Pharmacophore Mapping of a Series of 2,4-Diamino-5-deazapteridine Inhibitors of Mycobacterium avium Complex Dihydrofolate Reductase (English)
- New search for: Debnath, A. K.
- New search for: Debnath, A. K.
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JOURNAL OF MEDICINAL CHEMISTRY
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45
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41-53
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2002
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ISSN:
- Article (Journal) / Print
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Title:Pharmacophore Mapping of a Series of 2,4-Diamino-5-deazapteridine Inhibitors of Mycobacterium avium Complex Dihydrofolate Reductase
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Contributors:Debnath, A. K. ( author )
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Published in:JOURNAL OF MEDICINAL CHEMISTRY ; 45 ; 41-53
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Publisher:
- New search for: ACS AMERICAN CHEMICAL SOCIETY
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Publication date:2002-01-01
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Size:13 pages
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ISSN:
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Type of media:Article (Journal)
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Type of material:Print
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Language:English
- New search for: 615
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Classification:
DDC: 615 -
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© Metadata Copyright the British Library Board and other contributors. All rights reserved.
Table of contents – Volume 45
The tables of contents are generated automatically and are based on the data records of the individual contributions available in the index of the TIB portal. The display of the Tables of Contents may therefore be incomplete.
- 1
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Design and Synthesis of Pyrrolidine-5,5-trans-lactams (5-Oxohexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 2. Potency and ChiralityBorthwick, Alan D. / Crame, Andrew J. / Ertl, Peter F. / Exall, Anne M. / Haley, Terry M. / Hart, Graham J. / Mason, Andrew M. / Pennell, Andrew M. K. / Singh, Onkar M. P. / Weingarten, Gordon G. et al. | 2002
- 5
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Perspective Series| 2002
- 19
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Novel 1-Hydroxyazole Bioisosteres of Glutamic Acid. Synthesis, Protolytic Properties, and PharmacologyStensbøl, Tine B. / Uhlmann, Peter / Morel, Sandrine / Eriksen, Birgitte L. / Felding, Jakob / Kromann, Hasse / Hermit, Mette B. / Greenwood, Jeremy R. / Braüner-Osborne, Hans / Madsen, Ulf et al. | 2002
- 32
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a2-Adrenoreceptors Profile Modulation and High Antinociceptive Activity of (S)-(-)-2-(1-(Biphenyl-2-yloxy)ethyl)-4,5-dihydro-1H-imidazoleGentili, F. et al. | 2002
- 32
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alpha~2-Adrenoreceptors Profile Modulation and High Antinociceptive Activity of (S)-(-)-2-[1-(Biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazoleGentili, F. / Bousquet, P. / Brasili, L. / Caretto, M. / Carrieri, A. / Dontenwill, M. / Giannella, M. / Marucci, G. / Perfumi, M. / Piergentili, A. et al. | 2002
- 32
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α2-Adrenoreceptors Profile Modulation and High Antinociceptive Activity of (S)-(−)-2-[1-(Biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazoleGentili, Francesco / Bousquet, Pascal / Brasili, Livio / Caretto, Mariangela / Carrieri, Antonio / Dontenwill, Monique / Giannella, Mario / Marucci, Gabriella / Perfumi, Marina / Piergentili, Alessandro et al. | 2002
- 41
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Pharmacophore Mapping of a Series of 2,4-Diamino-5-deazapteridine Inhibitors of Mycobacterium avium Complex Dihydrofolate ReductaseDebnath, Asim Kumar et al. | 2002
- 54
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New Serotonin 5-HT2A, 5-HT2B, and 5-HT2C Receptor Antagonists: Synthesis, Pharmacology, 3D-QSAR, and Molecular Modeling of (Aminoalkyl)benzo and HeterocycloalkanonesBrea, José / Rodrigo, Jordi / Carrieri, Antonio / Sanz, Ferran / Cadavid, M. Isabel / Enguix, María J. / Villazón, María / Mengod, Guadalupe / Caro, Yolanda / Masaguer, Christian F. et al. | 2002
- 72
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Hierarchy of Simulation Models in Predicting Structure and Energetics of the Src SH2 Domain Binding to Tyrosyl PhosphopeptidesVerkhivker, Gennady M. / Bouzida, Djamal / Gehlhaar, Daniel K. / Rejto, Paul A. / Schaffer, Lana / Arthurs, Sandra / Colson, Anthony B. / Freer, Stephan T. / Larson, Veda / Luty, Brock A. et al. | 2002
- 90
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Structure-Based Design and Characterization of Novel Platforms for Ricin and Shiga Toxin InhibitionMiller, Darcie J. / Ravikumar, Kabyadi / Shen, Huafeng / Suh, Jung-Keun / Kerwin, Sean M. / Robertus, Jon D. et al. | 2002
- 99
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Synthesis of Novel Cationic Lipids: Effect of Structural Modification on the Efficiency of Gene TransferHeyes, James A. / Niculescu-Duvaz, Dan / Cooper, Robert G. / Springer, Caroline J. et al. | 2002
- 115
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7-Substituted 5-Amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A Adenosine Receptor Antagonists: A Study on the Importance of Modifications at the Side Chain on the Activity and SolubilityBaraldi, Pier Giovanni / Cacciari, Barbara / Romagnoli, Romeo / Spalluto, Giampiero / Monopoli, Angela / Ongini, Ennio / Varani, Katia / Borea, Pier Andrea et al. | 2002
- 127
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Inotropic Activity of Hydroindene AmidinohydrazonesSevillano, Luis G. / Melero, Concepción P. / Caballero, Esther / Tomé, Fernando / Lelièvre, Lionel G. / Geering, Käthi / Crambert, Gilles / Carrón, Rosalía / Medarde, Manuel / San Feliciano, Arturo et al. | 2002
- 137
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Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound LibrariesRoche, Olivier / Schneider, Petra / Zuegge, Jochen / Guba, Wolfgang / Kansy, Manfred / Alanine, Alexander / Bleicher, Konrad / Danel, Franck / Gutknecht, Eva-Maria / Rogers-Evans, Mark et al. | 2002
- 143
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Anti-Helicobacter p ylori Agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and Aryloxazole AnaloguesKatsura, Yousuke / Nishino, Shigetaka / Inoue, Yoshikazu / Sakane, Kazuo / Matsumoto, Yoshimi / Morinaga, Chizu / Ishikawa, Hirohumi / Takasugi, Hisashi et al. | 2002
- 151
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Rational Determination of Transfer Free Energies of Small Drugs across the Water−Oil InterfaceBas, Delphine / Dorison-Duval, Delphine / Moreau, Stéphanie / Bruneau, Pierre / Chipot, Christophe et al. | 2002
- 160
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Design, Synthesis, and Discovery of Novel trans-Stilbene Analogues as Potent and Selective Human Cytochrome P450 1B1 InhibitorsKim, Sanghee / Ko, Hyojin / Park, Jae Eun / Jung, Sungkyu / Lee, Sang Kwang / Chun, Young-Jin et al. | 2002
- 165
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Improvement in the Selectivity and Metabolic Stability of the Serotonin 5-HT1A Ligand, S 15535: A Series of cis- and trans-2-(Arylcycloalkylamine) 1-IndanolsPeglion, Jean-Louis / Goument, Bertrand / Despaux, Nicole / Charlot, Valérie / Giraud, Hélène / Nisole, Christian / Newman-Tancredi, Adrian / Dekeyne, Anne / Bertrand, Marc / Genissel, Patrick et al. | 2002
- 177
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Design and Synthesis of Potent Nonpeptidic Farnesyltransferase Inhibitors Based on a Terphenyl ScaffoldOhkanda, Junko / Lockman, Jeffrey W. / Kothare, Mohit A. / Qian, Yimin / Blaskovich, Michelle A. / Sebti, Said M. / Hamilton, Andrew D. et al. | 2002
- 189
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Synthesis and Inotropic Activity of 1-(O-Aminoalkyloximes) of Perhydroindene Derivatives as Simplified Digitalis-like Compounds Acting on the Na+,K+-ATPaseCerri, Alberto / Almirante, Nicoletta / Barassi, Paolo / Benicchio, Alessandra / De Munari, Sergio / Marazzi, Giuseppe / Molinari, Isabella / Serra, Fulvio / Melloni, Piero et al. | 2002
- 208
