Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients (Unknown)
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In:
OncoImmunology
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11
, 1
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2022
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients
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Contributors:Lipp, Jesse J. ( author ) / Wang, Limei ( author ) / Yang, Haitang ( author ) / Yao, Feng ( author ) / Harrer, Nathalie ( author ) / Müller, Stefan ( author ) / Berezowska, Sabina ( author ) / Dorn, Patrick ( author ) / Marti, Thomas M. ( author ) / Schmid, Ralph A. ( author )
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Published in:OncoImmunology ; 11, 1
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Publisher:
- New search for: Taylor & Francis
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Publication date:2022-12-31
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:Unknown
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Keywords:
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Source:
Table of contents – Volume 11, Issue 1
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
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Mesenchymal stem cells shuttling miR-503 via extracellular vesicles enhance glioma immune escapeWang, Xiao-Song / Yu, Xiao-Jun / Wei, Kang / Wang, Shan-Xi / Liu, Qi-Kun / Wang, Ying-Guang / Li, Han / Huang, Cheng et al. | 2022
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Mice transgenic for human CTLA4-CD28 fusion gene show proliferation and transformation of ATLL-like and AITL-like T cellsLee, Gyu Jin / Jun, Yukyung / Jeon, Yoon Kyung / Lee, Daekee / Lee, Sanghyuk / Kim, Jaesang et al. | 2022
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Generation and functional characterization of a multigene-modified NK101 cell line exerting diverse mechanisms of antitumor actionHwang, Injung / Jin, Hyun Tak / Kang, Moon Cheol / Kim, Tae Yoon / Sung, Young Chul / Kim, Sae Won et al. | 2022
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Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patientsLipp, Jesse J. / Wang, Limei / Yang, Haitang / Yao, Feng / Harrer, Nathalie / Müller, Stefan / Berezowska, Sabina / Dorn, Patrick / Marti, Thomas M. / Schmid, Ralph A. et al. | 2022
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Potential of Mycobacterium tuberculosis chorismate mutase (Rv1885c) as a novel TLR4-mediated adjuvant for dendritic cell-based cancer immunotherapyJeong, Hyein / Lee, So-Young / Seo, Hyejun / Kim, Dong Hyun / Lee, Duhyung / Kim, Bum-Joon et al. | 2022
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Identification of a unique tumor cell subset employing myeloid transcriptional circuits to create an immunomodulatory microenvironment in glioblastomaYang, Kaidi / Shi, Yu / Luo, Min / Mao, Min / Zhang, Xiaoning / Chen, Cong / Liu, Yuqi / He, Zhicheng / Liu, Qing / Wang, Wenying et al. | 2022
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Coupling the immunomodulatory properties of the HDAC6 inhibitor ACY241 with Oxaliplatin promotes robust anti-tumor response in non-small cell lung cancerBag, Arup / Schultz, Andrew / Bhimani, Saloni / Stringfield, Olya / Dominguez, William / Mo, Qianxing / Cen, Ling / Adeegbe, Dennis et al. | 2022
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Correction| 2022
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Immune suppressive microenvironment in brain metastatic non-small cell lung cancer: comprehensive immune microenvironment profiling of brain metastases versus paired primary lung tumors (GASTO 1060)Li, Meichen / Hou, Xue / Sai, Ke / Wu, Lihong / Chen, Jing / Zhang, Baishen / Wang, Na / Wu, Lijia / Zheng, Hongbo / Zhang, Jiao et al. | 2022
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A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitorsHackett, Justin B. / Glassbrook, James E. / Muñiz, Maria C. / Bross, Madeline / Fielder, Abigail / Dyson, Gregory / Movahhedin, Nasrin / McCasland, Jennifer / McCarthy-Leo, Claire / Gibson, Heather M. et al. | 2022
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Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regressionKudling, Tatiana V. / Clubb, James H.A. / Quixabeira, Dafne C.A. / Santos, Joao M. / Havunen, Riikka / Kononov, Alexander / Heiniö, Camilla / Cervera-Carrascon, Victor / Pakola, Santeri / Basnet, Saru et al. | 2022
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A nanoparticle-based tour de force for enhancing immunogenic cell death elicited by photodynamic therapyKepp, Oliver / Kroemer, Guido et al. | 2022
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Synergistic effect of combining sunitinib with a peptide-based vaccine in cancer treatment after microenvironment remodelingMougel, Alice / Méjean, Fanny / Tran, Thi / Adimi, Yasmine / Galy-Fauroux, Isabelle / Kaboré, Christelle / Mercier, Erwan / Urquia, Pauline / Terme, Magali / Tartour, Eric et al. | 2022
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An adjuvant-containing cDC1-targeted recombinant fusion vaccine conveys strong protection against murine melanoma growth and metastasisArabpour, Mohammad / Paul, Sanchari / Grauers Wiktorin, Hanna / Kaya, Mustafa / Kiffin, Roberta / Lycke, Nils / Hellstrand, Kristoffer / Martner, Anna et al. | 2022
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Immunosuppressive tumor microenvironment modulation by chemotherapies and targeted therapies to enhance immunotherapy effectivenessBarnestein, Robby / Galland, Loïck / Kalfeist, Laura / Ghiringhelli, François / Ladoire, Sylvain / Limagne, Emeric et al. | 2022
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CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapyLi, Xiaofei / Lu, Mingjie / Yuan, Manman / Ye, Jing / Zhang, Wei / Xu, Lingyan / Wu, Xiaohan / Hui, Bingqing / Yang, Yuchen / Wei, Bin et al. | 2022
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Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligandsChoi, Haeyoun / Lee, Yunkyung / Park, Soon A / Lee, Ji Hyeon / Park, Junseong / Park, Jang Hyun / Lee, Heung Kyu / Kim, Tai-Gyu / Jeun, Sin-Soo / Ahn, Stephen et al. | 2022
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T and NK cell abundance defines two distinct subgroups of renal cell carcinomaLee, Moon Hee / Järvinen, Petrus / Nísen, Harry / Brück, Oscar / Ilander, Mette / Uski, Ilona / Theodoropoulos, Jason / Kankainen, Matti / Mirtti, Tuomas / Mustjoki, Satu et al. | 2022
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Dissecting the heterogeneity of the microenvironment in primary and recurrent nasopharyngeal carcinomas using single-cell RNA sequencingPeng, Wen-Sa / Zhou, Xin / Yan, Wen-Bin / Li, Yu-Jiao / Du, Cheng-Run / Wang, Xiao-Shen / Shen, Chun-Ying / Wang, Qi-Feng / Ying, Hong-Mei / Lu, Xue-Guan et al. | 2022
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Local therapy with an engineered oncolytic adenovirus enables antitumor response in non-injected melanoma tumors in mice treated with aPD-1Quixabeira, Dafne C. A. / Cervera-Carrascon, Victor / Santos, Joao M. / Clubb, James H.A. / Kudling, Tatiana V. / Basnet, Saru / Heiniö, Camilla / Grönberg-Vähä-Koskela, Susanna / Anttila, Marjukka / Havunen, Riikka et al. | 2022
