Evaluating the role of FAMIly history of cancer and diagnosis of multiple neoplasms in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: the multicenter FAMI-L1 study (English)
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In:
OncoImmunology
;
9
, 1
;
2020
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ISSN:
- Article (Journal) / Electronic Resource
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Title:Evaluating the role of FAMIly history of cancer and diagnosis of multiple neoplasms in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: the multicenter FAMI-L1 study
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Contributors:Cortellini, Alessio ( author ) / Buti, Sebastiano ( author ) / Bersanelli, Melissa ( author ) / Giusti, Raffaele ( author ) / Perrone, Fabiana ( author ) / Di Marino, Pietro ( author ) / Tinari, Nicola ( author ) / De Tursi, Michele ( author ) / Grassadonia, Antonino ( author ) / Cannita, Katia ( author )
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Published in:OncoImmunology ; 9, 1
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Publisher:
- New search for: Taylor & Francis
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Publication date:2020-01-01
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 9, Issue 1
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
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Correction| 2020
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Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemiaStokes, Jessica / Hoffman, Emely A. / Molina, Megan S. / Kummet, Nicole / Simpson, Richard J. / Zeng, Yi / Katsanis, Emmanuel et al. | 2020
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Transimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancerAlvero, Ayesha B. / Hanlon, Douglas / Pitruzzello, Mary / Filler, Renata / Robinson, Eve / Sobolev, Olga / Tedja, Roslyn / Ventura, Alessandra / Bosenberg, Marcus / Han, Patrick et al. | 2020
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Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibitionCervera-Carrascon, Victor / Quixabeira, Dafne C.A. / Santos, Joao Manuel / Havunen, Riikka / Zafar, Sadia / Hemminki, Otto / Heiniö, Camilla / Munaro, Eleonora / Siurala, Mikko / Sorsa, Suvi et al. | 2020
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Adoptive cell therapy of triple negative breast cancer with redirected cytokine-induced killer cellsSommaggio, Roberta / Cappuzzello, Elisa / Dalla Pietà, Anna / Tosi, Anna / Palmerini, Pierangela / Carpanese, Debora / Nicolè, Lorenzo / Rosato, Antonio et al. | 2020
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Immunotherapy with NK cells: recent developments in gene modification open up new avenuesReindl, Lisa Marie / Albinger, Nawid / Bexte, Tobias / Müller, Stephan / Hartmann, Jessica / Ullrich, Evelyn et al. | 2020
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Age-related mutational signature negatively associated with immune activity and survival outcome in triple-negative breast cancerChen, Hao / Chong, Wei / Yang, Xiaorong / Zhang, Yuan / Sang, Shaowei / Li, Xiangchun / Lu, Ming et al. | 2020
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B lymphocytes contribute to stromal reaction in pancreatic ductal adenocarcinomaMinici, Claudia / Rigamonti, Elena / Lanzillotta, Marco / Monno, Antonella / Rovati, Lucrezia / Maehara, Takashi / Kaneko, Naoki / Deshpande, Vikram / Protti, Maria Pia / De Monte, Lucia et al. | 2020
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NK cells beat T cells at early breast cancer controlBuque, Aitziber / Bloy, Norma / Petroni, Giulia / Kroemer, Guido / Galluzzi, Lorenzo et al. | 2020
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Potential lung attack and lethality generated by EpCAM-specific CAR-T cells in immunocompetent mouse modelsQin, Diyuan / Li, Dan / Zhang, Benxia / Chen, Yue / Liao, Xuelian / Li, Xiaoyu / Alexander, Peter B. / Wang, Yongsheng / Li, Qi-Jing et al. | 2020
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Multiverse of immune microenvironment in metastatic colorectal cancerVan den Eynde, Marc / Mlecnik, Bernhard / Bindea, Gabriela / Galon, Jérôme et al. | 2020
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Better prognosis of gastric cancer patients with high levels of tumor infiltrating lymphocytes is counteracted by PD-1 expressionPötzsch, M. / Berg, E. / Hummel, M. / Stein, U. / von Winterfeld, M. / Jöhrens, K. / Rau, B. / Daum, S. / Treese, C. et al. | 2020
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Immunotherapy or other anti-cancer treatments and risk of exacerbation and mortality in cancer patients with COVID-19: a systematic review and meta-analysisWang, Bolin / Huang, Yan et al. | 2020
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Baseline plasma levels of soluble PD-1, PD-L1, and BTN3A1 predict response to nivolumab treatment in patients with metastatic renal cell carcinoma: a step toward a biomarker for therapeutic decisionsIncorvaia, Lorena / Fanale, Daniele / Badalamenti, Giuseppe / Porta, Camillo / Olive, Daniel / De Luca, Ida / Brando, Chiara / Rizzo, Mimma / Messina, Carlo / Rediti, Mattia et al. | 2020
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Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironmentYang, Min / Du, Wenwen / Yi, Lixian / Wu, Shaoxian / He, Chunyan / Zhai, Wensi / Yue, Cuihua / Sun, Runzi / Menk, Ashley V. / Delgoffe, Greg M. et al. | 2020
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Evaluating the role of FAMIly history of cancer and diagnosis of multiple neoplasms in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: the multicenter FAMI-L1 studyCortellini, Alessio / Buti, Sebastiano / Bersanelli, Melissa / Giusti, Raffaele / Perrone, Fabiana / Di Marino, Pietro / Tinari, Nicola / De Tursi, Michele / Grassadonia, Antonino / Cannita, Katia et al. | 2020
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Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune systemKlarenbeek, Sjoerd / Doornebal, Chris W. / Kas, Sjors M. / Bonzanni, Nicola / Bhin, Jinhyuk / Braumuller, Tanya M. / van der Heijden, Ingrid / Opdam, Mark / Schouten, Philip C. / Kersten, Kelly et al. | 2020
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T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sourcesBonte, Sarah / De Munter, Stijn / Goetgeluk, Glenn / Ingels, Joline / Pille, Melissa / Billiet, Lore / Taghon, Tom / Leclercq, Georges / Vandekerckhove, Bart / Kerre, Tessa et al. | 2020
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LAG-3 and PD-1+LAG-3 inhibition promote anti-tumor immune responses in human autologous melanoma/T cell co-culturesGestermann, Nicolas / Saugy, Damien / Martignier, Christophe / Tillé, Laure / Fuertes Marraco, Silvia A. / Zettl, Markus / Tirapu, Iñigo / Speiser, Daniel E. / Verdeil, Grégory et al. | 2020
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Nanovaccine administration route is critical to obtain pertinent iNKt cell help for robust anti-tumor T and B cell responsesDölen, Yusuf / Valente, Michael / Tagit, Oya / Jäger, Eliezer / Van Dinther, Eric A. W. / van Riessen, N. Koen / Hruby, Martin / Gileadi, Uzi / Cerundolo, Vincenzo / Figdor, Carl G. et al. | 2020
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Antibody targeting of B7-H4 enhances the immune response in urothelial carcinomaPodojil, Joseph R. / Glaser, Alexander P. / Baker, Dylan / Courtois, Elise T. / Fantini, Damiano / Yu, Yanni / Eaton, Valerie / Sivajothi, Santhosh / Chiang, Mingyi / Das, Arighno et al. | 2020
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Regulatory T cells and cytotoxic T cells close to the epithelial–stromal interface are associated with a favorable prognosisRudolf, Julian / Büttner-Herold, Maike / Erlenbach-Wünsch, Katharina / Posselt, Rebecca / Jessberger, Jonas / Haderlein, Marlen / Hecht, Markus / Hartmann, Arndt / Fietkau, Rainer / Distel, Luitpold et al. | 2020
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Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutationLee, Gyu Jin / Jun, Yukyung / Yoo, Hae Yong / Jeon, Yoon Kyung / Lee, Daekee / Lee, Sanghyuk / Kim, Jaesang et al. | 2020
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The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patientsMargaroli, Camilla / Cardenas, Maria A. / Jansen, Caroline S. / Moon Reyes, Adriana / Hosseinzadeh, Fares / Hong, Gordon / Zhang, Yilin / Kissick, Haydn / Tirouvanziam, Rabindra / Master, Viraj A. et al. | 2020
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Effect of excess weight and immune-related adverse events on the efficacy of cancer immunotherapy with anti-PD-1 antibodiesRogado, Jacobo / Romero-Laorden, Nuria / Sanchez-Torres, José Miguel / Ramos-Levi, Ana María / Pacheco-Barcia, Vilma / Ballesteros, Ana Isabel / Arranz, Reyes / Lorenzo, Alicia / Gullon, Pedro / Garrido, Ana et al. | 2020
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Staphylococcus aureus alpha-toxin inhibits CD8+ T cell-mediated killing of cancer cells in cutaneous T-cell lymphomaBlümel, Edda / Munir Ahmad, Shamaila / Nastasi, Claudia / Willerslev-Olsen, Andreas / Gluud, Maria / Fredholm, Simon / Hu, Tengpeng / Surewaard, Bas G. J. / Lindahl, Lise M. / Fogh, Hanne et al. | 2020
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Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor modelYe, Xuan / Waite, Janelle C. / Dhanik, Ankur / Gupta, Namita / Zhong, Maggie / Adler, Christina / Malahias, Evangelia / Ni, Min / Wei, Yi / Gurer, Cagan et al. | 2020
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Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcomeBrunekreeft, Kim L. / Paijens, Sterre T. / Wouters, Maartje C.A. / Komdeur, Fenne L. / Eggink, Florine A. / Lubbers, Joyce M. / Workel, Hagma H. / Van Der Slikke, Elisabeth C. / Pröpper, Noor E.J. / Leffers, Ninke et al. | 2020
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Blood eosinophilic relative count is prognostic for breast cancer and associated with the presence of tumor at diagnosis and at time of relapseOnesti, Concetta Elisa / Josse, Claire / Boulet, Delphine / Thiry, Jérôme / Beaumecker, Barbara / Bours, Vincent / Jerusalem, Guy et al. | 2020
