A multicenter characterization of hepatitis associated with immune checkpoint inhibitors (English)
Free access
- New search for: Patrinely, J. RandallJr.
- New search for: McGuigan, Ben
- New search for: Chandra, Sunandana
- New search for: Fenton, Sarah E.
- New search for: Chowdhary, Akansha
- New search for: Kennedy, Lucy B.
- New search for: Mooradian, Meghan J.
- New search for: Palmeri, Marisa
- New search for: Portal, Daniella
- New search for: Horst, Sara N.
- New search for: Scoville, Elizabeth A.
- New search for: Long, Georgina V.
- New search for: Shi, Chanjuan
- New search for: Mehnert, Janice M.
- New search for: Sullivan, Ryan J.
- New search for: Salama, April K.
- New search for: Sosman, Jeffrey A.
- New search for: Menzies, Alexander M.
- New search for: Johnson, Douglas B.
- New search for: Patrinely, J. RandallJr.
- New search for: McGuigan, Ben
- New search for: Chandra, Sunandana
- New search for: Fenton, Sarah E.
- New search for: Chowdhary, Akansha
- New search for: Kennedy, Lucy B.
- New search for: Mooradian, Meghan J.
- New search for: Palmeri, Marisa
- New search for: Portal, Daniella
- New search for: Horst, Sara N.
- New search for: Scoville, Elizabeth A.
- New search for: Long, Georgina V.
- New search for: Shi, Chanjuan
- New search for: Mehnert, Janice M.
- New search for: Sullivan, Ryan J.
- New search for: Salama, April K.
- New search for: Sosman, Jeffrey A.
- New search for: Menzies, Alexander M.
- New search for: Johnson, Douglas B.
In:
OncoImmunology
;
10
, 1
;
2021
-
ISSN:
- Article (Journal) / Electronic Resource
-
Title:A multicenter characterization of hepatitis associated with immune checkpoint inhibitors
-
Contributors:Patrinely, J. RandallJr. ( author ) / McGuigan, Ben ( author ) / Chandra, Sunandana ( author ) / Fenton, Sarah E. ( author ) / Chowdhary, Akansha ( author ) / Kennedy, Lucy B. ( author ) / Mooradian, Meghan J. ( author ) / Palmeri, Marisa ( author ) / Portal, Daniella ( author ) / Horst, Sara N. ( author )
-
Published in:OncoImmunology ; 10, 1
-
Publisher:
- New search for: Taylor & Francis
-
Publication date:2021-01-01
-
ISSN:
-
DOI:
-
Type of media:Article (Journal)
-
Type of material:Electronic Resource
-
Language:English
-
Keywords:
-
Source:
Table of contents – Volume 10, Issue 1
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
-
Primary tumors from mucosal barrier organs drive unique eosinophil infiltration patterns and clinical associationsGrisaru-Tal, Sharon / Itan, Michal / Grass, Daniel G / Torres-Roca, Javier / Eschrich, Steven A / Gordon, Yaara / Dolitzky, Avishay / Hazut, Inbal / Avlas, Shmuel / Jacobsen, Elizabeth A et al. | 2021
-
A gene expression signature associated with B cells predicts benefit from immune checkpoint blockade in lung adenocarcinomaBudczies, Jan / Kirchner, Martina / Kluck, Klaus / Kazdal, Daniel / Glade, Julia / Allgäuer, Michael / Kriegsmann, Mark / Heußel, Claus-Peter / Herth, Felix J. / Winter, Hauke et al. | 2021
-
Anti-PD-1 antibody HX008 combined with oxaliplatin plus capecitabine for advanced gastric or esophagogastric junction cancer: a multicenter, single-arm, open-label, phase Ib trialXu, Jianming / Xu, Nong / Bai, Yuxian / Liu, Rongrui / Mao, Chenyu / Sui, Hong / Wang, Xiaofei / Jiang, Qian / Dou, Yiwei et al. | 2021
-
NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcriptionZao, Xiaobin / Cheng, Jin / Shen, Congle / Guan, Guiwen / Feng, Xiaoyu / Zou, Jun / Zhang, Jing / Liu, Tianxu / Zheng, Huiling / Zhang, Ting et al. | 2021
-
Characterization of CD8+ T-cell responses to non-anchor-type HLA class I neoantigens with single amino-acid substitutionsShinkawa, Tomoyo / Tokita, Serina / Nakatsugawa, Munehide / Kikuchi, Yasuhiro / Kanaseki, Takayuki / Torigoe, Toshihiko et al. | 2021
-
Cross-reactivity between cancer and microbial antigensZitvogel, Laurence / Kroemer, Guido et al. | 2021
-
IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancerJordakieva, Galateja / Bianchini, Rodolfo / Reichhold, Daniel / Piehslinger, Jakob / Groschopf, Alina / Jensen, Sebastian A. / Mearini, Ettore / Nocentini, Giuseppe / Crevenna, Richard / Zlabinger, Gerhard J. et al. | 2021
-
Activin A backs-up TGF-ß to promote regulatory T cellsDe Martino, Mara / Daviaud, Camille / Vanpouille-Box, Claire et al. | 2021
-
Impact of treatment schedule on the efficacy of cytostatic and immunostimulatory agentsPetroni, Giulia / Galluzzi, Lorenzo et al. | 2021
-
A novel multimeric IL15/IL15Rα-Fc complex to enhance cancer immunotherapyXu, Hong / Buhtoiarov, Ilia N. / Guo, Hongfen / Cheung, Nai-Kong V. et al. | 2021
-
The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancerHe, Chaobin / Sun, Shuxin / Zhang, Yu / Xie, Fengxiao / Li, Shengping et al. | 2021
-
Association of TRF2 expression and myeloid-derived suppressor cells infiltration with clinical outcome of patients with cutaneous melanomaIlié, Marius / Lantéri, Elisabeth / Chamorey, Emmanuel / Thamphya, Brice / Hamila, Marame / Montaudié, Henri / Picard-Gauci, Alexandra / Gardrat, Sophie / Passeron, Thierry / Lassalle, Sandra et al. | 2021
-
Analysis of the tumor microenvironment and anti-tumor efficacy of subcutaneous vs systemic delivery of the bifunctional agent bintrafusp alfaOzawa, Yohei / Hicks, Kristin C. / Minnar, Christine M. / Knudson, Karin M. / Schlom, Jeffrey / Gameiro, Sofia R. et al. | 2021
-
Poor clinical outcomes and immunoevasive contexture in CXCL13+CD8+ T cells enriched gastric cancer patientsJin, Kaifeng / Cao, Yifan / Gu, Yun / Fang, Hanji / Fei, Yuchao / Wang, Jieti / Liu, Xin / Lv, Kunpeng / He, Xudong / Lin, Chao et al. | 2021
-
What role for AHR activation in IL4I1-mediated immunosuppression ?Castellano, Flavia / Prevost-Blondel, Armelle / Cohen, José L. / Molinier-Frenkel, Valérie et al. | 2021
-
A novel role for an old target: CD45 for breast cancer immunotherapyRaiter, Annat / Zlotnik, Oran / Lipovetsky, Julia / Mugami, Shany / Dar, Shira / Lubin, Ido / Sharon, Eran / Cohen, Cyrille J. / Yerushalmi, Rinat et al. | 2021
-
Development of a novel gene signature to predict prognosis and response to PD-1 blockade in clear cell renal cell carcinomaYin, Xiaomao / Wang, Zaoyu / Wang, Jianfeng / Xu, Yunze / Kong, Wen / Zhang, Jin et al. | 2021
-
Correlation between PD-L1 expression ON CTCs and prognosis of patients with cancer: a systematic review and meta-analysisKong, Defeng / Zhang, Wen / Yang, Zhenrong / Li, Guoliang / Cheng, Shujun / Zhang, Kaitai / Feng, Lin et al. | 2021
-
Prognostic value of the PrPC-ILK-IDO1 axis in the mesenchymal colorectal cancer subtypeGhazi, Alexandre / Le Corre, Delphine / Pilati, Camilla / Taieb, Julien / Aparicio, Thomas / Didelot, Audrey / Dedhar, Shoukat / Mulot, Claire / Le Malicot, Karine / Djouadi, Fatima et al. | 2021
-
Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytesMarotte, L / Capitao, M / Deleine, C / Beauvais, T / Cadiou, G / Perrin, J. / Chérel, M / Scotet, E / Guilloux, Y / Bruchertseifer, F et al. | 2021
-
Expression of the immune checkpoint receptors PD-1, LAG3, and TIM3 in the immune context of stage II and III gastric cancer by using single and chromogenic multiplex immunohistochemistryPark, Yujun / Seo, An Na / Koh, Jiwon / Nam, Soo Kyoung / Kwak, Yoonjin / Ahn, Sang-Hoon / Park, Do Joong / Kim, Hyung-Ho / Lee, Hye Seung et al. | 2021
-
Immuno-phenotyping of IDH-mutant grade 3 astrocytoma and IDH-wildtype glioblastoma reveals specific differences in cells of myeloid originRaghavan, Jayashree V. / Ganesh, Raksha A. / Sonpatki, Pranali / Naik, Divya / John, Arivusudar Everad / Arunachalam, Priyanka / Shah, Darshat / P. S., Hari / Lakshmikantha, Akhila / Pillai, Shibu et al. | 2021
-
The effect of concomitant use of statins, NSAIDs, low-dose aspirin, metformin and beta-blockers on outcomes in patients receiving immune checkpoint inhibitors: a systematic review and meta-analysisZhang, Yongchao / Chen, Hualei / Chen, Shanshan / Li, Zhen / Chen, Jinglong / Li, Wei et al. | 2021