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TNFSF15 facilitates differentiation and polarization of macrophages toward M1 phenotype to inhibit tumor growthZhao, Can-Can / Han, Qiu-Ju / Ying, Hao-Yan / Gu, Xiang-Xiang / Yang, Na / Li, Lu-Yuan / Zhang, Qiang-Zhe et al. | 2022
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Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposureWachsmann, Tassilo L. A. / Wouters, Anne K. / Remst, Dennis F. G. / Hagedoorn, Renate S. / Meeuwsen, Miranda H. / van Diest, Eline / Leusen, Jeanette / Kuball, Jürgen / Falkenburg, J. H. Frederik / Heemskerk, Mirjam H. M. et al. | 2022
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Accumulation of dysfunctional tumor-infiltrating PD-1+ DCs links PD-1/PD-L1 blockade immunotherapeutic response in cervical cancerWang, Yu-meng / Qiu, Jun-jun / Qu, Xin-yu / Peng, Jing / Lu, Chong / Zhang, Meng / Zhang, Ming-Xing / Qi, Xing-ling / Lv, Bin / Guo, Jing-Jing et al. | 2022
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Antibody–drug conjugates harboring a kinesin spindle protein inhibitor with immunostimulatory propertiesSommer, Anette / Berndt, Sandra / Lerchen, Hans-Georg / Forveille, Sabrina / Sauvat, Allan / Mumberg, Dominik / Kroemer, Guido / Kepp, Oliver et al. | 2022
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QPCTL regulates macrophage and monocyte abundance and inflammatory signatures in the tumor microenvironmentBresser, Kaspar / Logtenberg, Meike E. W. / Toebes, Mireille / Proost, Natalie / Sprengers, Justin / Siteur, Bjorn / Boeije, Manon / Kroese, Lona J. / Schumacher, Ton N. et al. | 2022
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CXCL5-mediated accumulation of mature neutrophils in lung cancer tissues impairs the differentiation program of anticancer CD8 T cells and limits the efficacy of checkpoint inhibitorsSimoncello, Francesca / Piperno, Giulia Maria / Caronni, Nicoletta / Amadio, Roberto / Cappelletto, Ambra / Canarutto, Giulia / Piazza, Silvano / Bicciato, Silvio / Benvenuti, Federica et al. | 2022
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NPM1 and DNMT3A mutations are associated with distinct blast immunophenotype in acute myeloid leukemiaKuželová, Kateřina / Brodská, Barbora / Marková, Jana / Petráčková, Martina / Schetelig, Johannes / Ransdorfová, Šárka / Gašová, Zdenka / Šálek, Cyril et al. | 2022
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TH-MYCN tumors, but not tumor-derived cell lines, are adrenergic lineage, GD2+, and responsive to anti-GD2 antibody therapyMcNerney, KO / Karageorgos, S / Ferry, GM / Wolpaw, AJ / Burudpakdee, C / Khurana, P / Toland, CN / Vemu, R / Vu, A / Hogarty, MD et al. | 2022
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Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responsesZettl, Markus / Wurm, Melanie / Schaaf, Otmar / Mostböck, Sven / Tirapu, Iñigo / Apfler, Ilse / Lorenz, Ivo C. / Frego, Lee / Kenny, Cynthia / Thibodeau, Michael et al. | 2022
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CRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myelomaBexte, Tobias / Alzubi, Jamal / Reindl, Lisa Marie / Wendel, Philipp / Schubert, Ralf / Salzmann-Manrique, Emilia / von Metzler, Ivana / Cathomen, Toni / Ullrich, Evelyn et al. | 2022
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Immune suppressive function of IL-1α release in the tumor microenvironment regulated by calpain 1Lin, Dandan / Mei, Yu / Lei, Lei / Binte Hanafi, Zuhairah / Jin, Ziqi / Liu, Yonghao / Song, Yuan / Zhang, Yinsheng / Hu, Bo / Liu, Chunliang et al. | 2022
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Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-tumor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent responseJin, Chuan / Ali, Arwa / Iskantar, Alexandros / Fotaki, Grammatiki / Wang, Hai / Essand, Magnus / Karlsson-Parra, Alex / Yu, Di et al. | 2022
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scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activityZhong, Genshen / Wang, Qi / Wang, Ying / Guo, Ying / Xu, Meiqi / Guan, Yaya / Zhang, Xiaoying / Wu, Minna / Xu, Zhishan / Zhao, Weidong et al. | 2022
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Single-cell RNA-sequencing reveals predictive features of response to pembrolizumab in Sézary syndromeSu, Tianying / Duran, George E. / Kwang, Alexa C. / Ramchurren, Nirasha / Fling, Steven P. / Kim, Youn H. / Khodadoust, Michael S. et al. | 2022
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Expression of cartilage oligomeric matrix protein in periampullary adenocarcinoma is associated with pancreatobiliary-type morphology, higher levels of fibrosis and immune cell exclusionPapadakos, Konstantinos S. / Lundgren, Sebastian / Gialeli, Chrysostomi / Micke, Patrick / Mezheyeuski, Artur / Elebro, Jacob / Jirström, Karin / Blom, Anna M. et al. | 2022
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RNA with chemotherapeutic base analogues as a dual-functional anti-cancer drugJarzebska, Natalia Teresa / Tusup, Marina / Frei, Julia / Weiss, Tobias / Holzinger, Tim / Mellett, Mark / Diken, Mustafa / Bredl, Simon / Weller, Michael / Speck, Roberto F. et al. | 2022
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Impaired CXCL12 signaling contributes to resistance of pancreatic cancer subpopulations to T cell-mediated cytotoxicityLin, Yuan-Na / Schmidt, Marcel O. / Sharif, Ghada M. / Vietsch, Eveline E. / Kiliti, Amber J. / Barefoot, Megan E. / Riegel, Anna T. / Wellstein, Anton et al. | 2022
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T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG miceSonzogni, Olmo / Zak, Daniel E. / Sasso, Maria Stella / Lear, Rochelle / Muntzer, Alice / Zonca, Manuela / West, Katy / Champion, Brian R. / Rottman, James B. et al. | 2022
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CD4+ T cells in classical Hodgkin lymphoma express exhaustion associated transcription factors TOX and TOX2Veldman, Johanna / Rodrigues Plaça, Jessica / Chong, Lauren / Terpstra, Miente Martijn / Mastik, Mirjam / van Kempen, Léon C. / Kok, Klaas / Aoki, Tomohiro / Steidl, Christian / van den Berg, Anke et al. | 2022
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IFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA formationXiong, Hui / Xi, Yu / Yuan, Zhiwei / Wang, Boyu / Hu, Shaojie / Fang, Can / Cai, Yixin / Fu, Xiangning / Li, Lequn et al. | 2022
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Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockadeLiu, Jiao / Kang, Rui / Kroemer, Guido / Tang, Daolin et al. | 2022
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The endoplasmic reticulum chaperone BiP: a target for immunogenic cell death inducers?Kepp, Oliver / Bezu, Lucillia / Kroemer, Guido et al. | 2022
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Homologous recombination repair deficient prostate cancer represents an immunologically distinct subtypevan Wilpe, Sandra / Simnica, Donjetë / Slootbeek, Peter / van Ee, Thomas / Pamidimarri Naga, Samhita / Gorris, Mark A. J. / van der Woude, Lieke L. / Sultan, Shabaz / Koornstra, Rutger H. T. / van Oort, Inge M. et al. | 2022
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Schweinfurthin induces ICD without ER stress and caspase activationZhang, Ruoheng / Neighbors, J.D. / Schell, T.D. / Hohl, R.J. et al. | 2022
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Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ TregsHarris, Robert J / Willsmore, Zena / Laddach, Roman / Crescioli, Silvia / Chauhan, Jitesh / Cheung, Anthony / Black, Anna / Geh, Jenny L. C. / MacKenzie Ross, Alastair D / Healy, Ciaran et al. | 2022
