Targeting senescent cells alleviates obesity‐induced metabolic dysfunction (English)
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In:
Aging Cell
;
18
, 3
;
2019
- Article (Journal) / Electronic Resource
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Title:Targeting senescent cells alleviates obesity‐induced metabolic dysfunction
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Contributors:Palmer, Allyson K. ( author ) / Xu, Ming ( author ) / Zhu, Yi ( author ) / Pirtskhalava, Tamar ( author ) / Weivoda, Megan M. ( author ) / Hachfeld, Christine M. ( author ) / Prata, Larissa G. ( author ) / van Dijk, Theo H. ( author ) / Verkade, Esther ( author ) / Casaclang‐Verzosa, Grace ( author )
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Published in:Aging Cell ; 18, 3
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Publisher:
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Publication date:2019-06-01
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Size:15 pages
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ISSN:
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DOI:
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Type of media:Article (Journal)
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Type of material:Electronic Resource
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Language:English
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Keywords:
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Source:
Table of contents – Volume 18, Issue 3
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
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The leptin sensitizer celastrol reduces age‐associated obesity and modulates behavioral rhythmsChellappa, Karthikeyani / Perron, Isaac J. / Naidoo, Nirinjini / Baur, Joseph A. et al. | 2019
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The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathwayXu, Shun / Wu, Weijia / Huang, Haijiao / Huang, Ruxiao / Xie, Luoyijun / Su, Ailing / Liu, Shuang / Zheng, Ruinian / Yuan, Yuan / Zheng, Hui‐ling et al. | 2019
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Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in miceKim, Ha‐Neui / Chang, Jianhui / Iyer, Srividhya / Han, Li / Campisi, Judith / Manolagas, Stavros C. / Zhou, Daohong / Almeida, Maria et al. | 2019
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Systemic clearance of p16INK4a‐positive senescent cells mitigates age‐associated intervertebral disc degenerationPatil, Prashanti / Dong, Qing / Wang, Dong / Chang, Jianhui / Wiley, Christopher / Demaria, Marco / Lee, Joon / Kang, James / Niedernhofer, Laura J. / Robbins, Paul D. et al. | 2019
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Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4aKim, So‐Jin / Shan, Peiying / Hwangbo, Cheol / Zhang, Yi / Min, Jin‐Na / Zhang, Xuchen / Ardito, Taylor / Li, Alfred / Peng, Tien / Sauler, Maor et al. | 2019
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Caloric restriction controls stationary phase survival through Protein Kinase A (PKA) and cytosolic pHDolz‐Edo, Laura / van der Deen, Margaretha / Brul, Stanley / Smits, Gertien Jacoba et al. | 2019
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Increased intron retention is a post‐transcriptional signature associated with progressive aging and Alzheimer’s diseaseAdusumalli, Swarnaseetha / Ngian, Zhen‐Kai / Lin, Wei‐Qi / Benoukraf, Touati / Ong, Chin‐Tong et al. | 2019
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Tau overexpression impairs neuronal endocytosis by decreasing the GTPase dynamin 1 through the miR‐132/MeCP2 pathwayXie, Ao‐Ji / Hou, Tong‐Yao / Xiong, Wan / Huang, He‐Zhou / Zheng, Jie / Li, Ke / Man, Heng‐Ye / Hu, Ya‐Zhuo / Han, Zhi‐Tao / Zhang, Hong‐Hong et al. | 2019
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mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolismTang, Huibin / Inoki, Ken / Brooks, Susan V. / Okazawa, Hideki / Lee, Myung / Wang, Junying / Kim, Michael / Kennedy, Catherine L. / Macpherson, Peter C. D. / Ji, Xuhuai et al. | 2019
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Targeting senescent cells alleviates obesity‐induced metabolic dysfunctionPalmer, Allyson K. / Xu, Ming / Zhu, Yi / Pirtskhalava, Tamar / Weivoda, Megan M. / Hachfeld, Christine M. / Prata, Larissa G. / van Dijk, Theo H. / Verkade, Esther / Casaclang‐Verzosa, Grace et al. | 2019
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Corrigendum| 2019
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Long‐term caloric restriction ameliorates deleterious effects of aging on white and brown adipose tissue plasticityCorrales, Patricia / Vivas, Yurena / Izquierdo‐Lahuerta, Adriana / Horrillo, Daniel / Seoane‐Collazo, Patricia / Velasco, Ismael / Torres, Lucia / Lopez, Yamila / Martínez, Carmen / López, Miguel et al. | 2019
