Optimization of a Stable Linker Involved DEVD Peptide-Doxorubicin Conjugate That Is Activated upon Radiation-Induced Caspase-3-Mediated Apoptosis (English)
- New search for: Chung, Seung Woo
- New search for: Chung, Seung Woo
- New search for: Lee, Beom Suk
- New search for: Choi, Jeong uk
- New search for: Kim, Seong Who
- New search for: Kim, In-San
- New search for: Kim, Sang Yoon
- New search for: Byun, Youngro
In:
Journal of medicinal chemistry
;
58
, 16
; 6435
;
2015
-
ISSN:
- Article (Journal) / Print
-
Title:Optimization of a Stable Linker Involved DEVD Peptide-Doxorubicin Conjugate That Is Activated upon Radiation-Induced Caspase-3-Mediated Apoptosis
-
Contributors:Chung, Seung Woo ( author ) / Lee, Beom Suk / Choi, Jeong uk / Kim, Seong Who / Kim, In-San / Kim, Sang Yoon / Byun, Youngro
-
Published in:Journal of medicinal chemistry ; 58, 16 ; 6435
-
Publisher:
- New search for: American Chemical Society
-
Place of publication:Easton, Pa.
-
Publication date:2015
-
ISSN:
-
ZDBID:
-
Type of media:Article (Journal)
-
Type of material:Print
-
Language:English
- New search for: 770/4230
- New search for: 44.42 / 44.42
- Further information on Basic classification
-
Keywords:
-
Classification:
-
Source:
Table of contents – Volume 58, Issue 16
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 6321
-
Ligand Binding Thermodynamics in Drug Discovery: Still a Hot Tip?Geschwindner, Stefan / Ulander, Johan / Johansson, Patrik et al. | 2015
- 6336
-
Activation of the γ‑Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric ModulatorsBrown, Katie M. / Roy, Kuldeep K. / Hockerman, Gregory H. / Doerksen, Robert J. / Colby, David A. et al. | 2015
- 6348
-
Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt TumorsHolzer, Philipp / Masuya, Keiichi / Furet, Pascal / Kallen, Joerg / Valat-Stachyra, Therese / Ferretti, Stéphane / Berghausen, Joerg / Bouisset-Leonard, Michèle / Buschmann, Nicole / Pissot-Soldermann, Carole et al. | 2015
- 6359
-
Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin ReceptorsCai, Minying / Marelli, Udaya Kiran / Bao, Jennifer / Beck, Johannes G. / Opperer, Florian / Rechenmacher, Florian / McLeod, Kaitlyn R. / Zingsheim, Morgan R. / Doedens, Lucas / Kessler, Horst et al. | 2015
- 6368
-
Study on Antitumor Platinum(II) Complexes of Chiral Diamines with Dicyclic Species as Steric HindranceLiu, Fengfan / Gou, Shaohua / Chen, Feihong / Fang, Lei / Zhao, Jian et al. | 2015
- 6378
-
The N‑Terminal T–T Motif of a Third-Generation HIV‑1 Fusion Inhibitor Is Not Required for Binding Affinity and Antiviral ActivityChong, Huihui / Qiu, Zonglin / Su, Yang / He, Yuxian et al. | 2015
- 6389
-
Discovery of a Teraryl Oxazolidinone Compound (S)‑N‑((3-(3-Fluoro-4-(4-(pyridin-2-yl)‑1H‑pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and EfficaciesYang, Tao / Chen, Gong / Sang, Zitai / Liu, Yuanyuan / Yang, Xiaoyan / Chang, Ying / Long, Haiyue / Ang, Wei / Tang, Jianying / Wang, Zhenling et al. | 2015
- 6410
-
Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction InhibitorJiang, Zheng-Yu / Xu, Li−Li / Lu, Meng-Chen / Chen, Zhi-Yun / Yuan, Zhen-Wei / Xu, Xiao-Li / Guo, Xiao-Ke / Zhang, Xiao-Jin / Sun, Hao-Peng / You, Qi-Dong et al. | 2015
- 6422
-