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IRE1α overexpression in malignant cells limits tumor progression by inducing an anti-cancer immune responseMartinez-Turtos, Adriana / Paul, Rachel / Grima-Reyes, Manuel / Issaoui, Hussein / Krug, Adrien / Mhaidly, Rana / Bossowski, Jozef P. / Chiche, Johanna / Marchetti, Sandrine / Verhoeyen, Els et al. | 2022
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CCL22-based peptide vaccines induce anti-cancer immunity by modulating tumor microenvironmentLecoq, Inés / Kopp, Katharina L. / Chapellier, Marion / Mantas, Panagiotis / Martinenaite, Evelina / Perez-Penco, Maria / Rønn Olsen, Lars / Zocca, Mai-Britt / Wakatsuki Pedersen, Ayako / Andersen, Mads Hald et al. | 2022
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Type I interferon induces cancer stem cells-mediated chemotherapy resistanceDe Martino, Mara / Vanpouille-Box, Claire et al. | 2022
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AAV-mediated gene transfer of a checkpoint inhibitor in combination with HER2-targeted CAR-NK cells as experimental therapy for glioblastomaStrecker, M.I. / Wlotzka, K. / Strassheimer, F. / Roller, B. / Ludmirski, G. / König, S. / Röder, J. / Opitz, C. / Alekseeva, T. / Reul, J. et al. | 2022
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Fibroblasts and macrophages cooperate to create a pro-tumorigenic and immune resistant environment via activation of TGF-β/IL-6 pathway in neuroblastomaLouault, Kevin / Porras, Tania / Lee, Meng-Hua / Muthugounder, Sakunthala / Kennedy, Rebekah J. / Blavier, Laurence / Sarte, Emily / Fernandez, G. Esteban / Yang, Fusheng / Pawel, Bruce R. et al. | 2022
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Enhancing anti-tumor efficacy and immune memory by combining 3p-GPC-3 siRNA treatment with PD-1 blockade in hepatocellular carcinomaShao, Liwei / Yu, Xin / Han, Qiuju / Zhang, Xinke / Lu, Nan / Zhang, Cai et al. | 2022
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CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor developmentMelese, Etienne S. / Franks, Elizabeth / Cederberg, Rachel A. / Harbourne, Bryant T. / Shi, Rocky / Wadsworth, Brennan J. / Collier, Jenna L. / Halvorsen, Elizabeth C. / Johnson, Fraser / Luu, Jennifer et al. | 2022
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Association between immune-related adverse event timing and treatment outcomesHsiehchen, David / Naqash, Abdul Rafeh / Espinoza, Magdalena / Von Itzstein, Mitchell S. / Cortellini, Alessio / Ricciuti, Biagio / Owen, Dwight H. / Laharwal, Mehak / Toi, Yukihiro / Burke, Michael et al. | 2022
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A first-in-class, non-invasive, immunodynamic biomarker approach for precision immuno-oncologySprooten, Jenny / Coosemans, An / Garg, Abhishek D. et al. | 2022
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Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophilsLeclercq, Gabrielle / Servera, Llucia Alberti / Danilin, Sabrina / Challier, John / Steinhoff, Nathalie / Bossen, Claudia / Odermatt, Alex / Nicolini, Valeria / Umaña, Pablo / Klein, Christian et al. | 2022
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Single-cell analysis by mass cytometry reveals CD19 CAR T cell spatiotemporal plasticity in patientsGoldberg, Lior / Haas, Eric R. / Vyas, Vibhuti / Urak, Ryan / Forman, Stephen J. / Wang, Xiuli et al. | 2022
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Serial changes in liquid biopsy-derived variant allele frequency predict immune checkpoint inhibitor responsiveness in the pan-cancer settingKato, Shumei / Li, Bing / Adashek, Jacob J. / Cha, Seong Won / Bianchi-Frias, Daniella / Qian, Dajun / Kim, Lisa / so, Tiffany W / Mitchell, Marcus / Kamei, Naoki et al. | 2022
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Synapse topology and downmodulation events determine the functional outcome of anti-CD19 T cell-redirecting strategiesRamírez-Fernández, Ángel / Aguilar-Sopeña, Óscar / Díez-Alonso, Laura / Segura-Tudela, Alejandro / Domínguez-Alonso, Carmen / Roda-Navarro, Pedro / Álvarez-Vallina, Luis / Blanco, Belén et al. | 2022
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Evaluation of radio-immunotherapy sequence on immunological responses and clinical outcomes in patients with melanoma brain metastases (ELEKTRA)Hassel, Jessica C. / Schank, Timo E. / Smetak, Heiko / Mühlbauer, Jasmin / Salzmann, Martin / Machiraju, Devayani / Menzer, Christian / Lang, Kristin / König, Laila / Haefner, Matthias F. et al. | 2022
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Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinomaGartrell, Robyn D. / Enzler, Thomas / Kim, Pan S. / Fullerton, Benjamin T. / Fazlollahi, Ladan / Chen, Andrew X. / Minns, Hanna E. / Perni, Subha / Weisberg, Stuart P. / Rizk, Emanuelle M. et al. | 2022
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Novel approach to identify putative Epstein–Barr–virus microRNAs regulating host cell genes with relevance in tumor biology and immunologyJasinski-Bergner, Simon / Blümke, Juliane / Bauer, Marcus / Skiebe, Saskia Luise / Mandelboim, Ofer / Wickenhauser, Claudia / Seliger, Barbara et al. | 2022
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Novel strategies for the mitigation of cytokine release syndrome induced by T cell engaging therapies with a focus on the use of kinase inhibitorsLeclercq, Gabrielle / Steinhoff, Nathalie / Haegel, Hélène / De Marco, Donata / Bacac, Marina / Klein, Christian et al. | 2022
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Trial watch: Dendritic cell (DC)-based immunotherapy for cancerLaureano, Raquel S / Sprooten, Jenny / Vanmeerbeerk, Isaure / Borras, Daniel M / Govaerts, Jannes / Naulaerts, Stefan / Berneman, Zwi N / Beuselinck, Benoit / Bol, Kalijn F / Borst, Jannie et al. | 2022
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Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesisThümmler, Katja / Williams, Mark TS / Kitson, Susan / Sood, Shatakshi / Akbar, Moeed / Cole, John J / Hunter, Ewan / Soutar, Richard / Goodyear, Carl S et al. | 2022
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Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibodyWeaver, Jessica D. / Stack, Edward C. / Buggé, Joshua A. / Hu, Changyun / McGrath, Lara / Mueller, Amy / Wong, Masie / Klebanov, Boris / Rahman, Tanzila / Kaufman, Rosemary et al. | 2022
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Tbc1d10c is a selective, constitutive suppressor of the CD8 T-cell anti-tumor responseCohen, Adrienne O. / Woo, Seung-Hyun / Zhang, Junya / Cho, Jiyoon / Ruiz, Marlon E. / Gong, Jianli / Du, Rong / Yarygina, Olga / Jafri, Danya Z. / Bachelor, Michael A. et al. | 2022
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Chemokine switch regulated by TGF-β1 in cancer-associated fibroblast subsets determines the efficacy of chemo-immunotherapyVienot, Angélique / Pallandre, Jean-René / Renaude, Elodie / Viot, Julien / Bouard, Adeline / Spehner, Laurie / Kroemer, Marie / Abdeljaoued, Syrine / van der Woning, Bas / de Haard, Hans et al. | 2022
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BCL11B depletion induces the development of highly cytotoxic innate T cells out of IL-15 stimulated peripheral blood αβ CD8+ T cellsForkel, Hannes / Grabarczyk, Piotr / Depke, Maren / Troschke-Meurer, Sascha / Simm, Stefan / Hammer, Elke / Michalik, Stephan / Hentschker, Christian / Corleis, Björn / Loyal, Lucie et al. | 2022