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Methanocarba Modification of Uracil and Adenine Nucleotides: High Potency of Northern Ring Conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but Not P2Y6 ReceptorsKim, Hak Sung / Ravi, R. Gnana / Marquez, Victor E. / Maddileti, Savitri / Wihlborg, Anna-Karin / Erlinge, David / Malmsjö, Malin / Boyer, José L. / Harden, T. Kendall / Jacobson, Kenneth A. et al. | 2002
- 219
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Phenoxyphenyl Sulfone N-Formylhydroxylamines (Retrohydroxamates) as Potent, Selective, Orally Bioavailable Matrix Metalloproteinase InhibitorsWada, Carol K. / Holms, James H. / Curtin, Michael L. / Dai, Yujia / Florjancic, Alan S. / Garland, Robert B. / Guo, Yan / Heyman, H. Robin / Stacey, Jamie R. / Steinman, Douglas H. et al. | 2002
- 233
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Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium Dihydrofolate Reductases by 2,4-Diamino-5-[2-methoxy-5-(ω-carboxyalkyloxy)benzyl]pyrimidines: Marked Improvement in Potency Relative to Trimethoprim and Species Selectivity Relative to PiritreximRosowsky, Andre / Forsch, Ronald A. / Queener, Sherry F. et al. | 2002
- 233
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Inhibition of Pneumocystis carinii, Toxoplasmagondii, and Mycobacterium avium Dihydrofolate Reductases by 2,4-Diamino-5-(2-methoxy-5-(w-carboxyalkyloxy)benzyl)pyrimidines: Marked Improvement in Potency Relative to Trimethoprim and Species Selectivity Relative to PiritreximRosowsky, A. et al. | 2002
- 233
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Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium Dihydrofolate Reductases by 2,4-Diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)-benzyl]pyrimidines: Marked Improvement in Potency Relative to Trimethoprim and Species Selectivity Relative to PiritreximRosowsky, A. / Forsch, R. A. / Queener, S. F. et al. | 2002
- 242
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Synthesis of New Dihydroindeno[1,2-c]isoquinoline and Indenoisoquinolinium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal ModelJayaraman, Muthusamy / Fox, Brian M. / Hollingshead, Melinda / Kohlhagen, Glenda / Pommier, Yves / Cushman, Mark et al. | 2002
- 251
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Looking for Selectivity among Cytochrome P450s InhibitorsCavalli, Andrea / Recanatini, Maurizio et al. | 2002
- 255
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Bacteriopurpurinimides: Highly Stable and Potent Photosensitizers for Photodynamic TherapyChen, Yihui / Graham, Andrew / Potter, William / Morgan, Janet / Vaughan, Lurine / Bellnier, David A. / Henderson, Barbara W. / Oseroff, Allan / Dougherty, Thomas J. / Pandey, Ravindra K. et al. | 2002
- 259
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Design of Substrate-Based Inhibitors of Human β-SecretaseTung, Jay S. / Davis, David L. / Anderson, John P. / Walker, Don E. / Mamo, Shumeye / Jewett, Nancy / Hom, Roy K. / Sinha, Sukanto / Thorsett, Eugene D. / John, Varghese et al. | 2002
- 259
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Design of Substrate-Based Inhibitors of Human beta-SecretaseTung, J. S. / Davis, D. L. / Anderson, J. P. / Walker, D. E. / Mamo, S. / Jewett, N. / Hom, R. K. / Sinha, S. / Thorsett, E. D. / John, V. et al. | 2002
- 259
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Design of Substrate-Based Inhibitors of Human b-SecretaseTung, J.S. et al. | 2002
- 263
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Inhibition of nNOS Activity in Rat Brain by Synthetic Kynurenines: Structure−Activity DependenceCamacho, Encarnación / León, Josefa / Carrión, Adoración / Entrena, Antonio / Escames, Germaine / Khaldy, Huda / Acuña-Castroviejo, Darío / Gallo, Miguel A. / Espinosa, Antonio et al. | 2002
- 275
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Antagonistic Effects of Human Cyclic MBP87-99 Altered Peptide Ligands in Experimental Allergic Encephalomyelitis and Human T-Cell ProliferationTselios, Theodore / Apostolopoulos, Vasso / Daliani, Ioanna / Deraos, Spyros / Grdadolnik, Simona / Mavromoustakos, Thomas / Melachrinou, Maria / Thymianou, Sotiria / Probert, Lesley / Mouzaki, Athanasia et al. | 2002
- 284
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Carbonic Anhydrase Activators: High Affinity Isozymes I, II, and IV Activators, Incorporating a b-Alanyl-histidine ScaffoldScozzafava, A. et al. | 2002
- 284
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Carbonic Anhydrase Activators: High Affinity Isozymes I, II, and IV Activators, Incorporating a β-Alanyl-histidine ScaffoldScozzafava, Andrea / Supuran, Claudiu T. et al. | 2002
- 284
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Carbonic Anhydrase Activators: High Affinity Isozymes I, II, and IV Activators, Incorporating a beta-Alanyl-histidine ScaffoldScozzafava, A. / Supuran, C. T. et al. | 2002
- 292
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Structure−Activity Relationships of the Antimalarial Agent Artemisinin. 6. The Development of Predictive In Vitro Potency Models Using CoMFA and HQSAR MethodologiesAvery, Mitchell A. / Alvim-Gaston, Maria / Rodrigues, Carlos R. / Barreiro, Eliezer J. / Cohen, Fred E. / Sabnis, Yogesh A. / Woolfrey, John R. et al. | 2002
- 304
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Graphical Model for Estimating Oral Bioavailability of Drugs in Humans and Other Species from Their Caco-2 Permeability and in Vitro Liver Enzyme Metabolic Stability RatesMandagere, Arun K. / Thompson, Thomas N. / Hwang, Kin-Kai et al. | 2002
- 312
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Carbonic Anhydrase Inhibitors: Anticonvulsant Sulfonamides Incorporating Valproyl and Other Lipophilic MoietiesMasereel, Bernard / Rolin, Stéphanie / Abbate, Francesco / Scozzafava, Andrea / Supuran, Claudiu T. et al. | 2002
- 321
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Synthesis, Structure, and Activity of Diclofenac Analogues as Transthyretin Amyloid Fibril Formation InhibitorsOza, Vibha B. / Smith, Craig / Raman, Prakash / Koepf, Edward K. / Lashuel, Hilal A. / Petrassi, H. Mike / Chiang, Kyle P. / Powers, Evan T. / Sachettinni, James / Kelly, Jeffery W. et al. | 2002
- 333
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Elucidating the Inhibiting Mode of AHPBA Derivatives against HIV-1 Protease and Building Predictive 3D-QSAR ModelsHuang, Xaioqin / Xu, Liaosa / Luo, Xiaomin / Fan, Kangnian / Ji, Ruyun / Pei, Gang / Chen, Kaixian / Jiang, Hualiang et al. | 2002
- 344
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Pyrrolo[1,3]benzothiazepine-Based Atypical Antipsychotic Agents. Synthesis, Structure−Activity Relationship, Molecular Modeling, and Biological StudiesCampiani, Giuseppe / Butini, Stefania / Gemma, Sandra / Nacci, Vito / Fattorusso, Caterina / Catalanotti, Bruno / Giorgi, Gianluca / Cagnotto, Alfredo / Goegan, Mara / Mennini, Tiziana et al. | 2002
- 360
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Design, Synthesis, and Preliminary Pharmacological Evaluation of N-Acyl-3-aminoglutarimides as Broad-Spectrum Chemokine Inhibitors in Vitro and Anti-inflammatory Agents in VivoFox, David J. / Reckless, Jill / Warren, Stuart G. / Grainger, David J. et al. | 2002
- 371
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b-Strand Mimicking Macrocyclic Amino Acids: Templates for Protease Inhibitors with Antiviral ActivityGlenn, M.P. et al. | 2002
- 371
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beta-Strand Mimicking Macrocyclic Amino Acids: Templates for Protease Inhibitors with Antiviral ActivityGlenn, M. P. / Pattenden, L. K. / Reid, R. C. / Tyssen, D. P. / Tyndall, J. D. A. / Birch, C. J. / Fairlie, D. P. et al. | 2002
- 371
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β-Strand Mimicking Macrocyclic Amino Acids: Templates for Protease Inhibitors with Antiviral ActivityGlenn, Matthew P. / Pattenden, Leonard K. / Reid, Robert C. / Tyssen, David P. / Tyndall, Joel D. A. / Birch, Christopher J. / Fairlie, David P. et al. | 2002
- 382
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2-Amino-3-aroyl-4,5-alkylthiophenes: Agonist Allosteric Enhancers at Human A1 Adenosine ReceptorsTranberg, C. Elisabet / Zickgraf, Andrea / Giunta, Brian N. / Luetjens, Henning / Figler, Heidi / Murphree, Lauren J. / Falke, Ruediger / Fleischer, Holger / Linden, Joel / Scammells, Peter J. et al. | 2002
- 390
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C-7 Analogues of Progesterone as Potent Inhibitors of the P-Glycoprotein Efflux PumpLeonessa, Fabio / Kim, Ji-Hyun / Ghiorghis, Alem / Kulawiec, Robert J. / Hammer, Charles / Talebian, Abdelhossein / Clarke, Robert et al. | 2002
- 399