2‑Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor ProfilePrati, Federica / Bergamini, Christian / Molina, Maria Teresa / Falchi, Federico / Cavalli, Andrea / Kaiser, Marcel / Brun, Reto / Fato, Romana / Bolognesi, Maria Laura et al. | 2015
- 6435
-
Optimization of a Stable Linker Involved DEVD Peptide-Doxorubicin Conjugate That Is Activated upon Radiation-Induced Caspase-3-Mediated ApoptosisChung, Seung Woo / Lee, Beom Suk / Choi, Jeong uk / Kim, Seong Who / Kim, In-San / Kim, Sang Yoon / Byun, Youngro et al. | 2015
- 6448
-
Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of AntimalarialsMcConville, Matthew / Fernández, Jorge / Angulo-Barturen, Íñigo / Bahamontes-Rosa, Noemi / Ballell-Pages, Lluis / Castañeda, Pablo / de Cózar, Cristina / Crespo, Benigno / Guijarro, Laura / Jiménez-Díaz, María Belén et al. | 2015
- 6456
-
Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative ActivityFeng, Wei / Teo, Xin-Yi / Novera, Wisna / Ramanujulu, Pondy Murugappan / Liang, Dong / Huang, Dejian / Moore, Philip K. / Deng, Lih-Wen / Dymock, Brian W. et al. | 2015
- 6481
-
A Ligand-Based Drug Design. Discovery of 4‑Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2Liu, Jiawang / Pham, Peter T. / Skripnikova, Elena V. / Zheng, Shilong / Lovings, La’nese J. / Wang, Yuji / Goyal, Navneet / Bellow, Sydni M. / Mensah, Lydia M. / Chatters, Amari J. et al. | 2015
- 6494
-
Novel Resveratrol-Based Aspirin Prodrugs: Synthesis, Metabolism, and Anticancer ActivityZhu, Yingdong / Fu, Junsheng / Shurlknight, Kelly L. / Soroka, Dominique N. / Hu, Yuhui / Chen, Xiaoxin / Sang, Shengmin et al. | 2015
- 6507
-
Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human PlasmaIakovleva, Irina / Brännström, Kristoffer / Nilsson, Lina / Gharibyan, Anna L. / Begum, Afshan / Anan, Intissar / Walfridsson, Malin / Sauer-Eriksson, A. Elisabeth / Olofsson, Anders et al. | 2015
- 6516
-
Introduction of Peripheral Carboxylates to Decrease the Charge on Tm3+ DOTAM-Alkyl Complexes: Implications for Detection Sensitivity and in Vivo Toxicity of PARACEST MRI Contrast AgentsSuchý, Mojmír / Milne, Mark / Elmehriki, Adam A. H. / McVicar, Nevin / Li, Alex X. / Bartha, Robert / Hudson, Robert H. E. et al. | 2015
- 6533
-
N‑Lipidated Peptide Dimers: Effective Antibacterial Agents against Gram-Negative Pathogens through Lipopolysaccharide PermeabilizationKoh, Jun-Jie / Lin, Huifen / Caroline, Vonny / Chew, Yu Siang / Pang, Li Mei / Aung, Thet Tun / Li, Jianguo / Lakshminarayanan, Rajamani / Tan, Donald T. H. / Verma, Chandra et al. | 2015
- 6549
-
N‑Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) SignalingLai, Mei-Jung / Lee, Hsueh-Yun / Chuang, Hsun-Yueh / Chang, Li-Hsun / Tsai, An-Chi / Chen, Mei-Chuan / Huang, Han-Lin / Wu, Yi-Wen / Teng, Che-Ming / Pan, Shiow-Lin et al. | 2015
- 6559
-
A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer CellsFouqué, Amélie / Delalande, Olivier / Jean, Mickael / Castellano, Rémy / Josselin, Emmanuelle / Malleter, Marine / Shoji, Kenji F. / Hung, Mac Dinh / Rampanarivo, Hariniaina / Collette, Yves et al. | 2015
- 6574
-
Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAPChessari, Gianni / Buck, Ildiko M. / Day, James E. H. / Day, Philip J. / Iqbal, Aman / Johnson, Christopher N. / Lewis, Edward J. / Martins, Vanessa / Miller, Darcey / Reader, Michael et al. | 2015
