Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity (English)
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In:
MedChemComm
;
4
, 2
;
456-462
;
2013
- Article (Journal) / Electronic Resource
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Title:Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity
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Contributors:McCoull, William ( author ) / Barton, Peter ( author ) / Broo, Ander ( author ) / Brown, Alastair J. H. ( author ) / Clarke, David S. ( author ) / Coope, Gareth ( author ) / Davies, Robert D. M. ( author ) / Dossetter, Alexander G. ( author ) / Kelly, Elizabeth E. ( author ) / Knerr, Laurent ( author )
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Published in:MedChemComm ; 4, 2 ; 456-462
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Publisher:
- New search for: The Royal Society of Chemistry
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Publication date:2013-01-30
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Size:7 pages
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Source:
Table of contents – Volume 4, Issue 2
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 297
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Front cover| 2013
- 299
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Contents list| 2013
- 309
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European Federation for Medicinal Chemistry in partnership with MedChemComm| 2013
- 310
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Preparation and evaluation of BBB-permeable trehalose derivatives as potential therapeutic agents for Huntington's diseaseIm, Jungkyun / Kim, Sangjune / Jeong, Young-Hun / Kim, Wanil / Lee, Dohyun / Lee, Woo Sirl / Chang, Young-Tae / Kim, Kyong-Tai / Chung, Sung-Kee et al. | 2013
- 317
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Selective antitumour activity and ERα molecular docking studies of newly synthesized d -homo fused steroidal tetrazolesPenov-Gaši, Katarina M. / Oklješa, Aleksandar M. / Petri, Edward T. / Ćelić, Andjelka S. / Djurendić, Evgenija A. / Klisurić, Olivera R. / Csanadi, Janos J. / Batta, Gyula / Nikolić, Andrea R. / Jakimov, Dimitar S. et al. | 2013
- 324
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Novel FK506 and FK520 analogues via mutasynthesis: mutasynthon scope and product characteristicsMoss, Steven J. / Stanley-Smith, Anna E. / Schell, Ursula / Coates, Nigel J. / Foster, Teresa A. / Gaisser, Sabine / Gregory, Matthew A. / Martin, Christine J. / Nur-e-Alam, Mohammad / Piraee, Mahmood et al. | 2013
- 332
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Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viabilityXia, Zebin / Cao, Xihua / Rico-Bautista, Elizabeth / Yu, Jinghua / Chen, Liqun / Chen, Jiebo / Bobkov, Andrey / Wolf, Dieter A. / Zhang, Xiao-Kun / Dawson, Marcia I. et al. | 2013
- 340
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Dinaphthonaphthyridines – a class of novel molecules with potent antioxidant and anticancer activityPrabha, K. / Prasad, K. J. Rajendra et al. | 2013
- 347
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A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosisKrause-Heuer, Anwen M. / Howell, Nicholas R. / Matesic, Lidia / Dhand, Geetanjali / Young, Emma L. / Burgess, Leena / Jiang, Cathy D. / Lengkeek, Nigel A. / Fookes, Christopher J. R. / Pham, Tien Q. et al. | 2013
- 353
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Structure–activity relationships of tetrahydrocarbazole derivatives as antifungal lead compoundsWang, Wenya / Dong, Guoqiang / Gu, Julin / Zhang, Yongqiang / Wang, Shengzheng / Zhu, Shiping / Liu, Yang / Miao, Zhenyuan / Yao, Jianzhong / Zhang, Wannian et al. | 2013
- 363
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A new route towards fimbrolide analogues: importance of the exomethylene motif in LuxR dependent quorum sensing inhibitionSabbah, Mohamad / Bernollin, Maud / Doutheau, Alain / Soulère, Laurent / Queneau, Yves et al. | 2013
- 367
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3,3-Dimethyl-1H-pyrrolo[3,2-g]quinolin-2(3H)-one derivatives as novel Raf kinase inhibitorsLi, Yanyang / Shi, Xiangfei / Xie, Ning / Zhao, Yanjin / Li, Shuxin et al. | 2013