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Hormone replacement therapy attenuates hearing loss: Mechanisms involving estrogen and the IGF‐1 pathwayWilliamson, Tanika T. / Ding, Bo / Zhu, Xiaoxia / Frisina, Robert D. et al. | 2019
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SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long‐lived Myc hypomorphic miceZhao, Xiaoai / Petrashen, Anna P. / Sanders, Jennifer A. / Peterson, Abigail L. / Sedivy, John M. et al. | 2019
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The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activationRomero, Alejandra / San Hipólito‐Luengo, Álvaro / Villalobos, Laura A. / Vallejo, Susana / Valencia, Inés / Michalska, Patrycja / Pajuelo‐Lozano, Natalia / Sánchez‐Pérez, Isabel / León, Rafael / Bartha, José Luis et al. | 2019
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Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse modelsTrujillo‐Estrada, Laura / Nguyen, Cassidy / da Cunha, Celia / Cai, Lena / Forner, Stefania / Martini, Alessandra C. / Ager, Rahasson R. / Prieto, Gilberto Aleph / Cotman, Carl W. / Baglietto‐Vargas, David et al. | 2019
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Decoy fitness peaks, tumor suppression, and agingHiga, Kelly C. / DeGregori, James et al. | 2019
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JNK modifies neuronal metabolism to promote proteostasis and longevityWang, Lifen / Davis, Sonnet S. / Borch Jensen, Martin / Rodriguez‐Fernandez, Imilce A. / Apaydin, Cagsar / Juhasz, Gabor / Gibson, Bradford W. / Schilling, Birgit / Ramanathan, Arvind / Ghaemmaghami, Sina et al. | 2019
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Accelerated bio‐cognitive aging in Down syndrome: State of the art and possible deceleration strategiesFranceschi, Claudio / Garagnani, Paolo / Gensous, Noémie / Bacalini, Maria Giulia / Conte, Maria / Salvioli, Stefano et al. | 2019
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Short‐term starvation stress at young adult stages enhances meiotic activity of germ cells to maintain spermatogenesis in aged male Caenorhabditis elegansChou, Wan‐Yi / Lin, Yu‐Chun / Lee, Ying‐Hue et al. | 2019
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Noncoding variations in Cyp24a1gene are associated with Klotho‐mediated aging phenotypes in different strains of miceSingh, Amit / Verma, Anjali / Sallin, Michelle A. / Lang, Florian / Sen, Ranjan / Sen, Jyoti Misra et al. | 2019
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Glycine supplementation extends lifespan of male and female miceMiller, Richard A. / Harrison, David E. / Astle, C. Michael / Bogue, Molly A. / Brind, Joel / Fernandez, Elizabeth / Flurkey, Kevin / Javors, Martin / Ladiges, Warren / Leeuwenburgh, Christiaan et al. | 2019
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NMNAT2‐mediated NAD+ generation is essential for quality control of aged oocytesWu, Xinghan / Hu, Feifei / Zeng, Juan / Han, Longsen / Qiu, Danhong / Wang, Haichao / Ge, Juan / Ying, Xiaoyan / Wang, Qiang et al. | 2019
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DAF‐16 stabilizes the aging transcriptome and is activated in mid‐aged Caenorhabditis elegans to cope with internal stressLi, Shang‐Tong / Zhao, Han‐Qing / Zhang, Pan / Liang, Chung‐Yi / Zhang, Yan‐Ping / Hsu, Ao‐Lin / Dong, Meng‐Qiu et al. | 2019
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Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitizationMartín‐Segura, Adrián / Ahmed, Tariq / Casadomé‐Perales, Álvaro / Palomares‐Perez, Irene / Palomer, Ernest / Kerstens, Axelle / Munck, Sebastian / Balschun, Detlef / Dotti, Carlos G. et al. | 2019
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Astrocyte senescence: Evidence and significanceCohen, Justin / Torres, Claudio et al. | 2019
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Effects of IGF‐1 isoforms on muscle growth and sarcopeniaAscenzi, Francesca / Barberi, Laura / Dobrowolny, Gabriella / Villa Nova Bacurau, Aline / Nicoletti, Carmine / Rizzuto, Emanuele / Rosenthal, Nadia / Scicchitano, Bianca Maria / Musarò, Antonio et al. | 2019
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KCNQ1OT1 promotes autophagy by regulating miR‐200a/FOXO3/ATG7 pathway in cerebral ischemic strokeYu, Shijia / Yu, Mingjun / He, Xin / Wen, Lulu / Bu, Zhongqi / Feng, Juan et al. | 2019
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Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarctionWalaszczyk, Anna / Dookun, Emily / Redgrave, Rachael / Tual‐Chalot, Simon / Victorelli, Stella / Spyridopoulos, Ioakim / Owens, Andrew / Arthur, Helen M. / Passos, João F. / Richardson, Gavin D. et al. | 2019