-
CD34+ progenitor-derived NK cell and gemcitabine combination therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rgnull miceVan der Meer, Jolien M.R. / de Jonge, Paul K.J.D. / van der Waart, Anniek B. / Geerlings, Alexander C. / Moonen, Jurgen P. / Brummelman, Jolanda / de Klein, Janne / Vermeulen, Malou C. / Maas, Ralph J.A. / Schaap, Nicolaas P.M. et al. | 2021
-
Implantation of a neoantigen-targeted hydrogel vaccine prevents recurrence of pancreatic adenocarcinoma after incomplete resectionDelitto, Daniel / Zabransky, Daniel J. / Chen, Fangluo / Thompson, Elizabeth D. / Zimmerman, Jacquelyn W. / Armstrong, Todd D. / Leatherman, James M. / Suri, Reecha / Lopez-Vidal, Tamara Y. / Huff, Amanda L. et al. | 2021
-
Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axisHendriks, Mark A.J.M. / Britsch, Isabel / Ke, Xiurong / van Wijngarden, Anne P. / Samplonius, Douwe F. / Ploeg, Emily M. / Helfrich, Wijnand et al. | 2021
-
Engineering of a trispecific tumor-targeted immunotherapy incorporating 4-1BB co-stimulation and PD-L1 blockadeWarmuth, Stefan / Gunde, Tea / Snell, Daniel / Brock, Matthias / Weinert, Christopher / Simonin, Alexandre / Hess, Christian / Tietz, Julia / Johansson, Maria / Spiga, Fabio Mario et al. | 2021
-
Keratinocyte differentiation antigen-specific T cells in immune checkpoint inhibitor-treated NSCLC patients are associated with improved survivalBerner, Fiamma / Niederer, Rebekka / Luimstra, Jolien J. / Pop, Oltin Tiberiu / Jochum, Ann-Kristin / Purde, Mette-Triin / Hasan Ali, Omar / Bomze, David / Bauer, Jens / Freudenmann, Lena Katharina et al. | 2021
-
Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinomaHayashi, Ryusuke / Nagato, Toshihiro / Kumai, Takumi / Ohara, Kenzo / Ohara, Mizuho / Ohkuri, Takayuki / Hirata-Nozaki, Yui / Harabuchi, Shohei / Kosaka, Akemi / Nagata, Marino et al. | 2021
-
Prognostic role of stromal tumor-infiltrating lymphocytes in locally advanced upper tract urothelial carcinoma: A retrospective multicenter study (TSU-02 study)Cheng, Sida / Zhong, Wenlong / Xia, Kun / Hong, Peng / Lin, Rongcheng / Wang, Bo / Li, Xinfei / Chen, Junyu / Liu, Zining / Zhang, Hongxian et al. | 2021
-
Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signaturesWang, Xiaonan / Peticone, Carlotta / Kotsopoulou, Ekaterini / Göttgens, Berthold / Calero-Nieto, Fernando J et al. | 2021
-
Oral administration of Bifidobacterium breve promotes antitumor efficacy via dendritic cells-derived interleukin 12Li, Qingxiang / Li, Yuke / Wang, Yifei / Xu, Le / Guo, Yuxing / Wang, Yixiang / Wang, Lin / Guo, Chuanbin et al. | 2021
-
The dark side of ferroptosis in pancreatic cancerLiu, Jiao / Dai, Enyong / Kang, Rui / Kroemer, Guido / Tang, Daolin et al. | 2021
-
Efficiency of human monocyte-derived suppressor cell-based treatment in graft-versus-host disease prevention while preserving graft-versus-leukemia effectJanikashvili, Nona / Gérard, Claire / Thébault, Marine / Brazdova, Andrea / Boibessot, Clovis / Cladière, Claudie / Ciudad, Marion / Greigert, Hélène / Ouandji, Séthi / Ghesquière, Thibault et al. | 2021
-
Novel deep learning-based survival prediction for oral cancer by analyzing tumor-infiltrating lymphocyte profiles through CIBERSORTKim, Yeongjoo / Kang, Ji Wan / Kang, Junho / Kwon, Eun Jung / Ha, Mihyang / Kim, Yoon Kyeong / Lee, Hansong / Rhee, Je-Keun / Kim, Yun Hak et al. | 2021
-
Soluble immune checkpoints and T-cell subsets in blood as biomarkers for resistance to immunotherapy in melanoma patientsMachiraju, Devayani / Wiecken, Melanie / Lang, Nina / Hülsmeyer, Ingrid / Roth, Jasmin / Schank, Timo E. / Eurich, Rosa / Halama, Niels / Enk, Alexander / Hassel, Jessica C. et al. | 2021
-
Effects of concomitant proton pump inhibitor use on immune checkpoint inhibitor efficacy among patients with advanced cancerQin, Bao-Dong / Jiao, Xiao-Dong / Zhou, Xin-Cheng / Shi, Bin / Wang, Jian / Liu, Ke / Wu, Ying / Ling, Yan / Zang, Yuan-Sheng et al. | 2021
-
CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effectsZhang, Wenliang / Zeng, Binghui / Lin, Huancai / Guan, Wen / Mo, Jing / Wu, Song / Wei, Yanjie / Zhang, Qianshen / Yu, Dongsheng / Li, Weizhong et al. | 2021
-
Impact of IL-1β and the IL-1R antagonist on relapse risk and survival in AML patients undergoing immunotherapy for remission maintenanceGrauers Wiktorin, Hanna / Aydin, Ebru / Christenson, Karin / Issdisai, Nuttida / Thorén, Fredrik B. / Hellstrand, Kristoffer / Martner, Anna et al. | 2021
-
Hypoxia increases melanoma-associated fibroblasts immunosuppressive potential and inhibitory effect on T cell-mediated cytotoxicityZiani, Linda / Buart, Stéphanie / Chouaib, Salem / Thiery, Jerome et al. | 2021
-
Have CD19-directed immunotherapy and haploidentical hematopoietic cell transplantation transformed pediatric B-cell acute lymphoblastic leukemia into a chronic disease?Pariury, Holly / Truscott, Laurel / Katsanis, Emmanuel et al. | 2021
-
Integrating CD4+ T cell help for therapeutic cancer vaccination in a preclinical head and neck cancer modelShibata, Hirofumi / Xu, Na / Saito, Shin / Zhou, Liye / Ozgenc, Ibrahim / Webb, Jason / Fu, Cong / Zolkind, Paul / Egloff, Ann Marie / Uppaluri, Ravindra et al. | 2021
-
An immunogenic first-in-human immune modulatory vaccine with PD-L1 and PD-L2 peptides is feasible and shows early signs of efficacy in follicular lymphomaKlausen, Uffe / Grønne Dahlager Jørgensen, Nicolai / Grauslund, Jacob Handlos / Munir Ahmad, Shamaila / Gang, Anne Ortved / Martinenaite, Evelina / Weis-Banke, Stine Emilie / Breinholt, Marie Fredslund / Novotny, Guy Wayne / Kjeldsen, Julie Westerlin et al. | 2021
-
CD8+ T lymphocytes are sensitive to NKG2A/HLA-E licensing interaction: role in the survival of cancer patientsGimeno, Lourdes / González-Lozano, Isabel / Soto-Ramírez, María F. / Martínez-Sánchez, María V. / López-Cubillana, Pedro / Fuster, José L. / Martínez-García, Jerónimo / Martínez-Escribano, Jorge / Campillo, José A. / Pons-Fuster, Eduardo et al. | 2021
-
Correction| 2021
-
Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapseKamal, Yasmin / Dwan, Dennis / Hoehn, Hannah J. / Sanz-Pamplona, Rebeca / Alonso, M. Henar / Moreno, Victor / Cheng, Chao / Schell, Michael J. / Kim, Youngchul / Felder, Seth I. et al. | 2021
-
Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%: real-world dataDudnik, Elizabeth / Moskovitz, Mor / Rottenberg, Yakir / Lobachov, Anastasiya / Mandelboim, Rinat / Shochat, Tzippy / Urban, Damien / Wollner, Mira / Nechushtan, Hovav / Rotem, Ofer et al. | 2021
-
CDK1/2/5 blockade: killing two birds with one stoneLiu, Jiao / Kang, Rui / Tang, Daolin et al. | 2021
-
Stromal-like Wilms tumor cells induce human Natural Killer cell degranulation and display immunomodulatory properties towards NK cellsCantoni, Claudia / Serra, Martina / Parisi, Erica / Azzarone, Bruno / Sementa, Angela Rita / Nasto, Luigi Aurelio / Moretta, Lorenzo / Candiano, Giovanni / Bottino, Cristina / Ghiggeri, Gian Marco et al. | 2021
-
Efficacy of immune-checkpoint inhibitors in PD-L1 selected or unselected patients vs. control group in patients with advanced or metastatic urothelial carcinomaGuo, Lifang / Wang, Xin / Wang, Shihui / Hua, Linbin / Song, Nan / Hu, Bin / Tong, Zhaohui et al. | 2021
-
Precision immunity: Immunoscore and neoadjuvant treatment in bladder cancerNassif, Elise F. / Thibault, Constance / Oudard, Stéphane / Galon, Jérôme et al. | 2021
-
Influence of tumor-infiltrating immune cells on local control rate, distant metastasis, and survival in patients with soft tissue sarcomaSmolle, Maria A / Herbsthofer, Laurin / Goda, Mark / Granegger, Barbara / Brcic, Iva / Bergovec, Marko / Scheipl, Susanne / Prietl, Barbara / El-Heliebi, Amin / Pichler, Martin et al. | 2021
-
Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota compositionLione, Lucia / Salvatori, Erika / Petrazzuolo, Adriana / Massacci, Alice / Maggio, Roberta / Conforti, Antonella / Compagnone, Mirco / Aurisicchio, Luigi / Ciliberto, Gennaro / Palombo, Fabio et al. | 2021