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Serum CCL27 predicts the response to Bacillus Calmette-Guerin immunotherapy in non-muscle-invasive bladder cancerZhong, Wenlong / Wang, Bo / Yu, Hao / Lin, Jianxun / Xia, Kun / Hou, Weibin / Yang, Meihua / Chen, Junyu / Yang, Meng / Wang, Xiaofei et al. | 2020
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Current Clinical Evidence and Potential Solutions to Increase Benefit of CAR T-Cell Therapy for Patients with Solid TumorsAlcantara, Marion / Du Rusquec, Pauline / Romano, Emanuela et al. | 2020
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Surface-exposed and soluble calreticulin: conflicting biomarkers for cancer prognosisKepp, Oliver / Liu, Peng / Zhao, Liwei / Plo, Isabelle / Kroemer, Guido et al. | 2020
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Anti-GD2 antibody and Vorinostat immunocombination therapy is highly effective in an aggressive orthotopic neuroblastoma modelvan den Bijgaart, Renske J. E. / Kroesen, Michiel / Brok, Ingrid C. / Reijnen, Daphne / Wassink, Melissa / Boon, Louis / Hoogerbrugge, Peter M. / Adema, Gosse J et al. | 2020
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Differential gene expression of tumor-infiltrating CD4+ T cells in advanced versus early stage colorectal cancer and identification of a gene signature of poor prognosisSasidharan Nair, Varun / Saleh, Reem / Taha, Rowaida Z / Toor, Salman M / Murshed, Khaled / Ahmed, Ayman A / Kurer, Mohamed A / Abu Nada, Mohamed / Al Ejeh, Fares / Elkord, Eyad et al. | 2020
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Immunity to live: an immunopathoscore using the consensus Immunoscore to best define the risk of recurrence and death in stage IV metastatic patientsBaldin, Pamela / Van den Eynde, Marc / Mlecnik, Bernhard / Galon, Jérôme et al. | 2020
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Immunotherapy as sensitizer for local radiotherapyVanneste, Ben G.L. / Van Limbergen, Evert J / Dubois, Ludwig / Samarska, Iryna V. / Wieten, L. / Aarts, M. J.B. / Marcelissen, T. / De Ruysscher, Dirk et al. | 2020
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Is the survival of patients treated with ipilimumab affected by antibiotics? An analysis of 1585 patients from the French National hospital discharge summary database (PMSI)Cren, Pierre-Yves / Bertrand, Nicolas / Le Deley, Marie-Cécile / Génin, Michaël / Mortier, Laurent / Odou, Pascal / Penel, Nicolas / Chazard, Emmanuel et al. | 2020
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The promise of adoptive cellular immunotherapies in hepatocellular carcinomaHendrickson, Peter G. / Olson, Michael / Luetkens, Tim / Weston, Siani / Han, Tiffany / Atanackovic, Djordje / Fine, Gabriel C. et al. | 2020
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The prognostic impact of immune-related adverse events during anti-PD1 treatment in melanoma and non–small-cell lung cancer: a real-life retrospective studyDupont, R. / Bérard, E. / Puisset, F. / Comont, T. / Delord, J.-P. / Guimbaud, R. / Meyer, N. / Mazieres, J. / Alric, L. et al. | 2020
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The M2 macrophage marker CD206: a novel prognostic indicator for acute myeloid leukemiaXu, Zi-Jun / Gu, Yu / Wang, Cui-Zhu / Jin, Ye / Wen, Xiang-Mei / Ma, Ji-Chun / Tang, Li-Juan / Mao, Zhen-Wei / Qian, Jun / Lin, Jiang et al. | 2020
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Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6Czerwinska, Patrycja / Rucinski, Marcin / Wlodarczyk, Nikola / Jaworska, Anna / Grzadzielewska, Iga / Gryska, Katarzyna / Galus, Lukasz / Mackiewicz, Jacek / Mackiewicz, Andrzej et al. | 2020
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ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancerYe, Wenda / Gunti, Sreenivasulu / Allen, Clint T. / Hong, Youji / Clavijo, Paul E. / Van Waes, Carter / Schmitt, Nicole C. et al. | 2020
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Establishing a model system for evaluating CAR T cell therapy using dogs with spontaneous diffuse large B cell lymphomaPanjwani, M. Kazim / Atherton, Matthew J. / MaloneyHuss, Martha A. / Haran, Kumudhini P. / Xiong, Ailian / Gupta, Minnal / Kulikovsaya, Irina / Lacey, Simon F. / Mason, Nicola J. et al. | 2020
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Comedications influence immune infiltration and pathological response to neoadjuvant chemotherapy in breast cancerHamy, Anne-Sophie / Derosa, Lisa / Valdelièvre, Constance / Yonekura, Satoru / Opolon, Paule / Priour, Maël / Guerin, Julien / Pierga, Jean-Yves / Asselain, Bernard / De Croze, Diane et al. | 2020
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Preclinical evaluation of an affinity-enhanced MAGE-A4-specific T-cell receptor for adoptive T-cell therapySanderson, Joseph P / Crowley, Darragh J / Wiedermann, Guy E / Quinn, Laura L / Crossland, Katherine L / Tunbridge, Helen M / Cornforth, Terri V / Barnes, Christopher S / Ahmed, Tina / Howe, Karen et al. | 2020
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Identification of a CD8+ T-cell response to a predicted neoantigen in malignant mesotheliomaSneddon, Sophie / Rive, Craig M. / Ma, Shaokang / Dick, Ian M. / Allcock, Richard J. N. / Brown, Scott D. / Holt, Robert A. / Watson, Mark / Leary, Shay / Lee, Y. C. Gary et al. | 2020
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Secreted calreticulin mutants subvert anticancer immunosurveillanceLiu, Peng / Zhao, Liwei / Kroemer, Guido / Kepp, Oliver et al. | 2020
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Durable tumor regression in highly refractory metastatic KIT/PDGFRA wild-type GIST following treatment with nivolumabSchroeder, Brett A. / Kohli, Karan / O’Malley, Ryan B. / Kim, Theresa S. / Jones, Robin L. / Pierce, Robert H. / Pollack, Seth M. et al. | 2020
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Deep neural network classification based on somatic mutations potentially predicts clinical benefit of immune checkpoint blockade in lung adenocarcinomaPeng, Jie / Zou, Dan / Gong, Wuxing / Kang, Shuai / Han, Lijie et al. | 2020
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Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responsesShevchenko, Ivan / Mathes, Andreas / Groth, Christopher / Karakhanova, Svetlana / Müller, Verena / Utikal, Jochen / Werner, Jens / Bazhin, Alexandr V. / Umansky, Viktor et al. | 2020
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ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistanceOrme, Jacob J. / Jazieh, Khalid A. / Xie, Tiancheng / Harrington, Susan / Liu, Xin / Ball, Matthew / Madden, Benjamin / Charlesworth, M. Cristine / Azam, Tariq U. / Lucien, Fabrice et al. | 2020
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Prognostic value of CD73 expression in resected colorectal cancer liver metastasisMessaoudi, Nouredin / Cousineau, Isabelle / Arslanian, Elizabeth / Henault, David / Stephen, David / Vandenbroucke-Menu, Franck / Dagenais, Michel / Létourneau, Richard / Plasse, Marylène / Roy, André et al. | 2020
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CD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancerYoshimura, Katsuhiro / Suzuki, Yuzo / Inoue, Yusuke / Tsuchiya, Kazuo / Karayama, Masato / Iwashita, Yuji / Kahyo, Tomoaki / Kawase, Akikazu / Tanahashi, Masayuki / Ogawa, Hiroshi et al. | 2020
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The prognostic role of NK cells and their ligands in squamous cell carcinoma of the head and neck: a systematic review and meta-analysisBisheshar, Sangeeta K. / De Ruiter, Emma J. / Devriese, Lot A. / Willems, Stefan M. et al. | 2020
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Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustionBalkhi, Mumtaz Y. et al. | 2020
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Exosomal communication by metastatic osteosarcoma cells modulates alveolar macrophages to an M2 tumor-promoting phenotype and inhibits tumoricidal functionsWolf-Dennen, Kerri / Gordon, Nancy / Kleinerman, Eugenie S. et al. | 2020
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The ambiguous role of FPR1 in immunity and inflammationVacchelli, Erika / Le Naour, Julie / Kroemer, Guido et al. | 2020
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Heterogeneity of immune microenvironment in ovarian cancer and its clinical significance: a retrospective studyGao, Yue / Chen, Lingxi / Cai, Guangyao / Xiong, Xiaoming / Wu, Yuan / Ma, Ding / Li, Shuai Cheng / Gao, Qinglei et al. | 2020
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COVID-19: a challenge for oncology servicesRouty, Bertrand / Derosa, Lisa / Zitvogel, Laurence / Kroemer, Guido et al. | 2020
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Trial watch: TLR3 agonists in cancer therapyLe Naour, Julie / Galluzzi, Lorenzo / Zitvogel, Laurence / Kroemer, Guido / Vacchelli, Erika et al. | 2020
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Elucidating the gut microbiota composition and the bioactivity of immunostimulatory commensals for the optimization of immune checkpoint inhibitorsDaillère, Romain / Routy, Bertrand / Goubet, Anne-Gaëlle / Cogdill, Alexandria / Ferrere, Gladys / Alves-Costa Silva, Carolina / Fluckiger, Aurélie / Ly, Pierre / Haddad, Yacine / Pizzato, Eugenie et al. | 2020
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The consensus Immunoscore in phase 3 clinical trial (N0147) and impact on patient management decisionsLanzi, Anastasia / Sinicrope, F. A. / Benson, A. B. / Galon, Jérôme et al. | 2020
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Primary and metastatic breast tumors cross-talk to influence immunotherapy responsesOliver, Amanda J / Keam, Simon P / von Scheidt, Bianca / Zanker, Damien J / Harrison, Aaron J / Tantalo, Daniela GM / Darcy, Phillip K / Kershaw, Michael H / Slaney, Clare Y et al. | 2020
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Immune responses during COVID-19 infectionMelenotte, Cléa / Silvin, Aymeric / Goubet, Anne-Gaëlle / Lahmar, Imran / Dubuisson, Agathe / Zumla, Alimuddin / Raoult, Didier / Merad, Mansouria / Gachot, Bertrand / Hénon, Clémence et al. | 2020
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Firing up the cold tumors by targeting Vps34Janji, Bassam / Hasmim, Meriem / Parpal, Santiago / Berchem, Guy / Noman, Muhammad Zaeem et al. | 2020