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The role of NKT cells in gastrointestinal cancersBurks, Julian / Olkhanud, Purevdorj B. / Berzofsky, Jay A. et al. | 2022
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Bystander CD4+ T cells infiltrate human tumors and are phenotypically distinctLi, Shamin / Zhuang, Summer / Heit, Antja / Koo, Si-Lin / Tan, Aaron C. / Chow, I-Ting / Kwok, William W. / Tan, Iain Beehuat / Tan, Daniel S.W. / Simoni, Yannick et al. | 2022
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Reprogramming monocyte-derived macrophages through caspase inhibitionChaintreuil, Paul / Laplane, Lucie / Esnault, Florian / Ghesquier, Victoria / Savy, Coline / Furstoss, Nathan / Arcangeli, Marie-Laure / Cluzeau, Thomas / Robert, Guillaume / Droin, Nathalie et al. | 2022
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Immune sunrise: from the immunome to the cancer immune landscapeBindea, Gabriela / Mlecnik, Bernhard / Galon, Jérôme et al. | 2022
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CD29 targeted near-infrared photoimmunotherapy (NIR-PIT) in the treatment of a pigmented melanoma modelFurusawa, Aki / Okada, Ryuhei / Inagaki, Fuyuki / Wakiyama, Hiroaki / Kato, Takuya / Furumoto, Hideyuki / Fukushima, Hiroshi / Okuyama, Shuhei / Choyke, Peter L. / Kobayashi, Hisataka et al. | 2022
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Identification of Claudin 6-specific HLA class I- and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancerMatsuzaki, Junko / Lele, Shashikant / Odunsi, Kunle / Tsuji, Takemasa et al. | 2022
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Targeting NKG2A to boost anti-tumor CD8 T-cell responses in human colorectal cancerDucoin, Kathleen / Oger, Romain / Bilonda Mutala, Linda / Deleine, Cécile / Jouand, Nicolas / Desfrançois, Juliette / Podevin, Juliette / Duchalais, Emilie / Cruard, Jonathan / Benlalam, Houssem et al. | 2022
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Platinum-based chemotherapy inflames the ovarian carcinoma microenvironment through cellular senescenceÁlvarez-Abril, Beatriz / García-Martínez, Elena / Galluzzi, Lorenzo et al. | 2022
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DOT1L affects colorectal carcinogenesis via altering T cell subsets and oncogenic pathwaySun, Danfeng / Wang, Weichao / Guo, Fangfang / Pitter, Michael R. / Du, Wan / Wei, Shuang / Grove, Sara / Vatan, Linda / Chen, Yingxuan / Kryczek, Ilona et al. | 2022
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PD-L1 blockade potentiates the antitumor effects of ALA-PDT and optimizes the tumor microenvironment in cutaneous squamous cell carcinomaZeng, Qingyu / Yang, Jiayi / Ji, Jie / Wang, Peiru / Zhang, Linglin / Yan, Guorong / Wu, Yuhao / Chen, Qi / Liu, Jia / Zhang, Guolong et al. | 2022
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Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasisCarretero-González, Alberto / Hergueta-Redondo, Marta / Sánchez-Redondo, Sara / Ximénez-Embún, Pilar / Manso Sánchez, Luis / Gil, Eva Ciruelos / Castellano, Daniel / de Velasco, Guillermo / Peinado, Héctor et al. | 2022
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Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progressionLiu, Zhou / Gao, Zhijie / Li, Bei / Li, Juanjuan / Ou, Yangyang / Yu, Xin / Zhang, Zun / Liu, Siqin / Fu, Xiaoyu / Jin, Hongzhong et al. | 2022
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PD-1 blockade synergizes with oxaliplatin-based, but not cisplatin-based, chemotherapy of gastric cancerLiu, Peng / Chen, Jianzhou / Zhao, Liwei / Hollebecque, Antoine / Kepp, Oliver / Zitvogel, Laurence / Kroemer, Guido et al. | 2022
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PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cellsPesini, Cecilia / Hidalgo, Sandra / Arias, Maykel A. / Santiago, Llipsy / Calvo, Carlota / Ocariz-Díez, Maitane / Isla, Dolores / Lanuza, Pilar M. / Agustín, M José / Galvez, Eva M et al. | 2022
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Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosisBella, Ángela / Arrizabalaga, Leire / Di Trani, Claudia Augusta / Cirella, Assunta / Fernandez-Sendin, Myriam / Gomar, Celia / Russo-Cabrera, Joan Salvador / Rodríguez, Inmaculada / González-Gomariz, José / Alvarez, Maite et al. | 2022
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Targeting stearoyl-coa desaturase enhances radiation induced ferroptosis and immunogenic cell death in esophageal squamous cell carcinomaLuo, Hui / Wang, Xiaohui / Song, Shuai / Wang, Yunhan / Dan, Qinfu / Ge, Hong et al. | 2022
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PARP1 inhibition elicits immune responses against non-small cell lung cancerJuncheng, Pan / Lafarge, Antoine / Kroemer, Guido / Castedo, Maria et al. | 2022
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Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged miceCastoldi, Francesca / Kroemer, Guido / Pietrocola, Federico et al. | 2022
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A short-term follow-up CT based radiomics approach to predict response to immunotherapy in advanced non-small-cell lung cancerGong, Jing / Bao, Xiao / Wang, Ting / Liu, Jiyu / Peng, Weijun / Shi, Jingyun / Wu, Fengying / Gu, Yajia et al. | 2022
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PKHB1, a thrombospondin-1 peptide mimic, induces anti-tumor effect through immunogenic cell death induction in breast cancer cellsCalvillo-Rodríguez, Kenny Misael / Mendoza-Reveles, Rodolfo / Gómez-Morales, Luis / Uscanga-Palomeque, Ashanti Concepción / Karoyan, Philippe / Martínez-Torres, Ana Carolina / Rodríguez-Padilla, Cristina et al. | 2022
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Carbon ion radiotherapy triggers immunogenic cell death and sensitizes melanoma to anti-PD-1 therapy in miceZhou, Heng / Tu, Chen / Yang, Pengfei / Li, Jin / Kepp, Oliver / Li, Haining / Zhang, Liying / Zhang, Lixin / Zhao, Yang / Zhang, Tianyi et al. | 2022
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The ART of tumor immune escapeWennerberg, Erik / Mukherjee, Sumit / Sainz, Ricardo M. / Stiles, Brendon M. et al. | 2022
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Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivoGargiulo, Ernesto / Viry, Elodie / Moussay, Etienne / Paggetti, Jerome et al. | 2022
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PDIA3 as a potential bridge between immunogenic cell death and autoreactivityPol, Jonathan G. / Plantureux, Céleste / Pérez-Lanzón, María / Kroemer, Guido et al. | 2022
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Nanoparticles releasing immunogenic cell death inducers upon near-infrared light exposureKepp, Oliver / Cerrato, Giulia / Sauvat, Allan / Kroemer, Guido et al. | 2022
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RHOA G17V induces T follicular helper cell specification and involves angioimmunoblastic T-cell lymphoma via upregulating the expression of PON2 through an NF-κB-dependent mechanismQue, Fenglian / Zhang, Lihong / Wang, Taoli / Xu, Meifang / Li, Wangen / Zang, Shengbing et al. | 2022
