You can adapt a Large-Scale Agile Framework suitable for your organization using the methodology presented or develop it yourself from scratch—for a deviating problem class, for example. In doing so, we present an approach and explain how this can be done based on the current state of research. In this chapter, we demonstrate how to proceed when adapting a Large-Scale Agile framework to perfectly fit the problem classes of software vendors. Undoubtedly, other problem classes prevail in other industries, but almost all of them are now software-driven to a greater or lesser extent, or develop software independently as well. To help you answer the question to what extent your organization is acting in the role of a software producer, a separate section is devoted to answering this exciting question and shows you exemplary companies whose IT strategy can be assessed from the outside in a way that is easily perceivable in large parts. The most pressing question in most companies is: “How do we switch as quickly as possible to an agile mode in which the most diverse teams within an organization work together efficiently?” On the other hand, the question “How do organizations perfectly operate in agile mode?” is on the mind of every organization—the only differences are in the maturity level of the respective organization in this regard. With the increasing shift of IT infrastructures to the cloud and with container-based virtualization of applications, the complexity level of IT applications is being extended by a new dimension. This increase in complexity in IT scenarios also has a significant impact on the establishment of an agile framework. Even though IT security has always had a high priority for the development and operation of software, cloud security poses different requirements than the protection of monolithic applications in traditionally largely sealed-off corporate networks. The cloud trend is also changing many workflows and business processes within an organization. The move to the cloud or the expansion of cloud scenarios therefore inevitably necessitates both process-related and organizational changes within an organization. A separate section explains the interrelationships that exist here and the dimensions in which this has a concrete impact. The focus here is on cloud properties and cloud models. Cloud computing uses virtualization technology because of the cost-efficient advantages it offers, such as payload-oriented hardware and energy utilization, automated troubleshooting, consequently the quality improvement of software as well as increased flexibility and simple manageability. The concepts of virtualization and containerization are related in importance to this. Because the orchestration of containers is now an established standard in software development and in the deployment of software releases, and the interoperability of cloud technologies represents an important property for software architectures, it is advantageous to regularly obtain first-hand information. Interoperability and standardization: The relevant standardization bodies with regard to cloud standards are presented. IT security by design: software architecture & IT security—How is it possible to integrate and anchor IT security in an organization as a bundle of diverse activities and technical protective measures as an integral building block when IT systems are regularly highly complex and consist almost everywhere of countless individual components, basic technologies and frameworks? The artifacts of the software architecture—with an integrated IT security architecture and its communication within the organization—play the central role here. The earlier IT security requirements are taken into account, the more cost-effective their consideration becomes. You will therefore benefit immensely in terms of high software quality and avoiding unnecessary costs if you involve your IT security specialists at an early stage and establish agile processes in which IT security by design is taken into account in a practice-oriented manner. Coupled with the increasing use of cloud services and the resulting IT security and privacy challenges, fundamental aspects such as identity theft, data breaches, data integrity, and data confidentiality count. This makes trust management inevitable for cloud computing, microservices and API-based architectures. Precisely because cloud computing provides services from remote and globally distributed data centers and we cannot exercise any direct control from within our organization other than taking technical measures, there is a need to exercise an appropriate strategy to protect any data; this is exactly what the zero trust concept offers proven solutions for. Protection principles and their technical implementation based on Zero Trust are presented. In this context, the concepts of secret management and the extended protection requirements of virtual container environments are explained. Key management and cryptographic protection measures play a central role here. With the cloud trend taking place, applications designed as microservices are increasing in number and proliferation day by day. This software architecture approach of a distributed IT system is highlighted in the context of Cloud and the Large-Scale Agile frameworks and put in the context of APIs, RESTful design and the current architecture pattern of Service Mesh. With cloud services and distributed services, the importance of IT security and pentesting increases, so these security-related aspects and how they are handled using threat modeling are also addressed. With respect to Agile teams, roles, tasks, and processes are highlighted in an easy-to-understand manner and in the direct context of these important software development topics.