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Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor responseMashima, Hiroaki / Zhang, Rong / Kobayashi, Tsuyoshi / Hagiya, Yuichiro / Tsukamoto, Hirotake / Liu, Tianyi / Iwama, Tatsuaki / Yamamoto, Masateru / Lin, Chiahsuan / Nakatsuka, Ryusuke et al. | 2020
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Quantitative assessment of tumor-infiltrating lymphocytes in mismatch repair proficient colon cancerJimenez-Rodriguez, Rosa M. / Patil, Sujata / Keshinro, Ajaratu / Shia, Jinru / Vakiani, Efsevia / Stadler, Zsofia / Segal, Neil H. / Yaeger, Rona / Konishi, Tsuyoshi / Shimada, Yoshifumi et al. | 2020
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A Phase 1b Study Evaluating the Safety, Tolerability, and Immunogenicity of CMB305, a Lentiviral-Based Prime-Boost Vaccine Regimen, in Patients with Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1Somaiah, Neeta / Chawla, Sant P. / Block, Matthew S. / Morris, John C. / Do, Khanh / Kim, Joseph W. / Druta, Mihaela / Sankhala, Kamalesh K. / Hwu, Patrick / Jones, Robin L. et al. | 2020
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Cancer Risks in Solid Organ Transplant Recipients: Results from a Comprehensive Analysis of 72 Cohort StudiesHuo, Zhenyu / Li, Caichen / Xu, Xin / Ge, Fan / Wang, Runchen / Wen, Yaokai / Peng, Haoxin / Wu, Xiangrong / Liang, Hengrui / Peng, Guilin et al. | 2020
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Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophagesSmolag, Karolina I. / Mueni, Christine M. / Leandersson, Karin / Jirström, Karin / Hagerling, Catharina / Mörgelin, Matthias / Barlow, Paul N. / Martin, Myriam / Blom, Anna M. et al. | 2020
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Overproduction of IL-2 by Cbl-b deficient CD4+ T cells provides resistance against regulatory T cellsHan, SeongJun / Chung, Douglas C. / St. Paul, Michael / Liu, Zhe Qi / Garcia-Batres, Carlos / Elford, Alisha R. / Tran, Charles W. / Chapatte, Laurence / Ohashi, Pamela S. et al. | 2020
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Evaluation of PD-L1 expression on circulating tumor cells (CTCs) in patients with advanced urothelial carcinoma (UC)Bergmann, Sonja / Coym, Anja / Ott, Leonie / Soave, Armin / Rink, Michael / Janning, Melanie / Stoupiec, Malgorzata / Coith, Cornelia / Peine, Sven / von Amsberg, Gunhild et al. | 2020
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UniCAR T cell immunotherapy enables efficient elimination of radioresistant cancer cellsArndt, Claudia / Loureiro, Liliana R. / Feldmann, Anja / Jureczek, Justyna / Bergmann, Ralf / Máthé, Domokos / Hegedüs, Nikolett / Berndt, Nicole / Koristka, Stefanie / Mitwasi, Nicola et al. | 2020
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Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomasDancsok, Amanda R. / Gao, Dongxia / Lee, Anna F. / Steigen, Sonja Eriksson / Blay, Jean-Yves / Thomas, David M. / Maki, Robert G. / Nielsen, Torsten O. / Demicco, Elizabeth G. et al. | 2020
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Efficacy of adjuvant cytokine-induced killer cell immunotherapy in patients with colorectal cancer after radical resectionPan, Qiu-Zhong / Zhao, Jing-Jing / Yang, Chao-Pin / Zhou, Yu-Qing / Lin, Jun-Zhong / Tang, Yan / Gu, Jia-Mei / Wang, Qi-Jing / Li, Yong-Qiang / He, Jia et al. | 2020
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A meta-analysis comparing responses of Asian versus non-Asian cancer patients to PD-1 and PD-L1 inhibitor-based therapyPeng, Ling / Qin, Bao-Dong / Xiao, Kui / Xu, Song / Yang, Jin-Song / Zang, Yuan-Sheng / Stebbing, Justin / Xie, Li-Ping et al. | 2020
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Systemic inflammation is associated with circulating cell death released keratin 18 fragments in colorectal cancerSirniö, Päivi / Väyrynen, Juha P. / Mutt, Shivaprakash J. / Herzig, Karl-Heinz / Walkowiak, Jaroslaw / Klintrup, Kai / Mäkelä, Jyrki / Karttunen, Tuomo J. / Mäkinen, Markus J. / Tuomisto, Anne et al. | 2020
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Colon-specific immune microenvironment regulates cancer progression versus rejectionTrimaglio, Giulia / Tilkin-Mariamé, Anne-Françoise / Feliu, Virginie / Lauzéral-Vizcaino, Françoise / Tosolini, Marie / Valle, Carine / Ayyoub, Maha / Neyrolles, Olivier / Vergnolle, Nathalie / Rombouts, Yoann et al. | 2020
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Complete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccinationLövgren, Tanja / Wolodarski, Maria / Wickström, Stina / Edbäck, Ulrika / Wallin, Mette / Martell, Eva / Markland, Katrin / Blomberg, Pontus / Nyström, Maria / Lundqvist, Andreas et al. | 2020
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Human innate immune cell crosstalk induces melanoma cell senescenceFunck, Felix / Pahl, Jens / Kyjacova, Lenka / Freund, Lukas / Oehrl, Stephanie / Gräbe, Galina / Pezer, Silvia / Hassel, Jessica C. / Sleeman, Jonathan / Cerwenka, Adelheid et al. | 2020
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Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosisNugteren, Sandrine / Goos, Jeroen A.C.M. / Delis-van Diemen, Pien M. / Simons-Oosterhuis, Ytje / Lindenbergh-Kortleve, Dicky J. / van Haaften, Daniëlle H. / Sanders, Joyce / Meijer, Gerrit A. / Fijneman, Remond J.A. / Samsom, Janneke N. et al. | 2020
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MIF inhibition as a strategy for overcoming resistance to immune checkpoint blockade therapy in melanomade Azevedo, Ricardo A. / Shoshan, Einav / Whang, Shanzhi / Markel, Gal / Jaiswal, Ashvin R. / Liu, Arthur / Curran, Michael A. / Travassos, Luiz R. / Bar-Eli, Menashe et al. | 2020
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Close proximity of immune and tumor cells underlies response to anti-PD-1 based therapies in metastatic melanoma patientsGide, Tuba N. / Silva, Ines P. / Quek, Camelia / Ahmed, Tasnia / Menzies, Alexander M. / Carlino, Matteo S. / Saw, Robyn P.M. / Thompson, John F. / Batten, Marcel / Long, Georgina V. et al. | 2020
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Isolated limb perfusion with melphalan activates interferon-stimulated genes to induce tumor regression in patients with melanoma in-transit metastasisJohansson, Junko / Kiffin, Roberta / Aydin, Ebru / Nilsson, Malin S. / Hellstrand, Kristoffer / Lindnér, Per / Naredi, Peter / Olofsson Bagge, Roger / Martner, Anna et al. | 2020
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B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse modelsHuang, Baozhu / Luo, Liqun / Wang, Jun / He, Bailin / Feng, Rui / Xian, Na / Zhang, Qiong / Chen, Lieping / Huang, Gangxiong et al. | 2020
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Efficacy and safety of anticancer drug combinations: a meta-analysis of randomized trials with a focus on immunotherapeutics and gene-targeted compoundsJardim, Denis L. / De Melo Gagliato, Débora / Nikanjam, Mina / Barkauskas, Donald A. / Kurzrock, Razelle et al. | 2020
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Potent immunomodulatory effects of an anti-CEA-IL-2 immunocytokine on tumor therapy and effects of stereotactic radiationKujawski, Maciej / Sherman, Mark / Hui, Susanta / Zuro, Darren / Lee, Wen-Hui / Yazaki, Paul / Sherman, Anakim / Szpikowska, Barbara / Chea, Junie / Lasiewski, Desiree et al. | 2020
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Tumor-targeting oncolytic virus elicits potent immunotherapeutic vaccine responses to tumor antigensLuo, Yong / Lin, Chaolong / Zou, Yidi / Ju, Fei / Ren, Wenfeng / Lin, Yanhua / Wang, Yale / Huang, Xiaoxuan / Liu, Huiling / Yu, Zeng et al. | 2020
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Valproic acid attenuates CCR2-dependent tumor infiltration of monocytic myeloid-derived suppressor cells, limiting tumor progressionXie, Zhiqi / Ikegami, Tamami / Ago, Yukio / Okada, Naoki / Tachibana, Masashi et al. | 2020
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Blockade of programmed cell death protein 1 (PD-1) in Sézary syndrome reduces Th2 phenotype of non-tumoral T lymphocytes but may enhance tumor proliferationSaulite, Ieva / Ignatova, Desislava / Chang, Yun-Tsan / Fassnacht, Christina / Dimitriou, Florentia / Varypataki, Eleni / Anzengruber, Florian / Nägeli, Mirjam / Cozzio, Antonio / Dummer, Reinhard et al. | 2020
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Identifying optimal first-line interventions for advanced non-small cell lung carcinoma according to PD-L1 expression: a systematic review and network meta-analysisLiu, Jie / Li, Chengming / Seery, Samuel / Yu, Jinming / Meng, Xue et al. | 2020
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Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune responseSong, Mei / Wang, Chao / Wang, Huan / Zhang, Tuo / Li, Jiuqi / Benezra, Robert / Chouchane, Lotfi / Sun, Yin-Hao / Cui, Xin-Gang / Ma, Xiaojing et al. | 2020
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T cell receptor repertoire as a prognosis marker for heat shock protein peptide complex-96 vaccine trial against newly diagnosed glioblastomaZhang, Yang / Mudgal, Poorva / Wang, Liuyang / Wu, Haiyang / Huang, Na / Alexander, Peter B. / Gao, Zhixian / Ji, Nan / Li, Qi-Jing et al. | 2020
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MMP2 as an independent prognostic stratifier in oral cavity cancersHoffmann, Caroline / Vacher, Sophie / Sirven, Philémon / Lecerf, Charlotte / Massenet, Lucile / Moreira, Aurélie / Surun, Aurore / Schnitzler, Anne / Klijanienko, Jerzy / Mariani, Odette et al. | 2020
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Intravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma modelMurty, Surya / Haile, Samuel T. / Beinat, Corinne / Aalipour, Amin / Alam, Israt S. / Murty, Tara / Shaffer, Travis M. / Patel, Chirag B. / Graves, Edward E. / Mackall, Crystal L. et al. | 2020
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A novel gene signature to predict immune infiltration and outcome in patients with prostate cancerShao, Ning / Tang, Hong / Mi, Yuanyuan / Zhu, Yao / Wan, Fangning / Ye, Dingwei et al. | 2020