-
Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancerGunderson, Andrew J. / Rajamanickam, Venkatesh / Bui, Cynthia / Bernard, Brady / Pucilowska, Joanna / Ballesteros-Merino, Carmen / Schmidt, Mark / McCarty, Kayla / Philips, Michaela / Piening, Brian et al. | 2021
-
Genomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphomaYou, Hua / Xu-Monette, Zijun Y. / Wei, Li / Nunns, Harry / Nagy, Máté L. / Bhagat, Govind / Fang, Xiaosheng / Zhu, Feng / Visco, Carlo / Tzankov, Alexandar et al. | 2021
-
Low number of KIR ligands in lymphoma patients favors a good rituximab-dependent NK cell responseMakanga, Dhon Roméo / Jullien, Maxime / David, Gaëlle / Legrand, Nolwenn / Willem, Catherine / Dubreuil, Léa / Walencik, Alexandre / Touzeau, Cyrille / Gastinne, Thomas / Tessoulin, Benoit et al. | 2021
-
Sustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastomaChoi, John / Pant, Ayush / Medikonda, Ravi / Kim, Young-Hoon / Routkevitch, Denis / Saleh, Laura / Tong, Luqing / Chan, Hok Yee / Nedrow, Jessie / Jackson, Christopher et al. | 2021
-
DGKζ exerts greater control than DGKα over CD8+ T cell activity and tumor inhibitionGu, Junchen / Wang, Cindy / Cao, Carolyn / Huang, Jinwen / Holzhauer, Sandra / Desilva, Heshani / Wesley, Erin M. / Evans, Douglas B. / Benci, Joseph / Wichroski, Michael et al. | 2021
-
PD-L1/LAG-3 bispecific antibody enhances tumor-specific immunityJiang, Haiping / Ni, Haiqing / Zhang, Pan / Guo, Xiaoli / Wu, Min / Shen, Haoran / Wang, Jie / Wu, Weiwei / Wu, Zhihai / Ding, Jiazheng et al. | 2021
-
TCR repertoire characteristics predict clinical response to adoptive CTL therapy against nasopharyngeal carcinomaWang, Guoping / Mudgal, Poorva / Wang, Liuyang / Shuen, Timothy Wai Ho / Wu, Haiyang / Alexander, Peter B / Wang, Who-Whong / Wan, Ying / Toh, Han Chong / Wang, Xiao-Fan et al. | 2021
-
Crizotinib and ceritinib trigger immunogenic cell death via on-target effectsPetrazzuolo, Adriana / Perez-Lanzon, Maria / Liu, Peng / Maiuri, M. Chiara / Kroemer, Guido et al. | 2021
-
Negative prognostic implications of splenomegaly in nivolumab-treated advanced or recurrent pancreatic adenocarcinomaYang, Shih-Hung / Lu, Li-Chun / Kao, Hsiang-Fong / Chen, Bang-Bin / Kuo, Ting-Chun / Kuo, Sung-Hsin / Tien, Yu-Wen / Bai, Li-Yuan / Cheng, Ann-Lii / Yeh, Kun-Huei et al. | 2021
-
Immune inactivation by APOBEC3B enrichment predicts response to chemotherapy and survival in gastric cancerXia, Siyu / Gu, Yun / Zhang, Haijian / Fei, Yuchao / Cao, Yifan / Fang, Hanji / Wang, Jieti / Lin, Chao / Zhang, Heng / Li, He et al. | 2021
-
Local tumor microbial signatures and response to checkpoint blockade in non-small cell lung cancerBoesch, Maximilian / Baty, Florent / Albrich, Werner C. / Flatz, Lukas / Rodriguez, Regulo / Rothschild, Sacha I. / Joerger, Markus / Früh, Martin / Brutsche, Martin H. et al. | 2021
-
Apoptosis-induced translocation of centromere protein F in its corresponding autoantibody production in hepatocellular carcinomaLi, Xiaojin / Li, Yanmeng / Xu, Anjian / Zhou, Donghu / Zhang, Bei / Qi, Saiping / Chen, Zhibin / Wang, Xiaoming / Ou, Xiaojuan / Cao, Bangwei et al. | 2021
-
T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-γ, TNF-α or IL-2 productionvan Asten, Saskia D. / de Groot, Rosa / van Loenen, Marleen M. / Castenmiller, Suzanne M. / de Jong, Jeroen / Monkhorst, Kim / Haanen, John B.A.G. / Amsen, Derk / Bex, Axel / Spaapen, Robbert M. et al. | 2021
-
Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targetingLee, Kang Yi / Wong, Hiu Yi / Zeng, Qun / Le Lin, Jia / Cheng, Man Si / Kuick, Chik Hong / Chang, Kenneth Tou En / Loh, Amos Hong Pheng / Schwarz, Herbert et al. | 2021
-
Association of circulating protein biomarkers with clinical outcomes of durvalumab in head and neck squamous cell carcinomaArends, Rosalinda / Guo, Xiang / Baverel, Paul G. / González-García, Ignacio / Xie, James / Morsli, Nassim / Yovine, Alejandro / Roskos, Lorin K. et al. | 2021
-
Integrative evaluation of primary and metastatic lesion spectrum to guide anti-PD-L1 therapy of non-small cell lung cancer: results from two randomized studiesMa, Si-Cong / Tang, Xin-Ran / Long, Li-Li / Bai, Xue / Zhou, Jian-Guo / Duan, Zhi-Jiao / Wang, Jian / Fu, Qiang John / Zhu, Hong-Bo / Guo, Xue-Jun et al. | 2021
-
Vaccination with a nanoparticle E7 vaccine can prevent tumor recurrence following surgery in a human papillomavirus head and neck cancer modelDomingos-Pereira, Sonia / Roh, Vincent / Hiou-Feige, Agnès / Galliverti, Gabriele / Simon, Christian / Tolstonog, Genrich V. / Nardelli-Haefliger, Denise et al. | 2021
-
Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancerZhou, Lin / Xu, Bin / Liu, Yushan / Wang, Zhong et al. | 2021
-
The immune microenvironment and relation to outcome in patients with advanced breast cancer treated with docetaxel with or without gemcitabineStovgaard, Elisabeth S / Asleh, Karama / Riaz, Nazia / Leung, Samuel / Gao, Dongxia / Nielsen, Lise B / Lænkholm, Anne-Vibeke / Balslev, Eva / Jensen, Maj-Britt / Nielsen, Dorte et al. | 2021
-
Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapyLi, Xiaolei / Dai, Hanren / Wang, Hua et al. | 2021
-
The clinicopathological significance and predictive value for immunotherapy of programmed death ligand-1 expression in Epstein-Barr virus-associated gastric cancerWei, Xiao-Li / Liu, Qian-Wen / Liu, Fu-Rong / Yuan, Sha-Sha / Li, Xiao-Fen / Li, Jia-Ning / Yang, An-Li / Ling, Yi-Hong et al. | 2021
-
Pre-clinical development of a novel CD3-CD123 bispecific T-cell engager using cross-over dual-variable domain (CODV) format for acute myeloid leukemia (AML) treatmentBonnevaux, Hélène / Guerif, Stephane / Albrecht, Jana / Jouannot, Erwan / De Gallier, Thibaud / Beil, Christian / Lange, Christian / Leuschner, Wulf Dirk / Schneider, Marion / Lemoine, Cendrine et al. | 2021
-
Distinct microbial communities colonize tonsillar squamous cell carcinomaDe Martin, Angelina / Lütge, Mechthild / Stanossek, Yves / Engetschwiler, Céline / Cupovic, Jovana / Brown, Kirsty / Demmer, Izadora / Broglie, Martina A. / Geuking, Markus B. / Jochum, Wolfram et al. | 2021
-
Differential infection of murine and human dendritic cell subsets by oncolytic vesicular stomatitis virus variantsPipperger, Lisa / Riepler, Lydia / Kimpel, Janine / Siller, Anita / Stoitzner, Patrizia / Bánki, Zoltán / von Laer, Dorothee et al. | 2021
-
Characterization of immune landscape in papillary thyroid cancer reveals distinct tumor immunogenicity and implications for immunotherapySun, Jing / Shi, Run / Zhang, Xiaowen / Fang, Da / Rauch, Josefine / Lu, Shun / Wang, Xuanbin / Käsmann, Lukas / Ma, Jing / Belka, Claus et al. | 2021
-
In vivo trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpartMan, Francis / Koers, Alexander / Karagiannis, Panagiotis / Josephs, Debra H. / Bax, Heather J. / Gilbert, Amy E. / Dodev, Tihomir S. / Mele, Silvia / Chiaruttini, Giulia / Crescioli, Silvia et al. | 2021
-
“Suffocating” tumors by blocking adaptation to hypoxia: a new headway in melanoma immunotherapyJanji, Bassam / Chouaib, Salem et al. | 2021
-
An Open–Label, Randomized, Multi–Center Study Comparing the Sequence of High Dose Aldesleukin (Interleukin–2) and Ipilimumab (Yervoy) in Patients with Metastatic MelanomaHasanov, Merve / Milton, Denái R. / Sharfman, William H. / Taback, Bret / Cranmer, Lee D. / Daniels, Gregory A / Flaherty, Lawrence / Hallmeyer, Sigrun / Milhem, Mohammed / Feun, Lynn et al. | 2021
-
Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapyKonda, Prathyusha / Lifshits, Liubov M. / Roque, John A.III / Cole, Houston D. / Cameron, Colin G. / McFarland, Sherri A. / Gujar, Shashi et al. | 2021
-
Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapyBai, Peng / Li, Yongzheng / Zhou, Qiuping / Xia, Jiaqi / Wei, Peng-Cheng / Deng, Hexiang / Wu, Min / Chan, Sanny K. / Kappler, John W. / Zhou, Yu et al. | 2021