- 6589
-
Development of Selective Covalent Janus Kinase 3 InhibitorsTan, Li / Akahane, Koshi / McNally, Randall / Reyskens, Kathleen M. S. E. / Ficarro, Scott B. / Liu, Suhu / Herter-Sprie, Grit S. / Koyama, Shohei / Pattison, Michael J. / Labella, Katherine et al. | 2015
- 6607
-
Indole Glucocorticoid Receptor Antagonists Active in a Model of Dyslipidemia Act via a Unique Association with an Agonist Binding Site.Luz, John G. / Carson, Matthew W. / Condon, Bradley / Clawson, David / Pustilnik, Anna / Kohlman, Daniel T. / Barr, Robert J. / Bean, James S. / Dill, M. Joelle / Sindelar, Dana K et al. | 2015
- 6619
-
Role of Lipoylation of the Immunodominant Epitope of Pyruvate Dehydrogenase Complex: Toward a Peptide-Based Diagnostic Assay for Primary Biliary CirrhosisPacini, Giulia / Carotenuto, Alfonso / Rentier, Cedric / Nuti, Francesca / Real-Fernandez, Feliciana / Brancaccio, Diego / Sabatino, Giuseppina / Larregola, Maud / Peroni, Elisa / Migliorini, Paola et al. | 2015
- 6630
-
Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure–Activity Relationships of Glucosyl-Based SulfamatesMahon, Brian P. / Lomelino, Carrie L. / Ladwig, Janina / Rankin, Gregory M. / Driscoll, Jenna M. / Salguero, Antonieta L. / Pinard, Melissa A. / Vullo, Daniela / Supuran, Claudiu T. / Poulsen, Sally-Ann et al. | 2015
- 6639
-
Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological EvaluationFresno, N. / Macías-González, M. / Torres-Zaguirre, A. / Romero-Cuevas, M. / Sanz-Camacho, P. / Elguero, J. / Pavón, F. J. / Rodríguez de Fonseca, F. / Goya, P. / Pérez-Fernández, R. et al. | 2015
- 6653
-
Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)Christopher, John A. / Aves, Sarah J. / Bennett, Kirstie A. / Doré, Andrew S. / Errey, James C. / Jazayeri, Ali / Marshall, Fiona H. / Okrasa, Krzysztof / Serrano-Vega, Maria J. / Tehan, Benjamin G. et al. | 2015
- 6665
-
Chemistry and Pharmacology of a Series of Unichiral Analogues of 2‑(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3‑Pyridyl Ether Designed as α4β2-Nicotinic Acetylcholine Receptor AgonistsBolchi, Cristiano / Valoti, Ermanno / Gotti, Cecilia / Fasoli, Francesca / Ruggeri, Paola / Fumagalli, Laura / Binda, Matteo / Mucchietto, Vanessa / Sciaccaluga, Miriam / Budriesi, Roberta et al. | 2015
- 6678
-
Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor AgentsWang, Shengzheng / Fang, Kun / Dong, Guoqiang / Chen, Shuqiang / Liu, Na / Miao, Zhenyuan / Yao, Jianzhong / Li, Jian / Zhang, Wannian / Sheng, Chunquan et al. | 2015
- 6697
-
An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic ModulatorLiu, Li-Juan / Lu, Lihua / Zhong, Hai-Jing / He, Bingyong / Kwong, Daniel W. J. / Ma, Dik-Lung / Leung, Chung-Hang et al. | 2015
- 6704
-
CholesteroNitrones for StrokeAyuso, Maria I. / Chioua, Mourad / Martínez-Alonso, Emma / Soriano, Elena / Montaner, Joan / Masjuán, Jaime / Hadjipavlou-Litina, Dimitra J. / Marco-Contelles, José / Alcázar, Alberto et al. | 2015
- 6710
-
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative DisordersOtto, Robert / Penzis, Robert / Gaube, Friedemann / Adolph, Oliver / Föhr, Karl J. / Warncke, Paul / Robaa, Dina / Appenroth, Dorothea / Fleck, Christian / Enzensperger, Christoph et al. | 2015