Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity (English)
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- New search for: McCoull, William
- New search for: Hennessy, Edward J.
- New search for: Blades, Kevin
- New search for: Box, Matthew R.
- New search for: Chuaqui, Claudio
- New search for: Dowling, James E.
- New search for: Davies, Christopher D.
- New search for: Ferguson, Andrew D.
- New search for: Goldberg, Frederick W.
- New search for: Howe, Nicholas J.
- New search for: Kemmitt, Paul D.
- New search for: Lamont, Gillian M.
- New search for: Madden, Katrina
- New search for: McWhirter, Claire
- New search for: Varnes, Jeffrey G.
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- New search for: McCoull, William
- New search for: Hennessy, Edward J.
- New search for: Blades, Kevin
- New search for: Box, Matthew R.
- New search for: Chuaqui, Claudio
- New search for: Dowling, James E.
- New search for: Davies, Christopher D.
- New search for: Ferguson, Andrew D.
- New search for: Goldberg, Frederick W.
- New search for: Howe, Nicholas J.
- New search for: Kemmitt, Paul D.
- New search for: Lamont, Gillian M.
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In:
MedChemComm
;
5
, 10
;
1533-1539
;
2014
- Article (Journal) / Electronic Resource
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Title:Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity
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Contributors:McCoull, William ( author ) / Hennessy, Edward J. ( author ) / Blades, Kevin ( author ) / Box, Matthew R. ( author ) / Chuaqui, Claudio ( author ) / Dowling, James E. ( author ) / Davies, Christopher D. ( author ) / Ferguson, Andrew D. ( author ) / Goldberg, Frederick W. ( author ) / Howe, Nicholas J. ( author )
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Published in:MedChemComm ; 5, 10 ; 1533-1539
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Publisher:
- New search for: The Royal Society of Chemistry
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Publication date:2014-09-24
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Size:7 pages
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Source:
Table of contents – Volume 5, Issue 10
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1425
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Front cover| 2014
- 1426
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Inside front cover| 2014
- 1427
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Contents list| 2014
- 1435
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Protein–protein interactions of ASPP2: an emerging therapeutic targetIosub-Amir, Anat / Friedler, Assaf et al. | 2014
- 1444
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Gold compounds as aquaporin inhibitors: new opportunities for therapy and imagingde Almeida, Andreia / Soveral, Graça / Casini, Angela et al. | 2014
- 1454
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Antisense oligonucleotides: modifications and clinical trialsSharma, Vivek K. / Sharma, Raman K. / Singh, Sunil K. et al. | 2014
- 1472
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Peptide HIV fusion inhibitors: modifications and conjugationsLiu, Wei / Tan, Jianjun / Mehryar, Mohammadreza Mohammadzad / Teng, Zhiping / Zeng, Yi et al. | 2014
- 1483
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Conformational analysis of peramivir reveals critical differences between free and enzyme-bound statesRichards, Michele R. / Brant, Michael G. / Boulanger, Martin J. / Cairo, Christopher W. / Wulff, Jeremy E. et al. | 2014
- 1489
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N-Arylalkylbenzo[d]thiazole-2-carboxamides as anti-mycobacterial agents: design, new methods of synthesis and biological evaluationShah, Parth / Dhameliya, Tejas M. / Bansal, Rohit / Nautiyal, Manesh / Kommi, Damodara N. / Jadhavar, Pradeep S. / Sridevi, Jonnalagadda Padma / Yogeeswari, Perumal / Sriram, Dharmarajan / Chakraborti, Asit K. et al. | 2014
- 1496
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Diversity-oriented synthesis for novel, selective and drug-like inhibitors for a phosphatase from Mycobacterium tuberculosisHe, Rongjun / Bai, Yunpeng / Yu, Zhi-Hong / Wu, Li / Gunawan, Andrea Michelle / Zhang, Zhong-Yin et al. | 2014
- 1500
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A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitorsDevine, Shane M. / Lim, San Sui / Chandrashekaran, Indu R. / MacRaild, Christopher A. / Drew, Damien R. / Debono, Cael O. / Lam, Raymond / Anders, Robin F. / Beeson, James G. / Scanlon, Martin J. et al. | 2014