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Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunityWang, Hanfeng / Fan, Yang / Chen, Weihao / Lv, Zheng / Wu, Shengpan / Xuan, Yundong / Wang, Chenfeng / Lu, Yongliang / Guo, Tao / Shen, Donglai et al. | 2022
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Peptide vaccination activating Galectin-3-specific T cells offers a novel means to target Galectin-3-expressing cells in the tumor microenvironmentBendtsen, Simone Kloch / Perez-Penco, Maria / Hübbe, Mie Linder / Martinenaite, Evelina / Orebo Holmström, Morten / Weis-Banke, Stine Emilie / Grønne Dahlager Jørgensen, Nicolai / Jørgensen, Mia Aaboe / Munir Ahmad, Shamaila / Jensen, Kasper Mølgaard et al. | 2022
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Dual role of ARPC1B in regulating the network between tumor-associated macrophages and tumor cells in glioblastomaLiu, Tianqi / Zhu, Chen / Chen, Xin / Wu, Jianqi / Guan, Gefei / Zou, Cunyi / Shen, Shuai / Chen, Ling / Cheng, Peng / Cheng, Wen et al. | 2022
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MICA/B-targeted antibody promotes NK cell–driven tumor immunity in patients with intrahepatic cholangiocarcinomaOliviero, Barbara / Varchetta, Stefania / Mele, Dalila / Pessino, Greta / Maiello, Roberta / Falleni, Monica / Tosi, Delfina / Donadon, Matteo / Soldani, Cristiana / Franceschini, Barbara et al. | 2022
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Pivotal antitumor role of the immune checkpoint molecule B7-H1 in pancreatic cancerBazhin, Alexandr V. / von Ahn, Katharina / Fritz, Jasmin / Bunge, Henriette / Maier, Caroline / Isayev, Orkhan / Neff, Florian / Siveke, Jens T. / Karakhanova, Svetlana et al. | 2022
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Deep learning using bulk RNA-seq data expands cell landscape identification in tumor microenvironmentWang, Xin / Wang, Hongjiu / Liu, Dan / Wang, Na / He, Danni / Wu, Zheyu / Zhu, Xu / Wen, Xiaoling / Li, Xuhua / Li, Jin et al. | 2022
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Intratumoral T-cell repertoires in DNA mismatch repair-proficient and -deficient colon tumors containing high or low numbers of tumor-infiltrating lymphocytesKim, Jin K. / Chen, Chin-Tung / Keshinro, Ajaratu / Khan, Asama / Firat, Canan / Vanderbilt, Chad / Segal, Neil / Stadler, Zsofia / Shia, Jinru / Balachandran, Vinod P. et al. | 2022
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Innate lymphoid cells: NK and cytotoxic ILC3 subsets infiltrate metastatic breast cancer lymph nodesRethacker, Louise / Boy, Maxime / Bisio, Valeria / Roussin, France / Denizeau, Jordan / Vincent-Salomon, Anne / Borcoman, Edith / Sedlik, Christine / Piaggio, Eliane / Toubert, Antoine et al. | 2022
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Conventional amphotericin B elicits markers of immunogenic cell death on leukemic blasts, mediates immunostimulatory effects on phagocytic cells, and synergizes with PD-L1 blockadeKofla, G. / Radecke, C. / Frentsch, M. / Walther, W. / Stintzing, S. / Riess, H. / Bullinger, L. / Na, I-K. et al. | 2022
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Immunogenic stress induced by local anesthetics injected into neoplastic lesionsBezu, Lucillia / Kepp, Oliver / Kroemer, Guido et al. | 2022
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PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumorsStaniszewska, Anna D. / Armenia, Joshua / King, Matthew / Michaloglou, Chrysiis / Reddy, Avinash / Singh, Maneesh / San Martin, Maryann / Prickett, Laura / Wilson, Zena / Proia, Theresa et al. | 2022
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Toll-like receptor 2 promotes breast cancer progression and resistance to chemotherapyDi Lorenzo, Antonino / Bolli, Elisabetta / Ruiu, Roberto / Ferrauto, Giuseppe / Di Gregorio, Enza / Avalle, Lidia / Savino, Aurora / Poggio, Pietro / Merighi, Irene Fiore / Riccardo, Federica et al. | 2022
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Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionalitySchoutrop, Esther / Renken, Stefanie / Micallef Nilsson, Isabella / Hahn, Paula / Poiret, Thomas / Kiessling, Rolf / Wickström, Stina L / Mattsson, Jonas / Magalhaes, Isabelle et al. | 2022
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Peripheral gene signatures reveal distinct cancer patient immunotypes with therapeutic implications for autologous DC-based vaccinesHensler, Michal / Rakova, Jana / Kasikova, Lenka / Lanickova, Tereza / Pasulka, Josef / Holicek, Peter / Hraska, Marek / Hrnciarova, Tereza / Kadlecova, Pavla / Schoenenberger, Andreu et al. | 2022
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Targeting depletion of myeloid-derived suppressor cells potentiates PD-L1 blockade efficacy in gastric and colon cancersTang, Yao / Zhou, Cong / Li, Qingli / Cheng, Xiaojiao / Huang, Tinglei / Li, Fuli / He, Lina / Zhang, Baiweng / Tu, Shuiping et al. | 2022
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Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biologyLontos, Konstantinos / Wang, Yiyang / Colbert, Mason / Kumar, Alok / Joshi, Supriya / Philbin, Mary / Wang, Yupeng / Frisch, Andrew / Lohmueller, Jason / Rivadeneira, Dayana B. et al. | 2022
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CEBPA mutants down-regulate AML cell susceptibility to NK-mediated lysis by disruption of the expression of NKG2D ligands, which can be restored by LSD1 inhibitionLiu, Meng / Du, Mengbao / Yu, Jian / Qian, Zijun / Gao, Yang / Pan, Wenjue / Zhao, Xiujie / Wang, Mowang / Li, Huimin / Zheng, Jiaqi et al. | 2022
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Time-spatial analysis of T cell receptor repertoire in esophageal squamous cell carcinoma patients treated with combined radiotherapy and PD-1 blockadeYan, Cihui / Ma, Xiaoxue / Guo, Zhoubo / Wei, Xiaoying / Han, Dong / Zhang, Tian / Chen, Xi / Cao, Fuliang / Dong, Jie / Zhao, Gang et al. | 2022
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MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expressionLin, Jinti / Xu, Ankai / Jin, Jiakang / Zhang, Man / Lou, Jianan / Qian, Chao / Zhu, Jian / Wang, Yitian / Yang, Zhengming / Li, Xiumao et al. | 2022
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Targeting coagulation to unlock antitumor immunity?Galmiche, Antoine / Saidak, Zuzana / Ghiringhelli, François et al. | 2022
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Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stressCedervall, J. / Herre, M. / Dragomir, A. / Rabelo-Melo, F. / Svensson, A. / Thålin, C. / Rosell, A. / Hjalmar, V. / Wallén, H. / Lindman, H. et al. | 2022
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Mycobacterial surface characters remodeled by growth conditions drive different tumor-infiltrating cells and systemic IFN-γ/IL-17 release in bladder cancer treatmentGuallar-Garrido, Sandra / Campo-Pérez, Víctor / Pérez-Trujillo, Míriam / Cabrera, Cecilia / Senserrich, Jordi / Sánchez-Chardi, Alejandro / Rabanal, Rosa Maria / Gómez-Mora, Elisabet / Noguera-Ortega, Estela / Luquin, Marina et al. | 2022
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Superior antitumor immunotherapy efficacy of kynureninase modified CAR-T cells through targeting kynurenine metabolismYang, Quanjun / Hao, Juan / Chi, Mengyi / Wang, Yaxian / Xin, Bo / Huang, Jinglu / Lu, Jin / Li, Jie / Sun, Xipeng / Li, Chunyan et al. | 2022