-
Anti-Ly6G binding and trafficking mediate positive neutrophil selection to unleash the anti-tumor efficacy of radiation therapyBoivin, Gaël / Ancey, Pierre-Benoit / Vuillefroy de Silly, Romain / Kalambaden, Pradeep / Contat, Caroline / Petit, Benoit / Ollivier, Jonathan / Bourhis, Jean / Meylan, Etienne / Vozenin, Marie-Catherine et al. | 2021
-
Galectin-3 inhibition with belapectin combined with anti-OX40 therapy reprograms the tumor microenvironment to favor anti-tumor immunitySturgill, Elizabeth R. / Rolig, Annah S. / Linch, Stefanie N. / Mick, Courtney / Kasiewicz, Melissa J. / Sun, Zhaoyu / Traber, Peter G. / Shlevin, Harold / Redmond, William L. et al. | 2021
-
Construction of PD1/CD28 chimeric-switch receptor enhances anti-tumor ability of c-Met CAR-T in gastric cancerChen, Cong / Gu, Yan-Mei / Zhang, Fan / Zhang, Zheng-Chao / Zhang, Ya-Ting / He, Yi-Di / Wang, Ling / Zhou, Ning / Tang, Fu-Tian / Liu, Hong-Jian et al. | 2021
-
An Efficient Prognostic Immune Scoring System For Colorectal Cancer Patients With Peritoneal MetastasisZhao, Yamei / Chen, Chao / Xu, Xiaoming / Ge, Xiaoxu / Ding, Kefeng / Zheng, Shu / Wang, Jian / Sun, Lifeng et al. | 2021
-
Safety, Tolerability, and Long-Term Clinical Outcomes of an IL-15 analogue (N-803) Admixed with Bacillus Calmette-Guérin (BCG) for the Treatment of Bladder CancerRosser, Charles J. / Tikhonenkov, Sergei / Nix, Jeffrey W. / Chan, Owen T.M. / Ianculescu, Irina / Reddy, Sandeep / Soon-Shiong, Patrick et al. | 2021
-
Cldn-7 deficiency promotes experimental colitis and associated carcinogenesis by regulating intestinal epithelial integrityWang, Kun / Ding, Yuhan / Xu, Chang / Hao, Mengdi / Li, Huimin / Ding, Lei et al. | 2021
-
Immune-checkpoint blockade of CTLA-4 (CD152) in antigen-specific human T-cell responses differs profoundly between neonates, children, and adultsArra, Aditya / Pech, Maximilian / Fu, Hang / Lingel, Holger / Braun, Franziska / Beyer, Christian / Spiliopoulou, Myra / Bröker, Barbara M. / Lampe, Karen / Arens, Christoph et al. | 2021
-
Autoantibody profiling of alveolar rhabdomyosarcoma patients unveils tumor-associated antigens with diagnostic and prognostic significancePoli, Elena / Cattelan, Manuela / Zanetti, Ilaria / Scagnellato, Angela / Giordano, Giuseppe / Zin, Angelica / Bisogno, Gianni / Bonvini, Paolo et al. | 2021
-
LTX-315-enabled, radiotherapy-boosted immunotherapeutic control of breast cancer by NK cellsYamazaki, Takahiro / Wennerberg, Erik / Hensler, Michal / Buqué, Aitziber / Kraynak, Jeffrey / Fucikova, Jitka / Zhou, Xi Kathy / Sveinbjørnsson, Baldur / Rekdal, Øystein / Demaria, Sandra et al. | 2021
-
Beneficial autoimmunity links primary biliary cholangitis to the avoidance of cholangiocarcinomaPol, Jonathan G. / Paillet, Juliette / Plantureux, Céleste / Kroemer, Guido et al. | 2021
-
PD-1 checkpoint blockade enhances adoptive immunotherapy by human Vγ2Vδ2 T cells against human prostate cancerNada, Mohanad H. / Wang, Hong / Hussein, Auter J. / Tanaka, Yoshimasa / Morita, Craig T. et al. | 2021
-
DNMT1 constrains IFNβ-mediated anti-tumor immunity and PD-L1 expression to reduce the efficacy of radiotherapy and immunotherapyHuang, Kevin Chih-Yang / Chiang, Shu-Fen / Ke, Tao-Wei / Chen, Tsung-Wei / Hu, Ching-Han / Yang, Pei-Chen / Chang, Hsin-Yu / Liang, Ji-An / Chen, William Tzu-Liang / Chao, K. S. Clifford et al. | 2021
-
Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in Braf-mutated melanomaWhite, Michael G. / Szczepaniak Sloane, Robert / Witt, Russell G. / Reuben, Alexandre / Gaudreau, Pierre Olivier / Andrews, Miles C. / Feng, Ningping / Johnson, Sarah / Class, Caleb A. / Bristow, Christopher et al. | 2021
-
Radiochemotherapy-induced elevations of plasma HMGB1 levels predict therapeutic responses in cancer patientsKroemer, Guido / Kepp, Oliver et al. | 2021
-
Gas plasma irradiation of breast cancers promotes immunogenicity, tumor reduction, and an abscopal effect in vivoMahdikia, Hamed / Saadati, Fariba / Freund, Eric / Gaipl, Udo S. / Majidzadeh-a, Keivan / Shokri, Babak / Bekeschus, Sander et al. | 2021
-
Targeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody productionQiu, Connie C. / Kotredes, Kevin P. / Cremers, Tess / Patel, Sajan / Afanassiev, Alexandra / Slifker, Michael / Gallucci, Stefania / Gamero, Ana M. et al. | 2021
-
M1-like TAMs are required for the efficacy of PD-L1/PD-1 blockades in gastric cancerZhao, Rui / Wan, Qianyi / Wang, Yong / Wu, Yutao / Xiao, Shuomeng / Li, Qiqi / Shen, Xiaoding / Zhuang, Wen / Zhou, Yong / Xia, Lin et al. | 2021
-
Quantitative analysis of CMTM6 expression in tumor microenvironment in metastatic melanoma and association with outcome on immunotherapyMartinez-Morilla, Sandra / Zugazagoitia, Jon / Wong, Pok Fai / Kluger, Harriet M. / Rimm, David L. et al. | 2021
-
Tumors exploit CXCR4hiCD62Llo aged neutrophils to facilitate metastatic spreadPeng, Zhenzi / Liu, Cuiwei / Victor, Aaron R. / Cao, Duo-Yao / Veiras, Luciana C. / Bernstein, Ellen A. / Khan, Zakir / Giani, Jorge F. / Cui, Xiaojiang / Bernstein, Kenneth E. et al. | 2021
-
Efficacy and safety of anti-PD-1/PD-L1 combinations versus standard of care in cancer: a systematic review and meta-analysis.Carretero-González, Alberto / Otero, Irene / Lora, David / Carril-Ajuria, Lucía / Castellano, Daniel / de Velasco, Guillermo et al. | 2021
-
BAFF receptor antibody for mantle cell lymphoma therapyZhang, Keman / Roy, Nand K / Vicioso, Yorleny / Woo, Janghee / Beck, Rose / de Lima, Marcos / Caimi, Paolo / Feinberg, Daniel / Parameswaran, Reshmi et al. | 2021
-
A phase 1 study of NY-ESO-1 vaccine + anti-CTLA4 antibody Ipilimumab (IPI) in patients with unresectable or metastatic melanomaSlingluff, Craig L. / Zarour, Hassane M. / Tawbi, Hussein Abdul-Hassan / Kirkwood, John M. / Postow, Michael A. / Friedlander, Philip / Devoe, Craig E. / Gaughan, Elizabeth M. / Mauldin, Ileana S. / Olson, Walter C. et al. | 2021
-
Tumor regression and immunity in combination therapy with anti-CEA chimeric antigen receptor T cells and anti-CEA-IL2 immunocytokineCha, Seung E. / Kujawski, Maciej / J. Yazaki, Paul / Brown, Christine / Shively, John E. et al. | 2021
-
A bacterium-derived, cancer-associated immunopeptidomePerreault, Claude / Thibault, Pierre / Kroemer, Guido et al. | 2021
-
DIMEimmune: Robust estimation of infiltrating lymphocytes in CNS tumors from DNA methylation profilesSafaei, Sepehr / Mohme, Malte / Niesen, Judith / Schüller, Ulrich / Bockmayr, Michael et al. | 2021
-
The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemiaEdilova, Maria I. / Law, Jaclyn C. / Zangiabadi, Safoura / Ting, Kenneth / Mbanwi, Achire N. / Arruda, Andrea / Uehling, David / Isaac, Methvin / Prakesch, Michael / Al-awar, Rima et al. | 2021
-
Novel BCMA-OR-CD38 tandem-dual chimeric antigen receptor T cells robustly control multiple myelomaFeng, Yaru / Liu, Xiuying / Li, Xiaorui / Zhou, Yating / Song, Zhiru / Zhang, Jing / Shi, Bingjie / Wang, Jianxun et al. | 2021
-
Peripheral blood and tissue assessment highlights differential tumor-circulatory gradients of IL2 and MIF with prognostic significance in resectable pancreatic ductal adenocarcinomaAhmed, Azaz / Köhler, Sophia / Klotz, Rosa / Giese, Nathalia / Lasitschka, Felix / Hackert, Thilo / Springfeld, Christoph / Zörnig, Inka / Jäger, Dirk / Halama, Niels et al. | 2021
-
CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturationReyes, Ryan M / Zhang, Chenghao / Deng, Yilun / Ji, Niannian / Mukherjee, Neelam / Padron, Alvaro S / Clark, Curtis A / Svatek, Robert S / Curiel, Tyler J et al. | 2021
-
Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patientsde Jonge, Kaat / Tillé, Laure / Lourenco, Joao / Maby-El Hajjami, Hélène / Nassiri, Sina / Racle, Julien / Gfeller, David / Delorenzi, Mauro / Verdeil, Grégory / Baumgaertner, Petra et al. | 2021
-