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New Approach to Pharmacophore Mapping and QSAR Analysis Using Inductive Logic Programming. Application to Thermolysin Inhibitors and Glycogen Phosphorylase b InhibitorsMarchand-Geneste, Nathalie / Watson, Kimberly A. / Alsberg, Bjørn K. / King, Ross D. et al. | 2002
- 410
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Synthesis, Biological Evaluation, and Quantitative Structure−Activity Relationship Analysis of New Schiff Bases of Hydroxysemicarbazide as Potential Antitumor Agents †Ren, Shijun / Wang, Rubin / Komatsu, Kenichi / Bonaz-Krause, Patricia / Zyrianov, Yegor / McKenna, Charles E. / Csipke, Csaba / Tokes, Zoltan A. / Lien, Eric J. et al. | 2002
- 420
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2,5‘-Disubstituted Adenosine Derivatives: Evaluation of Selectivity and Efficacy for the Adenosine A1, A2A, and A3 Receptorvan Tilburg, Erica W. / von Frijtag Drabbe Künzel, Jacobien / de Groote, Miriam / IJzerman, Ad P. et al. | 2002
- 430
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A New Type of Mixed Anhydride and Its Applications to the Synthesis of 7-Substituted 8-Chloro-5,5-dioxoimidazo[1,2-b][1,4,2]benzodithiazines with in Vitro Antitumor ActivityBrzozowski, Zdzisław / Sa̧czewski, Franciszek et al. | 2002
- 438
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Novel Spiropiperidines as Highly Potent and Subtype Selective sigma-Receptor Ligands. Part 1Maier, C. A. / Wunsch, B. et al. | 2002
- 438
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Novel Spiropiperidines as Highly Potent and Subtype Selective s-Receptor Ligands. Part 1Maier, C.A. et al. | 2002
- 438
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Novel Spiropiperidines as Highly Potent and Subtype Selective σ-Receptor Ligands. Part 1Maier, Christoph A. / Wünsch, Bernhard et al. | 2002
- 449
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Water-Soluble, Core-Modified Porphyrins as Novel, Longer-Wavelength-Absorbing Sensitizers for Photodynamic Therapy. II. Effects of Core Heteroatoms and Meso-Substituents on Biological ActivityHilmey, David G. / Abe, Masako / Nelen, Marina I. / Stilts, Corey E. / Baker, Gary A. / Baker, Sheila N. / Bright, Frank V. / Davies, Sherry R. / Gollnick, Sandra O. / Oseroff, Allan R. et al. | 2002
- 462
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Synthesis and Characterization of a Series of Novel Monoacylated Ascorbic Acid Derivatives, 6-O-Acyl-2-O-a-d-glucopyranosyl-l-ascorbic Acids, as Skin AntioxidantsYamamoto, I. et al. | 2002
- 462
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Synthesis and Characterization of a Series of Novel Monoacylated Ascorbic Acid Derivatives, 6-O-Acyl-2-O-α-d-glucopyranosyl-l-ascorbic Acids, as Skin AntioxidantsYamamoto, Itaru / Tai, Akihiro / Fujinami, Yoshihito / Sasaki, Kenji / Okazaki, Shino et al. | 2002
- 462
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Synthesis and Characterization of a Series of Novel Monoacylated Ascorbic Acid Derivatives, 6-O-Acyl-2-O-alpha-D-glucopyranosyl-L-ascorbic Acids, as Skin AntioxidantsYamamoto, I. / Tai, A. / Fujinami, Y. / Sasaki, K. / Okazaki, S. et al. | 2002
- 469
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Radiolabeling and In Vivo Behavior of Copper-64-Labeled Cross-Bridged Cyclam LigandsSun, Xiankai / Wuest, Melinda / Weisman, Gary R. / Wong, Edward H. / Reed, David P. / Boswell, C. Andrew / Motekaitis, Ramunas / Martell, Arthur E. / Welch, Michael J. / Anderson, Carolyn J. et al. | 2002
- 478
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Structure-Activity Profiles of Complex Biantennary Glycans with Core Fucosylation and with/without Additional alpha2,3/alpha2,6 Sialylation: Synthesis of Neoglycoproteins and Their Properties in Lectin Assays, Cell Binding, and Organ UptakeUnverzagt, C. / Andre, S. / Seifert, J. / Kojima, S. / Fink, C. / Srikrishna, G. / Freeze, H. / Kayser, K. / Gabius, H.-J. et al. | 2002
- 478
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Structure-Activity Profiles of Complex Biantennary Glycans with Core Fucosylation and with-without Additional a2,3-a2,6 Sialylation: Synthesis of Neoglycoproteins and Their Properties in Lectin Assays, Cell Binding, and Organ UptakeUnverzagt, C. et al. | 2002
- 478
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Structure−Activity Profiles of Complex Biantennary Glycans with Core Fucosylation and with/without Additional α2,3/α2,6 Sialylation: Synthesis of Neoglycoproteins and Their Properties in Lectin Assays, Cell Binding, and Organ Uptake †Unverzagt, Carlo / André, Sabine / Seifert, Joachim / Kojima, Shuji / Fink, Christian / Srikrishna, Geetha / Freeze, Hudson / Kayser, Klaus / Gabius, Hans-Joachim et al. | 2002
- 492
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4-(Phenylsulfonyl)piperidines: Novel, Selective, and Bioavailable 5-HT2A Receptor AntagonistsFletcher, Stephen R. / Burkamp, Frank / Blurton, Peter / Cheng, Susan K. F. / Clarkson, Robert / O'Connor, Desmond / Spinks, Daniel / Tudge, Matthew / van Niel, Monique B. / Patel, Smita et al. | 2002
- 504
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Carbonic Anhydrase Activators: Design of High Affinity Isozymes I, II, and IV Activators, Incorporating Tri-/Tetrasubstituted-pyridinium-azole MoietiesIlies, Monica / Banciu, Mircea D. / Ilies, Marc A. / Scozzafava, Andrea / Caproiu, Miron T. / Supuran, Claudiu T. et al. | 2002
- 511
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Orally-Effective, Long-Acting Sorbitol Dehydrogenase Inhibitors: Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Novel Heterocycle-Substituted Piperazino-PyrimidinesChu-Moyer, Margaret Y. / Ballinger, William E. / Beebe, David A. / Berger, Richard / Coutcher, James B. / Day, Wesley W. / Li, Jiancheng / Mylari, Banavara L. / Oates, Peter J. / Weekly, R. Matthew et al. | 2002
- 529
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Aldisine Alkaloids from the Philippine Sponge Stylissa m assa Are Potent Inhibitors of Mitogen-Activated Protein Kinase Kinase-1 (MEK-1)Tasdemir, Deniz / Mallon, Robert / Greenstein, Michael / Feldberg, Larry R. / Kim, Steven C. / Collins, Karen / Wojciechowicz, Donald / Mangalindan, Gina C. / Concepción, Gisela P. / Harper, Mary Kay et al. | 2002
- 533
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Design, Synthesis, and Pharmacological Evaluation of New Farnesyl Protein Transferase InhibitorsHoussin, Raymond / Pommery, Jean / Salaün, Marie-Catherine / Deweer, Sophie / Goossens, Jean-François / Chavatte, Philippe / Hénichart, Jean-Pierre et al. | 2002
- 537
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4'-Arylpyrrolomorphinans: Effect of a Pyrrolo-N-benzyl Substituent in Enhancing delta-Opioid Antagonist ActivitySrivastava, S. K. / Husbands, S. M. / Aceto, M. D. / Miller, C. N. / Traynor, J. R. / Lewis, J. W. et al. | 2002
- 537
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4'-Arylpyrrolomorphinans: Effect of a Pyrrolo-N-benzyl Substituent in Enhancing d-Opioid Antagonist ActivitySrivastava, S.K. et al. | 2002
- 537
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4‘-Arylpyrrolomorphinans: Effect of a Pyrrolo-N-benzyl Substituent in Enhancing δ-Opioid Antagonist ActivitySrivastava, Sanjay K. / Husbands, Stephen M. / Aceto, Mario D. / Miller, Carl N. / Traynor, John R. / Lewis, John W. et al. | 2002
- 541
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Designing Non-Peptide Peptidomimetics in the 21st Century: Inhibitors Targeting Conformational EnsemblesBursavich, Matthew G. / Rich, Daniel H. et al. | 2002
- 559
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Design, Synthesis and Activity of Ascorbic Acid Prodrugs of Nipecotic, Kynurenic and Diclophenamic Acids, Liable to Increase Neurotropic ActivityManfredini, Stefano / Pavan, Barbara / Vertuani, Silvia / Scaglianti, Martina / Compagnone, Donatello / Biondi, Carla / Scatturin, Angelo / Tanganelli, Sergio / Ferraro, Luca / Prasad, Puttur et al. | 2002
- 563
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Discovery of a 3-Amino-6-phenyl-pyridazine Derivative as a New Synthetic Antineuroinflammatory CompoundMirzoeva, Salida / Sawkar, Anu / Zasadzki, Magdalena / Guo, Ling / Velentza, Anastasia V. / Dunlap, Vincent / Bourguignon, Jean-Jacques / Ramstrom, Helena / Haiech, Jacques / Van Eldik, Linda J. et al. | 2002
- 567
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Synthesis and Evaluation of Potent and Selective beta~3 Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid IsosteresUehling, D. E. / Donaldson, K. H. / Deaton, D. N. / Hyman, C. E. / Sugg, E. E. / Barrett, D. G. / Hughes, R. G. / Reitter, B. / Adkison, K. K. / Lancaster, M. E. et al. | 2002
- 567