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Myeloma-derived IL-32γ induced PD-L1 expression in macrophages facilitates immune escape via the PFKFB3-JAK1 axisLiu, Yang / Yan, Haimeng / Gu, Huiyao / Zhang, Enfan / He, Jingsong / Cao, Wen / Qu, Jianwei / Xu, Ruyi / Cao, Liqin / He, Donghua et al. | 2022
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Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous systemWei, Jun / Song, Renduo / Sabbagh, Aria / Marisetty, Anantha / Shukla, Neal / Fang, Dexing / Najem, Hinda / Ott, Martina / Long, James / Zhai, Lijie et al. | 2022
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Clostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitorsTomita, Yusuke / Goto, Yoshihiko / Sakata, Shinya / Imamura, Kosuke / Minemura, Ayaka / Oka, Kentaro / Hayashi, Atsushi / Jodai, Takayuki / Akaike, Kimitaka / Anai, Moriyasu et al. | 2022
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Oncolytic adenovirus promotes vascular normalization and nonclassical tertiary lymphoid structure formation through STING-mediated DC activationHe, Teng / Hao, Zhixing / Lin, Mingjie / Xin, Zhongwei / Chen, Yongyuan / Ouyang, Wei / Yang, Qi / Chen, Xiaoke / Zhou, Hui / Zhang, Wanying et al. | 2022
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Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancerWang, Qiuman / Ma, Xinyue / Wu, Huan / Zhao, Chen / Chen, Jingying / Li, Rongrong / Yan, Shi / Li, Yingwei / Zhang, Qing / Song, Kun et al. | 2022
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Enhancement of tumor immunogenicity by the introduction of non- proteinogenic amino acid azetidine-2-carboxylic acidLi, Siyu / Wang, Shiqing / Tian, Baorui / Li, Na / Chen, Yanan / Liu, Yanhua / Su, Weijun / Fan, Yan / Piao, Yongjun / Li, Jia et al. | 2022
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One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancerSteenbrugge, Jonas / Bellemans, Julie / Vander Elst, Niels / Demeyere, Kristel / De Vliegher, Josephine / Perera, Timothy / De Wever, Olivier / Van Den Broeck, Wim / De Spiegelaere, Ward / Sanders, Niek N. et al. | 2022
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A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancerAvanzino, Brian C. / Prabhakar, Kirthana / Dalvi, Pranjali / Hartstein, Sharon / Kehm, Hannes / Balasubramani, Aarti / Boudreau, Andrew A. / Buelow, Ben / Chang, Karen / Davison, Laura M. et al. | 2022
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Immune response to SARS-CoV-2 mRNA vaccination and booster dose in patients with multiple myeloma and monoclonal gammopathies: impact of Omicron variant on the humoral responseStorti, Paola / Marchica, Valentina / Vescovini, Rosanna / Franceschi, Valentina / Russo, Luca / Notarfranchi, Laura / Raimondi, Vincenzo / Toscani, Denise / Burroughs Garcia, Jessica / Costa, Federica et al. | 2022
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Therapeutic Targeting of MYC in Head and Neck Squamous Cell CarcinomaLiu, Shuo / Qin, Zhen / Mao, Yaqing / Zhang, Wenbo / Wang, Yujia / Jia, Lingfei / Peng, Xin et al. | 2022
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Combined targeting of soluble latent TGF-ß and a solid tumor-associated antigen with adapter CAR T cellsWerchau, Niels / Kotter, Bettina / Criado-Moronati, Elvira / Gosselink, Andre / Cordes, Nicole / Lock, Dominik / Lennartz, Simon / Kolbe, Carolin / Winter, Nora / Teppert, Karin et al. | 2022
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Personalized therapy with peptide-based neoantigen vaccine (EVX-01) including a novel adjuvant, CAF®09b, in patients with metastatic melanomaMørk, Sofie Kirial / Kadivar, Mohammad / Bol, Kalijn Fredrike / Draghi, Arianna / Westergaard, Marie Christine Wulff / Skadborg, Signe Koggersbøl / Overgaard, Nana / Sørensen, Anders Bundgård / Rasmussen, Ida Svahn / Andreasen, Lars Vibe et al. | 2022
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LCVM infection generates tumor antigen-specific immunity and inhibits growth of nonviral tumorsJacqueline, Camille / Dracz, Matthew / Xue, Jia / Binder, Robert J. / Minden, Jonathan / Finn, Olivera et al. | 2022
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Stimulatory and inhibitory activity of STING ligands on tumor-reactive human gamma/delta T cellsSerrano, Ruben / Lettau, Marcus / Zarobkiewicz, Michal / Wesch, Daniela / Peters, Christian / Kabelitz, Dieter et al. | 2022
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An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulationMuik, Alexander / Altintas, Isil / Gieseke, Friederike / Schoedel, Kristina B / Burm, Saskia M / Toker, Aras / Salcedo, Theodora W. / Verzijl, Dennis / Eisel, David / Grunwitz, Christian et al. | 2022
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What’s next in cancer immunotherapy? - The promise and challenges of neoantigen vaccinationRedwood, Alec J. / Dick, Ian M. / Creaney, Jenette / Robinson, Bruce W. S. et al. | 2022
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STING agonist cGAMP enhances anti-tumor activity of CAR-NK cells against pancreatic cancerDa, Yanyan / Liu, Yuxia / Hu, Yuan / Liu, Wenzeng / Ma, Junpeng / Lu, Nan / Zhang, Chengsheng / Zhang, Cai et al. | 2022
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Combination with Toll-like receptor 4 (TLR4) agonist reverses GITR agonism mediated M2 polarization of macrophage in Hepatocellular carcinomaPan, Caixu / Wu, Qinchuan / Wang, Shuai / Mei, Zhibin / Zhang, Lele / Gao, Xingxing / Qian, Junjie / Xu, Zhentian / Zhang, Ke / Su, Rong et al. | 2022
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MHC class II molecules on pancreatic cancer cells indicate a potential for neo-antigen-based immunotherapyBaleeiro, Renato B. / Bouwens, Christian J. / Liu, Peng / Di Gioia, Carmela / Dunmall, Louisa S. Chard / Nagano, Ai / Gangeswaran, Rathistevy / Chelala, Claude / Kocher, Hemant M. / Lemoine, Nicholas R. et al. | 2022
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Urinary T cells are detected in patients with immune checkpoint inhibitor-associated immune nephritis that are clonotypically identical to kidney T cell infiltratesSingh, Shailbala / Clemente, Leticia C. / Parra, Edwin R. / Tchakarov, Amanda / Yang, Chao / Li, Yisheng / Long, James P. / Yee, Cassian / Lin, Jamie S. et al. | 2022
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A novel membrane-bound interleukin-2 promotes NK-92 cell persistence and anti-tumor activityXiong, Qi / Zhang, Hantao / Ji, Xuanle / Zhang, Yong / Shi, Gang / Dai, Lei / Cheng, Fuyi / Wang, Huiling / Luo, Jieyan / Xu, Jia et al. | 2022
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A newly discovered PD-L1 B-cell epitope peptide vaccine (PDL1-Vaxx) exhibits potent immune responses and effective anti-tumor immunity in multiple syngeneic mice models and (synergizes) in combination with a dual HER-2 B-cell vaccine (B-Vaxx)Guo, Linlin / Overholser, Jay / Darby, Heather / Ede, Nicholas J. / Kaumaya, Pravin T.P et al. | 2022
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Ecto-calreticulin expression in multiple myeloma correlates with a failed anti-tumoral immune response and bad prognosisSerrano Del Valle, Alfonso / Beltrán-Visiedo, Manuel / de Poo-Rodríguez, Victoria / Jiménez-Alduán, Nelia / Azaceta, Gemma / Díez, Rosana / Martínez-Lázaro, Beatriz / Izquierdo, Isabel / Palomera, Luis / Naval, Javier et al. | 2022
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Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade gliomaKim, A-Reum / Choi, Seong Jin / Park, Junsik / Kwon, Minsuk / Chowdhury, Tamrin / Yu, Hyeon Jong / Kim, Sojin / Kang, Ho / Kim, Kyung-Min / Park, Su-Hyung et al. | 2022