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Anti-EGF antibodies as surrogate biomarkers of clinical efficacy in stage IIIB/IV non-small-cell lung cancer patients treated with an optimized CIMAvax-EGF vaccination schedulePopa, Xitlally / García, Beatriz / Fuentes, Karla P. / Huerta, Vivian / Alvarez, Karen / Viada, Carmen E. / Neninger, Elia / Rodríguez, Pedro C. / González, Zuyen / González, Amnely et al. | 2020
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Cancer immunotherapy using a polysaccharide from Codium fragile in a murine modelPark, Hae-Bin / Lim, Seong-Min / Hwang, Juyoung / Zhang, Wei / You, SangGuan / Jin, Jun-O et al. | 2020
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Identification of miR-200a-5p targeting the peptide transporter TAP1 and its association with the clinical outcome of melanoma patientsLazaridou, Maria-Filothei / Gonschorek, Evamaria / Massa, Chiara / Friedrich, Michael / Handke, Diana / Mueller, Anja / Jasinski-Bergner, Simon / Dummer, Reinhard / Koelblinger, Peter / Seliger, Barbara et al. | 2020
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Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade gliomaMarinari, Eliana / Allard, Mathilde / Gustave, Robin / Widmer, Valérie / Philippin, Géraldine / Merkler, Doron / Tsantoulis, Petros / Dutoit, Valérie / Dietrich, Pierre-Yves et al. | 2020
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Identification of tumor-infiltrating immune cells and prognostic validation of tumor-infiltrating mast cells in adrenocortical carcinoma: results from bioinformatics and real-world dataTian, Xi / Xu, Wenhao / Wang, Yuchen / Anwaier, Aihetaimujiang / Wang, Hongkai / Wan, Fangning / Zhu, Yu / Cao, Dalong / Shi, Guohai / Zhu, Yiping et al. | 2020
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Versatile chimeric antigen receptor platform for controllable and combinatorial T cell therapyFeldmann, Anja / Hoffmann, Anja / Bergmann, Ralf / Koristka, Stefanie / Berndt, Nicole / Arndt, Claudia / Rodrigues Loureiro, Liliana / Kittel-Boselli, Enrico / Mitwasi, Nicola / Kegler, Alexandra et al. | 2020
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Combination treatments with hydroxychloroquine and azithromycin are compatible with the therapeutic induction of anticancer immune responsesLiu, Peng / Zhao, Liwei / Ferrere, Gladys / Alves-Costa-Silva, Carolina / Ly, Pierre / Wu, Qi / Tian, Ai-Ling / Derosa, Lisa / Zitvogel, Laurence / Kepp, Oliver et al. | 2020
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Trial Watch: experimental TLR7/TLR8 agonists for oncological indicationsFrega, Giorgio / Wu, Qi / Le Naour, Julie / Vacchelli, Erika / Galluzzi, Lorenzo / Kroemer, Guido / Kepp, Oliver et al. | 2020
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IDH-mutant gliomas harbor fewer regulatory T cells in humans and miceRichardson, Leland G. / Nieman, Linda T. / Stemmer-Rachamimov, Anat O. / Zheng, Xijin S. / Stafford, Khalifa / Nagashima, Hiroaki / Miller, Julie J. / Kiyokawa, Juri / Ting, David T. / Wakimoto, Hiroaki et al. | 2020
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Pirfenidone facilitates immune infiltration and enhances the antitumor efficacy of PD-L1 blockade in miceQin, Wan / Zou, Jun / Huang, Yongbiao / Liu, Chaofan / Kang, Yalin / Han, Hu / Tang, Yang / Li, Long / Liu, Bo / Zhao, Weiheng et al. | 2020
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Improving the anti-solid tumor efficacy of CAR-T cells by inhibiting adenosine signaling pathwayLi, Na / Tang, Na / Cheng, Chen / Hu, Tao / Wei, Xiaofei / Han, Weidong / Wang, Haoyi et al. | 2020
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Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancerTinholt, Mari / Stavik, Benedicte / Tekpli, Xavier / Garred, Øystein / Borgen, Elin / Kristensen, Vessela / Sahlberg, Kristine Kleivi / Sandset, Per Morten / Iversen, Nina et al. | 2020
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Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patientsKalathil, Suresh Gopi / Wang, Katy / Hutson, Alan / Iyer, Renuka / Thanavala, Yasmin et al. | 2020
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Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodesLi, Yen-Liang / Chen, Chung-Hsing / Chen, Jing-Yi / Lai, You-Syuan / Wang, Shao-Chun / Jiang, Shih-Sheng / Hung, Wen-Chun et al. | 2020
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Immune infiltration and immune gene signature predict the response to fluoropyrimidine-based chemotherapy in colorectal cancer patientsMo, Xianwei / Huang, Xiaoliang / Feng, Yan / Wei, Chunyin / Liu, Haizhou / Ru, Haiming / Qin, Haiquan / Lai, Hao / Wu, Guo / Xie, Weishun et al. | 2020
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Regulatory approval of photoimmunotherapy: photodynamic therapy that induces immunogenic cell deathGomes-da-Silva, Lígia C. / Kepp, Oliver / Kroemer, Guido et al. | 2020
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Hist-Immune signature: a prognostic factor in colorectal cancer using immunohistochemical slide image analysisZhao, Ke / Li, Zhenhui / Li, Yong / Yao, Su / Huang, Yanqi / Wang, Yingyi / Zhang, Fang / Wu, Lin / Chen, Xin / Liang, Changhong et al. | 2020
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Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapiesMa, Yuting / Yang, Heng / Kroemer, Guido et al. | 2020
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GD2-targeted chimeric antigen receptor T cells prevent metastasis formation by elimination of breast cancer stem-like cellsSeitz, Christian M. / Schroeder, Sarah / Knopf, Philipp / Krahl, Ann-Christin / Hau, Jana / Schleicher, Sabine / Martella, Manuela / Quintanilla-Martinez, Leticia / Kneilling, Manfred / Pichler, Bernd et al. | 2020
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Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneityKato, Shumei / Okamura, Ryosuke / Kumaki, Yuichi / Ikeda, Sadakatsu / Nikanjam, Mina / Eskander, Ramez / Goodman, Aaron / Lee, Suzanna / Glenn, Sean T. / Dressman, Devin et al. | 2020
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Immune-related adverse events are clustered into distinct subtypes by T-cell profiling before and early after anti-PD-1 treatmentKim, Kyung Hwan / Hur, Joon Young / Cho, Jinhyun / Ku, Bo Mi / Koh, Jiae / Koh, June Young / Sun, Jong-Mu / Lee, Se-Hoon / Ahn, Jin Seok / Park, Keunchil et al. | 2020
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Oncolytic poxvirus CF33-hNIS-ΔF14.5 favorably modulates tumor immune microenvironment and works synergistically with anti-PD-L1 antibody in a triple-negative breast cancer modelChaurasiya, Shyambabu / Yang, Annie / Kang, Seonah / Lu, Jianming / Kim, Sang-In / Park, Anthony K. / Sivanandam, Venkatesh / Zhang, Zhifang / Woo, Yanghee / Warner, Susanne G. et al. | 2020
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Lactate dehydrogenase: a marker of diminished antitumor immunityVan Wilpe, Sandra / Koornstra, Rutger / Den Brok, Martijn / De Groot, Jan Willem / Blank, Christian / De Vries, Jolanda / Gerritsen, Winald / Mehra, Niven et al. | 2020
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Immune co-culture cell microarray – a feasible tool for high-throughput functional investigation of lymphocyte–cancer interactionsBaruch, Erez Nissim / Ortenberg, Rona / Avivi, Camila / Anafi, Liat / Dick-Necula, Daniela / Stossel, Chani / Moshkovits, Yonatan / Itzhaki, Orit / Besser, Michal Judith / Schachter, Jacob et al. | 2020
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RRx-001, a first-in-class small molecule inhibitor of MYC and a downregulator of CD47, is an "erythrophagoimmunotherapeutic"Oronsky, Bryan / Carter, Corey A. / Caroen, Scott / Scribner, Curtis / Oronsky, Arnold / Reid, Tony R. et al. | 2020
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CD44v3 protein-carrying tumor-derived exosomes in HNSCC patients’ plasma as potential noninvasive biomarkers of disease activityTheodoraki, Marie-Nicole / Matsumoto, Akihiro / Beccard, Inga / Hoffmann, Thomas K. / Whiteside, Theresa L. et al. | 2020
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ROS1-fusion protein induces PD-L1 expression via MEK-ERK activation in non-small cell lung cancerLiu, Zheng / Zhao, Kejia / Wei, Shiyou / Liu, Chengwu / Zhou, Jiankang / Gou, Qiheng / Wu, Xia / Yang, Zhenyu / Yang, Yanbo / Peng, Yong et al. | 2020
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Dexamethasone premedication suppresses vaccine-induced immune responses against cancerVormehr, Mathias / Lehar, Sophie / Kranz, Lena M. / Tahtinen, Siri / Oei, Yoko / Javinal, Vincent / Delamarre, Lélia / Walzer, Kerstin C. / Diken, Mustafa / Kreiter, Sebastian et al. | 2020
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A rationally-engineered IL-2 improves the antitumor effect of anti-CD20 therapyCasadesús, Ana Victoria / Deligne, Claire / Diallo, Béré Kadjdiatou / Sosa, Katya / Josseaume, Nathalie / Mesa, Circe / León, Kalet / Hernández, Tays / Teillaud, Jean-Luc et al. | 2020
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Proliferative potential and response to nivolumab in clear cell renal cell carcinoma patientsZhang, Tian / Pabla, Sarabjot / Lenzo, Felicia L. / Conroy, Jeffrey M. / Nesline, Mary K. / Glenn, Sean T. / Papanicolau-Sengos, Antonios / Burgher, Blake / Giamo, Vincent / Andreas, Jonathan et al. | 2020
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Efficacy and safety of immune checkpoint inhibitors in patients with advanced non–small cell lung cancer (NSCLC): a systematic literature reviewWagner, Gernot / Stollenwerk, Hannah Karolina / Klerings, Irma / Pecherstorfer, Martin / Gartlehner, Gerald / Singer, Josef et al. | 2020
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Tumor-derived exosomes: the next generation of promising cell-free vaccines in cancer immunotherapyNaseri, Marzieh / Bozorgmehr, Mahmood / Zöller, Margot / Ranaei Pirmardan, Ehsan / Madjd, Zahra et al. | 2020
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The consensus immunoscore: toward a new classification of colorectal cancerLanzi, Anastasia / Pagès, Franck / Lagorce-Pagès, Christine / Galon, Jérôme et al. | 2020
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Lurbinectedin: an FDA-approved inducer of immunogenic cell death for the treatment of small-cell lung cancerKepp, Oliver / Zitvogel, Laurence / Kroemer, Guido et al. | 2020