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Synthesis and Evaluation of Potent and Selective b3 Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid IsosteresUehling, D.E. et al. | 2002
- 567
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Synthesis and Evaluation of Potent and Selective β3 Adrenergic Receptor Agonists Containing Acylsulfonamide, Sulfonylsulfonamide, and Sulfonylurea Carboxylic Acid Isosteres †Uehling, David E. / Donaldson, Kelly H. / Deaton, David N. / Hyman, Clifton E. / Sugg, Elizabeth E. / Barrett, David G. / Hughes, Robert G. / Reitter, Barbara / Adkison, Kim K. / Lancaster, Mary E. et al. | 2002
- 584
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Identification of a Second Binding Site in the Estrogen Receptorvan Hoorn, Willem P. et al. | 2002
- 590
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Antitumor Polycyclic Acridines. 8.1 Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium SaltsHeald, R.A. et al. | 2002
- 590
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Antitumor Polycyclic Acridines. 8. Synthesis and Telomerase-Inhibitory Activity of Methylated Pentacyclic Acridinium SaltsHeald, Robert A. / Modi, Chetna / Cookson, Jenny C. / Hutchinson, Ian / Laughton, Charles A. / Gowan, Sharon M. / Kelland, Lloyd R. / Stevens, Malcolm F. G. et al. | 2002
- 598
-
Synthesis and Biological Activity of a Novel Class of Small Molecular Weight Peptidomimetic Competitive Inhibitors of Protein Tyrosine Phosphatase 1BLarsen, Scott D. / Barf, Tjeerd / Liljebris, Charlotta / May, Paul D. / Ogg, Derek / O'Sullivan, Theresa J. / Palazuk, Barbara J. / Schostarez, Heinrich J. / Stevens, F. Craig / Bleasdale, John E. et al. | 2002
- 623
-
Synthesis and Preliminary Characterization of a Novel Antiarrhythmic Compound (KB130015) with an Improved Toxicity Profile Compared with AmiodaroneCarlsson, Bo / Singh, B. N. / Temciuc, Marcel / Nilsson, Stefan / Li, Yi-Lin / Mellin, Charlotta / Malm, Johan et al. | 2002
- 631
-
Design, Synthesis, and Evaluation of Novel 2-Substituted 3-Hydroxypyridin-4-ones: Structure−Activity Investigation of Metalloenzyme Inhibition by Iron Chelators §Liu, Zu D. / Kayyali, Reem / Hider, Robert C. / Porter, John B. / Theobald, Anthony E. et al. | 2002
- 640
-
Synthesis and Optimization of a New Family of Type 3 17β-Hydroxysteroid Dehydrogenase Inhibitors by Parallel Liquid-Phase ChemistryMaltais, René / Luu-The, Van / Poirier, Donald et al. | 2002
- 640
-
Synthesis and Optimization of a New Family of Type 3 17beta-Hydroxysteroid Dehydrogenase Inhibitors by Parallel Liquid-Phase ChemistryMaltais, R. / Luu-The, V. / Poirier, D. et al. | 2002
- 640
-
Synthesis and Optimization of a New Family of Type 3 17b-Hydroxysteroid Dehydrogenase Inhibitors by Parallel Liquid-Phase ChemistryMaltais, R. et al. | 2002
- 654
-
Expansion of Structure−Activity Studies of Piperidine Analogues of 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) Compounds by Altering Substitutions in the N-Benzyl Moiety and Behavioral Pharmacology of Selected MoleculesDutta, Aloke K. / Davis, Matthew C. / Fei, Xiang-Shu / Beardsley, Patrick M. / Cook, Charles D. / Reith, Maarten. E. A. et al. | 2002
- 663
-
Correlation of the Antibacterial Activities of Cationic Peptide Antibiotics and Cationic Steroid AntibioticsDing, Bangwei / Guan, Qunying / Walsh, Joshua P. / Boswell, J. Scott / Winter, Tim W. / Winter, Erica S. / Boyd, Stephanie S. / Li, Chunhong / Savage, Paul B. et al. | 2002
- 663
-
Correlation of the Antibacterial Activities of Cationic Peptide Antibiotics and Cationic Steroid Antibiotics1Ding, B. et al. | 2002
- 670
-
Design and Synthesis of Motilin Antagonists Derived from the [1−4] Fragment of Porcine MotilinHaramura, Masayuki / Okamachi, Akira / Tsuzuki, Kouichi / Yogo, Kenji / Ikuta, Makoto / Kozono, Toshiro / Takanashi, Hisanori / Murayama, Eigoro et al. | 2002
- 676
-
Identification of Potent and Selective Mechanism-Based Inhibitors of the Cysteine Protease Cruzain Using Solid-Phase Parallel SynthesisHuang, Lily / Lee, Alice / Ellman, Jonathan A. et al. | 2002
- 685
-
Synthesis of 1-(3,4-Dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and Derivatives as Potent and Long-Acting Peripheral Inhibitors of Catechol-O-methyltransferaseLearmonth, David A. / Vieira-Coelho, Maria A. / Benes, Jan / Alves, Paula C. / Borges, Nuno / Freitas, Ana P. / Soares-da-Silva, Patrício et al. | 2002
- 696
-
2,6-Di(ω-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: Novel, Potent, Cytotoxic, and DNA-Binding AgentsAntonini, Ippolito / Polucci, Paolo / Magnano, Amelia / Gatto, Barbara / Palumbo, Manlio / Menta, Ernesto / Pescalli, Nicoletta / Martelli, Sante et al. | 2002
- 696
-
2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo-[3,4,5-mn]pyrimi do[5,6,1-de]acridine-5,7-diones: Novel, Potent, Cytotoxic, and DNA-Binding AgentsAntonini, I. / Polucci, P. / Magnano, A. / Gatto, B. / Palumbo, M. / Menta, E. / Pescalli, N. / Martelli, S. et al. | 2002
- 696
-
2,6-Di(w-aminoalkyl)-2,5,6,7-tetrahydropyrazolo(3,4,5-mn)pyrimido(5- ,6,1-de)acridine-5,7-diones: Novel, Potent, Cytotoxic, and DNA-Binding AgentsAntonini, I. et al. | 2002
- 703
-
Novel Mycophenolic Adenine Bis(phosphonate) Analogues As Potential Differentiation Agents against Human LeukemiaPankiewicz, Krzysztof W. / Lesiak-Watanabe, Krystyna B. / Watanabe, Kyoichi A. / Patterson, Steven E. / Jayaram, Hiremagalur N. / Yalowitz, Joel A. / Miller, Michael D. / Seidman, Michael / Majumdar, Alokes / Prehna, Gerd et al. | 2002
- 703
-
Novel Mycophenolic Adenine Bis(phosphonate) Analogues As Potential Differentiation Agents against Human Leukemia1Pankiewicz, K.W. et al. | 2002
- 713
-
Evaluation of the Dmt-Tic Pharmacophore: Conversion of a Potent d-Opioid Receptor Antagonist into a Potent d Agonist and Ligands with Mixed PropertiesBalboni, G. et al. | 2002
- 713
-
Evaluation of the Dmt−Tic Pharmacophore: Conversion of a Potent δ-Opioid Receptor Antagonist into a Potent δ Agonist and Ligands with Mixed PropertiesBalboni, Gianfranco / Guerrini, Remo / Salvadori, Severo / Bianchi, Clementina / Rizzi, Daniela / Bryant, Sharon D. / Lazarus, Lawrence H. et al. | 2002
- 713
-
Evaluation of the Dmt-Tic Pharmacophore: Conversion of a Potent delta-Opioid Receptor Antagonist into a Potent delta Agonist and Ligands with Mixed PropertiesBalboni, G. / Guerrini, R. / Salvadori, S. / Bianchi, C. / Rizzi, D. / Bryant, S. D. / Lazarus, L. H. et al. | 2002
- 721
-
Novel Angular Benzophenazines: Dual Topoisomerase I and Topoisomerase II Inhibitors as Potential Anticancer AgentsVicker, Nigel / Burgess, Luke / Chuckowree, Irina S. / Dodd, Rory / Folkes, Adrian J. / Hardick, David J. / Hancox, Timothy C. / Miller, Warren / Milton, John / Sohal, Sukhjit et al. | 2002
- 740
-
Structure−Activity Relationships for Pyrido-, Imidazo-, Pyrazolo-, Pyrazino-, and Pyrrolophenazinecarboxamides as Topoisomerase-Targeted Anticancer AgentsGamage, Swarna A. / Spicer, Julie A. / Rewcastle, Gordon W. / Milton, John / Sohal, Sukhjit / Dangerfield, Wendy / Mistry, Prakash / Vicker, Nigel / Charlton, Peter A. / Denny, William A. et al. | 2002
- 744
-
Antitumor Benzothiazoles. 16.1 Synthesis and Pharmaceutical Properties of Antitumor 2-(4-Aminophenyl)benzothiazole Amino Acid ProdrugsHutchinson, I. et al. | 2002
- 744
-
Antitumor Benzothiazoles. 16. Synthesis and Pharmaceutical Properties of Antitumor 2-(4-Aminophenyl)benzothiazole Amino Acid ProdrugsHutchinson, Ian / Jennings, Sharon A. / Vishnuvajjala, B. Rao / Westwell, Andrew D. / Stevens, Malcolm F. G. et al. | 2002
- 748
-
New Neplanocin Analogues. 12. Alternative Synthesis and Antimalarial Effect of (6‘R)-6‘-C-Methylneplanocin A, a Potent AdoHcy Hydrolase InhibitorShuto, Satoshi / Minakawa, Noriaki / Niizuma, Satoshi / Kim, Hye-Sook / Wataya, Yusuke / Matsuda, Akira et al. | 2002
- 748
-
New Neplanocin Analogues. 12. Alternative Synthesis and Antimalarial Effect of (6'R)-6'-C-Methylneplanocin A, a Potent AdoHcy Hydrolase Inhibitor1Shuto, S. et al. | 2002
- 752
-
Synthesis and Comparative Molecular Field Analysis (CoMFA) of Symmetric and Nonsymmetric Cyclic Sulfamide HIV-1 Protease Inhibitors.Schaal, Wesley / Karlsson, Anna / Ahlsén, Göran / Lindberg, Jimmy / Andersson, Hans O. / Danielson, U. Helena / Classon, Björn / Unge, Torsten / Samuelsson, Bertil / Hultén, Johan et al. | 2002
- 753
-
Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme and Cellular Activity of Straight Chain HydroxamatesRemiszewski, Stacy W. / Sambucetti, Lidia C. / Atadja, Peter / Bair, Kenneth W. / Cornell, Wendy D. / Green, Michael A. / Howell, Kobporn Lulu / Jung, Manfred / Kwon, Paul / Trogani, Nancy et al. | 2002
- 758
-