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MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancerHagiwara, Masayuki / Fushimi, Atsushi / Bhattacharya, Atrayee / Yamashita, Nami / Morimoto, Yoshihiro / Oya, Mototsugu / Withers, Henry G. / Hu, Qiang / Liu, Tao / Liu, Song et al. | 2022
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Vasculogenic mimicry structures in melanoma support the recruitment of monocytesTan, Lih Y. / Cockshell, Michaelia P. / Moore, Eli / Myo Min, Kay K. / Ortiz, Michael / Johan, M. Zahied / Ebert, Brenton / Ruszkiewicz, Andrew / Brown, Michael P. / Ebert, Lisa M. et al. | 2022
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Neutrophil extracellular traps induce tumor metastasis through dual effects on cancer and endothelial cellsJiang, Ze-Zhou / Peng, Zhi-Peng / Liu, Xing-Chen / Guo, Hao-Fan / Zhou, Meng-Meng / Jiang, Da / Ning, Wan-Ru / Huang, Yu-Fan / Zheng, Limin / Wu, Yan et al. | 2022
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A loss-of-function polymorphism in ATG16L1 compromises therapeutic outcome in head and neck carcinoma patientsLe Naour, Julie / Sztupinszki, Zsofia / Carbonnier, Vincent / Casiraghi, Odile / Marty, Virginie / Galluzzi, Lorenzo / Szallasi, Zoltan / Kroemer, Guido / Vacchelli, Erika et al. | 2022
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OX40 and 4-1BB delineate distinct immune profiles in sarcomaMelake, MJ / Smith, HG / Mansfield, D / Davies, E / Dillon, MT / Wilkins, AC / Patin, EC / Pedersen, M / Buus, R / Melcher, AA et al. | 2022
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Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cellsSubbarayan, Karthikeyan / Massa, Chiara / Leisz, Sandra / Steven, André / Bethmann, Daniel / Biehl, Katharina / Wickenhauser, Claudia / Seliger, Barbara et al. | 2022
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Intratumoural administration of an NKT cell agonist with CpG promotes NKT cell infiltration associated with an enhanced antitumour response and abscopal effectPrasit, Kef K / Ferrer-Font, Laura / Burn, Olivia K / Anderson, Regan J / Compton, Benjamin J / Schmidt, Alfonso J / Mayer, Johannes U / Chen, Chun-Jen J / Dasyam, Nathaniel / Ritchie, David S et al. | 2022
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Immunoreactivity against fibroblast growth factor 8 in alveolar rhabdomyosarcoma patients and its involvement in tumor aggressivenessPoli, Elena / Barbon, Vanessa / Lucchetta, Silvia / Cattelan, Manuela / Santoro, Luisa / Zin, Angelica / Milano, Giuseppe Maria / Zanetti, Ilaria / Bisogno, Gianni / Bonvini, Paolo et al. | 2022
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CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumorsSalewski, Inken / Henne, Julia / Engster, Leonie / Krone, Paula / Schneider, Bjoern / Redwanz, Caterina / Lemcke, Heiko / Henze, Larissa / Junghanss, Christian / Maletzki, Claudia et al. | 2022
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Helicobacter pylori serology is associated with worse overall survival in patients with melanoma treated with immune checkpoint inhibitorsTonneau, Marion / Nolin-Lapalme, Alexis / Kazandjian, Suzanne / Auclin, Edouard / Panasci, Justin / Benlaifaoui, Myriam / Ponce, Mayra / Al-Saleh, Afnan / Belkaid, Wiam / Naimi, Sabrine et al. | 2022
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CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphomaSu, Lihe / Wu, Lan / Lobb, Roy R. / Rennert, Paul D. / Ambrose, Christine et al. | 2022
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The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncologySecchiari, Florencia / Nuñez, Sol Yanel / Sierra, Jessica Mariel / Ziblat, Andrea / Regge, María Victoria / Raffo Iraolagoitia, Ximena Lucía / Rovegno, Agustín / Ameri, Carlos / Secin, Fernando Pablo / Richards, Nicolás et al. | 2022
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Immune targeting of three independent suppressive pathways (TIGIT, PD-L1, TGFβ) provides significant antitumor efficacy in immune checkpoint resistant modelsFranks, S. Elizabeth / Fabian, Kellsye P. / Santiago-Sánchez, Ginette / Wolfson, Benjamin / Hodge, James W. et al. | 2022
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The efficacy and safety of first-line treatment in cisplatin-ineligible advanced upper tract urothelial carcinoma patients: a comparison of PD-1 inhibitor and carboplatin plus gemcitabine chemotherapyHuang, Jiwei / Su, Ruopeng / Chen, Zeyu / Jiang, Shuai / Chen, Minfeng / Yuan, Yichu / Hu, Hailong / Fu, Changde / Huang, Zhiyang / Wang, Zhenyu et al. | 2022
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Comprehensive evaluation of the tumor immune microenvironment and its dynamic changes in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy: From the phase II ADORE studyCho, Hyungwoo / Kim, Jeong Eun / Hong, Yong Sang / Kim, Sun Young / Kim, Jihun / Ryu, Yeon-Mi / Kim, Sang-Yeob / Kim, Tae Won et al. | 2022
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Selective depletion of polymorphonuclear myeloid derived suppressor cells in tumor beds with near infrared photoimmunotherapy enhances host immune responseKato, Takuya / Fukushima, Hiroshi / Furusawa, Aki / Okada, Ryuhei / Wakiyama, Hiroaki / Furumoto, Hideyuki / Okuyama, Shuhei / Takao, Seiichiro / Choyke, Peter L. / Kobayashi, Hisataka et al. | 2022
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T cell-mediated elimination of cancer cells by blocking CEACAM6–CEACAM1 interactionPinkert, Jessica / Boehm, Hans-Henning / Trautwein, Mark / Doecke, Wolf-Dietrich / Wessel, Florian / Ge, Yingzi / Gutierrez, Eva Maria / Carretero, Rafael / Freiberg, Christoph / Gritzan, Uwe et al. | 2022
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Immunological responses to adjuvant vaccination with combined CD1c+ myeloid and plasmacytoid dendritic cells in stage III melanoma patientsBloemendal, Martine / Bol, Kalijn F. / Boudewijns, Steve / Gorris, Mark A.J. / de Wilt, Johannes H.W. / Croockewit, Sandra A.J. / van Rossum, Michelle M. / de Goede, Anna L. / Petry, Katja / Koornstra, Rutger H.T. et al. | 2022
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Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancerZheng, Shaoquan / Zou, Yutian / Tang, Yuhui / Yang, Anli / Liang, Jie-Ying / Wu, Linyu / Tian, Wenwen / Xiao, Weikai / Xie, Xinhua / Yang, Lu et al. | 2022
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Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinomaKono, Michihisa / Komatsuda, Hiroki / Yamaki, Hidekiyo / Kumai, Takumi / Hayashi, Ryusuke / Wakisaka, Risa / Nagato, Toshihiro / Ohkuri, Takayuki / Kosaka, Akemi / Ohara, Kenzo et al. | 2022
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Trispecific T-cell engagers for dual tumor-targeting of colorectal cancerTapia-Galisteo, Antonio / Sánchez Rodríguez, Íñigo / Aguilar-Sopeña, Oscar / Harwood, Seandean Lykke / Narbona, Javier / Ferreras Gutierrez, Mariola / Navarro, Rocío / Martín-García, Laura / Corbacho, Cesáreo / Compte, Marta et al. | 2022
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Toll-like receptor agonist combinations augment mouse T-cell anti-tumor immunity via IL-12- and interferon ß-mediated suppression of immune checkpoint receptor expressionJeon, Donghwan / McNeel, Douglas G. et al. | 2022