Prognostic and predictive significance of tumor infiltrating lymphocytes for ductal carcinoma in situXu, Fei-Fei / Zheng, Sai-Fang / Xu, Cheng / Cai, Gang / Wang, Shu-Bei / Qi, Wei-Xiang / Wang, Chao-Fu / Chen, Jia-Yi / Lu, Cao et al. | 2021
-
Irreversible electroporation ablation overcomes tumor-associated immunosuppression to improve the efficacy of DC vaccination in a mice model of pancreatic cancerYang, Jia / Eresen, Aydin / Shangguan, Junjie / Ma, Quanhong / Yaghmai, Vahid / Zhang, Zhuoli et al. | 2021
-
Phenotypic profiling and prognostic significance of immune infiltrates in esophageal squamous cell carcinomaPan, Chuqing / Wang, Yu / Liu, Qianwen / Hu, Yihuai / Fu, Jianhua / Xie, Xiuying / Zhang, Shuishen / Xi, Mian / Wen, Jing et al. | 2021
-
Synergistic anti-tumor efficacy of oncolytic influenza viruses and B7-H3 immune- checkpoint inhibitors against IC-resistant lung cancersMasemann, Dörthe / Meissner, Ramona / Schied, Tanja / Lichty, Brian D / Rapp, Ulf R / Wixler, Viktor / Ludwig, Stephan et al. | 2021
-
Expand to shield: IL-15 and in situ lymphocytic proliferationBindea, Gabriela / Mlecnik, Bernhard / Galon, Jérôme et al. | 2021
-
TIM-3 levels correlate with enhanced NK cell cytotoxicity and improved clinical outcome in AML patientsRakova, Jana / Truxova, Iva / Holicek, Peter / Salek, Cyril / Hensler, Michal / Kasikova, Lenka / Pasulka, Josef / Holubova, Monika / Kovar, Marek / Lysak, Daniel et al. | 2021
-
Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapiesN, Jacquelot / J, Tellier / Sl, Nutt / Gt, Belz et al. | 2021
-
PPARγ induces PD-L1 expression in MSS+ colorectal cancer cellsGutting, Tobias / Hauber, Veronika / Pahl, Jens / Klapproth, Kay / Wu, Wenyue / Dobrota, Ioana / Herweck, Frank / Reichling, Juliane / Helm, Laura / Schroeder, Torsten et al. | 2021
-
Investigating Mechanisms of Response or Resistance to Immune Checkpoint Inhibitors by Analyzing Cell-Cell Communications in Tumors Before and After Programmed Cell Death-1 (PD-1) Targeted Therapy: An Integrative Analysis Using Single-cell RNA and Bulk-RNA Sequencing DataJiang, Yi-Quan / Wang, Zi-Xian / Zhong, Ming / Shen, Lu-Jun / Han, Xue / Zou, Xuxiazi / Liu, Xin-Yi / Deng, Yi-Nan / Yang, Yang / Chen, Gui-Hua et al. | 2021
-
Combination immunotherapy with ipilimumab and nivolumab in patients with advanced adrenocortical carcinoma: a subgroup analysis of CA209-538Klein, Oliver / Senko, Clare / Carlino, Matteo S / Markman, Ben / Jackett, Louise / Gao, Bo / Lum, Caroline / Kee, Damien / Behren, Andreas / Palmer, Jodie et al. | 2021
-
PD-1 and LAG-3 blockade improve anti-tumor vaccine efficacyZahm, Christopher D. / Moseman, Jena E / Delmastro, Lauren E. / G. Mcneel, Douglas et al. | 2021
-
Low-dose CDK4/6 inhibitors induce presentation of pathway specific MHC ligands as potential targets for cancer immunotherapyCharles, Angel / Bourne, Christopher M. / Korontsvit, Tanya / Aretz, Zita E. H. / Mun, Sung Soo / Dao, Tao / Klatt, Martin G. / Scheinberg, David A. et al. | 2021
-
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancersTata, Angela / Dodard, Garvin / Fugère, Céline / Leget, Corinne / Ors, Mélody / Rossi, Benjamin / Vivier, Eric / Brossay, Laurent et al. | 2021
-
Type 2 innate lymphoid cells: a novel actor in anti-melanoma immunityJacquelot, Nicolas / Belz, Gabrielle T. et al. | 2021
-
Alternol triggers immunogenic cell death via reactive oxygen species generationLi, Changlin / Zhang, Ying / Yan, Siyuan / Zhang, Guoan / Wei, Wei / Qi, Zhi / Li, Benyi et al. | 2021
-
Identification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancerSong, Wei / Ren, Jun / Xiang, Rensheng / Kong, Can / Fu, Tao et al. | 2021
-
Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent mannerXia, Wenjiao / Qi, Xin / Li, Mingfeng / Wu, Yu / Sun, Lulu / Fan, Xinglong / Yuan, Yuan / Li, Jing et al. | 2021
-
Combined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastomaShirinbak, Soheila / Chan, Randall Y. / Shahani, Shilpa / Muthugounder, Sakunthala / Kennedy, Rebekah / Hung, Long T. / Fernandez, G. Esteban / Hadjidaniel, Michael D. / Moghimi, Babak / Sheard, Michael A. et al. | 2021
-
Ferroptosis becomes immunogenic: implications for anticancer treatmentsTang, Daolin / Kepp, Oliver / Kroemer, Guido et al. | 2021
-
An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapyBernardo, Marie / Tolstykh, Tatiana / Zhang, Yu-an / Bangari, Dinesh S. / Cao, Hui / Heyl, Kerstin A. / Lee, Joon Sang / Malkova, Natalia V. / Malley, Katie / Marquez, Eladio et al. | 2021
-
Double-edged effects of interferons on the regulation of cancer-immunity cycleZhang, Xiao / Wang, Song / Zhu, Yuanyuan / Zhang, Minghui / Zhao, Yan / Yan, Zhengbin / Wang, Qiuxu / Li, Xiaobo et al. | 2021
-
Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patientsPaijens, S. T. / Vledder, A. / Loiero, D. / Duiker, E. W. / Bart, J. / Hendriks, A. M. / Jalving, M. / Workel, H. H. / Hollema, H. / Werner, N. et al. | 2021
-
Combined STING levels and CD103+ T cell infiltration have significant prognostic implications for patients with cervical cancerKol, Arjan / Lubbers, Joyce M. / Terwindt, Anouk L.J. / Workel, Hagma H. / Plat, Annechien / Wisman, G. Bea A. / Bart, Joost / Nijman, Hans W. / De Bruyn, Marco et al. | 2021
-
Integrated analyses of m1A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancerGao, Yuzhen / Wang, Hao / Li, Huiming / Ye, Xinxin / Xia, Yan / Yuan, Shijin / Lu, Jie / Xie, Xinyou / Wang, Liangjing / Zhang, Jun et al. | 2021
-
Impact of cancer cachexia on the therapeutic outcome of combined chemoimmunotherapy in patients with non-small cell lung cancer: a retrospective studyMorimoto, Kenji / Uchino, Junji / Yokoi, Takashi / Kijima, Takashi / Goto, Yasuhiro / Nakao, Akira / Hibino, Makoto / Takeda, Takayuki / Yamaguchi, Hiroyuki / Takumi, Chieko et al. | 2021
-
Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancersJoseph, Adrien / Pan, Juncheng / Michels, Judith / Kroemer, Guido / Castedo, Maria et al. | 2021
-
Comprehensive analyses reveal TKI-induced remodeling of the tumor immune microenvironment in EGFR/ALK-positive non-small-cell lung cancerFang, Yisheng / Wang, Yuanyuan / Zeng, Dongqiang / Zhi, Shimeng / Shu, Tingting / Huang, Na / Zheng, Siting / Wu, Jianhua / Liu, Yantan / Huang, Genjie et al. | 2021
-
In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionalityBonte, Sarah / de Munter, Stijn / Billiet, Lore / Goetgeluk, Glenn / Ingels, Joline / Jansen, Hanne / Pille, Melissa / de Cock, Laurenz / Weening, Karin / Taghon, Tom et al. | 2021
-
Association of PIK3CA mutation and PTEN loss with expression of CD274 (PD-L1) in colorectal carcinomaUgai, Tomotaka / Zhao, Melissa / Shimizu, Takashi / Akimoto, Naohiko / Shi, Shanshan / Takashima, Yasutoshi / Zhong, Rong / Lau, Mai Chan / Haruki, Koichiro / Arima, Kota et al. | 2021
-
Durvalumab after concurrent chemotherapy and high-dose radiotherapy for locally advanced non-small cell lung cancerLandman, Yosef / Jacobi, Oded / Kurman, Noga / Yariv, Orly / Peretz, Idit / Rotem, Ofer / Dudnik, Elizabeth / Zer, Alona / Allen, Aaron M. et al. | 2021
-
IFN-γ-induced ER stress impairs autophagy and triggers apoptosis in lung cancer cellsFang, Can / Weng, Tao / Hu, Shaojie / Yuan, Zhiwei / Xiong, Hui / Huang, Bing / Cai, Yixin / Li, Lequn / Fu, Xiangning et al. | 2021
-
YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non–small-cell lung cancerTsuchiya, Kazuo / Yoshimura, Katsuhiro / Inoue, Yusuke / Iwashita, Yuji / Yamada, Hidetaka / Kawase, Akikazu / Watanabe, Takuya / Tanahashi, Masayuki / Ogawa, Hiroshi / Funai, Kazuhito et al. | 2021
-
Prognostic significance of OX40+ lymphocytes in tumor stroma of surgically resected small-cell lung cancerYokouchi, Hiroshi / Nishihara, Hiroshi / Harada, Toshiyuki / Amano, Toraji / Ohkuri, Takayuki / Yamazaki, Shigeo / Kikuchi, Hajime / Oizumi, Satoshi / Uramoto, Hidetaka / Tanaka, Fumihiro et al. | 2021
-
Single-cell profiling of infiltrating B cells and tertiary lymphoid structures in the TME of gastric adenocarcinomasJia, Lizhou / Wang, Tengqi / Zhao, Youcai / Zhang, Shuyu / Ba, Teer / Kuai, Xingwang / Wang, Bin / Zhang, Ning / Zhao, Wei / Yang, Zhiping et al. | 2021