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Mitochondrial control of innate immune signaling by irradiated cancer cellsYamazaki, Takahiro / Galluzzi, Lorenzo et al. | 2020
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Characterization of the human tumor microbiome reveals tumor-type specific intra-cellular bacteriaLivyatan, Ilana / Nejman, Deborah / Shental, Noam / Straussman, Ravid et al. | 2020
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Intratumoral CCR5+ neutrophils identify immunogenic subtype muscle-invasive bladder cancer with favorable prognosis and therapeutic responsesXiang, Zhuoyi / Zhou, Quan / Zeng, Han / Wang, Zewei / Zhang, Hongyu / Liu, Zhaopei / Huang, Qiuren / Chang, Yuan / Bai, Qi / Xia, Yu et al. | 2020
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The consensus Immunoscore in phase 3 clinical trials; potential impact on patient management decisionsPagès, Franck / Taieb, Julien / Laurent-Puig, Pierre / Galon, Jérôme et al. | 2020
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IAP inhibitor, Embelin increases VCAM-1 levels on the endothelium, producing lymphocytic infiltration and antitumor immunityNakajima, Kosei / Ino, Yoshinori / Yamazaki-Itoh, Rie / Naito, Chie / Shimasaki, Mari / Takahashi, Mami / Esaki, Minoru / Nara, Satoshi / Kishi, Yoji / Shimada, Kazuaki et al. | 2020
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Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4Choi, Sung Hee / Barker, Emily C. / Gerber, Kyle J. / Letterio, John J. / Kim, Byung-Gyu et al. | 2020
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Quantitative MRI cell tracking of immune cell recruitment to tumors and draining lymph nodes in response to anti-PD-1 and a DPX-based immunotherapyTremblay, Marie-Laurence / O’Brien-Moran, Zoe / Rioux, James A. / Nuschke, Andrea / Davis, Christa / Kast, W. Martin / Weir, Genevieve / Stanford, Marianne / Brewer, Kimberly D. et al. | 2020
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PD-L1 is overexpressed on breast cancer stem cells through notch3/mTOR axisMansour, Fatmah A. / Al-Mazrou, Amer / Al-Mohanna, Falah / Al-Alwan, Monther / Ghebeh, Hazem et al. | 2020
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Response and survival of metastatic melanoma patients treated with immune checkpoint inhibition for recurrent disease on adjuvant dendritic cell vaccinationvan Willigen, Wouter W. / Bloemendal, Martine / Boers-Sonderen, Marye J. / de Groot, Jan Willem B. / Koornstra, Rutger H.T. / van der Veldt, Astrid A.M. / Haanen, John B. A. G. / Boudewijns, Steve / Schreibelt, Gerty / Gerritsen, Winald R. et al. | 2020
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Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinomaLiu, Fangming / Liu, Weiren / Sanin, David E. / Jia, Guangshuai / Tian, Mengxin / Wang, Han / Zhu, Bijun / Lu, Yan / Qiao, Tiankui / Wang, Xiangdong et al. | 2020
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Identification and validation of poor prognosis immunoevasive subtype of muscle-invasive bladder cancer with tumor-infiltrating podoplanin+ cell abundanceZhou, Quan / Wang, Zewei / Zeng, Han / Zhang, Hongyu / Liu, Zhaopei / Huang, Qiuren / Wang, Jiajun / Chang, Yuan / Bai, Qi / Liu, Li et al. | 2020
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B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cellsLu, Huimin / Shi, Tongguo / Wang, Mingyuan / Li, Xiaomi / Gu, Yanzheng / Zhang, Xueguang / Zhang, Guangbo / Chen, Weichang et al. | 2020
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Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptideMirando, Adam C. / Patil, Akash / Rafie, Christine I. / Christmas, Brian J. / Pandey, Niranjan B. / Stearns, Vered / Jaffee, Elizabeth M. / Roussos Torres, Evanthia T. / Popel, Aleksander S. et al. | 2020
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Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancerLiang, Tingting / Tong, Weihua / Ma, Siyang / Chang, Pengyu et al. | 2020
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Trial watch: STING agonists in cancer therapyLe Naour, Julie / Zitvogel, Laurence / Galluzzi, Lorenzo / Vacchelli, Erika / Kroemer, Guido et al. | 2020
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Trial watch: IDO inhibitors in cancer therapyLe Naour, Julie / Galluzzi, Lorenzo / Zitvogel, Laurence / Kroemer, Guido / Vacchelli, Erika et al. | 2020
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Tumor mutational burden is not predictive of cytotoxic chemotherapy responseNikanjam, Mina / Riviere, Paul / Goodman, Aaron / Barkauskas, Donald A. / Frampton, Garrett / Kurzrock, Razelle et al. | 2020
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SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4Carmona-Rodríguez, Lorena / Martínez-Rey, Diego / Mira, Emilia / Mañes, Santos et al. | 2020
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Adjuvant MUC vaccination with tecemotide after resection of colorectal liver metastases: a randomized, double-blind, placebo-controlled, multicenter AIO phase II trial (LICC)Schimanski, Carl Christoph / Kasper, Stefan / Hegewisch-Becker, Susanna / Schröder, Jan / Overkamp, Friedrich / Kullmann, Frank / Bechstein, Wolf Otto / Vöhringer, Matthias / Öllinger, Robert / Lordick, Florian et al. | 2020
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Identification of novel autoantibodies based on the protein chip encoded by cancer-driving genes in detection of esophageal squamous cell carcinomaSun, Guiying / Ye, Hua / Wang, Xiao / Cheng, Lin / Ren, Pengfei / Shi, Jianxiang / Dai, Liping / Wang, Peng / Zhang, Jianying et al. | 2020
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Cancer testis antigens in myelodysplastic syndromes revisited: a targeted RNA-seq approachHurtado López, Ana María / Chen-Liang, Tzu Hua / Zurdo, María / Carrillo-Tornel, Salvador / Panadero, Joaquín / Salido, Eduardo José / Beltrán, Victor / Muiña, Begoña / Amigo, MariLuz / Navarro-Villamor, Noelia et al. | 2020
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Efficacy and biomarker analysis of CD133-directed CAR T cells in advanced hepatocellular carcinoma: a single-arm, open-label, phase II trialDai, Hanren / Tong, Chuan / Shi, Daiwei / Chen, Meixia / Guo, Yelei / Chen, Deyun / Han, Xiao / Wang, Hua / Wang, Yao / Shen, Pingping et al. | 2020
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Skin inflammatory response and efficacy of anti-epidermal growth factor receptor therapy in metastatic colorectal cancer (CUTACETUX)Tougeron, David / Emambux, Sheik / Favot, Laure / Lecomte, Thierry / Wierzbicka-Hainaut, Ewa / Samimi, Mahtab / Frouin, Eric / Azzopardi, Nicolas / Chevrier, Jocelyn / Serres, Laura et al. | 2020
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A classification based on tumor budding and immune score for patients with hepatocellular carcinomaWei, Li / Delin, Zhang / Kefei, Yuan / Hong, Wu / Jiwei, Huang / Yange, Zhang et al. | 2020
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Targeting ST2 expressing activated regulatory T cells in Kras-mutant lung cancerKim, Byung-Seok / Clinton, Jelita / Wang, Qing / Chang, Seon Hee et al. | 2020
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HLA class-I and class-II restricted neoantigen loads predict overall survival in breast cancerRen, Yingxue / Cherukuri, Yesesri / Wickland, Daniel P. / Sarangi, Vivekananda / Tian, Shulan / Carter, Jodi M. / Mansfield, Aaron S. / Block, Matthew S. / Sherman, Mark E. / Knutson, Keith L. et al. | 2020
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Liver metastases and the efficacy of the PD-1 or PD-L1 inhibitors in cancer: a meta-analysis of randomized controlled trialsLi, Shan / Sun, Shanquan / Xiang, Hui / Yang, Jing / Peng, Minyong / Gao, Qing et al. | 2020
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Tumor-associated tertiary lymphoid structure predicts postoperative outcomes in patients with primary gastrointestinal stromal tumorsLin, Qiaowei / Tao, Ping / Wang, Jiongyuan / Ma, Lijie / Jiang, Quan / Li, Jinglei / Zhang, Ge / Liu, Ju / Zhang, Yong / Hou, Yingyong et al. | 2020
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CD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse modelsLv, Zhuangwei / Zhang, Ping / Li, Dandan / Qin, Mengting / Nie, Longzhu / Wang, Xiaoqian / Ai, Li / Feng, Zhaozu / Odhiambo, Woodvine Otieno / Ma, Yunfeng et al. | 2020
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Results of the phase I open label clinical trial SAKK 06/14 assessing safety of intravesical instillation of VPM1002BC, a recombinant mycobacterium Bacillus Calmette Guérin (BCG), in patients with non-muscle invasive bladder cancer and previous failure of conventional BCG therapyRentsch, Cyrill A. / Bosshard, Piet / Mayor, Grégoire / Rieken, Malte / Püschel, Heike / Wirth, Grégory / Cathomas, Richard / Parzmair, Gerald P. / Grode, Leander / Eisele, Bernd et al. | 2020
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Dose dependence of treatment-related adverse events for immune checkpoint inhibitor therapies: a model-based meta-analysisShulgin, Boris / Kosinsky, Yuri / Omelchenko, Andrey / Chu, Lulu / Mugundu, Ganesh / Aksenov, Sergey / Pimentel, Rodrigo / DeYulia, Garrett / Kim, Geoffrey / Peskov, Kirill et al. | 2020
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Hypoxia increases mutational load of breast cancer cells through frameshift mutationsHassan Venkatesh, Goutham / Bravo, Pamela / Shaaban Moustafa Elsayed, Walid / Amirtharaj, Francis / Wojtas, Bartosz / Abou Khouzam, Raefa / Hussein Nawafleh, Husam / Mallya, Sandeep / Satyamoorthy, Kapaettu / Dessen, Philippe et al. | 2020
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Clinical and immune responses to anti-CD3 x anti-EGFR bispecific antibody armed activated T cells (EGFR BATs) in pancreatic cancer patientsLum, Lawrence G. / Thakur, Archana / Choi, Minsig / Deol, Abhinav / Kondadasula, Vidya / Schalk, Dana / Fields, Kristie / Dufrense, Melissa / Philip, Philip / Dyson, Gregory et al. | 2020
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Myeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarizationHe, Yuexi / Du, Juan / Dong, Zhongjun et al. | 2020
