Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity (English)
- New search for: Hennessy, Edward J
- New search for: Hennessy, Edward J
In:
Bioorganic & medicinal chemistry letters
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26
, 9
; 2105
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2016
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ISSN:
- Article (Journal) / Print
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Title:Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity
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Contributors:Hennessy, Edward J ( author )
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Published in:Bioorganic & medicinal chemistry letters ; 26, 9 ; 2105
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Publisher:
- New search for: Elsevier
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Place of publication:Amsterdam [u.a.]
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Publication date:2016
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DOI:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 35.70 / 44.33 / 44.42
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Table of contents – Volume 26, Issue 9
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 2105
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Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicityHennessy, Edward J. et al. | 2016
- 2105
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Selective inhibitors of Bcl-2 and Bcl-xHennessy, Edward J et al. | 2016
- 2115
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Synthesis, biological evaluation and molecular docking studies of 2-amino-3,4,5-trimethoxyaroylindole derivatives as novel anticancer agentsPatel, Vijay K. / Rajak, Harish et al. | 2016
- 2119
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A synthetic 2,3-diarylindole induces cell death via apoptosis and autophagy in A549 lung cancer cellsRukkijakan, Thanya / Ngiwsara, Lukana / Lirdprapamongkol, Kriengsak / Svasti, Jisnuson / Phetrak, Nared / Chuawong, Pitak et al. | 2016
- 2124
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Development and evaluation of a highly reliable assay for SUMO-specific protease inhibitorsXie, Wenjuan / Wang, Zhongli / Zhang, Jianchen / Wang, Lie / Zhao, Yaxue / Zhou, Huchen et al. | 2016
- 2129
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Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogsLu, Dai / Wei, Han-Xun / Zhang, Jing / Gu, Yongli / Osenkowski, Pamela / Ye, Wenjuan / Selkoe, Dennis J. / Wolfe, Michael S. / Augelli-Szafran, Corinne E. et al. | 2016
- 2133
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Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcoholsWei, Han-Xun / Lu, Dai / Sun, Vivien / Zhang, Jing / Gu, Yongli / Osenkowski, Pamela / Ye, Wenjuan / Selkoe, Dennis J. / Wolfe, Michael S. / Augelli-Szafran, Corinne E. et al. | 2016
- 2138
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Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinonesZhang, Jing / Lu, Dai / Wei, Han-Xun / Gu, Yongli / Selkoe, Dennis J. / Wolfe, Michael S. / Augelli-Szafran, Corinne E. et al. | 2016
- 2142
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l-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluationGao, Ling-Jie / De Jonghe, Steven / Daelemans, Dirk / Herdewijn, Piet et al. | 2016
- 2142
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Aspartic andGao, Ling-Jie et al. | 2016
- 2147
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Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from 3-(1-phenylethyl)- and 3-benzyl-pyrrolidine-2,5-dioneRybka, Sabina / Obniska, Jolanta / Rapacz, Anna / Furgała, Anna / Filipek, Barbara / Żmudzki, Paweł et al. | 2016
- 2152
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Metabolic investigation on ZL006 for the discovery of a potent prodrug for the treatment of cerebral ischemiaChen, Dongyin / Zhao, Ting / Ni, Kaidong / Dai, Peng / Yang, Lei / Xu, Yi / Li, Fei et al. | 2016
- 2156
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Natural products as sources of new fungicides (III): Antifungal activity of 2,4-dihydroxy-5-methylacetophenone derivativesShi, Wei / Dan, Wen-Jia / Tang, Jiang-Jiang / Zhang, Yan / Nandinsuren, Tseden / Zhang, An-Ling / Gao, Jin-Ming et al. | 2016
- 2159