-
Fn14-targeted BiTE and CAR-T cells demonstrate potent preclinical activity against glioblastomaLi, Gaowei / Zhang, Zongliang / Cai, Linjun / Tang, Xin / Huang, Jianhan / Yu, Lingyu / Wang, Guoqing / Zhong, Kunhong / Cao, Yi / Liu, Chang et al. | 2021
-
Universal extracellular vesicles and PD-L1+ extracellular vesicles detected by single molecule array technology as circulating biomarkers for diffuse large B cell lymphomaLi, Ji-Wei / Shi, Di / Wan, Xiao-Chun / Hu, Jue / Su, Yi-Fan / Zeng, Yu-Peng / Hu, Zi-Juan / Yu, Bao-Hua / Zhang, Qun-Ling / Wei, Ping et al. | 2021
-
Manufacturing T cells in hollow fiber membrane bioreactors changes their programming and enhances their potencyYoo, Seung Mi / Lau, Vivan W.C. / Aarts, Craig / Bojovic, Bojana / Steinberg, Gregory / Hammill, Joanne A. / Dvorkin-Gheva, Anna / Ghosh, Raja / Bramson, Jonathan L. et al. | 2021
-
Tumor cell-derived IL-10 promotes cell-autonomous growth and immune escape in diffuse large B-cell lymphomaStirm, Kristin / Leary, Peter / Bertram, Katrin / Núñez, Nicolás Gonzalo / Wüst, Daria / Boudesco, Christophe / Verhoeyen, Els / Zenz, Thorsten / Becher, Burkhard / Menter, Thomas et al. | 2021
-
A major genetic accelerator of cancer diagnosis: rs867228 in FPR1Sztupinszki, Zsofia / Le Naour, Julie / Vacchelli, Erika / Laurent-Puig, Pierre / Delaloge, Suzette / Szallasi, Zoltan / Kroemer, Guido et al. | 2021
-
A stratified phase I dose escalation trial of hypofractionated radiotherapy followed by ipilimumab in metastatic melanoma: long-term follow-up and final outcomesMaity, Amit / Mick, Rosemarie / Rengan, Ramesh / Mitchell, Tara C. / Amaravadi, Ravi K. / Schuchter, Lynn M. / Pryma, Daniel A. / Patsch, Dana M. / Maity, Alisha P. / Minn, Andy J. et al. | 2021
-
Increase of α-dicarbonyls in liver and receptor for advanced glycation end products on immune cells are linked to nonalcoholic fatty liver disease and liver cancerPetriv, Nataliia / Neubert, Lavinia / Vatashchuk, Myroslava / Timrott, Kai / Suo, Huizhen / Hochnadel, Inga / Huber, René / Petzold, Christina / Hrushchenko, Anastasiia / Yatsenko, Andriy S. et al. | 2021
-
A multicenter characterization of hepatitis associated with immune checkpoint inhibitorsPatrinely, J. RandallJr. / McGuigan, Ben / Chandra, Sunandana / Fenton, Sarah E. / Chowdhary, Akansha / Kennedy, Lucy B. / Mooradian, Meghan J. / Palmeri, Marisa / Portal, Daniella / Horst, Sara N. et al. | 2021
-
Tumor-intrinsic determinants of immunogenic cell death modalitiesWorkenhe, Samuel T / Pol, Jonathan / Kroemer, Guido et al. | 2021
-
Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cellsWang, Yun / Cui, Long / Georgiev, Peter / Singh, Latika / Zheng, Yanyan / Yu, Ying / Grein, Jeff / Zhang, Chunsheng / Muise, Eric S. / Sloman, David L. et al. | 2021
-
Re-polarization of immunosuppressive macrophages to tumor-cytotoxic macrophages by repurposed metabolic drugsOyarce, Cesar / Vizcaino-Castro, Ana / Chen, Shipeng / Boerma, Annemarie / Daemen, Toos et al. | 2021
-
Crystal structure of human interleukin-2 in complex with TCB2, a new antibody-drug candidate with antitumor activityKim, Jieun / Lee, Jun-Young / Park, Suk-Youl / Lee, You Jeong / Kim, Min-Sung et al. | 2021
-
Integrative analysis identifies an immune-relevant epigenetic signature for prognostication of non-G-CIMP glioblastomasYin, Anan / Shang, Zhende / Etcheverry, Amandine / He, Yalong / Aubry, Marc / Lu, Nan / Liu, Yuhe / Mosser, Jean / Lin, Wei / Zhang, Xiang et al. | 2021
-
CD80 expression is upregulated by TP53 activation in human cancer epithelial cellsScarpa, Melania / Marchiori, Chiara / Scarpa, Marco / Castagliuolo, Ignazio et al. | 2021
-
Identification and characterization of B220+/B220− subpopulations in murine Gr1+CD11b+ cells during tumorigenesisZhang, Zhiqian / Huang, Xu / Wang, Enlin / Huang, Yugang / Yang, Rongcun et al. | 2021
-
T cells, B cells, and PD-L1 expression in esophageal and gastric adenocarcinoma before and after neoadjuvant chemotherapy: relationship with histopathological response and survivalChristina Svensson, Maria / Lindén, Albin / Nygaard, Jakob / Borg, David / Hedner, Charlotta / Nodin, Björn / Leandersson, Karin / Jirström, Karin et al. | 2021
-
Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitorsBertucci, François / Boudin, Laurys / Finetti, Pascal / Van Berckelaer, Christophe / Van Dam, Peter / Dirix, Luc / Viens, Patrice / Gonçalves, Anthony / Ueno, Naoto T. / Van Laere, Steven et al. | 2021
-
Priming of pancreatic cancer cells with bispecific antibody armed activated T cells sensitizes tumors for enhanced chemoresponsivenessThakur, Archana / Ung, Johnson / Tomaszewski, Elyse N. / Schienschang, Amy / LaBrie, Timothy M. / Schalk, Dana L. / Lum, Lawrence G. et al. | 2021
-
Phased differentiation of γδ T and T CD8 tumor-infiltrating lymphocytes revealed by single-cell transcriptomics of human cancersCerapio, Juan-Pablo / Perrier, Marion / Balança, Camille-Charlotte / Gravelle, Pauline / Pont, Fréderic / Devaud, Christel / Franchini, Don-Marc / Féliu, Virginie / Tosolini, Marie / Valle, Carine et al. | 2021
-
Early changes in the immune microenvironment of oral potentially malignant disorders reveal an unexpected association of M2 macrophages with oral cancer free survivalBouaoud, Jebrane / Foy, Jean-Philippe / Tortereau, Antonin / Michon, Lucas / Lavergne, Vincent / Gadot, Nicolas / Boyault, Sandrine / Valantin, Julie / De Souza, Geneviève / Zrounba, Philippe et al. | 2021
-
Modeling ex vivo tumor-infiltrating lymphocyte expansion from established solid malignanciesKnochelmann, Hannah M / Rivera-Reyes, Amalia M / Wyatt, Megan M / Smith, Aubrey S / Chamness, Reilley / Dwyer, Connor J / Bobian, Michael / Rangel Rivera, Guillermo O / Horton, Joshua D / Lilly, Michael et al. | 2021
-
Clonal dynamics of tumor-infiltrating T-cell receptor beta-chain repertoires in the peripheral blood in response to concurrent chemoradiotherapy for Epstein–Barr virus-associated nasopharyngeal carcinomaChung, Yih-Lin / Wu, Mei-Ling et al. | 2021
-
Immunoseroproteomic profiling in autoantibody to ENO1 as potential biomarker in immunodiagnosis of osteosarcoma by serological proteome analysis (SERPA) approachLi, Jitian / Dai, Liping / Huang, Manyu / Ma, Yan / Guo, Zhiping / Wang, Xiao / Li, Wuyin / Zhang, Jian-Ying et al. | 2021
-
Stromal infiltrating mast cells identify immunoevasive subtype high-grade serous ovarian cancer with poor prognosis and inferior immunotherapeutic responseCao, Kankan / Zhang, Guodong / Zhang, Xiangyun / Yang, Moran / Wang, Yiying / He, Mengdi / Lu, Jiaqi / Liu, Haiou et al. | 2021
-
Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneityCorreia, Margareta P. / Stojanovic, Ana / Wels, Winfried S. / Cerwenka, Adelheid et al. | 2021
-
Spatial heterogeneity of immune infiltration predicts the prognosis of nasopharyngeal carcinoma patientsWang, Ya-Qin / Liu, Xu / Xu, Cheng / Jiang, Wei / Xu, Shuo-Yu / Zhang, Yu / Liang, Ye Lin / Li, Jun-Yan / Li, Qian / Chen, Yu-Pei et al. | 2021
-
Trial watch: intratumoral immunotherapyHumeau, Juliette / Le Naour, Julie / Galluzzi, Lorenzo / Kroemer, Guido / Pol, Jonathan G. et al. | 2021
-
Small cell lung cancer responds to immunogenic chemotherapy followed by PD-1 blockadeKroemer, Guido / Kepp, Oliver et al. | 2021
-
CS1-specific single-domain antibodies labeled with Actinium-225 prolong survival and increase CD8+ T cells and PD-L1 expression in Multiple MyelomaDe Veirman, Kim / Puttemans, Janik / Krasniqi, Ahmet / Ertveldt, Thomas / Hanssens, Heleen / Romao, Ema / Hose, Dirk / Goyvaert, Cleo / Vlummens, Philip / Muyldermans, Serge et al. | 2021
-
PD-1 blockade improves the anti-tumor potency of exhausted CD3+CD56+ NKT-like cells in patients with primary hepatocellular carcinomaTao, Longxiang / Wang, Shanshan / Kang, Guijie / Jiang, Shanyue / Yin, Wenwei / Zong, Lu / Li, Jing / Wang, Xuefu et al. | 2021