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PKR knockout in the 5xFAD model of Alzheimer's disease reveals beneficial effects on spatial memory and brain lesionsTible, Marion / Mouton Liger, François / Schmitt, Julien / Giralt, Albert / Farid, Karim / Thomasseau, Sylvie / Gourmaud, Sarah / Paquet, Claire / Rondi Reig, Laure / Meurs, Eliane et al. | 2019
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KIN‐4/MAST kinase promotes PTEN‐mediated longevity of Caenorhabditis elegans via binding through a PDZ domainAn, Seon Woo A. / Choi, Eun‐Seok / Hwang, Wooseon / Son, Heehwa G. / Yang, Jae‐Seong / Seo, Keunhee / Nam, Hyun‐Jun / Nguyen, Nhung T. H. / Kim, Eun Ji E. / Suh, Bo Kyoung et al. | 2019
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The exceptional longevity of the naked mole‐rat may be explained by mitochondrial antioxidant defensesMunro, Daniel / Baldy, Cécile / Pamenter, Matthew E. / Treberg, Jason R. et al. | 2019
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Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neuronsTheurey, Pierre / Connolly, Niamh M. C. / Fortunati, Ilaria / Basso, Emy / Lauwen, Susette / Ferrante, Camilla / Moreira Pinho, Catarina / Joselin, Alvin / Gioran, Anna / Bano, Daniele et al. | 2019
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Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammationHeadley, Colwyn A. / Gerberick, Abigail / Mehta, Sumiran / Wu, Qian / Yu, Lianbo / Fadda, Paolo / Khan, Mahmood / Ganesan, Latha Prabha / Turner, Joanne / Rajaram, Murugesan V. S. et al. | 2019
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An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro‐inflammatory programGnani, Daniela / Crippa, Stefania / della Volpe, Lucrezia / Rossella, Valeria / Conti, Anastasia / Lettera, Emanuele / Rivis, Silvia / Ometti, Marco / Fraschini, Gianfranco / Bernardo, Maria Ester et al. | 2019
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Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson’s diseasesSong, Chengjie / Zhang, Jun / Qi, Shasha / Liu, Zhen / Zhang, Xiaoyang / Zheng, Yue / Andersen, John‐Paul / Zhang, Weiping / Strong, Randy / Martinez, Paul Anthony et al. | 2019
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Hyperadrenocorticism of calorie restriction contributes to its anti‐inflammatory action in miceAllen, Brian D. / Liao, Chen‐Yu / Shu, Jianhua / Muglia, Louis J. / Majzoub, Joseph A. / Diaz, Vivian / Nelson, James F. et al. | 2019
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Announcement| 2019
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Aged‐senescent cells contribute to impaired heart regenerationLewis‐McDougall, Fiona C. / Ruchaya, Prashant J. / Domenjo‐Vila, Eva / Shin Teoh, Tze / Prata, Larissa / Cottle, Beverley J. / Clark, James E. / Punjabi, Prakash P. / Awad, Wael / Torella, Daniele et al. | 2019
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1,25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signalingChen, Lulu / Yang, Renlei / Qiao, Wanxin / Zhang, Wei / Chen, Jie / Mao, Li / Goltzman, David / Miao, Dengshun et al. | 2019
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Issue Information| 2019
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Genetically heterogeneous mice exhibit a female survival advantage that is age‐ and site‐specific: Results from a large multi‐site studyCheng, Catherine J. / Gelfond, Jonathan A. L. / Strong, Randy / Nelson, James F. et al. | 2019
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Dynamin‐like protein 1 cleavage by calpain in Alzheimer’s diseaseJiang, Sirui / Shao, Changjuan / Tang, Fangqiang / Wang, Wenzhang / Zhu, Xiongwei et al. | 2019
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NAD+ supplementation rejuvenates aged gut adult stem cellsIgarashi, Masaki / Miura, Masaomi / Williams, Eric / Jaksch, Frank / Kadowaki, Takashi / Yamauchi, Toshimasa / Guarente, Leonard et al. | 2019
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Vascular smooth muscle cell‐specific progerin expression in a mouse model of Hutchinson–Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitritedel Campo, Lara / Sánchez‐López, Amanda / Salaices, Mercedes / von Kleeck, Ryan A. / Expósito, Elba / González‐Gómez, Cristina / Cussó, Lorena / Guzmán‐Martínez, Gabriela / Ruiz‐Cabello, Jesús / Desco, Manuel et al. | 2019
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Tendinosis develops from age‐ and oxygen tension‐dependent modulation of Rac1 activityMcBeath, Rowena / Edwards, Richard W. / O’Hara, Brian J. / Maltenfort, Mitchell G. / Parks, Susan M. / Steplewski, Andrzej / Osterman, A. Lee / Shapiro, Irving M. et al. | 2019
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IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotypeWiggins, Kimberley A. / Parry, Aled J. / Cassidy, Liam D. / Humphry, Melanie / Webster, Steve J. / Goodall, Jane C. / Narita, Masashi / Clarke, Murray C. H. et al. | 2019