DNA Cleavage Potency, Cytotoxicity, and Mechanism of Action of a Novel Class of Enediyne ProdrugsDai, Wei-Min / Lai, Kwong Wah / Wu, Anxin / Hamaguchi, Wataru / Lee, Mavis Yuk Ha / Zhou, Ling / Ishii, Atsushi / Nishimoto, Sei-ichi et al. | 2002
- 762
-
Environmental Mimic of Receptor Interaction: Conformational Analysis of CCK-15 in SolutionAlbrizio, Stefania / Carotenuto, Alfonso / Fattorusso, Caterina / Moroder, Luis / Picone, Delia / Temussi, Piero A. / D'Ursi, Annamaria et al. | 2002
- 770
-
Synthesis, Biological Activity, and Molecular Modeling Investigation of New Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Human A3 Adenosine Receptor AntagonistsBaraldi, Pier Giovanni / Cacciari, Barbara / Moro, Stefano / Spalluto, Giampiero / Pastorin, Giorgia / Da Ros, Tatiana / Klotz, Karl-Norbert / Varani, Katia / Gessi, Stefania / Borea, Pier Andrea et al. | 2002
- 781
-
A Three-Dimensional Quantitative Structure−Activity Relationship Study of Heparin-Binding Epidermal Growth Factor Shedding Inhibitors Using Comparative Molecular Field AnalysisBursi, Roberta / Sawa, Masaaki / Hiramatsu, Yasuyuki / Kondo, Hirosato et al. | 2002
- 789
-
Novel Tricyclic-a-alkyloxyphenylpropionic Acids: Dual PPARa-g Agonists with Hypolipidemic and Antidiabetic ActivitySauerberg, P. et al. | 2002
- 789
-
Novel Tricyclic-α-alkyloxyphenylpropionic Acids: Dual PPARα/γ Agonists with Hypolipidemic and Antidiabetic ActivitySauerberg, Per / Pettersson, Ingrid / Jeppesen, Lone / Bury, Paul S. / Mogensen, John P. / Wassermann, Karsten / Brand, Christian L. / Sturis, Jeppe / Wöldike, Helle F. / Fleckner, Jan et al. | 2002
- 789
-
Novel Tricyclic-alpha-alkyloxyphenylpropionic Acids: Dual PPARalpha/gamma Agonists with Hypolipidemic and Antidiabetic ActivitySauerberg, P. / Pettersson, I. / Jeppesen, L. / Bury, P. S. / Mogensen, J. P. / Wassermann, K. / Brand, C. L. / Sturis, J. / Woldike, H. F. / Fleckner, J. et al. | 2002
- 805
-
Minor Groove DNA Binders as Antimicrobial Agents. 1. Pyrrole Tetraamides Are Potent Antibacterials against Vancomycin Resistant Enteroccoci and Methicillin Resistant Staphylococcus aureusDyatkina, Natalia B. / Roberts, Christopher D. / Keicher, Jesse D. / Dai, Yuqin / Nadherny, Joshua P. / Zhang, Wentao / Schmitz, Uli / Kongpachith, Ana / Fung, Kevin / Novikov, Alexander A. et al. | 2002
- 818
-
Mining the National Cancer Institute's Tumor-Screening Database: Identification of Compounds with Similar Cellular ActivitiesRabow, Alfred A. / Shoemaker, Robert H. / Sausville, Edward A. / Covell, David G. et al. | 2002
- 841
-
CoMFA and CoMSIA 3D QSAR and Docking Studies on Conformationally-Restrained Cinnamoyl HIV-1 Integrase Inhibitors: Exploration of a Binding Mode at the Active SiteBuolamwini, John K. / Assefa, Haregewein et al. | 2002
- 853
-
Structural Basis of RasGRP Binding to High-Affinity PKC LigandsRong, Suo-Bao / Enyedy, Istvan J. / Qiao, Lixin / Zhao, Lianyun / Ma, Dawei / Pearce, Larry L. / Lorenzo, Patricia S. / Stone, James C. / Blumberg, Peter M. / Wang, Shaomeng et al. | 2002
- 861
-
DNA Cross-Linking by Azinomycin B: Monte Carlo Simulations in the Evaluation of Sequence SelectivityAlcaro, Stefano / Ortuso, Francesco / Coleman, Robert S. et al. | 2002
- 871
-
A 3·(ET743)-DNA Complex That Both Resembles an RNA-DNA Hybrid and Mimicks Zinc Finger-Induced DNA Structural DistortionsMarco, Esther / García-Nieto, Raquel / Mendieta, Jesús / Manzanares, Ignacio / Cuevas, Carmen / Gago, Federico et al. | 2002
- 881
-
Designing Analogues of Mini Atrial Natriuretic Peptide Based on Structural Analysis by NMR and Restrained Molecular DynamicsSugase, Kenji / Oyama, Yoshiaki / Kitano, Katsuhiko / Iwashita, Takashi / Fujiwara, Toshimichi / Akutsu, Hideo / Ishiguro, Masaji et al. | 2002
- 888
-
Structural Aspects of Isozyme Selectivity in the Binding of Inhibitors to Carbonic Anhydrases II and IVKim, Chu-Young / Whittington, Douglas A. / Chang, Jeanne S. / Liao, John / May, Jesse A. / Christianson, David W. et al. | 2002
- 894
-
Kinetic Studies of the Binding of Acridinecarboxamide Topoisomerase Poisons to DNA: Implications for Mode of Binding of Ligands with Uncharged ChromophoresWakelin, Laurence P. G. / Adams, Adrienne / Denny, William A. et al. | 2002
- 902
-
Pyridophens: Binary Pyridostigmine−Aprophen Prodrugs with Differential Inhibition of Acetylcholinesterase, Butyrylcholinesterase, and Muscarinic ReceptorsLeader, Haim / Wolfe, Alan David / Chiang, Peter K. / Gordon, Richard K. et al. | 2002
- 911
-
Cysteine Derivatives as Inhibitors for Carboxypeptidase A: Synthesis and Structure−Activity RelationshipsPark, Jung Dae / Kim, Dong H. et al. | 2002
- 919
-
New Type of Metalloproteinase Inhibitor: Design and Synthesis of New Phosphonamide-Based Hydroxamic AcidsSawa, Masaaki / Kiyoi, Takao / Kurokawa, Kiriko / Kumihara, Hiroshi / Yamamoto, Minoru / Miyasaka, Tomohiro / Ito, Yasuko / Hirayama, Ryoichi / Inoue, Tomomi / Kirii, Yasuyuki et al. | 2002
- 930
-
New Strategy for Antedrug Application: Development of Metalloproteinase Inhibitors as Antipsoriatic DrugsSawa, Masaaki / Tsukamoto, Takako / Kiyoi, Takao / Kurokawa, Kiriko / Nakajima, Fumio / Nakada, Yuichiro / Yokota, Koichi / Inoue, Yoshimasa / Kondo, Hirosato / Yoshino, Kohichiro et al. | 2002
- 937
-
Synthesis and Biological Activity of the Prodrug of Class I Major Histocompatibility Peptide GILGFVFTL Activated by β-GlucuronidaseRawale, Sharad / Hrihorczuk, Lew M. / Wei / Zemlicka, Jiri et al. | 2002
- 937
-
Synthesis and Biological Activity of the Prodrug of Class I Major Histocompatibility Peptide GILGFVFTL Activated by b-Glucuronidase1Rawale, S. et al. | 2002
- 937
-
Synthesis and Biological Activity of the Prodrug of Class I Major Histocompatibility Peptide GILGFVFTL Activated by beta-GlucuronidaseRawale, S. / Hrihorczuk, L. M. / Wei, W.-Z. / Zemlicka, J. et al. | 2002
- 944
-
N-Aryl N‘-Hydroxyguanidines, A New Class of NO-Donors after Selective Oxidation by Nitric Oxide Synthases: Structure−Activity RelationshipRenodon-Cornière, Axelle / Dijols, Sylvie / Perollier, Céline / Lefevre-Groboillot, David / Boucher, Jean-Luc / Attias, Roger / Sari, Marie-Agnes / Stuehr, Dennis / Mansuy, Daniel et al. | 2002
- 955
-
Syntheses, Calcium Channel Agonist−Antagonist Modulation Activities, Nitric Oxide Release, and Voltage-Clamp Studies of 2-Nitrooxyethyl 1,4-Dihydro- 2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate EnantiomersShan, Rudong / Howlett, Susan E. / Knaus, Edward E. et al. | 2002
- 962
-
Novel Antagonists Acting at the P2Y1 Purinergic Receptor: Synthesis and Conformational Analysis Using Potentiometric and Nuclear Magnetic Resonance Titration TechniquesRaboisson, Pierre / Baurand, Anthony / Cazenave, Jean-Pierre / Gachet, Christian / Retat, Myriam / Spiess, Bernard / Bourguignon, Jean-Jacques et al. | 2002
- 973
-
Computational Studies on Tetrahydropyrimidine-2-one HIV-1 Protease Inhibitors: Improving Three-Dimensional Quantitative Structure−Activity Relationship Comparative Molecular Field Analysis Models by Inclusion of Calculated Inhibitor- and Receptor-Based PropertiesNair, Anil C. / Jayatilleke, Philippa / Wang, Xia / Miertus, Stanislav / Welsh, William J. et al. | 2002
- 984
-
Cyclohexylmethylpiperidinyltriphenylpropioamide: A Selective Muscarinic M3 Antagonist Discriminating against the Other Receptor SubtypesSagara, Yufu / Sagara, Takeshi / Mase, Toshiaki / Kimura, Toshifumi / Numazawa, Tomoshige / Fujikawa, Toru / Noguchi, Kazuhito / Ohtake, Norikazu et al. | 2002
- 988
-
Selective Antagonists at Group I Metabotropic Glutamate Receptors: Synthesis and Molecular Pharmacology of 4-Aryl-3-isoxazolol Amino AcidsKromann, Hasse / Sløk, Frank A. / Stensbøl, Tine B. / Bräuner-Osborne, Hans / Madsen, Ulf / Krogsgaard-Larsen, Povl et al. | 2002
- 992
-
The Sigma-RBI Handbook of Receptor Classification and Signal Transduction. Fourth Edition Edited by Keith J. Watling. Sigma-RBI, Natick, MA. 2001. viii + 231 pp. 28 x 23 cm. ISBN 0-9640548-3-3. 55.00.Cannon, J.G. et al. | 2002
- 992
-
Medicinal Chemistry into the Millennium Edited by M. M. Campbell and I. S. Blagbrough. The Royal Society of Chemistry, Cambridge, U.K. 2001. x + 398 pp. 16 × 24 cm. ISBN 0-854-04-769-7. £69.50.Wolff, Manfred E. et al. | 2002
- 992
-
Medicinal Chemistry into the Millennium Edited by M. M. Campbell and I. S. Blagbrough. The Royal Society of Chemistry, Cambridge, U.K. 2001. x + 398 pp. 16 x 24 cm. ISBN 0-854-04-769-7. (GBP)69.50.Wolff, M.E. et al. | 2002
- 992
-
The Sigma-RBI Handbook of Receptor Classification and Signal Transduction. Fourth Edition Edited by Keith J. Watling. Sigma-RBI, Natick, MA. 2001. viii + 231 pp. 28 × 23 cm. ISBN 0-9640548-3-3. $55.00.Cannon, Joseph G. et al. | 2002
- 993
-
Advances in Chromatography. Volume 41 Edited by Phyllis R. Brown and Eli Grushka. Marcel Dekker, New York. 2001. xx + 425 pp. 15 × 23 cm. ISBN 0-8247-0509-2. $195.00.Born, Jerry L. et al. | 2002
