Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase (English)
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- New search for: Khan, A.
- New search for: Leśniak, R. K.
- New search for: Brem, J.
- New search for: Rydzik, A. M.
- New search for: Choi, H.
- New search for: Leung, I. K. H.
- New search for: McDonough, M. A.
- New search for: Schofield, C. J.
- New search for: Claridge, T. D. W.
- New search for: Khan, A.
- New search for: Leśniak, R. K.
- New search for: Brem, J.
- New search for: Rydzik, A. M.
- New search for: Choi, H.
- New search for: Leung, I. K. H.
- New search for: McDonough, M. A.
- New search for: Schofield, C. J.
- New search for: Claridge, T. D. W.
In:
MedChemComm
;
7
, 5
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873-880
;
2016
- Article (Journal) / Electronic Resource
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Title:Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylase
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Contributors:Khan, A. ( author ) / Leśniak, R. K. ( author ) / Brem, J. ( author ) / Rydzik, A. M. ( author ) / Choi, H. ( author ) / Leung, I. K. H. ( author ) / McDonough, M. A. ( author ) / Schofield, C. J. ( author ) / Claridge, T. D. W. ( author )
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Published in:MedChemComm ; 7, 5 ; 873-880
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Publisher:
- New search for: The Royal Society of Chemistry
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Publication date:2016-05-19
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Size:8 pages
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ISSN:
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Coden:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Source:
Table of contents – Volume 7, Issue 5
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 737
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Front cover| 2016
- 739
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Contents list| 2016
- 749
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Pyrimidine-based antimalarials: design strategies and antiplasmodial effectsSingh, Kamaljit / Kaur, Tavleen et al. | 2016
- 769
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Label-free technologies for target identification and validationLi, Jing / Xu, Hua / West, Graham M. / Jones, Lyn H. et al. | 2016
- 778
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Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapyNhu, Duong / Lessene, Guillaume / Huang, David C. S. / Burns, Christopher J. et al. | 2016
- 788
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The evolution of drug discovery: from phenotypes to targets, and backAl-Ali, Hassan et al. | 2016
- 799
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Enlarging the chemical space of anti-leishmanials: a structure–activity relationship study of peptoids against Leishmania mexicana, a causative agent of cutaneous leishmaniasisBolt, H. L. / Eggimann, G. A. / Denny, Paul W. / Cobb, Steven L. et al. | 2016
- 806
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Cobalt(ii) 8-hydroxyquinoline complexes: structure, cytotoxicity and action mechanismZhang, Hai-Rong / Huang, Ke-Bin / Chen, Zhen-Feng / Liu, Yan-Cheng / Liu, You-Nian / Meng, Ting / Qin, Qi-Pin / Zou, Bi-Qun / Liang, Hong et al. | 2016
- 813
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Discovery of a novel binding pocket for CYP 2C9 inhibitors: crystallography, pharmacophore modelling and inhibitor SARSkerratt, Sarah E. / de Groot, Marcel J. / Phillips, Chris et al. | 2016
- 820
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Curcumin inspired synthesis of unsymmetrical diarylpentanoids with highly potent anti-parasitic activities: in silico studies and DFT-based stereochemical calculationDin, Zia Ud / Santos, Alef dos / Trapp, Marilia Almeida / Lazarin-Bidóia, Danielle / Garcia, Francielle Pelegrin / Peron, Francieli / Nakamura, Celso Vataru / Rodrigues-Filho, Edson et al. | 2016
- 832
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Design and synthesis of pyridine-pyrazole-sulfonate derivatives as potential anti-HBV agentsChuang, Hong / Huang, Lin-Chiang Sherlock / Kapoor, Mohit / Liao, Yi-Jen / Yang, Cheng-Lin / Chang, Chia-Ching / Wu, Chun-Yi / Hwu, Jih Ru / Huang, Tsurng-Juhn / Hsu, Ming-Hua et al. | 2016
- 837
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Chenopodium album metabolites act as dual topoisomerase inhibitors and induce apoptosis in the MCF7 cell lineChakraborty, Debanjana / Jain, Chetan Kumar / Maity, Arindam / Ghosh, Shekhar / Choudhury, Susanta Roy / Jha, Tarun / Majumder, Hemanta K. / Mondal, Nirup B. et al. | 2016
- 845
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Progress in the development of small molecules as new human A3adenosine receptor ligands based on the 3-thiophenylcoumarin coreMatos, M. J. / Vilar, S. / Kachler, S. / Vazquez-Rodriguez, S. / Varela, C. / Delogu, G. / Hripcsak, G. / Santana, L. / Uriarte, E. / Klotz, K.-N. et al. | 2016
- 853
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Biological evaluation of quinoline derivatives as inhibitors of human dihydroorotate dehydrogenaseWang, Jiawei / Diao, Yanyan / Zhu, Junsheng / Li, Shiliang / Zhao, Zhenjiang / Li, Honglin / Zhu, Lili et al. | 2016
- 859
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Systematic design of analogs of active compounds covering more than 1000 targetsDimova, Dilyana / Bajorath, Jürgen et al. | 2016
- 864
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Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design: N-α-acetyl-l-lysine as an amine nucleophileDahal, Upendra P. / Gilbert, Adam M. / Obach, R. Scott / Flanagan, Mark E. / Chen, Jinshan M. / Garcia-Irizarry, Carmen / Starr, Jeremy T. / Schuff, Brandon / Uccello, Daniel P. / Young, Jennifer A. et al. | 2016