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Iodine catalyzed simple and efficient synthesis of antiproliferative 2-pyridonesBuduma, Komuraiah / Chinde, Srinivas / Arigari, Niranjana Kumar / Grover, Paramjit / Srinivas, K.V.N.S. / Kotesh Kumar, J. et al. | 2016
- 2164
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Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cellsMadadi, Nikhil R. / Ketkar, Amit / Penthala, Narsimha R. / Bostian, April C.L. / Eoff, Robert L. / Crooks, Peter A. et al. | 2016
- 2170
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Modification on the O-glucoside of Sergliflozin-A: A new strategy for SGLT2 inhibitor designCao, Xuefeng / Zhang, Wenpeng / Yan, Xu / Huang, Zhi / Zhang, Zhenqing / Wang, Peng / Shen, Jie et al. | 2016
- 2170
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Modification on theCao, Xuefeng et al. | 2016
- 2174
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Selective non-zinc binding MMP-2 inhibitors: Novel benzamide Ilomastat analogs with anti-tumor metastasisSong, Jiao / Peng, Peng / Chang, Jun / Liu, Ming-Ming / Yu, Jian-Ming / Zhou, Lu / Sun, Xun et al. | 2016
- 2179
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Synthesis of a dansyl-labeled inhibitor of 17β-hydroxysteroid dehydrogenase type 3 for optical imagingKenmogne, Lucie Carolle / Maltais, René / Poirier, Donald et al. | 2016
- 2184
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Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF1) receptor antagonistsAhuja, Vijay T. / Hartz, Richard A. / Molski, Thaddeus F. / Mattson, Gail K. / Lentz, Kimberley A. / Grace, James E. Jr. / Lodge, Nicholas J. / Bronson, Joanne J. / Macor, John E. et al. | 2016
- 2188
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Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosisSantivañez-Veliz, Mery / Pérez-Silanes, Silvia / Torres, Enrique / Moreno-Viguri, Elsa et al. | 2016
- 2194
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A convenient synthesis of 5′-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acidMigawa, Michael T. / Prakash, Thazha P. / Vasquez, Guillermo / Wan, W. Brad / Yu, Jinghua / Kinberger, Garth A. / Østergaard, Michael E. / Swayze, Eric E. / Seth, Punit P. et al. | 2016
- 2194
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A convenient synthesis of 5′-triantennaryMigawa, Michael T et al. | 2016
- 2198
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Synthesis and molecular modeling of antimicrobial active fluoroquinolone–pyrazine conjugates with amino acid linkersPanda, Siva S. / Detistov, Oleksandr S. / Girgis, Adel S. / Mohapatra, Prabhu P. / Samir, Ahmed / Katritzky, Alan R. et al. | 2016
- 2206
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Synthesis and antitubercular activity of 1,2,4-trisubstitued piperazinesRohde, Kyle H. / Michaels, Heather A. / Nefzi, Adel et al. | 2016
- 2210
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Development of an activity-based probe for amyloid β-hydrolyzing antibodiesTaguchi, Hiroaki / Fujita, Yoshio / Tsuda, Yuko et al. | 2016
- 2214
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An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidaseChirkova, Zhanna V. / Kabanova, Mariya V. / Filimonov, Sergey I. / Abramov, Igor G. / Petzer, Anél / Petzer, Jacobus P. / Suponitsky, Kyrill Yu. et al. | 2016
- 2220
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Paecilonic acids A and B, bicyclic fatty acids from the jellyfish-derived fungus Paecilomyces variotii J08NF-1Wang, Haibo / Hong, Jongki / Yin, Jun / Liu, Juan / Liu, Yonghong / Choi, Jae Sue / Jung, Jee H. et al. | 2016
- 2224
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Synthesis and docking studies of pyrazine–thiazolidinone hybrid scaffold targeting dormant tuberculosisChitre, T.S. / Asgaonkar, K.D. / Miniyar, P.B. / Dharme, A.B. / Arkile, M.A. / Yeware, A. / Sarkar, D. / Khedkar, V.M. / Jha, P.C. et al. | 2016
- 2229
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Caatinga plants: Natural and semi-synthetic compounds potentially active against Trichomonas vaginalisVieira, Patrícia de Brum / Silva, Nícolas Luiz Feijó / da Silva, Gloria Narjara Santos / Silva, Denise Brentan / Lopes, Norberto Peporine / Gnoatto, Simone Cristina Baggio / da Silva, Márcia Vanusa / Macedo, Alexandre José / Bastida, Jaume / Tasca, Tiana et al. | 2016