- 993
-
The Handbook of Nucleoside Synthesis By Helmut Vorbrüggen and Carmen Ruh-Pohlenz. John Wiley & Sons, New York. 2001. xii + 631 pp. 15.5 x 23 cm. ISBN 0-471-09383-1 (paper). 79.95.Bergstrom, D.E. et al. | 2002
- 993
-
The Handbook of Nucleoside Synthesis By Helmut Vorbrüggen and Carmen Ruh-Pohlenz. John Wiley & Sons, New York. 2001. xii + 631 pp. 15.5 × 23 cm. ISBN 0-471-09383-1 (paper). $79.95.Bergstrom, Donald E. et al. | 2002
- 993
-
Quantitative Chromatographic Analysis. Volume 85 By Thomas Beesley, Benjamin Buglio, and P. W. Scott. Marcel Dekker, New York, 2001. xx + 378 pp. 15 x 23 cm. ISBN 0-8247-0503-3. 150.00.Born, J.L. et al. | 2002
- 993
-
Quantitative Chromatographic Analysis. Volume 85 By Thomas Beesley, Benjamin Buglio, and P. W. Scott. Marcel Dekker, New York, 2001. xx + 378 pp. 15 × 23 cm. ISBN 0-8247-0503-3. $150.00.Born, Jerry L. et al. | 2002
- 993
-
Advances in Chromatography. Volume 41 Edited by Phyllis R. Brown and Eli Grushka. Marcel Dekker, New York. 2001. xx + 425 pp. 15 x 23 cm. ISBN 0-8247-0509-2. 195.00.Born, J.L. et al. | 2002
- 995
-
Rhodacyanine Dyes as Antimalarials. 1. Preliminary Evaluation of Their Activity and ToxicityTakasu, Kiyosei / Inoue, Hiroshi / Kim, Hye-Sook / Suzuki, Makoto / Shishido, Tadao / Wataya, Yusuke / Ihara, Masataka et al. | 2002
- 999
-
Identification of Novel Inhibitors of the Transforming Growth Factor beta1 (TGF-beta1) Type 1 Receptor (ALK5)Callahan, J. F. / Burgess, J. L. / Fornwald, J. A. / Gaster, L. M. / Harling, J. D. / Harrington, F. P. / Heer, J. / Kwon, C. / Lehr, R. / Mathur, A. et al. | 2002
- 999
-
Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)Callahan, James F. / Burgess, Joelle L. / Fornwald, James A. / Gaster, Laramie M. / Harling, John D. / Harrington, Frank P. / Heer, Jag / Kwon, Chet / Lehr, Ruth / Mathur, A. et al. | 2002
- 999
-
Identification of Novel Inhibitors of the Transforming Growth Factor b1 (TGF-b1) Type 1 Receptor (ALK5)Callahan, J.F. et al. | 2002
- 1002
-
Bis(1H-2-indolyl)methanones as a Novel Class of Inhibitors of the Platelet-Derived Growth Factor Receptor KinaseMahboobi, Siavosh / Teller, Steffen / Pongratz, Herwig / Hufsky, Harald / Sellmer, Andreas / Botzki, Alexander / Uecker, Andrea / Beckers, Thomas / Baasner, Silke / Schächtele, Christoph et al. | 2002
- 1019
-
Solution Structure of a Putative HIV1 Immunogenic Peptide: Computer Simulation of the Principal CD4 Binding Domain of gp120Mihailescu, Dan / Smith, Jeremy C. / Reed, Jennifer et al. | 2002
- 1026
-
Secondary Structure of the Third Extracellular Loop Responsible for Ligand Selectivity of a Mammalian Gonadotropin-Releasing Hormone ReceptorPetry, Renate / Craik, David / Haaima, Gerald / Fromme, Bernhard / Klump, Horst / Kiefer, Wolfgang / Palm, Dieter / Millar, Robert et al. | 2002
- 1035
-
Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5-c]quinazoline-2-carboxylates as Novel Excitatory Amino Acid AntagonistsVarano, Flavia / Catarzi, Daniela / Colotta, Vittoria / Filacchioni, Guido / Galli, Alessandro / Costagli, Chiara / Carlà, Vincenzo et al. | 2002
- 1045
-
Nanomolar Small Molecule Inhibitors for avb6, avb5, and avb3 IntegrinsGoodman, S.L. et al. | 2002
- 1045
-
Nanomolar Small Molecule Inhibitors for αvβ6, αvβ5, and αvβ3 IntegrinsGoodman, Simon L. / Hölzemann, Günter / Sulyok, Gábor A. G. / Kessler, Horst et al. | 2002
- 1045
-
Nanomolar Small Molecule Inhibitors for alphavbeta6, alphavbeta5, and alphavbeta3 IntegrinsGoodman, S. L. / Holzemann, G. / Sulyok, G. A. G. / Kessler, H. et al. | 2002
- 1052
-
Mechanism-Based Design of Parasite-Targeted Artemisinin Derivatives: Synthesis and Antimalarial Activity of New Diamine Containing AnaloguesHindley, Stephen / Ward, Stephen A. / Storr, Richard C. / Searle, Natalie L. / Bray, Patrick G. / Park, B. Kevin / Davies, Jill / O'Neill, Paul M. et al. | 2002
- 1064
-
Synthesis and Nicotinic Binding Studies on Enantiopure Diazine Analogues of the Novel (2-Chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165Gohlke, Holger / Gündisch, Daniela / Schwarz, Simone / Seitz, Gunther / Tilotta, Maria Cristina / Wegge, Thomas et al. | 2002
- 1073
-
Synthesis and Biolocalization of Water-Soluble SapphyrinsKrál, Vladimir / Davis, Julian / Andrievsky, Andrei / Kralová, Jarmila / Synytsya, Alla / Poucková, Pavla / Sessler, Jonathan L. et al. | 2002
- 1079
-
Synthesis and Antitumor Activity of Several New Analogues of Penclomedine and Its MetabolitesTiwari, Anita / Riordan, James M. / Waud, William R. / Struck, Robert F. et al. | 2002
- 1086
-
6-Sulfonylchromenes as Highly Potent KATP-Channel OpenersSalamon, Ekkehart / Mannhold, Raimund / Weber, Horst / Lemoine, Horst / Frank, Walter et al. | 2002
- 1098
-
Feature Selection for Structure−Activity Correlation Using Binary Particle SwarmsAgrafiotis, Dimitris K. / Cedeño, Walter et al. | 2002
- 1108
-
Side-Chain Lactam-Bridge Conformational Constraints Differentiate the Activities of Salmon and Human Calcitonins and Reveal a New Design Concept for Potent Calcitonin AnaloguesTaylor, John W. / Jin, Qian K. / Sbacchi, Massimo / Wang, Lu / Belfiore, Piero / Garnier, Martine / Kazantzis, Athanasios / Kapurniotu, Aphrodite / Zaratin, Paola F. / Scheideler, Mark A. et al. | 2002
- 1122
-
Synthesis, Pharmacokinetics, Efficacy, and Rat Retinal Toxicity of a Novel Mitomycin C-Triamcinolone Acetonide ConjugateMacky, Tamer A. / Oelkers, Carsten / Rix, Uwe / Heredia, Martin L. / Künzel, Eva / Wimberly, Mark / Rohrer, Baerbel / Crosson, Craig E. / Rohr, Jürgen et al. | 2002
- 1128
-
Development of a New Class of Nonimidazole Histamine H3 Receptor Ligands with Combined Inhibitory Histamine N-Methyltransferase ActivityApelt, Joachim / Ligneau, Xavier / Pertz, Heinz H. / Arrang, Jean-Michel / Ganellin, C. Robin / Schwartz, Jean-Charles / Schunack, Walter / Stark, Holger et al. | 2002
- 1142
-
New Stereocontrolled Synthesis and Biological Evaluation of 5-(1‘-Hydroxyalkyl)-3-methylidenetetrahydro-2-furanones as Potential Cytotoxic AgentsJanecki, Tomasz / Błaszczyk, Edyta / Studzian, Kazimierz / Różalski, Marek / Krajewska, Urszula / Janecka, Anna et al. | 2002
- 1146
-
Synthesis and Biological Evaluation of a New Furo[2,3-h]quinolin-2(1H)-oneChilin, Adriana / Marzano, Christine / Guiotto, Adriano / Baccichetti, Francarosa / Carlassare, Francesco / Bordin, Franco et al. | 2002
- 1150
-
Reduction in Glucose Levels in STZ Diabetic Rats by 4-(2,2-Dimethyl-1-oxopropyl)benzoic Acid: A Prodrug Approach for Targeting the Liver.Bebernitz, Gregory R. / Dain, Jeremy G. / Deems, Rhonda O. / Otero, Dario A. / Simpson, W. Ronald / Strohschein, Robert J. et al. | 2002
- 1151
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Serine−Threonine Protein Phosphatase Inhibitors: Development of Potential Therapeutic StrategiesMcCluskey, Adam / Sim, Alistair T. R. / Sakoff, Jennette A. et al. | 2002
- 1176
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6,7-Dihydro-2-benzothiophen-4(5H)-ones: A Novel Class of GABA-A alpha5 Receptor Inverse AgonistsChambers, M. S. / Atack, J. R. / Bromidge, F. A. / Broughton, H. B. / Cook, S. / Dawson, G. R. / Hobbs, S. C. / Maubach, K. A. / Reeve, A. J. / Seabrook, G. R. et al. | 2002
- 1176
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6,7-Dihydro-2-benzothiophen-4(5H)-ones: A Novel Class of GABA-A a5 Receptor Inverse AgonistsChambers, M.S. et al. | 2002
- 1176
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6,7-Dihydro-2-benzothiophen-4(5H)-ones: A Novel Class of GABA-A α5 Receptor Inverse AgonistsChambers, Mark S. / Atack, John R. / Bromidge, Frances A. / Broughton, Howard B. / Cook, Susan / Dawson, Gerard R. / Hobbs, Sarah C. / Maubach, Karen A. / Reeve, Austin J. / Seabrook, Guy R. et al. | 2002
- 1180
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3-(1H-Pyrrol-1-yl)-2-oxazolidinones as Reversible, Highly Potent, and Selective Inhibitors of Monoamine Oxidase Type AMai, Antonello / Artico, Marino / Esposito, Monica / Sbardella, Gianluca / Massa, Silvio / Befani, Olivia / Turini, Paola / Giovannini, Valentina / Mondovì, Bruno et al. | 2002
- 1184
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Synthesis and X-ray Studies of Chiral Allosteric Modifiers of HemoglobinYoussef, Amal Mamdouh / Safo, Martin K. / Danso-Danquah, Richmond / Joshi, Gajanan S. / Kister, Jean / Marden, Michael C. / Abraham, Donald J. et al. | 2002
- 1196
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Ribose-Modified Nucleosides as Ligands for Adenosine Receptors: Synthesis, Conformational Analysis, and Biological Evaluation of 1‘-C-Methyl Adenosine AnaloguesCappellacci, Loredana / Barboni, Grazia / Palmieri, Micaela / Pasqualini, Michela / Grifantini, Mario / Costa, Barbara / Martini, Claudia / Franchetti, Palmarisa et al. | 2002