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Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cellsAguirre, Luis Augusto / Montalbán-Hernández, Karla / Avendaño-Ortiz, José / Marín, Elvira / Lozano, Roberto / Toledano, Víctor / Sánchez-Maroto, Laura / Terrón, Verónica / Valentín, Jaime / Pulido, Elisa et al. | 2020
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The role of trogocytosis in immune surveillance of Hodgkin lymphomaZeng, Qun / Schwarz, Herbert et al. | 2020
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Expression signature, prognosis value, and immune characteristics of Siglec-15 identified by pan-cancer analysisLi, Baihui / Zhang, Bailu / Wang, Xuezhou / Zeng, Ziqing / Huang, Ziqi / Zhang, Lin / Wei, Feng / Ren, Xiubao / Yang, Lili et al. | 2020
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Identification of a costimulatory molecule-based signature for predicting prognosis risk and immunotherapy response in patients with lung adenocarcinomaZhang, Chaoqi / Zhang, Zhihui / Sun, Nan / Zhang, Zhen / Zhang, Guochao / Wang, Feng / Luo, Yuejun / Che, Yun / He, Jie et al. | 2020
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Adapter chimeric antigen receptor (AdCAR)-engineered NK-92 cells: an off-the-shelf cellular therapeutic for universal tumor targetingGrote, Stefan / Mittelstaet, Joerg / Baden, Caroline / Chan, Kenneth Chun-Ho / Seitz, Christian / Schlegel, Patrick / Kaiser, Andrew / Handgretinger, Rupert / Schleicher, Sabine et al. | 2020
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Resveratrol exerts antitumor effects by downregulating CD8+CD122+ Tregs in murine hepatocellular carcinomaZhang, Qunfang / Huang, Haiding / Zheng, Fang / Liu, Huazhen / Qiu, Feifei / Chen, Yuchao / Liang, Chun-Ling / Dai, Zhenhua et al. | 2020
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Reduction of CD11b+ myeloid suppressive cells augments anti-neuroblastoma immune response induced by the anti-GD2 antibody ch14.18/CHOSiebert, Nikolai / Zumpe, Maxi / von Lojewski, Leon / Troschke-Meurer, Sascha / Marx, Madlen / Lode, Holger N. et al. | 2020
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Angiotensin-converting enzyme (ACE) inhibitor prescription affects non-small-cell lung cancer (NSCLC) patients response to PD-1/PD-L1 immune checkpoint blockersMedjebar, Soleine / Truntzer, Caroline / Perrichet, Anaïs / Limagne, Emeric / Fumet, Jean-David / Richard, Corentin / Elkrief, Arielle / Routy, Bertrand / Rébé, Cédric / Ghiringhelli, François et al. | 2020
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Anti-cancer immunotherapy using cancer-derived multiple epitope-peptides cocktail vaccination clinical studies in patients with refractory/persistent disease of uterine cervical cancer and ovarian cancer [phase 2]Takeuchi, Satoshi / Kagabu, Masahiro / Shoji, Tadahiro / Nitta, Yukari / Sugiyama, Toru / Sato, Junya / Nakamura, Yusuke et al. | 2020
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Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinomaMontemagno, Christopher / Hagege, Anais / Borchiellini, Delphine / Thamphya, Brice / Rastoin, Olivia / Ambrosetti, Damien / Iovanna, Juan / Rioux-Leclercq, Nathalie / Porta, Camillio / Negrier, Sylvie et al. | 2020
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Epstein–Barr virus-positive diffuse large B-cell lymphoma features disrupted antigen capture/presentation and hijacked T-cell suppressionJiang, Xiang-Nan / Yu, Bao-Hua / Yan, Wan-Hui / Lee, Jimmy / Zhou, Xiao-Yan / Li, Xiao-Qiu et al. | 2020
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PD-1 blockade in neoadjuvant setting of DNA mismatch repair-deficient/microsatellite instability-high colorectal cancerLiu, Ding-Xin / Li, Dan-Dan / He, Wan / Ke, Chuan-Feng / Jiang, Wu / Tang, Jing-Hua / Kong, Ling-Heng / Li, Yuan / Sui, Qiao-Qi / Xiao, Bin-Yi et al. | 2020
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PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor modelsYamazaki, Takahiro / Buqué, Aitziber / Ames, Tyler D. / Galluzzi, Lorenzo et al. | 2020
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Calreticulin arms NK cells against leukemiaFucikova, Jitka / Kline, Justin P. / Galluzzi, Lorenzo / Spisek, Radek et al. | 2020
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Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-SeqCarmona, Santiago J. / Siddiqui, Imran / Bilous, Mariia / Held, Werner / Gfeller, David et al. | 2020
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Identification and characterization of M6903, an antagonistic anti–TIM-3 monoclonal antibodyZhang, Dong / Jiang, Feng / Zaynagetdinov, Rinat / Huang, Hui / Sood, Vanita D. / Wang, Hong / Zhao, Xinyan / Jenkins, Molly H. / Ji, Qingyong / Wang, Youbin et al. | 2020
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Development of CAR-T cell therapy for B-ALL using a point-of-care approachde Macedo Abdo, Luiza / Barros, Luciana Rodrigues Carvalho / Saldanha Viegas, Mariana / Vieira Codeço Marques, Luisa / de Sousa Ferreira, Priscila / Chicaybam, Leonardo / Bonamino, Martín Hernán et al. | 2020
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IL-17 suppresses the therapeutic activity of cancer vaccines through the inhibition of CD8+ T-cell responsesDadaglio, Gilles / Fayolle, Catherine / Oberkampf, Marine / Tang, Alexandre / Rudilla, Francesc / Couillin, Isabelle / Torheim, Eirik A. / Rosenbaum, Pierre / Leclerc, Claude et al. | 2020
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The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccinesWeis-Banke, Stine Emilie / Hübbe, Mie Linder / Holmström, Morten Orebo / Jørgensen, Mia Aaboe / Bendtsen, Simone Kloch / Martinenaite, Evelina / Carretta, Marco / Svane, Inge Marie / Ødum, Niels / Pedersen, Ayako Wakatsuki et al. | 2020
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Regulatory T cells do not suppress rather activate human basophils by IL-3 and STAT5-dependent mechanismsDas, Mrinmoy / Stephen-Victor, Emmanuel / Bayry, Jagadeesh et al. | 2020
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Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapyDaillère, Romain / Derosa, Lisa / Bonvalet, Mélodie / Segata, Nicola / Routy, Bertrand / Gariboldi, Manuela / Budinská, Eva / De Vries, I. Jolanda M. / Naccarati, Alessio Gordon / Zitvogel, Valérie et al. | 2020
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IL15 synergizes with radiotherapy to reprogram the tumor immune contexture through a dendritic cell connectionPilones, Karsten A. / Charpentier, Maud / Garcia-Martinez, Elena / Demaria, Sandra et al. | 2020
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Specific immune landscapes and immune checkpoint expressions in histotypes and molecular subtypes of sarcomaDufresne, A. / Lesluyes, T. / Ménétrier-Caux, C. / Brahmi, M. / Darbo, E. / Toulmonde, M. / Italiano, A. / Mir, O. / Le Cesne, A. / Le Guellec, S. et al. | 2020
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RNA-electroporated T cells for cancer immunotherapyPohl-Guimarães, Fernanda / Hoang-Minh, Lan B. / Mitchell, Duane A. et al. | 2020
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Anti-tumor immunity influences cancer cell reliance upon ATG7Arensman, Michael D. / Yang, Xiaoran S. / Zhong, Wenyan / Bisulco, Stephanie / Upeslacis, Erik / Rosfjord, Edward C. / Deng, Shibing / Abraham, Robert T. / Eng, Christina H. et al. | 2020
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Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in miceVan Hoecke, Lien / Riederer, Stephanie / Saelens, Xavier / Sutter, Gerd / Rojas, Juan J. et al. | 2020
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Immune surveillance activation after neoadjuvant therapy for esophageal adenocarcinoma and complete responseKotsafti, Andromachi / Scarpa, Melania / Cavallin, Francesco / Fassan, Matteo / Salmaso, Roberta / Porzionato, Andrea / Saadeh, Luca / Cagol, Matteo / Alfieri, Rita / Castoro, Carlo et al. | 2020
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Metastasis immune-based scores predict patient survivalMlecnik, Bernhard / Bindea, Gabriela / Van den Eynde, Marc / Galon, Jérôme et al. | 2020
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Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspectiveHuang, Xing / Zhang, Gang / Bai, Xueli / Liang, Tingbo et al. | 2020
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No time to die: the consensus immunoscore for predicting survival and response to chemotherapy of locally advanced colon cancer patients in a multicenter international studyAscierto, Paolo A. / Marincola, Francesco M. / Fox, Bernard A. / Galon, Jérôme et al. | 2020
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Small-molecule PD-L1 inhibitor BMS1166 abrogates the function of PD-L1 by blocking its ER exportChen, Fang-Fang / Li, Zheng / Ma, Dawei / Yu, Qiang et al. | 2020
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Usefulness and robustness of Immunoscore for personalized management of cancer patientsMarliot, Florence / Pagès, Franck / Galon, Jérôme et al. | 2020
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Intratumoral CD103+CD4+ T cell infiltration defines immunoevasive contexture and poor clinical outcomes in gastric cancer patientsGu, Yun / Chen, Yifan / Jin, Kaifeng / Cao, Yifan / Liu, Xin / Lv, Kunpeng / He, Xudong / Lin, Chao / Liu, Hao / Li, He et al. | 2020
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PD-L1 expression in the microenvironment and the response to checkpoint inhibitors in head and neck squamous cell carcinomaEvrard, D. / Hourseau, M. / Couvelard, A. / Paradis, V. / Gauthier, H. / Raymond, E. / Halimi, C. / Barry, B. / Faivre, S. et al. | 2020
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A novel platinum-based chemotherapeutic inducing immunogenic cell deathKepp, Oliver / Kroemer, Guido et al. | 2020
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Eosinophil accumulation predicts response to melanoma treatment with immune checkpoint inhibitorsSimon, Sonja C. S. / Hu, Xiaoying / Panten, Jasper / Grees, Mareike / Renders, Simon / Thomas, Daniel / Weber, Rebekka / Schulze, Torsten J. / Utikal, Jochen / Umansky, Viktor et al. | 2020
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Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapyGeorganaki, Maria / Ramachandran, Mohanraj / Tuit, Sander / Núñez, Nicolás Gonzalo / Karampatzakis, Alexandros / Fotaki, Grammatiki / van Hooren, Luuk / Huang, Hua / Lugano, Roberta / Ulas, Thomas et al. | 2020