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Dissecting the cellular components of ex vivo γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trialsJonus, Hunter C. / Burnham, Rebecca E. / Ho, Andrew / Pilgrim, Adeiye A. / Shim, Jenny / Doering, Christopher B. / Spencer, H. Trent / Goldsmith, Kelly C. et al. | 2022
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Translocation of Helicobacter hepaticus synergizes with myeloid-derived suppressor cells and contributes to breast carcinogenesisDeng, Huan / Muthupalani, Sureshkumar / Erdman, Susan / Liu, Haibo / Niu, Zhengchuan / Wang, Timothy C. / Fox, James G. et al. | 2022
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LILRB4 promotes tumor metastasis by regulating MDSCs and inhibiting miR-1 family miRNAsSu, Mei-Tzu / Kumata, Sakiko / Endo, Shota / Okada, Yoshinori / Takai, Toshiyuki et al. | 2022
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Trial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapyPetrazzuolo, Adriana / Maiuri, M. Chiara / Zitvogel, Laurence / Kroemer, Guido / Kepp, Oliver et al. | 2022
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Glucose metabolism inhibitor PFK-015 combined with immune checkpoint inhibitor is an effective treatment regimen in cancerZheng, Jia Bo / Wong, Chau Wei / Liu, Jia / Luo, Xiao-Jing / Zhou, Wei-Yi / Chen, Yan-Xing / Luo, Hui-Yan / Zeng, Zhao-Lei / Ren, Chao / Xie, Xiao-Ming et al. | 2022
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IFNγ directly counteracts imatinib-induced apoptosis of primary human CD34+ CML stem/progenitor cells potentially through the upregulation of multiple key survival factorsUjvari, Dorina / Malyukova, Alena / Zovko, Ana / Yektaei-Karin, Elham / Madapura, Harsha S / Keszei, Marton / Nagy, Noemi / Lotfi, Kourosh / Björn, Niclas / Wallvik, Jonas et al. | 2022
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Immunotherapy approaches for the treatment of diffuse midline gliomasBernstock, Joshua D. / Hoffman, Samantha E. / Kappel, Ari D. / Valdes, Pablo A. / Essayed, Walid Ibn / Klinger, Neil V. / Kang, Kyung-Don / Totsch, Stacie K. / Olsen, Hannah E. / Schlappi, Charles W. et al. | 2022
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Tyk2 is a tumor suppressor in colorectal cancerMoritsch, Stefan / Mödl, Bernadette / Scharf, Irene / Janker, Lukas / Zwolanek, Daniela / Timelthaler, Gerald / Casanova, Emilio / Sibilia, Maria / Mohr, Thomas / Kenner, Lukas et al. | 2022
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Systemic T-cell and humoral responses against cancer testis antigens in hepatocellular carcinoma patientsNoordam, Lisanne / de Beijer, Monique T.A. / Mancham, Shanta / Vogler, Isabel / Boor, Patrick P.C. / de Ruiter, Valeska / Luijten, Robbie / IJzermans, Jan N.M. / Sahin, Ugur / Bruno, Marco J. et al. | 2022
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Bispecific T cell engagers kill resistant cells during KRAS-G12C blockade therapySong, Xinxin / Zhou, Zhuan / Kang, Rui / Tang, Daolin et al. | 2022
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Uric acid accumulation in DNA-damaged tumor cells induces NKG2D ligand expression and antitumor immunity by activating TGF-β-activated kinase 1Wang, Jingxiang / Liu, Kai / Xiao, Tianxiang / Liu, Penggang / Prinz, Richard A. / Xu, Xiulong et al. | 2022
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Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinomaAhmed, Azaz / Köhler, Sophia / Klotz, Rosa / Giese, Nathalia / Hackert, Thilo / Springfeld, Christoph / Zörnig, Inka / Jäger, Dirk / Halama, Niels et al. | 2022
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Fc-based Duokines: dual-acting costimulatory molecules comprising TNFSF ligands in the single-chain format fused to a heterodimerizing Fc (scDk-Fc)Aschmoneit, Nadine / Kocher, Katharina / Siegemund, Martin / Lutz, Martina S. / Kühl, Lennart / Seifert, Oliver / Kontermann, Roland E. et al. | 2022
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Beneficial autoimmunity and maladaptive inflammation shape epidemiological links between cancer and immune-inflammatory diseasesPol, Jonathan / Paillet, Juliette / Plantureux, Céleste / Kroemer, Guido et al. | 2022
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Immunostimulatory effects of vitamin B5 improve anticancer immunotherapyBourgin, Melanie / Kepp, Oliver / Kroemer, Guido et al. | 2022
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Tumor-associated macrophages promote intratumoral conversion of conventional CD4+ T cells into regulatory T cells via PD-1 signallingKos, Kevin / Salvagno, Camilla / Wellenstein, Max D. / Aslam, Muhammad A. / Meijer, Denize A. / Hau, Cheei-Sing / Vrijland, Kim / Kaldenbach, Daphne / Raeven, Elisabeth A.M. / Schmittnaegel, Martina et al. | 2022
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Overcoming T cell dysfunction in acidic pH to enhance adoptive T cell transfer immunotherapyNavarro, Flor / Casares, Noelia / Martín-Otal, Celia / Lasarte-Cía, Aritz / Gorraiz, Marta / Sarrión, Patricia / Llopiz, Diana / Reparaz, David / Varo, Nerea / Rodriguez-Madoz, Juan Roberto et al. | 2022
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Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in miceNath, Pulak R. / Pal-Nath, Dipasmita / Kaur, Sukhbir / Gangaplara, Arunkumar / Meyer, Thomas J. / Cam, Margaret C / Roberts, David D. et al. | 2022
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Nivolumab plus ipilimumab in metastatic uveal melanoma: a real-life, retrospective cohort of 47 patientsSalaün, Hélène / de Koning, Leanne / Saint-Ghislain, Mathilde / Servois, Vincent / Ramtohul, Toulsie / Garcia, Agathe / Matet, Alexandre / Cassoux, Nathalie / Mariani, Pascale / Piperno-Neumann, Sophie et al. | 2022
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Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activationLopez-Pelaez, Marta / Young, Lucy / Vazquez-Chantada, Mercedes / Nelson, Nadine / Durant, Steve / Wilkinson, Robert W. / Poon, Edmund / Gaspar, Miguel / Valge-Archer, Viia / Smith, Paul et al. | 2022
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Is ferroptosis immunogenic? The devil is in the details!Kepp, Oliver / Kroemer, Guido et al. | 2022
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Influencing tumor-associated macrophages in malignant melanoma with monoclonal antibodiesAdams, Rebecca / Osborn, Gabriel / Mukhia, Bipashna / Laddach, Roman / Willsmore, Zena / Chenoweth, Alicia / Geh, Jenny L C / MacKenzie Ross, Alastair D / Healy, Ciaran / Barber, Linda et al. | 2022
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Neoadjuvant PD-1 blockade plus chemotherapy induces a high pathological complete response rate and anti-tumor immune subsets in clinical stage III gastric cancerTang, Xiaohuan / Li, Mengyuan / Wu, Xiaolong / Guo, Ting / Zhang, Li / Tang, Lei / Jia, Fangzhou / Hu, Ying / Zhang, Yan / Xing, Xiaofang et al. | 2022
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SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade responseIbáñez-Molero, Sofía / van Vliet, Alex / Pozniak, Joanna / Hummelink, Karlijn / Terry, Alexandra M. / Monkhorst, Kim / Sanders, Joyce / Hofland, Ingrid / Landeloos, Ewout / Van Herck, Yannick et al. | 2022
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A role for EMT in CD73 regulation in breast cancerHasmim, Meriem / Berchem, Guy / Janji, Bassam et al. | 2022