- 1203
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Synthesis and Biological Evaluation of 2-Substituted 3beta-Tolyltropane Derivatives at Dopamine, Serotonin, and Norepinephrine TransportersXu, L. / Izenwasser, S. / Katz, J. L. / Kopajtic, T. / Klein-Stevens, C. / Zhu, N. / Lomenzo, S. A. / Winfield, L. / Trudell, M. L. et al. | 2002
- 1203
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Synthesis and Biological Evaluation of 2-Substituted 3b-Tolyltropane Derivatives at Dopamine, Serotonin, and Norepinephrine TransportersXu, L. et al. | 2002
- 1203
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Synthesis and Biological Evaluation of 2-Substituted 3β-Tolyltropane Derivatives at Dopamine, Serotonin, and Norepinephrine TransportersXu, Lifen / Izenwasser, Sari / Katz, Jonathan L. / Kopajtic, Theresa / Klein-Stevens, Cheryl / Zhu, Naiju / Lomenzo, Stacey A. / Winfield, Leyte / Trudell, Mark L. et al. | 2002
- 1211
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A Comprehensive Study of the Active Site Residues of DT-Diaphorase: Rational Design of Benzimidazolediones as DT-Diaphorase Substrates †Suleman, Ali / Skibo, Edward B. et al. | 2002
- 1221
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PRO_SELECT: Combining Structure-Based Drug Design and Array-Based Chemistry for Rapid Lead Discovery. 2. The Development of a Series of Highly Potent and Selective Factor Xa InhibitorsLiebeschuetz, John W. / Jones, Stuart D. / Morgan, Phillip J. / Murray, Chris W. / Rimmer, Andrew D. / Roscoe, Jonathan M. E. / Waszkowycz, Bohdan / Welsh, Pauline M. / Wylie, William A. / Young, Stephen C. et al. | 2002
- 1233
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Designing Small, Nonsugar Activators of Antithrombin Using Hydropathic Interaction Analyses †Gunnarsson, Gunnar T. / Desai, Umesh R. et al. | 2002
- 1244
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Development of 2,4-Diaminopyrimidines as Antimalarials Based on Inhibition of the S108N and C59R+S108N Mutants of Dihydrofolate Reductase from Pyrimethamine-Resistant Plasmodium f alciparumTarnchompoo, Bongkoch / Sirichaiwat, Chawanee / Phupong, Worrapong / Intaraudom, Chakapong / Sirawaraporn, Worachart / Kamchonwongpaisan, Sumalee / Vanichtanankul, Jarunee / Thebtaranonth, Yodhathai / Yuthavong, Yongyuth et al. | 2002
- 1253
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Substituted Diphenyl Sulfides as Selective Serotonin Transporter Ligands: Synthesis and In Vitro EvaluationEmond, Patrick / Vercouillie, Johnny / Innis, Robert / Chalon, Sylvie / Mavel, Sylvie / Frangin, Yves / Halldin, Christer / Besnard, Jean-Claude / Guilloteau, Denis et al. | 2002
- 1259
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Substituted Pentacyclic Carbazolones as Novel Muscarinic Allosteric Agents: Synthesis and Structure−Affinity and Cooperativity RelationshipsGharagozloo, Parviz / Lazareno, Sebastian / Miyauchi, Masao / Popham, Angela / Birdsall, Nigel J. M. et al. | 2002
- 1275
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Synthesis of New Covalently Bound κ-Carrageenan−AZT Conjugates with Improved Anti-HIV ActivitiesVlieghe, Patrick / Clerc, Thierry / Pannecouque, Christophe / Witvrouw, Myriam / De Clercq, Erik / Salles, Jean-Pierre / Kraus, Jean-Louis et al. | 2002
- 1275
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Synthesis of New Covalently Bound kappa-Carrageenan-AZT Conjugates with Improved Anti-HIV ActivitiesVlieghe, P. / Clerc, T. / Pannecouque, C. / Witvrouw, M. / De Clercq, E. / Salles, J.-P. / Kraus, J.-L. et al. | 2002
- 1275
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Synthesis of New Covalently Bound k-Carrageenan-AZT Conjugates with Improved Anti-HIV ActivitiesVlieghe, P. et al. | 2002
- 1284
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Carbocyclic Dinucleoside Polyphosphonates: Interaction with HIV Reverse Transcriptase and Antiviral Activity †Khandazhinskaya, Anastasya L. / Shirokova, Elena A. / Skoblov, Yurii S. / Victorova, Lyubov S. / Goryunova, Ludmila Ye. / Beabealashvilli, Robert S. / Pronyaeva, Tatyana R. / Fedyuk, Nina V. / Zolin, Vladimir V. / Pokrovsky, Andrey G. et al. | 2002
- 1292
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First Non-ATP Competitive Glycogen Synthase Kinase 3 β (GSK-3β) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's DiseaseMartinez, Ana / Alonso, Mercedes / Castro, Ana / Pérez, Concepción / Moreno, Francisco J. et al. | 2002
- 1292
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First Non-ATP Competitive Glycogen Synthase Kinase 3 b (GSK-3b) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's DiseaseMartinez, A. et al. | 2002
- 1292
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First Non-ATP Competitive Glycogen Synthase Kinase 3 beta (GSK-3beta) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's DiseaseMartinez, A. / Alonso, M. / Castro, A. / Perez, C. / Moreno, F. J. et al. | 2002
- 1300
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Novel 4-Anilinoquinazolines with C-7 Basic Side Chains: Design and Structure Activity Relationship of a Series of Potent, Orally Active, VEGF Receptor Tyrosine Kinase InhibitorsHennequin, Laurent F. / Stokes, Elaine S. E. / Thomas, Andrew P. / Johnstone, Craig / Plé, Patrick A. / Ogilvie, Donald J. / Dukes, Michael / Wedge, Stephen R. / Kendrew, Jane / Curwen, Jon O. et al. | 2002
- 1313
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Structure−Activity Relationships of 2‘-Fluoro-2‘,3‘-unsaturated d-Nucleosides as Anti-HIV-1 AgentsLee, Kyeong / Choi, Yongseok / Gumina, Giuseppe / Zhou, Wen / Schinazi, Raymond F. / Chu, Chung K. et al. | 2002
- 1321
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Development of Long-Acting Dopamine Transporter Ligands as Potential Cocaine-Abuse Therapeutic Agents: Chiral Hydroxyl-Containing Derivatives of 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazineHsin, Ling-Wei / Dersch, Christina M. / Baumann, Michael H. / Stafford, David / Glowa, John R. / Rothman, Richard B. / Jacobson, Arthur E. / Rice, Kenner C. et al. | 2002
- 1330
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Syntheses and Antiproliferative Activities of New Rebeccamycin Derivatives with the Sugar Unit Linked to Both Indole NitrogensMarminon, Christelle / Anizon, Fabrice / Moreau, Pascale / Léonce, Stéphane / Pierré, Alain / Pfeiffer, Bruno / Renard, Pierre / Prudhomme, Michelle et al. | 2002
- 1340
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Synthesis and Mode of Action of Hydrophobic Derivatives of the Glycopeptide Antibiotic Eremomycin and Des-(N-methyl-d-leucyl)eremomycin against Glycopeptide-Sensitive and -Resistant BacteriaPrintsevskaya, Svetlana S. / Pavlov, Andrey Y. / Olsufyeva, Evgenia N. / Mirchink, Elena P. / Isakova, Elena B. / Reznikova, Marina I. / Goldman, Robert C. / Branstrom, Arthur A. / Baizman, Eugene R. / Longley, Clifford B. et al. | 2002
- 1348
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Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 Based on a 1,3-Disubstituted Propan-2-one SkeletonConnolly, Stephen / Bennion, Colin / Botterell, Sarah / Croshaw, Pamela J. / Hallam, Catherine / Hardy, Kim / Hartopp, Paul / Jackson, Clive G. / King, Sarah J. / Lawrence, Louise et al. | 2002
- 1363
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Stereochemistry at Phosphorus of the Reaction Catalyzed by m yo-Inositol MonophosphataseFauroux, Christine M.-J. / Lee, Michael / Cullis, Paul M. / Douglas, Kenneth T. / Gore, Michael G. / Freeman, Sally et al. | 2002
- 1374
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Synthesis and Notable Antimalarial Activity of Acyclic Peroxides, 1-(Alkyldioxy)-1-(methyldioxy)cyclododecanesHamada, Yoshiaki / Tokuhara, Hidekazu / Masuyama, Araki / Nojima, Masatomo / Kim, Hye-Sook / Ono, Kanako / Ogura, Naoki / Wataya, Yusuke et al. | 2002
- 1379
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Design and Synthesis of a Novel L-Dopa−Entacapone CodrugLeppänen, Jukka / Huuskonen, Juhani / Nevalainen, Tapio / Gynther, Jukka / Taipale, Hannu / Järvinen, Tomi et al. | 2002
- 1383
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Synthesis and Antimycobacterial Activity of 6-Arylpurines: The Requirements for the N-9 Substituent in Active Antimycobacterial PurinesGundersen, Lise-Lotte / Nissen-Meyer, Jon / Spilsberg, Bjørn et al. | 2002
- 1387
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Lipoamino Acid-Based Adjuvant Carrier System: Enhanced Immunogenicity of Group A Streptococcal Peptide EpitopesHorváth, Anikó / Olive, Colleen / Wong, Allan / Clair, Timothy / Yarwood, Penny / Good, Michael / Toth, Istvan et al. | 2002