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Prophylactic and therapeutic antileukemic effects induced by the AAC-11-derived Peptide RT53Habault, Justine / Kaci, Anna / Pasquereau-Kotula, Ewa / Fraser, Claire / Chomienne, Christine / Dombret, Hervé / Braun, Thorsten / Pla, Marika / Poyet, Jean-Luc et al. | 2020
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Integration of intratumoral RASSF10 expression and tumor-associated macrophages into the established clinical indicators better predicts the prognosis of clear cell renal cell carcinoma patientsWang, Chao / Hong, Tianyu / Wang, Yuning / Gan, Sishun / Wang, Qifeng / Li, Jian / Zuo, Li / Cui, Xingang et al. | 2020
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Osteosarcoma and soft-tissue sarcomas with an immune infiltrate express PD-L1: relation to clinical outcome and Th1 pathway activationWunder, Jay S. / Lee, Minji J. / Nam, Junghyun / Lau, Beatrice Y. / Dickson, Brendan C. / Pinnaduwage, Dushanthi / Bull, Shelley B. / Ferguson, Peter C. / Seto, Andrew / Gokgoz, Nalan et al. | 2020
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Cancer immunotherapy based on blocking immune suppression mediated by an immune modulator LAIR-1Xu, Lijun / Wang, Shanlong / Li, Jufeng / Li, Jie / Li, Bingyu et al. | 2020
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Tumor-infiltrating IL-17A+ cells determine favorable prognosis and adjuvant chemotherapeutic response in muscle-invasive bladder cancerWang, Zewei / Zhou, Quan / Zeng, Han / Zhang, Hongyu / Liu, Zhaopei / Huang, Qiuren / Xiong, Ying / Wang, Jiajun / Chang, Yuan / Bai, Qi et al. | 2020
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FLT3LG - a biomarker reflecting clinical responses to the immunogenic cell death inducer oxaliplatinPol, Jonathan G. / Le Naour, Julie / Kroemer, Guido et al. | 2020
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Tumors escape immunosurveillance by overexpressing the proteasome activator PSME3Boulpicante, Mathilde / Darrigrand, Romain / Pierson, Alison / Salgues, Valérie / Rouillon, Marine / Gaudineau, Benoit / Khaled, Mehdi / Cattaneo, Angela / Bachi, Angela / Cascio, Paolo et al. | 2020
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A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in miceSalomon, Nadja / Vascotto, Fulvia / Selmi, Abderaouf / Vormehr, Mathias / Quinkhardt, Juliane / Bukur, Thomas / Schrörs, Barbara / Löewer, Martin / Diken, Mustafa / Türeci, Özlem et al. | 2020
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Impact of pseudoprogression and treatment beyond progression on outcome in patients with non-small cell lung cancer treated with immune checkpoint inhibitorsWon, Sang Eun / Park, Hyo Jung / Byun, Sangil / Pyo, Junhee / Kim, Jwa Hoon / Choi, Chang-Min / Lee, Jae Cheol / Lee, Dae Ho / Kim, Sang-We / Yoon, Shinkyo et al. | 2020
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Modeling human pediatric and adult gliomas in immunocompetent mice through costimulatory blockadeLan, Xiaoyan / Kedziorek, Dorota A. / Chu, Chengyan / Jablonska, Anna / Li, Shen / Kai, Mihoko / Liang, Yajie / Janowski, Miroslaw / Walczak, Piotr et al. | 2020
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The role of circulating monocytes and JAK inhibition in the infectious-driven inflammatory response of myelofibrosisBarone, Martina / Catani, Lucia / Ricci, Francesca / Romano, Marco / Forte, Dorian / Auteri, Giuseppe / Bartoletti, Daniela / Ottaviani, Emanuela / Tazzari, Pier Luigi / Vianelli, Nicola et al. | 2020
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An unexpected link between immunogenic cell death and inhibition of gene transcriptionHumeau, Juliette / Sauvat, Allan / Kepp, Oliver / Kroemer, Guido et al. | 2020
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Robust antigen-specific CD8 T cell tolerance to a model prostate cancer neoantigenLopez-Bujanda, Zoila A. / Chaimowitz, Matthew G. / Armstrong, Todd D. / Foote, Jeremy B. / Emens, Leisha A. / Drake, Charles G. et al. | 2020
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Identification and validation of an excellent prognosis subtype of muscle-invasive bladder cancer patients with intratumoral CXCR5+ CD8+ T cell abundanceHuang, Qiuren / Zhou, Quan / Zhang, Hongyu / Liu, Zhaopei / Zeng, Han / Chen, Yifan / Qu, Yang / Xiong, Ying / Wang, Jiajun / Chang, Yuan et al. | 2020
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Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockadeGreco, Rita / Qu, Hongjing / Qu, Hui / Theilhaber, Joachim / Shapiro, Gary / Gregory, Richard / Winter, Christopher / Malkova, Natalia / Sun, Frank / Jaworski, Julie et al. | 2020
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Immunogenicity and antitumor efficacy of a novel human PD-1 B-cell vaccine (PD1-Vaxx) and combination immunotherapy with dual trastuzumab/pertuzumab-like HER-2 B-cell epitope vaccines (B-Vaxx) in a syngeneic mouse modelKaumaya, Pravin T. P. / Guo, Linlin / Overholser, Jay / Penichet, Manuel L. / Bekaii-Saab, Tanios et al. | 2020
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Association of baseline systemic corticosteroid use with overall survival and time to next treatment in patients receiving immune checkpoint inhibitor therapy in real-world US oncology practice for advanced non-small cell lung cancer, melanoma, or urothelial carcinomaDrakaki, Alexandra / Dhillon, Preet K / Wakelee, Heather / Chui, Stephen Y / Shim, Jinjoo / Kent, Matthew / Degaonkar, Viraj / Hoang, Tien / McNally, Virginia / Luhn, Patricia et al. | 2020
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Heterologous prime-boost immunization co-targeting dual antigens inhibit tumor growth and relapseGuo, Qianqian / Wang, Lizheng / Xu, Ping / Geng, Fei / Guo, Jie / Dong, Ling / Bao, Xin / Zhou, Yi / Feng, Mengfan / Wu, Jiaxin et al. | 2020
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Increased occurrence of status epilepticus in patients with brain metastases and checkpoint inhibitionUrban, Hans / Willems, Laurent M. / Ronellenfitsch, Michael W. / Rosenow, Felix / Steinbach, Joachim P. / Strzelczyk, Adam et al. | 2020
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Intratumoral interleukin-9 delineates a distinct immunogenic class of gastric cancer patients with better prognosis and adjuvant chemotherapeutic responseFang, H. / Li, R. / Gu, Y. / Fei, Yuchao / Jin, Kaifeng / Chen, Yifan / Cao, Yifan / Liu, Xin / Lv, Kunpeng / Wang, Jieti et al. | 2020
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Immune-focused multi-omics analysis of prostate cancer: leukocyte Ig-Like receptors are associated with disease progressionVittrant, Benjamin / Bergeron, Alain / Molina, Oscar Eduardo / Leclercq, Mickael / Légaré, Xavier-Philippe / Hovington, Hélène / Picard, Valérie / Martin-Magniette, Marie-Laure / Livingstone, Julie / Boutros, Paul C. et al. | 2020
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Establishment and validation of an immunodiagnostic model for prediction of breast cancerQiu, Cuipeng / Wang, Peng / Wang, Bofei / Shi, Jianxiang / Wang, Xiao / Li, Tiandong / Qin, Jiejie / Dai, Liping / Ye, Hua / Zhang, Jianying et al. | 2020
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Destroy, what destroys youLuu, Khang / Nickles, Emily / Schwarz, Herbert et al. | 2020
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In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanomaKoster, Bas D. / de Jong, Tamarah D. / van den Hout, Mari F. C. M. / Sluijter, Berbel J. R. / Vuylsteke, Ronald J. C. L. M. / Molenkamp, Barbara G. / Vosslamber, Saskia / van den Tol, M. Petrousjka / van den Eertwegh, Alfons J. M. / de Gruijl, Tanja D. et al. | 2020
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Moderate-to-severe eosinophilia induced by treatment with immune checkpoint inhibitors: 37 cases from a national reference center for hypereosinophilic syndromes and the French pharmacovigilance databaseScanvion, Quentin / Béné, Johana / Gautier, Sophie / Grandvuillemin, Aurélie / Le Beller, Christine / Chenaf, Chouki / Etienne, Nicolas / Brousseau, Solenn / Cortot, Alexis B. / Mortier, Laurent et al. | 2020
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S100A4 promotes hepatocellular carcinogenesis by intensifying fibrosis-associated cancer cell stemnessLi, Yanan / Wang, Jun / Song, Kun / Liu, Shuangqing / Zhang, Huilei / Wang, Fei / Ni, Chen / Zhai, Wenlong / Liang, Jialu / Qin, Zhihai et al. | 2020
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Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncologyVanmeerbeek, Isaure / Sprooten, Jenny / De Ruysscher, Dirk / Tejpar, Sabine / Vandenberghe, Peter / Fucikova, Jitka / Spisek, Radek / Zitvogel, Laurence / Kroemer, Guido / Galluzzi, Lorenzo et al. | 2020
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Overexpression of microRNA-155 enhances the efficacy of dendritic cell vaccine against breast cancerHodge, Johnie / Wang, Fang / Wang, Junfeng / Liu, Qing / Saaoud, Fatma / Wang, Yuzhen / Singh, Udai P. / Chen, Hexin / Luo, Ming / Ai, Walden et al. | 2020
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Metabolism in the tumor microenvironment: insights from single-cell analysisXiao, Zhengtao / Locasale, Jason W. / Dai, Ziwei et al. | 2020
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Effectiveness and safety of nivolumab in the treatment of lung cancer patients in France: preliminary results from the real-world EVIDENS studyBarlesi, Fabrice / Dixmier, Adrien / Debieuvre, Didier / Raspaud, Christophe / Auliac, Jean-Bernard / Benoit, Nicolas / Bombaron, Pierre / Moro-Sibilot, Denis / Audigier-Valette, Clarisse / Asselain, Bernard et al. | 2020
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Endoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitorsde Andrea, Carlos Eduardo / Perez-Gracia, Jose Luis / Castanon, Eduardo / Ponz-Sarvise, Mariano / Echeveste, Jose I. / Melero, Ignacio / Sanmamed, Miguel F. / Rodriguez-Ruiz, Maria Esperanza et al. | 2020
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Turning tolerogenic into immunogenic ileal cell death through ileal microbiota: the key to unlock the mystery of colon cancer immunoscore?Roberti, Maria Paula / Picard, Marion / Yonekura, Satoru / Zitvogel, Laurence et al. | 2020