- 873
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Development and application of ligand-based NMR screening assays for γ-butyrobetaine hydroxylaseKhan, A. / Leśniak, R. K. / Brem, J. / Rydzik, A. M. / Choi, H. / Leung, I. K. H. / McDonough, M. A. / Schofield, C. J. / Claridge, T. D. W. et al. | 2016
- 881
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Design, synthesis and biological evaluation of indazole–pyrimidine based derivatives as anticancer agents with anti-angiogenic and antiproliferative activitiesElsayed, Nevine M. Y. / Abou El Ella, Dalal A. / Serya, Rabah A. T. / Tolba, Mai F. / Shalaby, Raed / Abouzid, Khaled A. M. et al. | 2016
- 900
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Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitorsNair, Reji N. / Mishra, Jitendra K. / Li, Fangzheng / Tortosa, Mariola / Yang, Chunying / Doherty, Joanne R. / Cameron, Michael / Cleveland, John L. / Roush, William R. / Bannister, Thomas D. et al. | 2016
- 906
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Improvement of the pharmacological properties of amidated kyotorphin by means of iodinationOliveira, Maria Cristina / Gano, Lurdes / Santos, Isabel / Correia, João D. G. / Serrano, Isa D. / Santos, Sónia Sá / Ribeiro, Marta / Perazzo, Juliana / Tavares, Isaura / Heras, Montserrat et al. | 2016
- 914
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Synthesis, cytotoxic and urease inhibitory activities of some novel isatin-derived bis-Schiff bases and their copper(ii) complexesPervez, Humayun / Ahmad, Maqbool / Zaib, Sumera / Yaqub, Muhammad / Naseer, Muhammad Moazzam / Iqbal, Jamshed et al. | 2016
- 924
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Synthesis and biological evaluation of Schiff base-linked imidazolyl naphthalimides as novel potential anti-MRSA agentsGong, Huo-Hui / Baathulaa, Kishore / Lv, Jing-Song / Cai, Gui-Xin / Zhou, Cheng-He et al. | 2016
- 932
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Synthesis, antibacterial evaluation and QSAR analysis of Schiff base complexes derived from [2,2′-(ethylenedioxy)bis(ethylamine)] and aromatic aldehydesDevi, Jai / Devi, Suman / Kumar, Ashwani et al. | 2016
- 948
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Efficacy of a novel ferrocenyl diaryl butene citrate compound as a biocide for preventing healthcare-associated infectionsEl Arbi, Mehdi / Jalléli, Karim / Trigui, Fatma / Pigeon, Pascal / Görmen, Meral / Top, Siden / Aifa, Sami / Fliss, Ismail / Jaouen, Gérard / Hammami, Riadh et al. | 2016
- 955
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Significantly improving the solubility of non-steroidal anti-inflammatory drugs in deep eutectic solvents for potential non-aqueous liquid administrationLu, Chao / Cao, Jun / Wang, Ning / Su, Erzheng et al. | 2016
- 960
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Design, synthesis and evaluation of novel tetrahydrothieno[3,2-c]pyridine derivatives as potent smoothened antagonistsChen, Xiaofeng / Sun, Chiyu / Zhang, Jingzhou / Ding, Huaiwei / Song, Hongrui et al. | 2016
- 966
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Design and synthesis of thiamine analogues to study their binding to the ECF transporter for thiamine in bacteriaMonjas, L. / Swier, L. J. Y. M. / de Voogd, A. R. / Oudshoorn, R. C. / Hirsch, A. K. H. / Slotboom, D. J. et al. | 2016
- 972
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Synthesis and cytotoxic evaluation of several oleanolic acid–uracil/thymine conjugatesCheng, Ke-Guang / Su, Chun-Hua / Huang, Jia-Yan / Wang, Heng-Shan / Liu, Jun / Zheng, Yuan-Ting / Chen, Zhen-Feng et al. | 2016
- 982
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New transition metal complexes containing imidazole rings endowed with potential antiamoebic activityWani, Mohmmad Younus / Bhat, Abdul Roouf / Azam, Amir / Athar, Fareeda / Sobral, Abilio J. F. N. et al. | 2016
- 990
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Synthesis and evaluation of donepezil–ferulic acid hybrids as multi-target-directed ligands against Alzheimer's diseaseXu, Wei / Wang, Xiao-Bing / Wang, Zhi-Min / Wu, Jia-Jia / Li, Fan / Wang, Jin / Kong, Ling-Yi et al. | 2016
- 999
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A cyclosporine derivative is a substrate of the oligopeptide transporter PepT1Foley, David W. / Bermudez, Isabel / Bailey, Patrick D. / Meredith, David et al. | 2016
- 1003
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Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitorHagimori, Masayori / Murakami, Takahiro / Shimizu, Kinue / Nishida, Motohiro / Ohshima, Takashi / Mukai, Takahiro et al. | 2016
- 1007
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Predictive proteochemometric models for kinases derived from 3D protein field-based descriptorsSubramanian, Vigneshwari / Prusis, Peteris / Xhaard, Henri / Wohlfahrt, Gerd et al. | 2016
- 1016
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Non-substrate based, small molecule inhibitors of the human isoprenylcysteine carboxyl methyltransferaseButler, Kyle V. / Bohn, Kelsey / Hrycyna, Christine A. / Jin, Jian et al. | 2016
- 1022
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Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathwayTantry, Subramanyam J. / Shinde, Vikas / Balakrishnan, Gayathri / Markad, Shankar D. / Gupta, Amit K. / Bhat, Jyothi / Narayan, Ashwini / Raichurkar, Anandkumar / Jena, Lalit Kumar / Sharma, Sreevalli et al. | 2016
- 1033
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Back cover| 2016