu, Zhiqing / Mei, Fang C. / Wild, Christopher / Chen, Haiying / Cheng, Xiaodong / Zhou, Jia et al. | 2015
- 6048
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Discovery of Novel Indazole Derivatives as Highly Potent and Selective Human β3‑Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side EffectsWada, Yasuhiro / Shirahashi, Hiromitsu / Iwanami, Taisuke / Ogawa, Masami / Nakano, Seiji / Morimoto, Akifumi / Kasahara, Ken-ichi / Tanaka, Eiichi / Takada, Yoshio / Ohashi, Shigeki et al. | 2015
- 6058
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Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission TomographySander, Kerstin / Galante, Eva / Gendron, Thibault / Yiannaki, Elena / Patel, Niral / Kalber, Tammy L. / Badar, Adam / Robson, Mathew / Johnson, Sean P. / Bauer, Florian et al. | 2015
- 6081
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Deepening the Topology of the Translocator Protein Binding Site by Novel N,N‑Dialkyl-2-arylindol-3-ylglyoxylamidesBarresi, Elisabetta / Bruno, Agostino / Taliani, Sabrina / Cosconati, Sandro / Da Pozzo, Eleonora / Salerno, Silvia / Simorini, Francesca / Daniele, Simona / Giacomelli, Chiara / Marini, Anna Maria et al. | 2015
- 6093
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Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for AsthmaItadani, Satoshi / Yashiro, Kentaro / Aratani, Yoshiyuki / Sekiguchi, Tetsuya / Kinoshita, Atsushi / Moriguchi, Hideki / Ohta, Nobukazu / Takahashi, Shinya / Ishida, Akiharu / Tajima, Yohei et al. | 2015
- 6114
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Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-NucleotidesWeinschenk, Lina / Schols, Dominique / Balzarini, Jan / Meier, Chris et al. | 2015
- 6131
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Structure–Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)‑3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic AcidKrogsgaard-Larsen, Niels / Storgaard, Morten / Møller, Charlotte / Demmer, Charles S. / Hansen, Jeanette / Han, Liwei / Monrad, Rune N. / Nielsen, Birgitte / Tapken, Daniel / Pickering, Darryl S. et al. | 2015
- 6151
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Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain InhibitorsBamborough, Paul / Chung, Chun-wa / Furze, Rebecca C. / Grandi, Paola / Michon, Anne-Marie / Sheppard, Robert J. / Barnett, Heather / Diallo, Hawa / Dixon, David P. / Douault, Clement et al. | 2015
- 6179
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N‑Phenyl-4,5-dibromopyrrolamides and N‑Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and EvaluationZidar, Nace / Macut, Helena / Tomašič, Tihomir / Brvar, Matjaž / Montalvão, Sofia / Tammela, Päivi / Solmajer, Tom / Peterlin Mašič, Lucija / Ilaš, Janez / Kikelj, Danijel et al. | 2015
- 6195
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High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout MiceBoateng, Comfort A. / Bakare, Oluyomi M. / Zhan, Jia / Banala, Ashwini K. / Burzynski, Caitlin / Pommier, Elie / Keck, Thomas M. / Donthamsetti, Prashant / Javitch, Jonathan A. / Rais, Rana et al. | 2015
- 6214
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Synthesis and in Vivo Evaluation of [123I]Melanin-Targeted AgentsRoberts, Maxine P. / Nguyen, Vu / Ashford, Mark E. / Berghofer, Paula / Wyatt, Naomi A. / Krause-Heuer, Anwen M. / Pham, Tien Q. / Taylor, Stephen R. / Hogan, Leena / Jiang, Cathy D. et al. | 2015
- 6225