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Generation of highly activated, antigen-specific tumor-infiltrating CD8+ T cells induced by a novel T cell-targeted immunotherapyVila-Leahey, Ava / MacKay, Alecia / Portales-Cervantes, Liliana / Weir, Genevieve M. / Merkx-Jacques, Alexandra / Stanford, Marianne M. et al. | 2020
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An integrated classifier improves prognostic accuracy in non-metastatic gastric cancerXing, Xiaofang / Jia, Shuqin / Leng, Yuxin / Wang, Qian / Li, Zhongwu / Dong, Bin / Guo, Ting / Cheng, Xiaojing / Du, Hong / Hu, Ying et al. | 2020
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Repurposing CD8+ T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?Gujar, Shashi / Pol, Jonathan G. / Kim, Youra / Kroemer, Guido et al. | 2020
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Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα “don’t eat me” immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentationHendriks, Mark A. J. M. / Ploeg, Emily M. / Koopmans, Iris / Britsch, Isabel / Ke, Xiurong / Samplonius, Douwe F. / Helfrich, Wijnand et al. | 2020
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Significantly different immunological score in lung adenocarcinoma and squamous cell carcinoma and a proposal for a new immune staging systemZeng, Ziqing / Yang, Fan / Wang, Yunliang / Zhao, Hua / Wei, Feng / Zhang, Peng / Zhang, Xiying / Ren, Xiubao et al. | 2020
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Converging focal radiation and immunotherapy in a preclinical model of triple negative breast cancer: contribution of VISTA blockadePilones, Karsten A. / Hensler, Michal / Daviaud, Camille / Kraynak, Jeffrey / Fucikova, Jitka / Galluzzi, Lorenzo / Demaria, Sandra / Formenti, Silvia C. et al. | 2020
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NK cells in pancreatic cancer demonstrate impaired cytotoxicity and a regulatory IL-10 phenotypeMarcon, Francesca / Zuo, Jianmin / Pearce, Hayden / Nicol, Samantha / Margielewska-Davies, Sandra / Farhat, Mustafa / Mahon, Brinder / Middleton, Gary / Brown, Rachel / Roberts, Keith J. et al. | 2020
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Presence of tumor-infiltrating CD8+ T cells and macrophages correlates to longer overall survival in patients undergoing isolated hepatic perfusion for uveal melanoma liver metastasisJohansson, Junko / Siarov, Jan / Kiffin, Roberta / Mölne, Johan / Mattsson, Jan / Naredi, Peter / Olofsson Bagge, Roger / Martner, Anna / Lindnér, Per et al. | 2020
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No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19Petrazzuolo, Adriana / Le Naour, Julie / Vacchelli, Erika / Gaussem, Pascale / Ellouze, Syrine / Jourdi, Georges / Solary, Eric / Fontenay, Michaela / Smadja, David M. / Kroemer, Guido et al. | 2020
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Helper T cell-dominant tertiary lymphoid structures are associated with disease relapse of advanced colorectal cancerYamaguchi, Kyoko / Ito, Mamoru / Ohmura, Hirofumi / Hanamura, Fumiyasu / Nakano, Michitaka / Tsuchihashi, Kenji / Nagai, Shuntaro / Ariyama, Hiroshi / Kusaba, Hitoshi / Yamamoto, Hidetaka et al. | 2020
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A non-linear association between blood tumor mutation burden and prognosis in NSCLC patients receiving atezolizumabNie, Wei / Qian, Jie / Xu, Mi-Die / Gu, Kai / Qian, Fang-Fei / Hu, Min-Juan / Lu, Jun / Gan, Lu / Zhang, Xue-Yan / Cao, Shu-Hui et al. | 2020
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A TP53-associated gene signature for prediction of prognosis and therapeutic responses in lung squamous cell carcinomaXu, Feng / Lin, Haoyu / He, Pei / He, Lulu / Chen, Jiexin / Lin, Ling / Chen, Yongsong et al. | 2020
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An innovative plasmacytoid dendritic cell line-based cancer vaccine primes and expands antitumor T-cells in melanoma patients in a first-in-human trialCharles, Julie / Chaperot, Laurence / Hannani, Dalil / Bruder Costa, Juliana / Templier, Isabelle / Trabelsi, Sabiha / Gil, Hugo / Moisan, Anaick / Persoons, Virginie / Hegelhofer, Harald et al. | 2020
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Doxorubicin pretreatment enhances FAPα/survivin co-targeting DNA vaccine anti-tumor activity primarily through decreasing peripheral MDSCs in the 4T1 murine breast cancer modelGeng, Fei / Bao, Xin / Dong, Ling / Guo, Qian-Qian / Guo, Jie / Xie, Yu / Zhou, Yi / Yu, Bin / Wu, Hui / Wu, Jia-Xin et al. | 2020
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Genomic and immunologic correlates of LAG-3 expression in cancerPanda, Anshuman / Rosenfeld, Jeffrey A. / Singer, Eric A. / Bhanot, Gyan / Ganesan, Shridar et al. | 2020
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Heat shock protein 90α in thymic epithelial tumors and non-thymomatous myasthenia gravisThanner, Jürgen / Bekos, Christine / Veraar, Cecilia / Janik, Stefan / Laggner, Maria / Boehm, Panja M / Schiefer, Ana-Iris / Müllauer, Leonhard / Klepetko, Walter / Ankersmit, Hendrik Jan et al. | 2020
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Progesterone receptor promotes degradation of STAT2 to inhibit the interferon response in breast cancerWalter, Katherine R. / Balko, Justin M. / Hagan, Christy R. et al. | 2020
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IL-33 reduces tumor growth in models of colorectal cancer with the help of eosinophilsKienzl, Melanie / Hasenoehrl, Carina / Valadez-Cosmes, Paulina / Maitz, Kathrin / Sarsembayeva, Arailym / Sturm, Eva / Heinemann, Akos / Kargl, Julia / Schicho, Rudolf et al. | 2020
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PD-1 checkpoint blockade in advanced melanoma patients: NK cells, monocytic subsets and host PD-L1 expression as predictive biomarker candidatesPico de Coaña, Yago / Wolodarski, Maria / van der Haar Àvila, Irene / Nakajima, Takahiro / Rentouli, Stamatina / Lundqvist, Andreas / Masucci, Giuseppe / Hansson, Johan / Kiessling, Rolf et al. | 2020
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Immune vulnerability of ovarian cancer stem-like cells due to low CD47 expression is protected by surrounding bulk tumor cellsChang, Chih-Long / Wu, Chao-Chih / Hsu, Yun-Ting / Hsu, Yi-Chiung et al. | 2020
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Tropomyosin autoantibodies associated with checkpoint inhibitor myositisZaenker, Pauline / Prentice, David / Ziman, Melanie et al. | 2020
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β-Catenin inhibition shapes tumor immunity and synergizes with immunotherapy in colorectal cancerWang, Caihong / Yan, Jingjing / Yin, Pan / Gui, Liming / Ji, Lu / Ma, Bin / Gao, Wei-Qiang et al. | 2020
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Live-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy of HPV16-positive cancerSchmidt, Sarah / Bonilla, Weldy V. / Reiter, Andrea / Stemeseder, Felix / Kleissner, Theresa / Oeler, Daniel / Berka, Ursula / El-Gazzar, Ahmed / Kiefmann, Bettina / Schulha, Sophie C. et al. | 2020
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Tumor-infiltrating TNFRSF9+ CD8+ T cells define different subsets of clear cell renal cell carcinoma with prognosis and immunotherapeutic responseLi, Yaohui / Wang, Zewei / Jiang, Wenbin / Zeng, Han / Liu, Zhaopei / Lin, Zhiyuan / Qu, Yang / Xiong, Ying / Wang, Jiajun / Chang, Yuan et al. | 2020
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TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancerMaas, Ralph Ja / Hoogstad-van Evert, Janneke S / Van der Meer, Jolien Mr / Mekers, Vera / Rezaeifard, Somayeh / Korman, Alan J / de Jonge, Paul Kjd / Cany, Jeannette / Woestenenk, Rob / Schaap, Nicolaas Pm et al. | 2020
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Tumor-infiltrating podoplanin+ cells in gastric cancer: clinical outcomes and association with immune contextureLiu, Xin / Cao, Yifan / Lv, Kunpeng / Gu, Yun / Jin, Kaifeng / He, Xudong / Fang, Hanji / Fei, Yuchao / Shi, Mingsu / Lin, Chao et al. | 2020
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Novel galenic formulations for delivering immunochemotherapies: kill intelligently, remove the checkpoint and let the T cells in!Kepp, Oliver / Kroemer, Guido et al. | 2020
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Co-localization of CD169+ macrophages and cancer cells in lymph node metastases of breast cancer patients is linked to improved prognosis and PDL1 expressionBjörk Gunnarsdottir, Frida / Auoja, Nathalie / Bendahl, Pär-Ola / Rydén, Lisa / Fernö, Mårten / Leandersson, Karin et al. | 2020
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Identification of a neo-epitope dominating endogenous CD8 T cell responses to MC-38 colorectal cancerHos, Brett J. / Camps, Marcel G.M. / Bulk, Jitske van den / Tondini, Elena / Ende, Thomas C. van den / Ruano, Dina / Franken, Kees / Janssen, George M.C. / Ru, Arnoud / Filippov, Dmitri V. et al. | 2020
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TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunityLee, Jun-Young / Lee, Eunjin / Hong, Sung-Wook / Kim, Daeun / Eunju, O. / Sprent, Jonathan / Im, Sin-Hyeog / Lee, You Jeong / Surh, Charles D. et al. | 2020
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A pipeline for identification and validation of tumor-specific antigens in a mouse model of metastatic breast cancerDeVette, Christa I. / Gundlapalli, Harika / Lai, Shu-Chin Alicia / McMurtrey, Curtis P. / Hoover, Ashley R. / Gurung, Hem R. / Chen, Wei R. / Welm, Alana L. / Hildebrand, William H. et al. | 2020
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Pre-treatment tumor neo-antigen responses in draining lymph nodes are infrequent but predict checkpoint blockade therapy outcomeMa, Shaokang / Chee, Jonathan / Fear, Vanessa S. / Forbes, Catherine A. / Boon, Louis / Dick, Ian M. / Robinson, Bruce W. S. / Creaney, Jenette et al. | 2020
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Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapyDe Martino, Mara / Tkach, Mercedes / Bruni, Sofía / Rocha, Darío / Mercogliano, María F. / Cenciarini, Mauro E. / Chervo, María F. / Proietti, Cecilia J. / Dingli, Florent / Loew, Damarys et al. | 2020