- 2229
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Caatinga plants: Natural and semi-synthetic compounds potentially active againstVieira, Patrícia de Brum et al. | 2016
- 2237
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Novel aminoalkylated azaphenothiazines as potential inhibitors of T98G, H460 and SNU80 cancer cell lines in vitroKushwaha, Khushbu / Kaushik, Nagendra Kumar / Kaushik, Neha / Chand, Mahesh / Kaushik, Reena / Choi, Eun ha / Jain, Subhash C. et al. | 2016
- 2245
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Seeking potent anti-tubercular agents: Design, synthesis, anti-tubercular activity and docking study of various ((triazoles/indole)-piperazin-1-yl/1,4-diazepan-1-yl)benzo[d]isoxazole derivativesNaidu, Kalaga Mahalakshmi / Srinivasarao, Singireddi / Agnieszka, Napiórkowska / Ewa, Augustynowicz-Kopeć / Kumar, Muthyala Murali Krishna / Chandra Sekhar, Kondapalli Venkata Gowri et al. | 2016
- 2251
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Glycan multivalency effects toward albumin enable N-glycan-dependent tumor targetingOgura, Akihiro / Tahara, Tsuyoshi / Nozaki, Satoshi / Onoe, Hirotaka / Kurbangalieva, Almira / Watanabe, Yasuyoshi / Tanaka, Katsunori et al. | 2016
- 2251
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Glycan multivalency effects toward albumin enableOgura, Akihiro et al. | 2016
- 2255
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Evaluation of fluorinated biphenyl ether pro-drug scaffolds employing the chemical-microbial approachHampton, Alex S. / Mikulski, Lena / Palmer-Brown, William / Murphy, Cormac D. / Sandford, Graham et al. | 2016
- 2259
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Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activityTeno, Naoki / Gohda, Keigo / Yamashita, Yukiko / Otsubo, Tadamune / Yamaguchi, Masafumi / Wanaka, Keiko / Tsuda, Yuko et al. | 2016
- 2262
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Synthesis, antimycobacterial and antibacterial activity of 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moietyHuang, Ju / Wang, Minghua / Wang, Bin / Wu, Zhaoyang / Liu, Mingliang / Feng, Lianshun / Zhang, Jun / Li, Xiaoning / Yang, Yang / Lu, Yu et al. | 2016
- 2268
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Design, synthesis and biological evaluation of bisabolangelone oxime derivatives as potassium-competitive acid blockers (P-CABs)Huang, Nian-Yu / Wang, Wen-Bin / Chen, Lei / Luo, Hua-Jun / Wang, Jun-Zhi / Deng, Wei-Qiao / Zou, Kun et al. | 2016
- 2273
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One-pot synthesis and antifungal activity against plant pathogens of quinazolinone derivatives containing an amide moietyZhang, Jin / Liu, Jia / Ma, Yangmin / Ren, Decheng / Cheng, Pei / Zhao, Jiawen / Zhang, Fan / Yao, Yuan et al. | 2016
- 2278
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Novel tetrazoloquinoline–rhodanine conjugates: Highly efficient synthesis and biological evaluationSubhedar, Dnyaneshwar D. / Shaikh, Mubarak H. / Nawale, Laxman / Yeware, Amar / Sarkar, Dhiman / Khan, Firoz A. Kalam / Sangshetti, Jaiprakash N. / Shingate, Bapurao B. et al. | 2016
- 2284
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Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure–activity relationship analysisWu, Xiaoai / Fang, Zhen / Yang, Bo / Zhong, Lei / Yang, Qiuyuan / Zhang, Chunhui / Huang, Shenzhen / Xiang, Rong / Suzuki, Takayoshi / Li, Lin-Li et al. | 2016
- 2289
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Re-exploration of the mGluGarcia-Barrantes, Pedro M et al. | 2016
- 2289
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Re-exploration of the mGlu1 PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SARGarcia-Barrantes, Pedro M. / Cho, Hyekyung P. / Starr, Tahj M. / Blobaum, Anna L. / Niswender, Colleen M. / Conn, P. Jeffrey / Lindsley, Craig W. et al. | 2016
- 2293
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Creation of a S1P Lyase bacterial surrogate for structure-based drug designArgiriadi, Maria A. / Banach, David / Radziejewska, Elzbieta / Marchie, Susan / DiMauro, Jennifer / Dinges, Jurgen / Dominguez, Eric / Hutchins, Charles / Judge, Russell A. / Queeney, Kara et al. | 2016
- 2297