- 1391
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The Nitro Group in Organic Synthesis By Noboru Ono. Wiley-VCH, New York. 2001. xvi + 372 pp. 16 x 24 cm. ISBN 0-471-31611-3. 130.00.Currie, B.L. et al. | 2002
- 1391
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Combinatorial Library Design and Evaluation Edited by Arup K. Ghose and Vellarkad N. Viswanadhan. Marcel Dekker Inc., New York. 2001. xv + 631 pp. 16 × 23.5 cm. ISBN 0-8247-0487-8. $195.00.Wasley, Jan W. F. et al. | 2002
- 1391
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The Nitro Group in Organic Synthesis By Noboru Ono. Wiley-VCH, New York. 2001. xvi + 372 pp. 16 × 24 cm. ISBN 0-471-31611-3. $130.00.Currie, Bruce L. et al. | 2002
- 1391
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Combinatorial Library Design and Evaluation Edited by Arup K. Ghose and Vellarkad N. Viswanadhan. Marcel Dekker Inc., New York. 2001. xv + 631 pp. 16 x 23.5 cm. ISBN 0-8247-0487-8. 195.00.Wasley, J.W.F. et al. | 2002
- 1391
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Combinatorial Library Design and EvaluationWasley, J. W. F. et al. | 2002
- 1391
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The Nitro Group in Organic SynthesisCurrie, B. L. et al. | 2002
- 1392
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Chiral Intermediates Edited by Cynthia A. Challener. Ashgate Publishing, Burlington, VT. 2001. xxiii + 804 pp. 18 × 25 cm. ISBN 0-5660-8412-0. $295.00.Dussault, Patrick et al. | 2002
- 1392
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Methods in Enzymology. Volume 340. Drug-Nucleic Acid Interactions Edited by Jonathan B. Chaires and Michael J. Waring. Academic Press, New York. 2001. xxxiv + 705 pp. 16 x 23.5 cm. ISBN 0-12-182241-9. 129.95.Walters, D.E. et al. | 2002
- 1392
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Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th EditionPatrick, K. S. et al. | 2002
- 1392
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Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th Edition Edited by J. G. Hardman, L. E. Limbird, and A. G. Gilman. McGraw Hill, New York. 2001. xxvii + 2148 pp. 21 x 26 cm. ISBN 0-07-1354469-7. 125.00.Patrick, K.S. et al. | 2002
- 1392
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Chiral Intermediates Edited by Cynthia A. Challener. Ashgate Publishing, Burlington, VT. 2001. xxiii + 804 pp. 18 x 25 cm. ISBN 0-5660-8412-0. 295.00.Dussault, P. et al. | 2002
- 1392
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Methods in Enzymology. Volume 340. Drug−Nucleic Acid Interactions Edited by Jonathan B. Chaires and Michael J. Waring. Academic Press, New York. 2001. xxxiv + 705 pp. 16 × 23.5 cm. ISBN 0-12-182241-9. $129.95.Walters, D. Eric et al. | 2002
- 1392
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Methods in Enzymology. Volume 340. Drug-Nucleic Acid InteractionsWalters, D. E. et al. | 2002
- 1392
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Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th Edition Edited by J. G. Hardman, L. E. Limbird, and A. G. Gilman. McGraw Hill, New York. 2001. xxvii + 2148 pp. 21 × 26 cm. ISBN 0-07-1354469-7. $125.00.Patrick, Kennerly S. et al. | 2002
- 1392
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Chiral IntermediatesDussault, P. et al. | 2002
- 1394
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Books of Interest| 2002
- 1394
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Book Review| 2002
- 1395
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Design, Synthesis, and Evaluation of Opioid Analogues with Non-Peptidic b-Turn Scaffold: Enkephalin and Endomorphin MimeticsEguchi, M. et al. | 2002
- 1395
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Design, Synthesis, and Evaluation of Opioid Analogues with Non-Peptidic beta-Turn Scaffold: Enkephalin and Endomorphin MimeticsEguchi, M. / Shen, R. Y. W. / Shea, J. P. / Lee, M. S. / Kahn, M. et al. | 2002
- 1395
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Design, Synthesis, and Evaluation of Opioid Analogues with Non-Peptidic β-Turn Scaffold: Enkephalin and Endomorphin MimeticsEguchi, Masakatsu / Shen, Richard Y. W. / Shea, J. Paul / Lee, Min S. / Kahn, Michael et al. | 2002
- 1399
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Toward Selective ERb Agonists for Central Nervous System Disorders: Synthesis and Characterization of Aryl BenzthiophenesSchopfer, U. et al. | 2002
- 1399
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Toward Selective ERβ Agonists for Central Nervous System Disorders: Synthesis and Characterization of Aryl BenzthiophenesSchopfer, Ulrich / Schoeffter, Philippe / Bischoff, Serge F. / Nozulak, Joachim / Feuerbach, Dominik / Floersheim, Philipp et al. | 2002
- 1399
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Toward Selective ERbeta Agonists for Central Nervous System Disorders: Synthesis and Characterization of Aryl BenzthiophenesSchopfer, U. / Schoeffter, P. / Bischoff, S. F. / Nozulak, J. / Feuerbach, D. / Floersheim, P. et al. | 2002
- 1402
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Identification of Novel Cyclooxygenase-2 Selective Inhibitors Using Pharmacophore ModelsPalomer, Albert / Cabré, Francesc / Pascual, Jaume / Campos, Joaquín / Trujillo, María A. / Entrena, Antonio / Gallo, Miguel A. / García, Lluïsa / Mauleón, David / Espinosa, Antonio et al. | 2002
- 1412
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Molecular Dynamics and Free Energy Analyses of Cathepsin D−Inhibitor Interactions: Insight into Structure-Based Ligand DesignHuo, Shuanghong / Wang, Junmei / Cieplak, Piotr / Kollman, Peter A. / Kuntz, Irwin D. et al. | 2002
- 1420
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Studies on the Mechanism of Hypoxic Selectivity in Copper Bis(Thiosemicarbazone) RadiopharmaceuticalsMaurer, Richard I. / Blower, Philip J. / Dilworth, Jonathan R. / Reynolds, Christopher A. / Zheng, Yifan / Mullen, Gregory E. D. et al. | 2002
- 1432
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Hydroxyethylamine Isostere of an HIV-1 Protease Inhibitor Prefers Its Amine to the Hydroxy Group in Binding to Catalytic Aspartates. A Synchrotron Study of HIV-1 Protease in Complex with a Peptidomimetic InhibitorDohnálek, Jan / Hašek, Jindřich / Dušková, Jarmila / Petroková, Hana / Hradilek, Martin / Souček, Milan / Konvalinka, Jan / Brynda, Jiří / Sedláček, Juraj / Fábry, Milan et al. | 2002
- 1439
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Structural Basis for the Glucocorticoid Response in a Mutant Human Androgen Receptor (ARccr) Derived from an Androgen-Independent Prostate CancerMatias, Pedro M. / Carrondo, Maria Arménia / Coelho, Ricardo / Thomaz, Monica / Zhao, Xiao-Yan / Wegg, Anja / Crusius, Kerstin / Egner, Ursula / Donner, Peter et al. | 2002
- 1447
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Molecular Interaction of the Antagonist N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 Cannabinoid ReceptorShim, Joong-Youn / Welsh, William J. / Cartier, Etienne / Edwards, James L. / Howlett, Allyn C. et al. | 2002
- 1460
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Modeling of Binding Modes and Inhibition Mechanism of Some Natural Ligands of Farnesyl Transferase Using Molecular DockingPedretti, Alessandro / Villa, Luigi / Vistoli, Giulio et al. | 2002
- 1466
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Carbonic Anhydrase Inhibitors. A General Approach for the Preparation of Water-Soluble Sulfonamides Incorporating Polyamino−Polycarboxylate Tails and of Their Metal Complexes Possessing Long-Lasting, Topical Intraocular Pressure-Lowering PropertiesScozzafava, Andrea / Menabuoni, Luca / Mincione, Francesco / Supuran, Claudiu T. et al. | 2002
- 1477
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Toward an Optimal Joint Recognition of the S1‘ Subsites of Endothelin Converting Enzyme-1 (ECE-1), Angiotensin Converting Enzyme (ACE), and Neutral Endopeptidase (NEP)Inguimbert, Nicolas / Coric, Pascale / Poras, Hervé / Meudal, Hervé / Teffot, Franck / Fournié-Zaluski, Marie-Claude / Roques, Bernard P. et al. | 2002
- 1487
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Synthesis and Structure−Activity Relationships of 3-Aryloxindoles: A New Class of Calcium-Dependent, Large Conductance Potassium (Maxi-K) Channel Openers with Neuroprotective PropertiesHewawasam, Piyasena / Erway, Matthew / Moon, Sandra L. / Knipe, Jay / Weiner, Harvey / Boissard, Christopher G. / Post-Munson, Debra J. / Gao, Qi / Huang, Stella / Gribkoff, Valentin K. et al. | 2002