-
Deep learning model enables the discovery of a novel immunotherapeutic agent regulating the kynurenine pathwayKim, Jeong Hun / Lee, Won Suk / Lee, Hye Jin / Yang, Hannah / Lee, Seung Joon / Kong, So Jung / Je, Soyeon / Yang, Hyun-Jin / Jung, Jongsun / Cheon, Jaekyung et al. | 2021
-
Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patientsReina-Ortiz, Chantal / Constantinides, Michael / Fayd-Herbe-de-Maudave, Alexis / Présumey, Jessy / Hernandez, Javier / Cartron, Guillaume / Giraldos, David / Díez, Rosana / Izquierdo, Isabel / Azaceta, Gemma et al. | 2021
-
Peripheral T cell receptor repertoire features predict durable responses to anti-PD-1 inhibitor monotherapy in advanced renal cell carcinomaKato, Taigo / Kiyotani, Kazuma / Tomiyama, Eisuke / Koh, Yoko / Matsushita, Makoto / Hayashi, Yujiro / Nakano, Kosuke / Ishizuya, Yu / Wang, Cong / Hatano, Koji et al. | 2021
-
Atezolizumab prolongs overall survival over docetaxel in advanced non-small-cell lung cancer patients harboring STK11 or KEAP1 mutationNie, Wei / Gan, Lu / Wang, Xin / Gu, Kai / Qian, Fang-Fei / Hu, Min-Juan / Zhang, Ding / Chen, Shi-Qing / Lu, Jun / Cao, Shu-Hui et al. | 2021
-
Prognostic value of the baseline circulating T cell receptor β chain diversity in advanced lung cancerWang, Jiaqi / Bie, Zhixin / Zhang, Yajing / Li, Lin / Zhu, Yujie / Zhang, Yi / Nie, Xin / Zhang, Ping / Cheng, Gang / Di, Xuebing et al. | 2021
-
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacyYuan, Qingyun / Liang, Qiaoyan / Sun, Zujun / Yuan, Xingxing / Hou, Weihua / Wang, Yuxiong / Wang, Huijie / Yu, Min et al. | 2021
-
Tumor spread or siege immunity: dissemination to distant metastasis or notBindea, Gabriela / Mlecnik, Bernhard / Galon, Jérôme et al. | 2021
-
Inhibition of RANK signaling as a potential immunotherapy in breast cancerGómez-Aleza, C / González-Suárez, E et al. | 2021
-
An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1)Chiang, Shu-Fen / Huang, Kevin Chih-Yang / Chen, William Tzu-Liang / Chen, Tsung-Wei / Ke, Tao-Wei / Chao, K. S. Clifford et al. | 2021
-
A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1Shah, Diana / Comba, Andrea / Faisal, Syed M. / Kadiyala, Padma / Baker, Gregory J. / Alghamri, Mahmoud S. / Doherty, Robert / Zamler, Daniel / Nuñez, Gabriel / Castro, Maria G. et al. | 2021
-
T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancerO’Connor, Richard A / Chauhan, Vishwani / Mathieson, Layla / Titmarsh, Helen / Koppensteiner, Lilian / Young, Irene / Tagliavini, Giulia / Dorward, David A / Prost, Sandrine / Dhaliwal, Kevin et al. | 2021
-
A therapeutic DNA vaccine and gemcitabine act synergistically to eradicate HPV-associated tumors in a preclinical modelRamos da Silva, Jamile / Ramos Moreno, Ana Carolina / Silva Sales, Natiely / de Oliveira Silva, Mariângela / Aps, Luana R. M. M. / Porchia, Bruna F.M.M. / Bitencourt Rodrigues, Karine / Cestari Moreno, Natália / Venceslau-Carvalho, Aléxia Adrianne / Menck, Carlos Frederico M. et al. | 2021
-
Pre-treatment tumor-infiltrating T cells influence response to neoadjuvant chemoradiotherapy in esophageal adenocarcinomaGoedegebuure, R.S.A. / Harrasser, M. / de Klerk, L.K. / van Schooten, T.S. / van Grieken, N.C.T. / Eken, M. / Grifhorst, M.S. / Pocorni, N. / Jordanova, E.S. / van Berge Henegouwen, M.I. et al. | 2021
-
Prognostic value of Thyroid Transcription Factor-1 expression in lung adenocarcinoma in patients treated with anti PD-1/PD-L1Galland, Loïck / Le Page, Anne Laure / Lecuelle, Julie / Bibeau, Frederic / Oulkhouir, Youssef / Derangère, Valentin / Truntzer, Caroline / Ghiringhelli, François et al. | 2021
-
Avelumab internalization by human circulating immune cells is mediated by both Fc gamma receptor and PD-L1 bindingJin, Hulin / D'Urso, Vittorio / Neuteboom, Berend / McKenna, Sean D. / Schweickhardt, Rene / Gross, Alec W. / Fomekong Nanfack, Yves / Paoletti, Andrea / Carter, Carina / Toleikis, Lars et al. | 2021
-
Antitumor activity of the third generation EphA2 CAR-T cells against glioblastoma is associated with interferon gamma induced PD-L1an, Zhijing / Hu, Yi / Bai, Yue / Zhang, Can / Xu, Chang / Kang, Xun / Yang, Shoubo / Li, Wenbin / Zhong, Xiaosong et al. | 2021
-
Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancerKienzl, Melanie / Hasenoehrl, Carina / Maitz, Kathrin / Sarsembayeva, Arailym / Taschler, Ulrike / Valadez-Cosmes, Paulina / Kindler, Oliver / Ristic, Dusica / Raftopoulou, Sofia / Santiso, Ana et al. | 2021
-
Downregulating testosterone levels enhance immunotherapy efficiencyWang, Luoyang / Jiang, Guoqiang / Jing, Nan / Liu, Xuerun / Zhuang, Huiren / Zeng, Wenfeng / Liang, Wei / Liu, Zheng et al. | 2021
-
Improving cancer immunotherapy by targeting IL-1Xiao, Zhilan / Singh, Shubhra / Singh, Manisha et al. | 2021
-
Anti-NKG2D single domain-based antibodies for the modulation of anti-tumor immune responseRaynaud, Adeline / Desrumeaux, Klervi / Vidard, Laurent / Termine, Elise / Baty, Daniel / Chames, Patrick / Vigne, Emmanuelle / Kerfelec, Brigitte et al. | 2021
-
Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosisNaicker, Serika D / Feerick, Claire L / Lynch, Kevin / Swan, Dawn / McEllistrim, Cian / Henderson, Robert / Leonard, Niamh A / Treacy, Oliver / Natoni, Alessandro / Rigalou, Athina et al. | 2021
-
Infliximab for the treatment of patients with checkpoint inhibitor associated acute tubular interstitial nephritisLin, Jamie S. / Mamlouk, Omar / Selamet, Umut / Tchakarov, Amanda / Glass, William F. / Sheth, Rahul A. / Layman, Rachel M. / Dadu, Ramona / Abdel-Wahab, Noha / Abdelrahim, Maen et al. | 2021
-
Exosome-mediated communication between tumor cells and tumor-associated macrophages: implications for tumor microenvironmentHan, Chen / Zhang, Cong / Wang, Hengxiao / Zhao, Lianmei et al. | 2021
-
Bromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemiaBaragaño Raneros, Aroa / Rodriguez, Ramon M / Bernardo Flórez, Aida / Palomo, Pilar / Colado, Enrique / Minguela, Alfredo / Suarez-Alvarez, Beatriz / López-Larrea, Carlos et al. | 2021
-
License to kill: microsatellite instability and immune contextureMaby, Pauline / Bindea, Gabriela / Mlecnik, Bernhard / Galon, Jérôme et al. | 2021
-
Evasion before invasion: Pre-cancer immunosurveillanceAngelova, Mihaela / Mascaux, Céline / Galon, Jérôme et al. | 2021
-
Incidence, predictors, and survival impact of acute kidney injury in patients with melanoma treated with immune checkpoint inhibitors: a 10-year single-institution analysisAbdelrahim, Maen / Mamlouk, Omar / Lin, Heather / Lin, Jamie / Page, Valda / Abdel-Wahab, Noha / Swan, Joshua / Selamet, Umut / Yee, Cassian / Diab, Adi et al. | 2021
-
Generation of neoantigen-specific T cells for adoptive cell transfer for treating head and neck squamous cell carcinomaWei, Teng / Leisegang, Matthias / Xia, Ming / Kiyotani, Kazuma / Li, Ning / Zeng, Chenquan / Deng, Chunyan / Jiang, Jinxing / Harada, Makiko / Agrawal, Nishant et al. | 2021
-
Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cellsFan, Dandan / Yue, Qi / Chen, Jian / Wang, Cong / Yu, Ruilin / Jin, Ziyi / Yin, Shujie / Wang, Qinyue / Chen, Luo / Liao, Xueling et al. | 2021
-
Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AMLBrauneck, F. / Haag, F / Woost, R. / Wildner, N. / Tolosa, E. / Rissiek, A. / Vohwinkel, G. / Wellbrock, J. / Bokemeyer, C. / Schulze zur Wiesch, J. et al. | 2021
-
Cisplatin inhibits frequency and suppressive activity of monocytic myeloid-derived suppressor cells in cancer patientsVan Wigcheren, Glenn F. / De Haas, Nienke / Mulder, Tom A. / Horrevorts, Sophie K. / Bloemendal, Martine / Hins-Debree, Simone / Mao, Yumeng / Kiessling, Rolf / van Herpen, Carla M.L. / Flórez-Grau, Georgina et al. | 2021
-
Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumorsDillard, Pierre / Casey, Nicholas / Pollmann, Sylvie / Vernhoff, Patrik / Gaudernack, Gustav / Kvalheim, Gunnar / Wälchli, Sébastien / Inderberg, Else Marit et al. | 2021