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Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitorsDinges, Jurgen / Harris, Christopher M. / Wallace, Grier A. / Argiriadi, Maria A. / Queeney, Kara L. / Perron, Denise C. / Dominguez, Eric / Kebede, Tegest / Desino, Kelly E. / Patel, Hetal et al. | 2016
- 2303
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Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonistsBlanco, Maria-Jesus / Vetman, Tatiana / Chandrasekhar, Srinivasan / Fisher, Matthew J. / Harvey, Anita / Kuklish, Steven L. / Chambers, Mark / Lin, Chaohua / Mudra, Daniel / Oskins, Jennifer et al. | 2016
- 2308
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2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modelingDelogu, Giovanna L. / Matos, Maria J. / Fanti, Maura / Era, Benedetta / Medda, Rosaria / Pieroni, Enrico / Fais, Antonella / Kumar, Amit / Pintus, Francesca et al. | 2016
- 2314
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Detection of NAD(P)H-dependent enzyme activity by time-domain ratiometry of terbium luminescenceTerai, Takuya / Ito, Hiroki / Hanaoka, Kenjiro / Komatsu, Toru / Ueno, Tasuku / Nagano, Tetsuo / Urano, Yasuteru et al. | 2016
- 2318
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Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumoursBarlaam, Bernard / Cosulich, Sabina / Degorce, Sébastien / Fitzek, Martina / Green, Stephen / Hancox, Urs / Lambert-van der Brempt, Christine / Lohmann, Jean-Jacques / Maudet, Mickaël / Morgentin, Rémy et al. | 2016
- 2324
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Minimum structural requirements for cell membrane leakage-mediated anti-MRSA activity of macrocyclic bis(bibenzyl)sFujii, Kana / Morita, Daichi / Onoda, Kenji / Kuroda, Teruo / Miyachi, Hiroyuki et al. | 2016
- 2328
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- 2328
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- 2333
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Synthesis of azepino[4,5Rentería-Gómez, Angel et al. | 2016
- 2333
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Synthesis of azepino[4,5-b]indol-4-ones via MCR/free radical cyclization and in vitro–in silico studies as 5-Ht6R ligandsRentería-Gómez, Angel / Islas-Jácome, Alejandro / Díaz-Cervantes, Erik / Villaseñor-Granados, Tayde / Robles, Juvencio / Gámez-Montaño, Rocío et al. | 2016
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Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporationWalsh, Shawn P. / Shahripour, Aurash / Tang, Haifeng / de Jesus, Reynalda K. / Teumelsan, Nardos / Zhu, Yuping / Frie, Jessica / Priest, Birgit T. / Swensen, Andrew M. / Alonso-Galicia, Magdalena et al. | 2016
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Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2Cheng, Yuan-Bin / Lee, Jin-Ching / Lo, I-Wen / Chen, Shu-Rong / Hu, Hao-Chun / Wu, Yu-Hsuan / Wu, Yang-Chang / Chang, Fang-Rong et al. | 2016
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Ecdysones fromCheng, Yuan-Bin et al. | 2016
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Preparation and characterization of the pH and thermosensitive magnetic molecular imprinted nanoparticle polymer for the cancer drug deliveryKaamyabi, Sharif / Habibi, Davood / Amini, Mostafa M. et al. | 2016
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Synthesis and antitumor activity of ATB-429 derivatives containing a nitric oxide-releasing moietyWang, Chunlan / Xia, Guimin / Liu, Xiujun / Zhang, Rui / Chai, Yun / Zhang, Jun / Li, Xiaoning / Yang, Yang / Wang, Juxian / Liu, Mingliang et al. | 2016
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Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assaySon, Dohyun / Kim, Chung Sub / Lee, Kang Ro / Park, Hyun-Ju et al. | 2016
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Development of a potent and selective FLT3 kinase inhibitor by systematic expansion of a non-selective fragment-screening hitNakano, Hirofumi / Hasegawa, Tsukasa / Imamura, Riyo / Saito, Nae / Kojima, Hirotatsu / Okabe, Takayoshi / Nagano, Tetsuo et al. | 2016
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Two novel phenanthraquinones with anti-cancer activity isolated from Bletilla striataSun, Aijing / Liu, Jieqing / Pang, Suqiu / Lin, Junsheng / Xu, Ruian et al. | 2016
- 2380
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- IFC
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Editorial board| 2016