- 1507
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Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studiesFrett, Brendan / McConnell, Nick / Wang, Yuanxiang / Xu, Zhigang / Ambrose, Andrew / Li, Hong-yu et al. | 2014
- 1515
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A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cellsWakabayashi, Rie / Ishiyama, Ryutaro / Kamiya, Noriho / Goto, Masahiro et al. | 2014
- 1520
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Discovery of novel guanidinophenylpyrazole human acrosin inhibitors by molecular hybridizationZhao, Juntao / Sun, Nannan / Gao, Yue / Lv, Diya / Liu, Yang / Jiang, Yan / Dong, Guoqiang / Chen, Qianqian / Li, Wei / Zhou, Youjun et al. | 2014
- 1528
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Identification of tanshinone IIA as a natural monoacylglycerol lipase inhibitor by combined in silico and in vitro approachYang, Ruolin / Lu, Yang / Liu, Jianhua et al. | 2014
- 1533
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Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivityMcCoull, William / Hennessy, Edward J. / Blades, Kevin / Box, Matthew R. / Chuaqui, Claudio / Dowling, James E. / Davies, Christopher D. / Ferguson, Andrew D. / Goldberg, Frederick W. / Howe, Nicholas J. et al. | 2014
- 1540
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Osthol and curcumin as inhibitors of human Pgp and multidrug efflux pumps of Staphylococcus aureus: reversing the resistance against frontline antibacterial drugsJoshi, Prashant / Singh, Samsher / Wani, Abubakar / Sharma, Sadhana / Jain, Shreyans K. / Singh, Baljinder / Gupta, Bishan D. / Satti, Naresh K. / Koul, Surrinder / Khan, Inshad A. et al. | 2014
- 1548
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A double effect molecular switch leads to a novel potent negative allosteric modulator of metabotropic glutamate receptor 5Gómez-Santacana, X. / Rovira, X. / Dalton, J. A. / Goudet, C. / Pin, J. P. / Gorostiza, P. / Giraldo, J. / Llebaria, A. et al. | 2014
- 1555
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Design, synthesis and molecular docking of novel bipyrazolyl thiazolone scaffold as a new class of antibacterial agentsKalaria, Piyush N. / Makawana, Jigar A. / Satasia, Shailesh P. / Raval, Dipak K. / Zhu, Hai-Liang et al. | 2014
- 1563
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Non-classical β-carbonic anhydrase inhibitors-towards novel anti-mycobacterialsvon Gnielinski, Natascha / Nienaber, Lisa / Mason, Lyndel / Ellis, Samantha / Triccas, James A. / Davis, Rohan A. / Hofmann, Andreas et al. | 2014
- 1567
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Exploring the substrate promiscuity of an antibiotic inactivating enzymeAgarwal, Vinayak / Vondenhoff, Gaston / Gadakh, Bharat / Severinov, Konstantin / Van Aerschot, Arthur / Nair, Satish K. et al. | 2014
- 1571
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Naphthalene and 2,3-dihydrobenzo[b][1,4]dioxine derivatives with extended side chains as new scaffolds of CB 2 -selective ligandsOsman, Noha A. / Mahmoud, Amr H. / Klein, Christian D. / Allarà, Marco / Di Marzo, Vincenzo / Abouzid, Khaled M. / Abadi, Ashraf H. et al. | 2014
- 1577
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Cytoprotective effects of hydrogen sulfide-releasing N-methyl- d -aspartate receptor antagonists mediated by intracellular sulfane sulfurMarutani, Eizo / Sakaguchi, Masahiro / Chen, Wei / Sasakura, Kiyoshi / Liu, Jifeng / Xian, Ming / Hanaoka, Kenjiro / Nagano, Tetsuo / Ichinose, Fumito et al. | 2014
- 1584
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Synthesis of 1-O-acetylbritannilactone analogues from Inula britannica and in vitro evaluation of their anticancer potentialTang, Jiang-Jiang / Dong, Shuai / Han, Yang-Yang / Lei, Ming / Gao, Jin-Ming et al. | 2014
- 1590
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Correction: Synthesis, chiral resolution, absolute configuration assignment and pharmacological evaluation of a series of melatoninergic ligandsEttaoussi, Mohamed / Pérès, Basile / Jarry, Christian / Pallage, Viviane / Nosjean, Olivier / Boutin, Jean A. / Gohier, Arnaud / Mannoury la Cour, Clotilde / Caignard, Daniel-Henri / Delagrange, Philippe et al. | 2014
- 1591
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MedChemWatch Issue 21 and Back cover| 2014