- 371
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Combination of biotransformation by P450 BM3 mutants with on-line post-column bioaffinity and mass spectrometric profiling as a novel strategy to diversify and characterize p38α kinase inhibitorsRea, Vanina / Falck, David / Kool, Jeroen / de Kanter, Frans J. J. / Commandeur, Jan N. M. / Vermeulen, Nico P. E. / Niessen, Wilfried M. A. / Honing, Maarten et al. | 2013
- 378
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Inhibition of Ras–effector interactions by cyclic peptidesWu, Xianghong / Upadhyaya, Punit / Villalona-Calero, Miguel A. / Briesewitz, Roger / Pei, Dehua et al. | 2013
- 383
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Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and BFraser, Benjamin H. / Hamilton, Stephanie / Krause-Heuer, Anwen M. / Wright, Philip J. / Greguric, Ivan / Tucker, Simon P. / Draffan, Alistair G. / Fokin, Valery V. / Sharpless, K. Barry et al. | 2013
- 387
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Glycosidase inhibition by novel guanidinium and urea iminosugar derivativesKooij, Raymond / Branderhorst, Hilbert M. / Bonte, Simon / Wieclawska, Sara / Martin, Nathaniel I. / Pieters, Roland J. et al. | 2013
- 394
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Design, synthesis and crystal structure determination of dinuclear copper-based potential chemotherapeutic drug entities; in vitro DNA binding, cleavage studies and an evaluation of genotoxicity by micronucleus test and comet assayArjmand, Farukh / Muddassir, Mohd / Zaidi, Yusra / Ray, Debashis et al. | 2013
- 406
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A structure–activity relationship study on multi-heterocyclic molecules: two linked thiazoles are required for cytotoxic activityKim, Seong Jong / Lin, Chun-Chieh / Pan, Chung-Mao / Rananaware, Dimple P. / Ramsey, Deborah M. / McAlpine, Shelli R. et al. | 2013
- 411
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Identification of novel inhibitors of p53–MDM2 interaction facilitated by pharmacophore-based virtual screening combining molecular docking strategyWang, Weisi / Zhu, Xiaolei / Hong, Xueqin / Zheng, Lin / Zhu, Hong / Hu, Yongzhou et al. | 2013
- 417
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Developing novel C-4 analogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine siteDa, Chenxiao / Telang, Nakul / Hall, Kayleigh / Kluball, Emily / Barelli, Peter / Finzel, Kara / Jia, Xin / Gupton, John T. / Mooberry, Susan L. / Kellogg, Glen E. et al. | 2013
- 422
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Triazolopyrimidinones as γ-secretase modulators: structure–activity relationship, modulator profile, and in vivo profilingYngve, Ulrika / Paulsen, Kim / Macsari, Istvan / Sundström, Marie / Santangelo, Ellen / Linde, Christian / Bogar, Krisztian / Lake, Fredrik / Besidski, Yevgeni / Malmborg, Jonas et al. | 2013
- 432
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The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors – characterization of hydroxamate-based matrix metalloproteinase-12 inhibitorsGossas, Thomas / Nordström, Helena / Xu, Ming-Hua / Sun, Zhi-Hua / Lin, Guo-Qiang / Wallberg, Hans / Danielson, U. Helena et al. | 2013
- 443
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Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10ALi, Junfeng / Jin, Hongjun / Zhou, Haiying / Rothfuss, Justin / Tu, Zhude et al. | 2013
- 450
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Synthesis of hetero annulated carbazoles: exploration of in vitro cytotoxicity and molecular docking studiesIndumathi, Thangavel / Muthusankar, Aathi / Shanmughavel, P. / Prasad, K. J. Rajendra et al. | 2013
- 456
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Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesityMcCoull, William / Barton, Peter / Broo, Anders / Brown, Alastair J. H. / Clarke, David S. / Coope, Gareth / Davies, Robert D. M. / Dossetter, Alexander G. / Kelly, Elizabeth E. / Knerr, Laurent et al. | 2013
- 463
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Back cover| 2013