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Structure-Based Design of Macrocyclic Coagulation Factor VIIa InhibitorsPriestley, E. Scott / Cheney, Daniel L. / DeLucca, Indawati / Wei, Anzhi / Luettgen, Joseph M. / Rendina, Alan R. / Wong, Pancras C. / Wexler, Ruth R. et al. | 2015
- 6237
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Novel 9‑Alkyl- and 9‑Alkylidene-Substituted 1α,25-Dihydroxyvitamin D3 Analogues: Synthesis and Biological ExaminationsKulesza, Urszula / Plum, Lori A. / DeLuca, Hector F. / Mouriño, Antonio / Sicinski, Rafal R. et al. | 2015
- 6248
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α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5′-Nucleotidase (CD73) InhibitorsBhattarai, Sanjay / Freundlieb, Marianne / Pippel, Jan / Meyer, Anne / Abdelrahman, Aliaa / Fiene, Amelie / Lee, Sang-Yong / Zimmermann, Herbert / Yegutkin, Gennady G. / Sträter, Norbert et al. | 2015
- 6264
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Discovery of Novel DNA Gyrase Inhibiting Spiropyrimidinetriones: Benzisoxazole Fusion with N‑Linked Oxazolidinone Substituents Leading to a Clinical Candidate (ETX0914)Basarab, Gregory S. / Doig, Peter / Galullo, Vincent / Kern, Gunther / Kimzey, Amy / Kutschke, Amy / Newman, Joseph P. / Morningstar, Marshall / Mueller, John / Otterson, Linda et al. | 2015
- 6283
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Adjusting the DNA Interaction and Anticancer Activity of Pt(II) N‑Heterocyclic Carbene Complexes by Steric Shielding of the Trans Leaving GroupMuenzner, Julienne K. / Rehm, Tobias / Biersack, Bernhard / Casini, Angela / de Graaf, Inge A. M. / Worawutputtapong, Pawida / Noor, Awal / Kempe, Rhett / Brabec, Viktor / Kasparkova, Jana et al. | 2015
- 6293
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Enantiomerically Pure 2‑Methyltetrahydro-3-benzazepin-1-ols Selectively Blocking GluN2B Subunit Containing N‑Methyl‑d‑aspartate ReceptorsTewes, Bastian / Frehland, Bastian / Schepmann, Dirk / Robaa, Dina / Uengwetwanit, Tanaporn / Gaube, Friedemann / Winckler, Thomas / Sippl, Wolfgang / Wünsch, Bernhard et al. | 2015
- 6306
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A Selective, Cell-Permeable Nonphosphorylated Bicyclic Peptidyl Inhibitor against Peptidyl–Prolyl Isomerase Pin1Jiang, Bisheng / Pei, Dehua et al. | 2015
- 6313
-
Synthesis of Thrombolytic Sol–Gel Coatings: Toward Drug-Entrapped Vascular GraftsChapurina, Yulia / Vinogradov, Vasiliy V. / Vinogradov, Alexander V. / Sobolev, Vladimir E. / Dudanov, Ivan P. / Vinogradov, Vladimir V. et al. | 2015
- 6318
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Correction to Fragment-Based Discovery of Indole Inhibitors of Matrix Metalloproteinase-13Taylor, Steven J. / Abeywardane, Asitha / Liang, Shuang / Muegge, Ingo / Padyana, Anil K. / Xiong, Zhaoming / Hill-Drzewi, Melissa / Farmer, Bennett / Li, Xiang / Collins, Brandon et al. | 2015
- 6319
-
Correction to Design, Synthesis, and Antitumor Evaluation of Novel Histone Deacetylase Inhibitors Equipped with a Phenylsulfonylfuroxan Module as a Nitric Oxide DonorDuan, Wenwen / Li, Jin / Inks, Elizabeth S. / Chou, C. James / Jia, Yuping / Chu, Xiaojing / Li, Xiaoyang / Xu, Wenfang / Zhang, Yingjie et al. | 2015
- 6320
-
Correction to Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant BacteriaKlingler, Franca-M. / Wichelhaus, Thomas A. / Frank, Denia / Cuesta-Bernal, Jenifer / El-Delik, Jasmin / Müller, H. Florian / Sjuts, Hanno / Göttig, Stephan / Koenigs, Arno / Pos, Klaas M. et al. | 2015