-
YKT6, as a potential predictor of prognosis and immunotherapy response for oral squamous cell carcinoma, is related to cell invasion, metastasis, and CD8+ T cell infiltrationYang, Zongcheng / Yan, Guangxing / Zheng, Lixin / Gu, Wenchao / Liu, Fen / Chen, Wei / Cui, Xiujie / Wang, Yue / Yang, Yaling / Chen, Xiyan et al. | 2021
-
Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancersChang, Kwang-Yu / Chiang, Nai-Jung / Wu, Shang-Yin / Yen, Chia-Jui / Chen, Shang-Hung / Yeh, Yu-Min / Li, Chien-Feng / Feng, Xiaoxing / Wu, Katherine / Johnston, Amanda et al. | 2021
-
Evaluation of switch-mediated costimulation in trans on universal CAR-T cells (UniCAR) targeting CD123-positive AMLMeyer, Jan-Erik / Loff, Simon / Dietrich, Josephine / Spehr, Johannes / Jurado Jiménez, Gabriel / von Bonin, Malte / Ehninger, Gerhard / Cartellieri, Marc / Ehninger, Armin et al. | 2021
-
PD-L2 based immune signature confers poor prognosis in HNSCCQiao, Yu / Liu, Chao / Zhang, Xiaoyue / Zhou, Qianqian / Li, Yatian / Xu, Yini / Gao, Zhenyue / Xu, Yiqi / Kong, Lingping / Yang, Aifeng et al. | 2021
-
Combination checkpoint therapy with anti-PD-1 and anti-BTLA results in a synergistic therapeutic effect against murine glioblastomaChoi, John / Medikonda, Ravi / Saleh, Laura / Kim, Timothy / Pant, Ayush / Srivastava, Siddhartha / Kim, Young-Hoon / Jackson, Christina / Tong, Luqing / Routkevitch, Denis et al. | 2021
-
Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinomaSosnowska, Anna / Chlebowska-Tuz, Justyna / Matryba, Pawel / Pilch, Zofia / Greig, Alan / Wolny, Artur / Grzywa, Tomasz M. / Rydzynska, Zuzanna / Sokolowska, Olga / Rygiel, Tomasz P. et al. | 2021
-
Molecular subtypes based on ferroptosis-related genes and tumor microenvironment infiltration characterization in lung adenocarcinomaZhang, Weiju / Yao, Sumei / Huang, Hua / Zhou, Hao / Zhou, Haomiao / Wei, Qishuang / Bian, Tingting / Sun, Hui / Li, Xiaoli / Zhang, Jianguo et al. | 2021
-
Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancerFirmino, Natalie S / Cederberg, Rachel A / Lee, Che-Min / Shi, Rocky / Wadsworth, Brennan J / Franks, S Elizabeth / Thomas, Kiersten N / Decotret, Lisa R / Bennewith, Kevin L et al. | 2021
-
PD-1 inhibition in patient derived tissue cultures of human gastric and gastroesophageal adenocarcinomaHußtegge, Marlon / Hoang, Ngoc Anh / Rebstock, Jakob / Monecke, Astrid / Gockel, Ines / Weimann, Arved / Schumacher, Guido / Bechmann, Ingo / Lordick, Florian / Kallendrusch, Sonja et al. | 2021
-
Hsp70 modulates immune response in pancreatic cancer through dendritic cellsGiri, Bhuwan / Sharma, Prateek / Jain, Tejeshwar / Ferrantella, Anthony / Vaish, Utpreksha / Mehra, Siddharth / Garg, Bharti / Iyer, Srikanth / Sethi, Vrishketan / Malchiodi, Zoe et al. | 2021
-
Chronic stress promotes breast carcinoma metastasis by accumulating myeloid-derived suppressor cells through activating β-adrenergic signalingan, Jiale / Feng, Lifeng / Ren, Jiling / Li, Yafei / Li, Guangru / Liu, Chang / Yao, Yong / Yao, Ye / Jiang, Zecheng / Gao, Yang et al. | 2021
-
Immunological alternation in COVID-19 patients with cancer and its implications on mortalityCai, Guangyao / Gao, Yue / Zeng, Shaoqing / Yu, Yang / Liu, Xingyu / Liu, Dan / Wang, Ya / Yu, Ruidi / Desai, Aakash / Li, Chunrui et al. | 2021
-
Advances in identification and selection of personalized neoantigen/T-cell pairs for autologous adoptive T cell therapiesKast, Florian / Klein, Christian / Umaña, Pablo / Gros, Alena / Gasser, Stephan et al. | 2021
-
Enhancement of antibody-dependent cellular cytotoxicity is associated with treatment response to extracorporeal photopheresis in Sézary syndromeIselin, Christoph / Chang, Yun-Tsan / Schlaepfer, Tanja / Fassnacht, Christina / Dimitriou, Florentia / Nägeli, Mirjam / Pascolo, Steve / Hoetzenecker, Wolfram / Bobrowicz, Malgorzata / Guenova, Emmanuella et al. | 2021
-
Addition of anti-TIM3 or anti-TIGIT Antibodies to anti-PD1 Blockade Augments Human T cell Adoptive Cell TransferMartinez, Marina / Kim, Soyeon / St. Jean, Naomi / O’Brien, Shaun / Lian, Lurong / Sun, Jing / Verona, Raluca I. / Moon, Edmund et al. | 2021
-
B-cell clusters at the invasive margin associate with longer survival in early-stage oral-tongue cancer patientsPhanthunane, C. / Wijers, R. / de Herdt, M. / Langeveld, T.P.M. / Koljenovic, S. / Dasgupta, S. / Sleijfer, S. / Baatenburg de Jong, R. J. / Hardillo, J. / Balcioglu, H. E. et al. | 2021
-
Improved survival without increased toxicity with influenza vaccination in cancer patients treated with checkpoint inhibitorsValachis, Antonios / Rosén, Camilla / Koliadi, Anthoula / Digkas, Evangelos / Gustavsson, Alice / Nearchou, Andreas / Ullenhag, Gustav J et al. | 2021
-
VISTA and PD-L1 synergistically predict poor prognosis in patients with extranodal natural killer/T-cell lymphomaHe, Hai-Xia / Gao, Yan / Fu, Jian-Chang / Zhou, Qiang-Hua / Wang, Xiao-Xiao / Bai, Bing / Li, Peng-Fei / Huang, Cheng / Rong, Qi-Xiang / Ping, Li-Qin et al. | 2021
-
Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanomaZhang, Xin-Wen / Huck, Katrin / Jähne, Kristine / Cichon, Frederik / Sonner, Jana K. / Ufer, Friederike / Bauer, Simone / Woo, Marcel Seungsu / Green, Ed / Lu, Kevin et al. | 2021
-
TIGIT+ TIM-3+ NK cells are correlated with NK cell exhaustion and disease progression in patients with hepatitis B virus‑related hepatocellular carcinomaYu, Lihua / Liu, Xiaoli / Wang, Xinhui / Yan, Fengna / Wang, Peng / Jiang, Yuyong / Du, Juan / Yang, Zhiyun et al. | 2021
-
An immune-based risk-stratification system for predicting prognosis in pulmonary sarcomatoid carcinoma (PSC)Guo, Haoyue / Li, Binglei / Diao, Li / Wang, Hao / Chen, Peixin / Jiang, Minlin / Zhao, Lishu / He, Yayi / Zhou, Caicun et al. | 2021
-
Addition of camrelizumab to docetaxel, cisplatin, and radiation therapy in patients with locally advanced esophageal squamous cell carcinoma: a phase 1b studyZhang, Wencheng / Yan, Cihui / Zhang, Tian / Chen, Xi / Dong, Jie / Zhao, Jingjing / Han, Dong / Wang, Jun / Zhao, Gang / Cao, Fuliang et al. | 2021
-
Tumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity?Hassan Venkatesh, Goutham / Abou Khouzam, Raefa / Shaaban Moustafa Elsayed, Walid / Ahmed Zeinelabdin, Nagwa / Terry, Stéphane / Chouaib, Salem et al. | 2021
-
Blood microbiota diversity determines response of advanced colorectal cancer to chemotherapy combined with adoptive T cell immunotherapyYang, Duo / Wang, Xiaoli / Zhou, Xinna / Zhao, Jing / Yang, Huabing / Wang, Shuo / Morse, Michael A. / Wu, Jiangping / Yuan, Yanhua / Li, Sha et al. | 2021
-
Phase 2 trial of neoadjuvant toripalimab with chemotherapy for resectable stage III non-small-cell lung cancerZhao, Ze-Rui / Yang, Chao-Pin / Chen, Si / Yu, Hui / Lin, Yong-Bin / Lin, Yao-Bin / Qi, Han / Jin, Jie-Tian / Lian, Shan-Shan / Wang, Yi-Zhi et al. | 2021
-
Cancer-specific type-I interferon receptor signaling promotes cancer stemness and effector CD8+ T-cell exhaustionGong, Wang / Donnelly, Christopher R. / Heath, Blake R. / Bellile, Emily / Donnelly, Lorenza A. / Taner, Hülya F. / Broses, Luke / Brenner, J. Chad / Chinn, Steven B. / Ji, Ru-Rong et al. | 2021
-
Unifying heterogeneous expression data to predict targets for CAR-T cell therapySchreiner, Patrick / Velasquez, Mireya Paulina / Gottschalk, Stephen / Zhang, Jinghui / Fan, Yiping et al. | 2021
-
BDNF expression in GISTs predicts poor prognosis when associated with PD-L1 positive tumor-infiltrating lymphocytesTian, Guang-Ang / Xu, Wen-Ting / Sun, Yue / Wang, Jin / Ke, Qing / Yuan, Meng-Jiao / Wang, Jin-Jin / Zhuang, Chun / Gong, Qian et al. | 2021
-
Novel adapter CAR-T cell technology for precisely controllable multiplex cancer targetingSeitz, Christian M. / Mittelstaet, Joerg / Atar, Daniel / Hau, Jana / Reiter, Selina / Illi, Clara / Kieble, Verena / Engert, Fabian / Drees, Britta / Bender, Giulia et al. | 2021